Pocket, PeriodontalNCT06993519
Impact of Minimally Non-surgical Periodontal Treatment on Residual Pockets
A study testing Probin Pocket Depth reduction in people with Pocket, Periodontal and Periodontitis, run by University of Catania at 1 site in Italy.
Trial summary
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on residual pockets after active periodontal treatment Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Pocket, Periodontal, Periodontitis
- What is being tested?
- Probin Pocket Depth reduction
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 64 participants
- Where
- 1 siteItaly
- Study dates
- 2 Jan 2021to 10 Apr 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of Periodontitis
- Presence of residula periodontal pockets
Who cannot join
- Periodontal treatment
- Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
- Pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on Residual Periodontal Pockets
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on residual pockets after active periodontal treatment
Read the detailed description
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment in subjects with periodontitis. 60 patients: 30 with periodontitis and 30 healthy controls who underwent active periodontal treatment. All the patients are assessed for clinical, periodontal, blood following of minimally invasive approach MINST or Q-SI (quadrantwise).
Measurements are taken before and after initial periodontal treatment in the periodontal subjects in order to evaluate the best treatment for residual pockets.
- Conditions
- Pocket, Periodontal, Periodontitis
- Being tested
- Probin Pocket Depth reduction
- Medical subject headings
- Periodontal Pocket, Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Probin Pocket Depth reductionOther
Probin Pocket Depth reduction in millimetres before and after treatment
| Study group | Role | What they receive |
|---|---|---|
| MINST non surgical periodontal treatment | Experimental | Patients were treated with non-surgical MINST periodontal treatment in a single session on residual pockets Receives: Other: Probin Pocket Depth reduction |
| Q-SI non surgical periodontal treatment | Active comparator | Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week on residual pockets Receives: Other: Probin Pocket Depth reduction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Probin Pocket Depth reduction
Probin Pocket Depth reduction in millimetres before and after treatment
Measured: 1-year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 May 2025
- Study start2 Jan 2021
- Primary completion1 Apr 2025
- Study completion10 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pocket, PeriodontalStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Non-surgical periodontal treatment Subgingival biofilm ultrasonic debridement with MINST or Q-SI for residual pockets
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 64 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Catania
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gaetano Isola, University of Catania
- Investigators
- Gaetano Isola, DDS, Principal investigator, Università degli Studi di Catania - Dipartimento di Chirurgia Generale e Specialità Medico-Chirurgiche
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06993519
- Sponsor's protocol ID
- Residual-MINST
- Status last verified
- May 2025
- First submitted
- 19 May 2025
- Last updated
- 29 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Study results
Study at a glance
From the registry record, last updated by the sponsor on 29 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on Residual Periodontal Pockets
- ClinicalTrials.gov ID
- NCT06993519
- Acronym / sponsor ID
- Residual-MINST
- Conditions
- Pocket, Periodontal, Periodontitis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 64 participants (actual)
- Lead sponsor
- University of CataniaUniversity, hospital or other
- Study start
- 2 Jan 2021 (actual)
- Primary completion
- 1 Apr 2025 (actual)
- Study completion
- 10 Apr 2025 (actual)
- First posted
- 29 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on residual pockets after active periodontal treatment
Detailed description
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment in subjects with periodontitis. 60 patients: 30 with periodontitis and 30 healthy controls who underwent active periodontal treatment. All the patients are assessed for clinical, periodontal, blood following of minimally invasive approach MINST or Q-SI (quadrantwise).
Measurements are taken before and after initial periodontal treatment in the periodontal subjects in order to evaluate the best treatment for residual pockets.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 2
- Model description
- Non-surgical periodontal treatment Subgingival biofilm ultrasonic debridement with MINST or Q-SI for residual pockets
| Arm | Type | Receives |
|---|---|---|
| MINST non surgical periodontal treatment | Experimental | Other: Probin Pocket Depth reductionPatients were treated with non-surgical MINST periodontal treatment in a single session on residual pockets |
| Q-SI non surgical periodontal treatment | Active comparator | Other: Probin Pocket Depth reductionPeriodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week on residual pockets |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Diagnosis of Periodontitis
- Presence of residula periodontal pockets
Key exclusion criteria (3 listed)
- Periodontal treatment
- Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Probin Pocket Depth reductionProbin Pocket Depth reduction in millimetres before and after treatment | Other | MINST non surgical periodontal treatment, Q-SI non surgical periodontal treatment |
Primary outcome
Probin Pocket Depth reduction
Time frame: 1-year
Probin Pocket Depth reduction in millimetres before and after treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 May 2025.
- Individual participant dataSharing planned: Undecided. Study results
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gaetano Isola, DDS principal investigator
Università degli Studi di Catania - Dipartimento di Chirurgia Generale e Specialità Medico-Chirurgiche
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Probin Pocket Depth reduction in people with Pocket, Periodontal and Periodontitis, run by University of Catania at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Probin Pocket Depth reduction (time frame: 1-year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 May 2025.