Trauma, BrainNCT06992570
Risk Assessment of Mild Traumatic Brain Injury in Military Training
A study testing Quantification of mild trauma brain injury risk and Biomechanical Analysis of Head Impact Forces in people with Trauma, Brain, run by Charles University, Czech Republic at 1 site in Czechia.
Trial summary
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Trauma, Brain
- What is being tested?
- Quantification of mild trauma brain injury risk and Biomechanical Analysis of Head Impact Forces
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteCzechia
- Study dates
- 4 Nov 2025to 30 Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18-50 years
- Active-duty military personnel
- Participating in designated high-risk training activities
Who cannot join
- History of significant brain injury
- Current neurological disorders
- Use of anticoagulant medications
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Czechia1 site
Military University Hospital Prague
Prague, Czech Republic, 16902
About this study
Official title: Identification and Risk Assessment of Mild Traumatic Brain Injury (mTBI) in Czech Armed Forces Soldiers During Specific Training Activities
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study will utilize both diagnostic biomarker analysis and experimental biomechanical measurements to assess the physiological impact of these activities on brain health. The ultimate goal is to reduce mTBI incidence, improve operational readiness, and extend the active service duration of soldiers through targeted preventive measures.
Read the detailed description
The SNIPER-TBI study aims to quantify the risk of mild traumatic brain injury (mTBI) in Czech Armed Forces soldiers during high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study combines diagnostic biomarker analysis (GFAP, UCH-L1) and experimental biomechanical measurements using wearable sensors and high-speed cameras. These data will provide critical insights into the forces exerted on the brain during training and help establish exposure limits to minimize long-term neurological impairment. The results will guide the development of protective strategies and enhance soldier readiness.
- Conditions
- Trauma, Brain
- Being tested
- Quantification of mild trauma brain injury risk, Biomechanical Analysis of Head Impact Forces
- Keywords
- mTBI, Biomechanics, Military Training
- Medical subject headings
- Brain Injuries, Traumatic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Quantification of mild trauma brain injury riskDiagnostic test
Measure the incidence and severity of mTBI among soldiers engaged in high-risk training activities. (e.g. parachute jumps, high-caliber firearms shooting, artillery fire, explosions). Concentration of brain injury biomarkers (GFAP, UCH-L1) in blood samples collected within 24 hours post-exposure
Biomechanical Analysis of Head Impact ForcesOther
Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) and pressure wave analysis during training activities.
| Study group | Role | What they receive |
|---|---|---|
| High-Risk Military Training Exposure | Experimental | Active-duty soldiers participating in high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. Participants will undergo real-time biomechanical measurement and biomarker analysis to assess mild traumatic brain injury (mTBI) risk.
Diagnostic biomarker analysis (GFAP, UCH-L1) Real-time biomechanical monitoring (accelerometers, high-speed cameras) Receives: Diagnostic Test: Quantification of mild trauma brain injury risk; Other: Biomechanical Analysis of Head Impact Forces |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quantification of mTBI Risk 1
Measure the severity of mTBI among soldiers engaged in high-risk training activity.
Concentration of brain injury biomarker glial fibrillary acidic protein (GFAP) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.
Measured: Up to 24 hours post-exposure
Quantification of mTBI Risk 2
Measure the severity of mTBI among soldiers engaged in high-risk training activity.
Concentration of brain injury biomarker ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.
Measured: Up to 24 hours post-exposure
Biomechanical Analysis of Head Impact Forces 1
Evaluate the mechanical forces experienced by soldiers during high-risk activity using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) will be measured during training activity. Measured in meters per second squared.
Measured: Baseline
Biomechanical Analysis of Head Impact Forces 2
Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Pressure wave during training activity will be analyzed. Measures in Pascal.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 May 2025
- Study start4 Nov 2025
- Primary completion30 Sep 2027 (estimated)
- Study completion30 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Trauma, BrainStudies of the same condition, open and under way.
- More trials run by Charles University, Czech RepublicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Charles University, Czech Republic
- Sponsor type
- University, hospital or other
- Collaborators
- Military University Hospital, Prague
- Responsible party
- Principal investigator, Michal Soták, Charles University, Czech Republic
- Investigators
- Michal Soták, M.D., Ph.D., Principal investigator, Military University Hospital, Prague
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06992570
- Sponsor's protocol ID
- SNIPER-mTBI
- Status last verified
- Oct 2026
- First submitted
- 12 May 2025
- Last updated
- 29 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared due to concerns regarding participant confidentiality, data privacy, and the sensitive nature of the study involving military personnel.
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Identification and Risk Assessment of Mild Traumatic Brain Injury (mTBI) in Czech Armed Forces Soldiers During Specific Training Activities
- ClinicalTrials.gov ID
- NCT06992570
- Acronym / sponsor ID
- SNIPER-mTBI
- Conditions
- Trauma, Brain
- Keywords
- mTBI, Biomechanics, Military Training
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Charles University, Czech RepublicUniversity, hospital or other
- Collaborators
- Military University Hospital, Prague
- Study start
- 4 Nov 2025 (actual)
- Primary completion
- 30 Sep 2027 (estimated)
- Study completion
- 30 Nov 2027 (estimated)
- First posted
- 28 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study will utilize both diagnostic biomarker analysis and experimental biomechanical measurements to assess the physiological impact of these activities on brain health. The ultimate goal is to reduce mTBI incidence, improve operational readiness, and extend the active service duration of soldiers through targeted preventive measures.
Detailed description
The SNIPER-TBI study aims to quantify the risk of mild traumatic brain injury (mTBI) in Czech Armed Forces soldiers during high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study combines diagnostic biomarker analysis (GFAP, UCH-L1) and experimental biomechanical measurements using wearable sensors and high-speed cameras. These data will provide critical insights into the forces exerted on the brain during training and help establish exposure limits to minimize long-term neurological impairment. The results will guide the development of protective strategies and enhance soldier readiness.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| High-Risk Military Training Exposure | Experimental | Diagnostic Test: Quantification of mild trauma brain injury risk, Other: Biomechanical Analysis of Head Impact ForcesActive-duty soldiers participating in high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. Participants will undergo real-time biomechanical measurement and biomarker analysis to assess mild traumatic brain injury (mTBI) risk. Diagnostic biomarker analysis (GFAP, UCH-L1) Real-time biomechanical monitoring (accelerometers, high-speed cameras) |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Age 18-50 years
- Active-duty military personnel
- Participating in designated high-risk training activities
Key exclusion criteria (3 listed)
- History of significant brain injury
- Current neurological disorders
- Use of anticoagulant medications
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Quantification of mild trauma brain injury riskMeasure the incidence and severity of mTBI among soldiers engaged in high-risk training activities. (e.g. parachute jumps, high-caliber firearms shooting, artillery fire, explosions). Concentration of brain injury biomarkers (GFAP, UCH-L1) in blood samples collected within 24 hours post-exposure | Diagnostic test | High-Risk Military Training Exposure |
| Biomechanical Analysis of Head Impact ForcesEvaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) and pressure wave analysis during training activities. | Other | High-Risk Military Training Exposure |
Primary outcome
Quantification of mTBI Risk 1
Time frame: Up to 24 hours post-exposure
Measure the severity of mTBI among soldiers engaged in high-risk training activity. Concentration of brain injury biomarker glial fibrillary acidic protein (GFAP) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.
Quantification of mTBI Risk 2
Time frame: Up to 24 hours post-exposure
Measure the severity of mTBI among soldiers engaged in high-risk training activity. Concentration of brain injury biomarker ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.
Biomechanical Analysis of Head Impact Forces 1
Time frame: Baseline
Evaluate the mechanical forces experienced by soldiers during high-risk activity using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) will be measured during training activity. Measured in meters per second squared.
Biomechanical Analysis of Head Impact Forces 2
Time frame: Baseline
Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Pressure wave during training activity will be analyzed. Measures in Pascal.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared due to concerns regarding participant confidentiality, data privacy, and the sensitive nature of the study involving military personnel.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Michal Soták, M.D., Ph.D. principal investigator
Military University Hospital, Prague
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Quantification of mild trauma brain injury risk and Biomechanical Analysis of Head Impact Forces in people with Trauma, Brain, run by Charles University, Czech Republic at 1 site in Czechia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Czechia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quantification of mTBI Risk 1 (time frame: Up to 24 hours post-exposure). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026.