Neoadjuvant Therapy With Ivonescimab Combined With Chemotherapy for Triple-Negative Breast Cancer

Who cannot join

• 1. Cancer-related history and treatment history: a. Bilateral breast cancer. b. History of ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). c. History of invasive or metastatic breast cancer. d. Prior surgical resection or biopsy of the primary breast tumor or axillary metastatic lymph nodes before informed consent was obtained.e. Diagnosis of any malignancy within 5 years prior to signing informed consent, except for cured cervical in situ carcinoma, basal cell carcinoma, or squamous cell carcinoma of the skin.f. Systemic chemotherapy, targeted therapy, or local radiotherapy within 1 year prior to signing informed consent. g. Prior treatment with PD-1/PD-L1 antibodies, CTLA-4 antibodies, or other anti-PD-1/PD-L1 immunotherapies. h. Prior systemic treatment with anthracyclines, taxanes, or platinum-based agents for any malignancy.
• 2. Concomitant Diseases/History or Treatments: a.Immunodeficiency disease, b. Active or history of autoimmune disease requiring ongoing treatment, c. Known or suspected interstitial pneumonia; d. Severe cardiovascular or cerebrovascular diseases, e. Arterial thromboembolic events within 6 months prior to first dose, venous thromboembolic events ≥ Grade 3 according to NCI CTCAE v5.0, transient ischemic attack, cerebrovascular accident, hypertensive crisis, or hypertensive encephalopathy; current hypertension with systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg despite oral antihypertensive therapy; f. Receipt of live attenuated vaccines within 28 days; g. Active hepatitis B (defined as HBsAg positive and HBV-DNA ≥ 500 IU/mL); h. Hepatitis C (defined as HCV-RNA positive) i. History of tuberculosis infection or treatment within 1 year prior to signing informed consent; j. Major surgery within 28 days; k. Severe infection within 4 weeks prior to first dose, l. Prior allogeneic bone marrow transplantation or solid organ transplantation; m. Hemoptysis within 2 months prior to signing informed consent with maximum daily volume ≥ 2.5 mL; clinically significant bleeding event; n. Coagulation abnormalities; o. Peripheral neuropathy ≥ Grade 2 according to NCI CTCAE v5.0. p. Concurrent infectious diseases considered unsuitable for participation in the study.
• 3. Study Treatment-Related Criteria:
• Treatment with systemic immune-stimulatory agents within 4 weeks prior to first dose; b. Treatment with systemic immunosuppressive agents within 2 weeks prior to first dose, c. Known allergy to the investigational drug or any of its excipients; or history of severe allergic reactions to monoclonal antibodies;
• 4. Participation in any other clinical trial involving investigational drugs within 4 weeks prior to first dose, or less than five elimination half-lives since last investigational drug administration
• 5. History of substance abuse, alcoholism, or illicit drug use
• 6. Pregnant, lactating, or planning to become pregnant during the study period
• 7. Other serious physical or psychiatric illnesses or laboratory abnormalities that may increase the risk of participation, interfere with the study treatment or results, or in the opinion of the investigator, make the subject unsuitable for participation in the study.