AzTrials
AzTrials

Chronic Obstructive Pulmonary DiseasePhase 2NCT06981078

A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD

A Phase 2 study testing Verekitug in people with Chronic Obstructive Pulmonary Disease, run by Upstream Bio Inc. at 242 sites in 23 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

The purpose of this study is to assess the efficacy and safety of verekitug (UPB-101) in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), an inflammatory lung disease. Read more about this study

Who is it for?
Ages 40 to 85 years
Conditions the study is for
Chronic Obstructive Pulmonary Disease
What is being tested?
Verekitug
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
666 participants
Where
242 sitesin 23 countries
Study dates
2 Jul 2025to Nov 2027
Phase
Phase 2
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 to 85 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Physician diagnosis of COPD for >12 months.
  • Current or former smokers with a smoking history of 10 pack-years or more.
  • Post-bronchodilator FEV1/ Forced Vital Capacity (FVC) ratio <0.70 and predicted post-bronchodilator FEV1 >30% and ≤80%.
  • Modified Medical Research Council dyspnea scale Grade ≥2.
  • Background triple therapy (Inhaled Corticosteroid [ICS], Long-Acting Beta Agonist [LABA], Long-Acting Muscarinic Antagonist [LAMA]) for 3 months before randomization with a stable dose of medications for 1 or more months prior to Visit 1.
  • Are ≥80% compliant with background therapy during the screening period.

Who cannot join

  • Moderate or severe exacerbation of COPD within 4 weeks prior to or during the screening period.
  • Respiratory tract infection within 4 weeks prior to or during the screening period.
  • Treatment with oxygen of >4 liters/minute. Nocturnal oxygen use for sleep apnea is allowed.
  • Systemic or biologic immunosuppressant therapy to treat inflammatory disease or autoimmune disease within 24 weeks or 5 half-lives prior to Visit 1, whichever is longer, with the exception of oral corticosteroids. Treatment with cyclophosphamide and rituximab within 12 months of Visit 1.
  • Current diagnosis of asthma according to the 2023 Global Initiative for Asthma guidelines or other accepted guidelines
  • History or evidence of a clinically meaningful pulmonary condition other than COPD (e.g., pulmonary fibrosis, sarcoidosis, interstitial lung disease, pulmonary hypertension, bronchiectasis, Churg-Strauss Syndrome) or another diagnosed pulmonary or systemic disease associated with elevated peripheral eosinophil counts.
  • Chronic hypercapnia requiring Bilevel Positive Airway Pressure (BiPAP). Participants requiring BiPAP periodically for an acute COPD exacerbation are not excluded.
  • Any of the following in the previous 6 months prior to Visit 1: acute myocardial infarction, transient ischemic attack or stroke, hospitalization for any cardiovascular or cerebrovascular event, pulmonary embolism, deep vein thrombosis and cardiac arrhythmias including paroxysmal (e.g., intermittent). Participants with persistent atrial fibrillation as defined by continuous atrial fibrillation for at least 6 months and controlled with a rate control strategy (i.e., selective beta blocker, calcium channel blocker, pacemaker placement, digoxin or ablation therapy) and stable appropriate level of anticoagulation for at least 6 months may be considered for inclusion.

Trial locations and contacts

242 sites in 23 countries.

242 sites in 23 countries

United States29 sites

  • Velocity Clinical Research, Anderson

    Anderson, South Carolina, 29621

  • Kern Research Inc.

    Bakersfield, California, 93301

  • Christie Clinic, LLC

    Champaign, Illinois, 61820

  • American Health Research, Inc.

    Charlotte, North Carolina, 28277

  • SleepMed Inc.

    Columbia, South Carolina, 29201

  • D&H Doral Research Center, LLC

    Doral, Florida, 33122

  • El Paso Pulmonary Association

    El Paso, Texas, 79902

  • PulmoCrit Associates

    Encino, California, 91436

  • Velocity Clinical Research, Gaffney

    Greenville, South Carolina, 29615

  • Qway Research, LLC

    Hialeah, Florida, 33010

  • Victorium Clinical Research

    Houston, Texas, 77024

  • Synergy Groups Medical LLC

    Houston, Texas, 77036

  • Synergy Groups Medical LLC

    Houston, Texas, 77061

  • Torrance Clinical Research Institute

    Lomita, California, 90717-2101

  • Metroplex Pulmonary and Sleep Center

    McKinney, Texas, 75069

  • Finlay Medical Research

    Miami, Florida, 33126

  • MplusM - ITB Research

    Miami, Florida, 33173

  • Synergy Groups Medical LLC

    Missouri City, Texas, 77459

  • Florida Institute for Clinical Research,LLC

    Orlando, Florida, 32825

  • Dream Team Clinical Research

    Pomona, California, 91767

  • Velocity Clinical Research-Rockville

    Rockville, Maryland, 20854

  • HealthPartners

    Saint Paul, Minnesota, 55130

  • Apex Clinical Research

    San Diego, California, 92120

  • Velocity Clinical Research-Savannah - Internal Medicine

    Savannah, Georgia, 31406

  • Velocity Clinical Research, Spartanburg - Pulmonology

    Spartanburg, South Carolina, 29303

  • Velocity Clinical Research - Suffolk

    Suffolk, Virginia, 23435

  • Velocity Clinical Research- Union

    Union, South Carolina, 29379

  • Allianz Research Institute

    Westminster, California, 92683

  • Chesapeake Clinical Research, Inc

    White Marsh, Maryland, 21162

Other trials in United States

Bulgaria22 sites

  • Specialized Hospital For Active Treatment Of Pulmonary Diseases Sv.Panteleymon EOOD

    Dupnitsa, Pernik, 2307

  • Medical Center Pulmo-2018 EOOD

    Haskovo, Haskovo, 6300

  • Medical Center - Zdrave1

    Kozloduy, Vratsa, 3320

  • Medical Center Medconsult Pleven, Lovech branch

    Lovech, Lovech, 5500

  • MEDICAL CENTER HERA EOOD; Office of Pulmonology and Phtisiatrics

    Montana, Montana, 3400

  • Dr. Filip Shterev IAPSMCPP EOOD

    Plovdiv, Plovdiv, 4000

  • Medical Center Etika Ambulatory For Specialized Outpatient Medical Care OOD

    Plovdiv, Plovdiv, 4000

  • Multiprofile Hospital for Active Treatment "St. Panteleimon "- Plovdiv

    Plovdiv, Plovdiv, 4004

  • Medical Center Prolet EOOD - Pulmonary, Allergy Diseases

    Rousse, Ruse, 7002

  • Specialized Hospital For Active Treatment Of Pneumo-Phthisiatric Diseases Dr. Dimitar Gramatikov-Ruse EOOD

    Rousse, Ruse, 7002

  • Diagnostic consultative center 1 -Sliven

    Sliven, Sliven, 8800

  • MHAT Sliven to MMA Sofia

    Sliven, Sliven, 8800

  • Medical Center Excelsior OOD, Base 2

    Sofia, Sofia, 1111

  • Acibadem City Clinic Tokuda University Hospital EAD

    Sofia, Sofia, 1407

  • First Multiprofile Hospital for Active Treatment - Sofia

    Sofia, Sofia-Grad, 1142

  • Specialized Hospital For Active Treatment Of Pulmonary Diseases - Sofia EOOD

    Sofia, Sofia-Grad, 1202

  • National Multiprofile Transport Hospital (NMTB) - Internal Diseases

    Sofia, Sofia-Grad, 1233

  • Medical Center Excelsior OOD, Base 1

    Sofia, Sofia-Grad, 1407

  • Medical Center Hera

    Sofia, Sofia-Grad, 1510

  • DCC Convex EOOD

    Sofia, Sofia-Grad, 1680

  • Medical Center for Outpatient Care Preventsia 2000

    Stara Zagora, Stara Zagora, 6000

  • SHLTTRPD "Sveta Petka Balgarska" EOOD

    Velingrad, Pazardzhik, 4600

Other trials in Bulgaria

United Kingdom21 sites

  • Royal Primary Care - Ashgate

    Chesterfield, Derbyshire, S40 4AA

  • Lakeside Healthcare

    Corby, Northamptonshire, NN17 2UR

  • NHS Tayside - Ninewells Hospital

    Dundee, United Kingdom, DD1 9SY

  • Synexus Midlands Clinical Research Centre

    Edgbaston, Birmingham, B15 2SQ

  • Panthera Biopartners - North London

    Enfield, London, EN3 4GS

  • NHS Greater Glasgow & Clyde - Gartnavel General Hospital - Respiratory

    Glasgow, Glasgow City, G12 0YN

  • Panthera Biopartners - Glasgow

    Glasgow, Glasgow City, G51 4TY

  • Futuremeds - Glasgow

    Glasgow, Scotland, G20 7BE

  • Velocity Clinical Research - High Wycombe

    High Wycombe, Buckinghamshire, HP11 2QW

  • Leeds Teaching Hospitals NHS Trust - St James' University Hospital

    Leeds, Leeds, LS9 7TF

  • FutureMeds Wirral

    Metropolitan Borough of Wirral, Liverpool, CH62 6EE

  • Futuremeds -Teesside

    Metropolitan Borough of Wirral, Wirral, TS19 8PE

  • Bioluminux Clinical Research

    Milton Keynes, Bedfordshire, MK15 0DU

  • FutureMeds - Newcastle

    Newcastle, United Kingdom, NE6 1SG

  • Ashburton Surgery

    Newton Abbot, Devon, TQ13 7AP

  • Panthera Biopartners - Preston

    Preston, Lancashire, PR2 9QB

  • Royal Berkshire Hospital

    Reading, United Kingdom, RG1 5AN

  • Panthera Biopartners - Manchester

    Rochdale, Manchester, OL11 4AU

  • Velocity Romford

    Romford, Essex, RM1 3PJ

  • Panthera Biopartners - Sheffield

    Sheffield, Sheffield, S2 5FX

  • Panthera Biopartners - York

    York, York, YO24 4LJ

Other trials in United Kingdom

Germany20 sites

  • Gemeinschaftspraxis Rolke / Rückert

    Aschaffenburg, Bavaria, 63739

  • Pneumologie, Schlafmedizin und Onkologie am Diako

    Augsburg, Bavaria, 86150

  • CIMS Studienzentrum Bamberg

    Bamberg, Bavaria, 96049

  • Studienpraxis Berlin-Brandenburg

    Berlin, State of Berlin, 10119

  • Lungenpraxis Hohenzollerndamm

    Berlin, State of Berlin, 10717

  • Velocity Clinical Research Germany GmBH

    Berlin, State of Berlin, 10787

  • MECS Research GmbH

    Berlin, State of Berlin, 12203

  • MECS GmbH

    Cottbus, Brandenburg, 3050

  • Pneumostudien Darmstadt GmbH

    Darmstadt, Hesse, 64283

  • IKF Pneumologie GmbH & Co. KG

    Frankfurt am Main, Hesse, 60596

  • Pneumologicum-Halle - Pulmonary

    Halle, Saxony-Anhalt, 6108

  • ME Clinical Respiratory Research

    Hamburg, Free and Hanseatic City of Hamburg, 22299

  • Pneumologische Praxis und Schlaflabor - Lutz Volgmann

    Hanover, Lower Saxony, 30167

  • Velocity Clinical Research Germany GmbH

    Lübeck, Schleswig-Holstein, 23552

  • IKF Pneumologie GmbH & Co. KG

    Mainz, Rhineland-Palatinate, 55128

  • Asklepios Lungenklinik Gauting GmbH - Zentrum für Pneumologie und Thoraxchirurgie

    München, Bavaria, 82131

  • Ballenberger, Freytag, Wenisch

    Neu-Isenburg, Hesse, 63263

  • Studienzentrum Dr.med. Christian Schlenska - Pneumologie/Allergologie/Innere Medizin

    Peine, Lower Saxony, 31224

  • Framol-Med GmbH

    Rheine, North Rhine-Westphalia, 48431

  • Gemeinschaftspraxis Franz, Weber

    Witten, North Rhine-Westphalia, 58452

Other trials in Germany

Poland15 sites

  • Centrum Medycyny Oddechowej, Mroz Spolka Jawna

    Bialystok, Podlaskie Voivodeship, 15-044

  • ClinicMed Daniluk, Nowak Sp. Komandytowa

    Bialystok, Podlaskie Voivodeship, 15-879

  • Centrum Medyczne Pratia Bydgoszcz

    Bydgoszcz, Greater Poland Voivodeship, 85-796

  • Uniwersyteckie Centrum Kliniczne - Klinika Alergologii

    Gdansk, Pomeranian Voivodeship, 80-214

  • Centrum Medyczne Pratia Katowice

    Katowice, Warmian-Masurian Voivodeship, 40-081

  • Centrum Medyczne ALL-MED

    Krakow, Lesser Poland Voivodeship, 30-033

  • Pratia MCM Kraków

    Krakow, Lesser Poland Voivodeship, 30-727

  • Clinical Best Solutions

    Lublin, Lubusz Voivodeship, 20-078

  • Twoja Przychodnia Nowosolskie Centrum Medyczne Sp. z o. o.

    Nowa Sól, Lubusz Voivodeship, 67-100

  • Specjalistyczna Przychodnia Lekarska Alergo - Med Sp. z o.o.

    Poznan, Greater Poland Voivodeship, 61-578

  • Prywatny Gabinet Lekarski

    Rzeszów, Podkarpackie Voivodeship, 35-051

  • EMED Centrum Uslug Medycznych Ewa Smialek

    Rzeszów, Podkarpackie Voivodeship, 35-205

  • Velocity Skierniewice Sp. z o.o.

    Skierniewice, Lódzkie, 96-100

  • RCMed Oddzial Sochaczew

    Sochaczew, Masovian Voivodeship, 96-500

  • Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o. o.

    Szczecin, West Pomeranian Voivodeship, 71-434

Other trials in Poland

Spain15 sites

  • Vithas Xanit International Hospital - Gastroenterology

    Benalmádena, Málaga, 29630

  • Hospital San Pedro de Alcántara

    Cáceres, Extremadura, 10003

  • Hospital Universitario Virgen de las Nieves

    Granada, Granada, 18014

  • Hospital De Jerez De La Frontera

    Jerez de la Frontera, Cádiz, 11407

  • Fundacion Jimenez Diaz

    Madrid, Madrid, 28040

  • Hospital Universitario La Paz - Neumologia

    Madrid, Madrid, 28046

  • Hospital Universitario Virgen de la Victoria

    Málaga, Málaga, 29010

  • Hospital Quirónsalud Marbella

    Marbella, Málaga, 29603

  • Hospital Universitario Son Espases

    Palma de Mallorca, Balearic Islands, 7120

  • Clinica Universidad de Navarra - Neumología

    Pamplona, Navarre, 31008

  • Complejo Hospitalario de Navarra

    Pamplona, Navarre, 31008

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, Madrid, 28223

  • Hospital Universitario Virgen del Rocio

    Seville, Sevilla, 41013

  • Hospital Sierrallana - Neumologia

    Torrelavega, Cantabria, 39300

  • Hospital Clinico Universitario De Valencia - Neumologia

    Valencia, Valencia, 46010

Other trials in Spain

India12 sites

  • JNMC

    Belgaum, West Bengal, 590010

  • S.P Medical College and Group of Hospitals, Bikaner

    Bikaner, Rajasthan, 334001

  • Shri Mahant Indiresh Hospital

    Dehradun, Uttarakhand, 248001

  • Medanta Medicity

    Gurgaon, Haryana, 122001

  • Astar Prime Hospitals - Internal Medicine

    Hyderabad, Andhra Pradesh, 500036

  • Rajarshi Chhatrapati Shahu Maharaj (RCSM) Government Medical College & CPR Hospital

    Kolhāpur, Maharashtra, 416002

  • NRS Medical College

    Kolkata, West Bengal, 700014

  • Shree Hospital & Critical Care Centre

    Nagpur, Maharashtra, 440009

  • A.C. Subba Reddy Government Medical College (ACSR) - Pulmonary

    Nellore, Andhra Pradesh, 524004

  • Sir Ganga Ram Hospital (SGRH) - Gastroenterology and Hepatology

    New Delhi, National Capital Territory of Delhi, 110 001

  • Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Pandit Bhagwat Dayal Sharma

    Rohtak, Haryana, 124001

  • Siddhartha Medical College

    Vijayawada, Andhra Pradesh, 520008

Other trials in India

Romania12 sites

  • Angisan Grup

    Bragadiru, Ilfov, 77025

  • Centrul Medical de Diagnostic si Tratament Ambulator Neomed - Multiple Specialties

    Brasov, Brașov County, 500283

  • Centrul Medical Sana

    Bucharest, Bucharest, 11025

  • Medsana CM Cotroceni Pulmonology

    Bucharest, Bucharest, 50521

  • Rimmed Centru Medical Pulmonology

    Bucharest, Bucharest, 61334

  • Anima Specialty Medical Services

    Bucharest, Bucharest, 616962

  • Fundatia Dr. Victor Babes

    Bucuresti, Ilfov, 30303

  • CM Pneumologie Dr Mincu Bogdan

    Cluj-Napoca, Cluj, 400275

  • Sp Pneumoftizio Leon Daniello CJ

    Cluj-Napoca, Cluj, 400371

  • Clintrial Medical Center

    Dobrosloveni, Olt, 237143

  • Sp.Clinic Pneumo Constanta Pulmon 2

    Palazu Mare, Constanța County, 900002

  • Sp Dr Victor Babes Timisoara Pulmon

    Timișoara, Timiș County, 300310

Other trials in Romania

Ukraine12 sites

  • KNP "Cherkaska oblasna likarnia"

    Cherkasy, Cherkasy Oblast, 18009

  • KNP"Ts inf.zakhv.Iv-Frank.obl.rady"

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018

  • Likuv.-diahn. tsentr Sviatoho Luky

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76019

  • MTs "Universalna klinika "Oberih"

    Kyiv, Kyiv Oblast, 2000

  • DU "NNTs im. Yanovskoho"

    Kyiv, Kyiv Oblast, 3038

  • Klin.likarnia na zal.transporti №2

    Kyiv, Kyiv Oblast, 3049

  • DU "NNTs im. Yanovskoho"

    Kyiv, Luhansk Oblast, 3038

  • MTs "Klinika Hospodarskykh"

    Ternopil, Ternopil Oblast, 46002

  • Uzh.miska bahatoprofilna klin.lik.

    Uzhhorod, Zakarpattia Oblast, 88009

  • Lik.z nevidkl. staniv ta ekstr.dop.

    Uzhhorod, Zakarpattia Oblast, 88017

  • Medychnyi tsentr "Puls"

    Vinnytsia, Vinnytsia Oblast, 21001

  • KNP "Likarnia №1" Zhytom.misk.rady

    Zhytomyr, Zhytomyr Oblast, 10002

Other trials in Ukraine

Hungary11 sites

  • Aranyklinika Kft

    Bordány, Csongrád megye, 6720

  • ClinExpert Kft.

    Budapest, Budapest, 1033

  • Pulmo Protect Kft.

    Budapest, Budapest, 1044

  • Debreceni Egyetem Klinikai Központ - Tüdőgyógyászati Klinika

    Debrecen, Debrecen, H-4012

  • Koch Róbert Kórház és Rendel?intézet

    Edelény, Borsod-Abauj Zemplen county, H-3780

  • Farkasgyepui Tudogyogyintezet

    Farkasgyepű, Veszprém megye, 8582

  • Erzsebet Gondozohaz Kft.

    Gödöllő, Pest County, 2100

  • Szalay Janos Rendelointezet

    Hajdúnánás, Hajdú-Bihar, 4080

  • Kek Pont Aquagyogyaszat Kft.

    Kecskemét, Bács-Kiskun county, 6000

  • Infer-Med Kft.

    Pécs, Baranya, 7635

  • Puspokladanyi Egeszsegugyi Szolgaltato Nonprotfit Kft

    Püspökladány, Heves County, 4150

Other trials in Hungary

Czechia10 sites

  • MUDr. I. Cierna Peterova s.r.o.

    Brandýs nad Labem, Stredoceský Kraj, 25001

  • EDUMED, s.r.o

    Broumov, Hradec Králové Region, 550 01

  • Plicni ambulance Kralupy s.r.o.

    Kralupy nad Vltavou, Stredoceský Kraj, 278 01

  • MUDr. Pavlisova Ilona s.r.o.

    Miroslav, South Moravian, 671 72

  • Plicni ambulance Alveolus s.r.o.

    Poruba, Moravian-Silesian Region, 70800

  • MEDICON a.s. - Plicni oddeleni

    Prague, Praha, Hlavní Mesto, 14000

  • Privatni plicni ambulance, s.r.o.

    Prague, Praha, Hlavní Mesto, 19061

  • Plicni ambulance Rokycany

    Rokycany, Rokycany, 33701

  • Plicni stredisko Teplice s.r.o. - Plicni ordinace

    Teplice, Ústí nad Labem Region, 41501

  • Pneumologie Varnsdorf s.r.o.

    Varnsdorf, Ústí nad Labem Region, 40747

Other trials in Czechia

Georgia9 sites

  • LTD "High Technology Hospital Medcenter"

    Batumi, Adjara, 6010

  • LTD MARNECOR - Internal Medicine

    Marneuli, Kvemo Kartli, 3000

  • LTD Clinic Rustavi

    Rustavi, Hvemo Kartli, 3700

  • A. Aladashvili clinic LLC

    Tbilisi, K'alak'i T'bilisi, 102

  • LTD "Israel-Georgian Medical Research Clinic Healthycore"

    Tbilisi, K'alak'i T'bilisi, 112

  • Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic

    Tbilisi, K'alak'i T'bilisi, 144

  • Center of Allergy and Immunology - Allergy/Immunology-Reumatology

    Tbilisi, K'alak'i T'bilisi, 159

  • LTD "Emergency Cardiology Center named by Acad.G.Chapidze"

    Tbilisi, K'alak'i T'bilisi, 159

  • Ltd Diacor

    Tbilisi, K'alak'i T'bilisi, 159

Other trials in Georgia

Slovakia8 sites

  • FNsP F.D.R. Banska Bystrica - Pneumologie a ftizeologie

    Banská Bystrica, Banská Bystrica Region, 97517

  • Pneumomed s.r.o. - Pneumo-Alergo Centrum

    Bratislava, Bratislava Region, 85101

  • INSPIRO s.r.o. - MUDr. Golubov Alexander - Pneumologia a ftizeologia

    Humenné, Presov, 066 01

  • PAFA, s.r.o.

    Kežmarok, Presov, 6001

  • MEDEKA s.r.o. - Pneumologia a ftizeologia

    Košice, Košice Region, 040 01

  • ZAPA JJ s.r.o. - Pneumologia a ftizeologia

    Levice, Nitra Region, 934 01

  • DIONEA, s.r.o. - Ambul. pneumologie

    Nové Zámky, Nitra Region, 940 01

  • Plucna ambulancia Hrebenar s.r.o.

    Spišská Nová Ves, Košice Region, 052 01

Other trials in Slovakia

South Korea8 sites

  • The Catholic University of Korea, Incheon St. Mary's Hospital

    Incheon, Incheon Gwang'Yeogsi [Inch'n-Kwangyokshi], 21431

  • Seoul National University Bundang Hospital - Pulmonology

    Seongnam-si, Gyeonggido [Kyonggi-do], 13620

  • Korea University Anam Hospital - Pulmonology

    Seoul, Seoul, 2841

  • Konkuk University Medical Center

    Seoul, Seoul, 5030

  • Kyung Hee Universtiy Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], 2447

  • Severance Hospital, Yonsei University Health System - Pulmonary

    Seoul, Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], 3722

  • Eunpyeong St. Mary's Hospital

    Seoul, Seoul Teugbyeolsi, 3312

  • Yonsei University, Wonju Severance Christian Hospital - Pulmonology

    Wŏnju, Gang'Weondo [Kang-won-do], 26426

Other trials in South Korea

Taiwan8 sites

  • National Taiwan University Hospital - Yunlin Branch - Douliou

    Douliu, Yunlin, 640203

  • KMU Chung-Ho Memorial Hospital

    Kaohsiung City, Kaohsiung, 80756

  • Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Hemato-Oncology

    Kaohsiung City, Kaohsiung, 833401

  • Taichung Veterans General Hospital - Chest Medicine

    Taichung, Taichung, 407219

  • Kuang Tien General Hospital - XiangShang

    Taichung, Taichung, 433

  • Chi Mei Medical Center - YongKang - Pulmonary Medicine

    Tainan, Tainan, 71004

  • Taipei Medical University - Taipei Medical University Hospital - Internal Medicine

    Taipei, Taipei, 110

  • Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Pulmonary

    Taoyuan, Taoyuan, 333423

Other trials in Taiwan

Argentina6 sites

  • CARE - Centro de Alergia y Enfermedades Respiratorias

    Buenos Aires, Buenos Aires, C1414AIF

  • Consultorios Médicos Dr. Doreski

    Buenos Aires, Buenos Aires, C1426ABP

  • Centro de Medicina Respiratoria

    Concepción del Uruguay, Entre Ríos Province, 3260

  • Fundacion Scherbovsky

    Mendoza, Mendoza Province, 5500

  • Fundacion Estudios Clinicos (FECLIN)

    Rosario, Santa Fe Province, 2000

  • Instituto Médico Fundación Grupo Colaborativo Rosario Invest

    Rosario, Santa Fe Province, 2000

Other trials in Argentina

Philippines6 sites

  • De Asis Medical Clinic (Norzel Medical and Diagnostic Clinic)

    Cebu, Cebu, 6000

  • Perpetual succour hospital of Cebu INC

    Cebu, Cebu, 6000

  • CARE Clinical Trial Group Inc.

    Dasmariñas, Cavite, 4114

  • Iloilo Doctors' Hospital Inc.

    Iloilo City, Iloilo, 5000

  • Health Cube Medical Clinics

    Mandaluyong, National Capital Region, 1552

  • Marilao Saint Michael Family Hospital, Inc. - Research Room

    Marilao, Bulacan, 3019

Other trials in Philippines

Malaysia5 sites

  • Hospital Pulau Pinang

    George Town, Pulau Pinang, 10990

  • Institut Perubatan Respiratori

    Kuala Lumpur, Kuala Lumpur, 53000

  • Universiti Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100

  • Thomson Hospital Kota Damansara

    Petaling Jaya, Selangor, 47500

  • Universiti Teknologi MARA

    Shah Alam, Selangor, 68100

Other trials in Malaysia

Latvia4 sites

  • Veselibas Centru apvieniba AS, Dubultu poliklinika

    Jūrmala, Jūrmala, LV-2010

  • Liepaja Regional Hospital

    Liepāja, Liepaja, LV-3414

  • Pauls Stradins Clinical University Hospital - Center of Lung Diseases

    Riga, Riga, LV-1002

  • SIA "Profesora Skrides Sirds klīnika"

    Riga, Riga, LV-1013

Other trials in Latvia

Ireland3 sites

  • Our Lady of Lourdes Hospital

    Drogheda, Louth, A92VW28

  • Connolly Hospital

    Dublin, Dublin, D15 X40D

  • Tallaght University Hospital

    Tallaght, Dublin, D24 NR0A

Other trials in Ireland

Lithuania3 sites

  • Hospital of Lithuanian University of Health Sciences Kauno Klinikos

    Kaunas, Kaunas County, LT 50161

  • Lithuanian University of Health Sciences Kaunas Hospital

    Kaunas, Kaunas County, LT-47116

  • Republic Klaipeda Hospital

    Klaipėda, Klaipėda County, LT-92231

Other trials in Lithuania

Chile2 sites

  • Centro de Investigación de Enfermedades Respiratorias e Inmunológicas

    Viña del Mar, Valparaiso, 2520000

  • Clinica Fundacion Medica San Cristobal

    Vitacura, Santiago Metropolitan, 7630226

Other trials in Chile

Serbia1 site

  • Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary Oncology

    Kamenitz, Vojvodina, 21204

Other trials in Serbia

About this study

Official title: A Phase 2b Randomized, Double-blind, Placebo-controlled, Parallel-Group Study to Assess Efficacy and Safety of Verekitug (UPB-101) in Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

The purpose of this study is to assess the efficacy and safety of verekitug (UPB-101) in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), an inflammatory lung disease.

Read the detailed description

This is a global, multicenter study to assess the efficacy, safety, and tolerability of verekitug in participants with moderate-to-severe COPD. Adult participants are planned to be enrolled and will be allocated randomly in a 1:1:1 ratio to one of two dose levels of verekitug or placebo, in addition to their COPD background medications. The study consists of a screening period of approximately 4 weeks; treatment periods of between 60 weeks and up to 108 weeks; and a follow-up period, with the end-of-study visit 16 weeks after last dose.

Being tested
Verekitug, Placebo
Keywords
Verekitug, UPB-101, Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis, Thymic Stromal Lymphopoetin Receptor, Lung Inflammation, Biologic, Monoclonal Antibody, VENTURE
Medical subject headings
Pulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic, Pneumonia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • VerekitugDrug

    Also called UPB-101

    Verekitug (UPB-101) formulated solution

  • PlaceboOther

    Matching Placebo to Verekitug (UPB-101)

Study groups in NCT06981078
Study groupRoleWhat they receive
Verekitug (UPB-101) 100 mg and PlaceboExperimentalParticipants will receive 0.5 milliliter (mL) of the formulated solution (containing 100 milligrams [mg] of verekitug [UPB-101]) and 2.0 mL of matching placebo subcutaneously in two separate injections every 12 weeks up to Week 96.
Receives: Drug: Verekitug; Other: Placebo
Verekitug (UPB-101) 400 mg and PlaceboExperimentalParticipants will receive 2.0 mL of the formulated solution (containing 400 mg of verekitug [UPB-101]) and 0.5 mL of matching placebo subcutaneously in two separate injections every 24 weeks up to Week 96. Participants will also receive 2.0 mL and 0.5 mL of matching placebo subcutaneously in two separate injections at Weeks 12, 36, 60 and 84 visits.
Receives: Drug: Verekitug; Other: Placebo
PlaceboPlacebo comparatorParticipants will receive 0.5 mL of matching placebo and 2.0 mL of matching placebo subcutaneously in two separate injections every 12 weeks up to Week 96.
Receives: Other: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Annualized rate of moderate or severe COPD exacerbation events

    Measured: From Day 1 (Baseline) up to Week 108

Secondary outcomes (5)

  1. Change in pre-bronchodilator forced expiratory capacity in 1 second (FEV1)

    Measured: From Day 1 (Baseline) to Week 60

  2. Annualized rate of severe COPD exacerbation events

    Measured: From Day 1 (Baseline) up to Week 108

  3. Change in St. George's Respiratory Questionnaire (SGRQ) total score

    Measured: From Day 1 (Baseline) to Week 60

  4. Proportion of participants with SGRQ improvement of >4 points

    Measured: At Week 60

  5. Incidence of treatment-emergent adverse events and serious adverse events

    Measured: From Day 1 (Baseline) up to Week 112

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted20 May 2025
  2. Study start2 Jul 2025
  3. Primary completionOct 2027 (estimated)
  4. Study completionNov 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
666 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06981078
Sponsor's protocol ID
UPB-CP-06
Other IDs
2025-520488-42-00, 2025
Status last verified
Jul 2026
First submitted
9 May 2025
Last updated
20 Jul 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing Verekitug in people with Chronic Obstructive Pulmonary Disease, run by Upstream Bio Inc. at 242 sites in 23 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 242 sites in United States, Bulgaria, United Kingdom, Germany, Poland and 18 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Annualized rate of moderate or severe COPD exacerbation events (time frame: From Day 1 (Baseline) up to Week 108). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06981078.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026.

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