Pain Intensity AssessmentWarmLidoNCT06962709
Studying Warmed Lidocaine for Increased Analgesic Effect During Intravitreal Injections
A study testing Warmed lidocaine in people with Pain Intensity Assessment and Pain Management, run by University of Missouri-Columbia at 1 site in United States.
Trial summary
Investigating whether warmed lidocaine increases analgesic effect for intravitreal injections Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Pain Intensity Assessment, Pain Management
- What is being tested?
- Warmed lidocaine
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 12 Jun 2024to 1 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Receiving intravitreal injection for any indication
Who cannot join
- Previous participant in study
Trial locations and contacts
1 site in 1 country.
United States1 site
University Hospital - Mason Eye Clinic
Columbia, Missouri, 65212
About this study
Official title: Comparing the Anesthetic Effect of Warmed Lidocaine to Room Temperature Lidocaine When Applied Topically for Intravitreal Injections
Investigating whether warmed lidocaine increases analgesic effect for intravitreal injections
- Conditions
- Pain Intensity Assessment, Pain Management
- Being tested
- Warmed lidocaine
- Keywords
- warmed lidocaine, intravitreal injections
- Medical subject headings
- Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Warmed lidocaineOther
Lidocaine warmed to 98 F
| Study group | Role | What they receive |
|---|---|---|
| Patients receiving warmed lidocaine | Experimental | Patients receive lidocaine jelly that has been warmed before they receive an intravitreal injection. Receives: Other: Warmed lidocaine |
| Patients receiving room temperature lidocaine | No intervention | Patients receive room temperature lidocaine before intravitreal injection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Rating
The level of pain associated with intravitreal injection as marked by patient on 10cm line.
Measured: immediately after the intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2025
- Study start12 Jun 2024
- Primary completion1 May 2026
- Study completion1 May 2026
Why it stopped: IRB requesting termination.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pain Intensity AssessmentStudies of the same condition, open and under way.
- More trials run by University of Missouri-ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Care provider
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Missouri-Columbia
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06962709
- Sponsor's protocol ID
- 2090898
- Acronym
- WarmLido
- Status last verified
- Sep 2026
- First submitted
- 24 Feb 2025
- Last updated
- 14 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing the Anesthetic Effect of Warmed Lidocaine to Room Temperature Lidocaine When Applied Topically for Intravitreal Injections
- ClinicalTrials.gov ID
- NCT06962709
- Acronym / sponsor ID
- WarmLido / 2090898
- Conditions
- Pain Intensity Assessment, Pain Management
- Keywords
- warmed lidocaine, intravitreal injections
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: IRB requesting termination.
- Enrolment
- 100 participants (actual)
- Lead sponsor
- University of Missouri-ColumbiaUniversity, hospital or other
- Study start
- 12 Jun 2024 (actual)
- Primary completion
- 1 May 2026 (actual)
- Study completion
- 1 May 2026 (actual)
- First posted
- 8 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Investigating whether warmed lidocaine increases analgesic effect for intravitreal injections
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, care provider)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patients receiving warmed lidocaine | Experimental | Other: Warmed lidocainePatients receive lidocaine jelly that has been warmed before they receive an intravitreal injection. |
| Patients receiving room temperature lidocaine | No intervention | –Patients receive room temperature lidocaine before intravitreal injection |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Receiving intravitreal injection for any indication
Key exclusion criteria (1 listed)
- Previous participant in study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Warmed lidocaineLidocaine warmed to 98 F | Other | Patients receiving warmed lidocaine |
Primary outcome
Pain Rating
Time frame: immediately after the intervention
The level of pain associated with intravitreal injection as marked by patient on 10cm line.
Results and safety
The study was stopped early (reason given: IRB requesting termination.). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Warmed lidocaine in people with Pain Intensity Assessment and Pain Management, run by University of Missouri-Columbia at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: IRB requesting termination.). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Rating (time frame: immediately after the intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.