Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS)NCT06994039
Left Lateral Position and Supine Position in EUS-PPG Measurement
An observational study of Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS) and Left Lateral Decubitus, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
Trial summary
The consistency of EUS-PPG measurements between left lateral decubitus and supine positions is unclear. In this prospective comparative study, we are aimed to evaluate the correlation between EUS-PPG measured in supine position (EUS-suPPG), and EUS-PPG measured in left lateral decubitus position (EUS-lePPG). Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Left Lateral Decubitus
- What is being tested?
- EUS-lePPG
- Type of treatment
- Surgery or procedure
- How many people
- 30 participants
- Where
- 1 siteChina
- Study dates
- 16 Jun 2025to 29 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Hospitalized patients with liver cirrhosis
Who may be able to join
- Hospitalized patients with liver cirrhosis, and are willing to sign the informed consent.
Who cannot join
- Unwilling to sign the informed consent
- Severe coagulopathy (INR>1.6)
- Severe thrombocytopenia (platelets <20,000/μL)
- Bacteremia
- Age<18, or≥81
- Pregnancy
Trial locations and contacts
1 site in 1 country.
China1 site
The 2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou
About this study
Official title: The Comparative Study on Left Lateral Position and Supine Position in Endoscopic Ultrasound Guided Portal Pressure Gradient Measurement
The consistency of EUS-PPG measurements between left lateral decubitus and supine positions is unclear. In this prospective comparative study, we are aimed to evaluate the correlation between EUS-PPG measured in supine position (EUS-suPPG), and EUS-PPG measured in left lateral decubitus position (EUS-lePPG).
Read the detailed description
The hepatic venous pressure gradient (HVPG) remains the gold standard for assessing portal hypertension, yet its clinical application faces several limitations. First, HVPG has restricted diagnostic scope, being unable to accurately evaluate prehepatic or presinusoidal portal hypertension. Second, the measurement process exposes both patients and physicians to radiation and involves complex techniques that preclude routine implementation in many hospitals. Finally, as HVPG indirectly estimates portal pressure through wedged hepatic venous pressure, its accuracy may be compromised by multiple factors including intrahepatic venous shunting, catheter insertion depth, excessive sedation or patient agitation during the procedure, and incomplete balloon occlusion of hepatic venous flow.
Endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement effectively addresses these limitations of HVPG. Current clinical studies on EUS-PPG have predominantly been conducted in the supine position. However, this position significantly increases the technical difficulty of endoscopic ultrasonography and complicates the simultaneous performance of endoscopic selective varices devascularization (EUS-ESVD) under single anesthesia. The consistency of EUS-PPG measurements between left lateral decubitus and supine positions requires further investigation.
This prospective comparative study enrolls hospitalized patients with liver cirrhosis. EUS-guided puncture of both the portal vein and hepatic vein were performed using a 25G needle. Pressure transducers measure the portal venous pressure (PVP) and hepatic venous pressure (HVP), with their differential defined as EUS-PPG. Measurements obtained in supine position are designated EUS-suPPG, while those in left lateral decubitus position are termed EUS-lePPG. Statistical analysis will evaluate the correlation between EUS-suPPG and EUS-lePPG values, with postoperative monitoring for complications including infection and hemorrhage.
- Conditions
- Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Left Lateral Decubitus
- Being tested
- EUS-lePPG
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EUS-lePPGProcedure or surgery
EUS-PPG measured in left lateral decubitus position
| Study group | Role | What they receive |
|---|---|---|
| EUS-suPPG | EUS-PPG measured in supine position Receives: Procedure: EUS-lePPG |
What is being measured
The primary outcome is the main question the study is designed to answer.
EUS-lePPG
EUS-PPG measured in left lateral decubitus position
Measured: From the begining of zero calibration for pressure transducer to the end of the endoscopic procedure, until up to 1 day.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 May 2025
- Study start16 Jun 2025
- Primary completion29 Dec 2025
- Study completion29 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS)Studies of the same condition, open and under way.
- More trials run by Second Affiliated Hospital, Zhejiang University, School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06994039
- Sponsor's protocol ID
- 2025-0729
- Status last verified
- May 2025
- First submitted
- 20 May 2025
- Last updated
- 6 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Comparative Study on Left Lateral Position and Supine Position in Endoscopic Ultrasound Guided Portal Pressure Gradient Measurement
- ClinicalTrials.gov ID
- NCT06994039
- Acronym / sponsor ID
- 2025-0729
- Conditions
- Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Left Lateral Decubitus
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of MedicineUniversity, hospital or other
- Study start
- 16 Jun 2025 (actual)
- Primary completion
- 29 Dec 2025 (actual)
- Study completion
- 29 Dec 2025 (actual)
- First posted
- 29 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The consistency of EUS-PPG measurements between left lateral decubitus and supine positions is unclear. In this prospective comparative study, we are aimed to evaluate the correlation between EUS-PPG measured in supine position (EUS-suPPG), and EUS-PPG measured in left lateral decubitus position (EUS-lePPG).
Detailed description
The hepatic venous pressure gradient (HVPG) remains the gold standard for assessing portal hypertension, yet its clinical application faces several limitations. First, HVPG has restricted diagnostic scope, being unable to accurately evaluate prehepatic or presinusoidal portal hypertension. Second, the measurement process exposes both patients and physicians to radiation and involves complex techniques that preclude routine implementation in many hospitals. Finally, as HVPG indirectly estimates portal pressure through wedged hepatic venous pressure, its accuracy may be compromised by multiple factors including intrahepatic venous shunting, catheter insertion depth, excessive sedation or patient agitation during the procedure, and incomplete balloon occlusion of hepatic venous flow.
Endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement effectively addresses these limitations of HVPG. Current clinical studies on EUS-PPG have predominantly been conducted in the supine position. However, this position significantly increases the technical difficulty of endoscopic ultrasonography and complicates the simultaneous performance of endoscopic selective varices devascularization (EUS-ESVD) under single anesthesia. The consistency of EUS-PPG measurements between left lateral decubitus and supine positions requires further investigation.
This prospective comparative study enrolls hospitalized patients with liver cirrhosis. EUS-guided puncture of both the portal vein and hepatic vein were performed using a 25G needle. Pressure transducers measure the portal venous pressure (PVP) and hepatic venous pressure (HVP), with their differential defined as EUS-PPG. Measurements obtained in supine position are designated EUS-suPPG, while those in left lateral decubitus position are termed EUS-lePPG. Statistical analysis will evaluate the correlation between EUS-suPPG and EUS-lePPG values, with postoperative monitoring for complications including infection and hemorrhage.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| EUS-suPPG | – | Procedure: EUS-lePPGEUS-PPG measured in supine position |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Hospitalized patients with liver cirrhosis
Key inclusion criteria (1 listed)
- Hospitalized patients with liver cirrhosis, and are willing to sign the informed consent.
Key exclusion criteria (6 listed)
- Unwilling to sign the informed consent
- Severe coagulopathy (INR>1.6)
- Severe thrombocytopenia (platelets <20,000/μL)
- Bacteremia
- Age<18, or≥81
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EUS-lePPGEUS-PPG measured in left lateral decubitus position | Procedure or surgery | EUS-suPPG |
Primary outcome
EUS-lePPG
Time frame: From the begining of zero calibration for pressure transducer to the end of the endoscopic procedure, until up to 1 day.
EUS-PPG measured in left lateral decubitus position
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Feb 2026.
- Individual participant dataSharing planned: No
Related trials for Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS)
Not yet recruitingObservational study
Evaluation of the Efficacy and Safety of Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS) in the Therapeutic Algorithm of Patients with Liver Cirrhosis.
Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Hepatic Cirrhosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS) and Left Lateral Decubitus, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
EUS-lePPG (time frame: From the begining of zero calibration for pressure transducer to the end of the endoscopic procedure, until up to 1 day.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Feb 2026.