AzTrials
AzTrials

Prostate CancerPhase 3NCT06925737

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

A Phase 3 study testing Ifinatamab deruxtecan, Docetaxel and Prednisone in people with Prostate Cancer and Prostatic Neoplasms, run by Merck Sharp & Dohme LLC at 303 sites in 35 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record

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Trial summary

Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. Read more about this study

Who is it for?
Ages 18 years and older, men only
Conditions the study is for
Prostate Cancer, Prostatic Neoplasms
What is being tested?
Ifinatamab deruxtecan, Docetaxel and Prednisone
Could I receive a placebo?
No, everyone receives an active treatment
How many people
1,440 participants
Where
303 sitesin 35 countries
Study dates
13 May 2025to 6 Jan 2031
Phase
Phase 3

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • Men only
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • The main inclusion criteria include but are not limited to the following:
  • Has histologically- or cytologically-confirmed adenocarcinoma of the prostate without small cell histology
  • Has prostate cancer progression while on androgen deprivation therapy (ADT) (or post bilateral orchiectomy) within 6 months prior to Screening
  • Has current evidence of distant metastatic disease (M1 disease) documented by either bone lesions on bone scan and/or soft tissue disease by computed tomography (CT)/magnetic resonance imaging (MRI)
  • Has received prior treatment with 1 or 2 androgen receptor pathway inhibitors (ARPIs) and progressed during or after at least 8 weeks of treatment
  • Has provided tumor tissue from a core or excisional biopsy from soft tissue not previously irradiated and obtained after disease progression on the most recent prior therapy
  • Has recovered from adverse events (AEs) due to previous anticancer therapies

Who cannot join

  • The main exclusion criteria include but are not limited to the following:
  • Is unable to swallow tablets/capsules
  • Has any of the following indicators of interstitial lung disease (ILD)/pneumonitis:
  • Has any history of ILD/pneumonitis that required steroid use, except for a history of radiation pneumonitis that did not require steroids
  • Has current ILD/pneumonitis
  • Has a clinical or radiographic suspicion of ILD for which the diagnosis of ILD cannot be ruled out
Show all 11Show fewer
  • Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses
  • Has uncontrolled or significant cardiovascular disease
  • Has received prior treatment with a taxane-based chemotherapy agent for metastatic castration-resistant prostate cancer (mCRPC)
  • Has had prior discontinuation of an antibody drug conjugate (ADC) that consists of an exatecan derivative (eg, trastuzumab deruxtecan) due to treatment-related toxicities
  • Has a "superscan" bone scan

Trial locations and contacts

303 sites in 35 countries. Contact the study team or a site near you to ask about taking part.

Toll Free Number contact

1-888-577-8839

Trialsites@msd.com

303 sites in 35 countries

United States55 sites, 51 recruiting

  • University of New Mexico Comprehensive Cancer Center ( Site 0022)

    Albuquerque, New Mexico, 87131

    Study Coordinator, 505-272-4946

    Recruiting

  • University of Michigan ( Site 0005)

    Ann Arbor, Michigan, 48109

    Study Coordinator, 734-647-8902

    Recruiting

  • Emory University School of Medicine- Grady Campus ( Site 0103)

    Atlanta, Georgia, 30303

    Study Coordinator, 404-727-6123

    Recruiting

  • Winship Cancer Institute, Emory University ( Site 0003)

    Atlanta, Georgia, 30322

    Study Coordinator, 404-778-4824

    Recruiting

  • Rocky Mountain Regional Veterans Affairs Medical Center ( Site 0053)

    Aurora, Colorado, 80045

    Study Coordinator, 303-399-8020

    Recruiting

  • Greenebaum Comprehensive Cancer Center ( Site 0021)

    Baltimore, Maryland, 21201

    Study Coordinator, 410-707-4011

    Recruiting

  • St. Vincent Frontier Cancer Center-Research ( Site 0037)

    Billings, Montana, 59102

    Study Coordinator, 406-238-6290

    Recruiting

  • Beth Israel Deaconess Medical Center ( Site 0043)

    Boston, Massachusetts, 02215

    Study Coordinator, 617-667-2100

    Recruiting

  • Dana Farber Cancer Institute ( Site 0012)

    Boston, Massachusetts, 02215

    Study Coordinator, 617-632-6049

    Recruiting

  • Rush University Medical Center-Hematology and Oncology ( Site 0028)

    Chicago, Illinois, 60607

    Study Coordinator, 312-563-2531

    Recruiting

  • University of Illinois at Chicago-University of Illinois Cancer Center ( Site 0063)

    Chicago, Illinois, 60612

    Study Coordinator, 312-355-1625

    Recruiting

  • Clermont Oncology Center ( Site 0087)

    Clermont, Florida, 34711

    Study Coordinator, 386-538-3169

    Recruiting

  • Community Cancer Institute ( Site 0081)

    Clovis, California, 93611

    Study Coordinator, 559-387-1600

    Recruiting

  • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0061)

    Columbus, Ohio, 43221

    Study Coordinator, 619-228-4010

    Recruiting

  • Parkland Health & Hospital System ( Site 0069)

    Dallas, Texas, 75235

    Study Coordinator, 214-645-4673

    Recruiting

  • UT Southwestern Medical Center ( Site 0039)

    Dallas, Texas, 75390

    Study Coordinator, 972-332-4682

    Recruiting

  • Henry Ford Hospital ( Site 0035)

    Detroit, Michigan, 48202

    Study Coordinator, 313-725-7920

    Recruiting

  • City of Hope Comprehensive Cancer Center ( Site 0049)

    Duarte, California, 91010

    Study Coordinator, 626-256-4673

    Recruiting

  • Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island ( Site 0076)

    Grand Island, Nebraska, 68803

    Completed

  • Cancer and Hematology Centers of Western Michigan ( Site 0015)

    Grand Rapids, Michigan, 49503

    Study Coordinator, 616-399-6500

    Recruiting

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0016)

    Hackensack, New Jersey, 07601

    Study Coordinator, 551-996-5900

    Recruiting

  • University of Texas-MD Anderson Cancer Center ( Site 0055)

    Houston, Texas, 77030

    Study Coordinator, 877-632-6789

    Recruiting

  • City of Hope Lennar Foundation Cancer Center ( Site 0059)

    Irvine, California, 92618

    Study Coordinator, 626-256-4673

    Recruiting

  • Mayo Clinic in Florida-Mayo Clinic Comprehensive Cancer Center ( Site 0077)

    Jacksonville, Florida, 32224

    Study Coordinator, 855-776-0015

    Recruiting

  • Moores Cancer Center ( Site 0010)

    La Jolla, California, 92093

    Study Coordinator, 858-822-6100

    Recruiting

  • Comprehensive Cancer Centers of Nevada ( Site 0082)

    Las Vegas, Nevada, 89148

    Study Coordinator, 702-952-1251

    Recruiting

  • University of Kentucky Chandler Medical Center ( Site 0048)

    Lexington, Kentucky, 40536

    Study Coordinator, 866-340-4488

    Recruiting

  • Veterans Affairs Long Beach Healthcare System ( Site 0058)

    Long Beach, California, 90822

    Study Coordinator, 562-826-8000

    Recruiting

  • Cedars-Sinai Medical Center ( Site 0068)

    Los Angeles, California, 90048

    Study Coordinator, 310-423-7600

    Recruiting

  • UCLA Hematology/Oncology - Santa Monica ( Site 0002)

    Los Angeles, California, 90404

    Study Coordinator, 310-825-2631

    Recruiting

  • University Hospital and UW Health Clinics ( Site 0065)

    Madison, Wisconsin, 53792

    Study Coordinator, 608-915-0100

    Recruiting

  • Memphis VA Medical Center ( Site 0072)

    Memphis, Tennessee, 38105

    Study Coordinator, 901-523-8990

    Recruiting

  • Medical College of Wisconsin ( Site 0008)

    Milwaukee, Wisconsin, 53226

    Study Coordinator, 414-805-0509

    Recruiting

  • SCRI Oncology Partners ( Site 0074)

    Nashville, Tennessee, 37203

    Study Coordinator, 615-329-7640

    Recruiting

  • Henry-Joyce Cancer Clinic ( Site 0042)

    Nashville, Tennessee, 37232

    Study Coordinator, 615-936-8422

    Recruiting

  • Yale-New Haven Hospital-Yale Cancer Center ( Site 0050)

    New Haven, Connecticut, 06510

    Study Coordinator, 203-737-6087

    Recruiting

  • Icahn School of Medicine at Mount Sinai ( Site 0009)

    New York, New York, 10029

    Study Coordinator, 212-241-6756

    Recruiting

  • Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0026)

    Omaha, Nebraska, 68130

    Completed

  • University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0006)

    Orange, California, 92868

    Study Coordinator, 714-509-2371

    Recruiting

  • Mid Florida Hematology and Oncology Center ( Site 0086)

    Orange City, Florida, 32763

    Study Coordinator, 386-774-1223

    Recruiting

  • Stanford Cancer Center ( Site 0046)

    Palo Alto, California, 94304

    Study Coordinator, 650-725-2078

    Recruiting

  • Perelman Center for Advanced Medicine ( Site 0067)

    Philadelphia, Pennsylvania, 19104

    Study Coordinator, 215-360-0737

    Recruiting

  • Abramson Cancer Center - Penn Medicine ( Site 0079)

    Philadelphia, Pennsylvania, 19106

    Study Coordinator, 215-829-6088

    Recruiting

  • Mayo Clinic in Arizona - Phoenix ( Site 0044)

    Phoenix, Arizona, 85054

    Study Coordinator, 855-776-0015

    Recruiting

  • VA Portland Health Care System ( Site 0038)

    Portland, Oregon, 97239

    Study Coordinator, 503-220-8262

    Recruiting

  • Blue Ridge Cancer Care ( Site 0024)

    Roanoke, Virginia, 24014

    Active, not recruiting

  • Mayo Clinic in Rochester, Minnesota-Mayo Clinic Comprehensive Cancer Center ( Site 0078)

    Rochester, Minnesota, 55905

    Study Coordinator, 855-776-0015

    Recruiting

  • HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0032)

    Saint Louis Park, Minnesota, 55426

    Study Coordinator, 612-341-4800

    Recruiting

  • HealthPartners Cancer Center at Regions Hospital ( Site 0052)

    Saint Paul, Minnesota, 55101

    Study Coordinator, 612-341-4800

    Recruiting

  • VA Puget Sound Health Care System ( Site 0054)

    Seattle, Washington, 98108

    Study Coordinator, 206-762-1010

    Recruiting

  • Fred Hutchinson Cancer Center ( Site 0060)

    Seattle, Washington, 98109

    Study Coordinator, 206-606-7307

    Recruiting

  • The GW Medical Faculty Associates ( Site 0057)

    Washington D.C., District of Columbia, 20037

    Completed

  • Washington DC Veterans Affairs Medical Center ( Site 0056)

    Washington D.C., District of Columbia, 20422

    Study Coordinator, 202-745-8000

    Recruiting

  • Veterans Affairs Connecticut Healthcare System ( Site 0062)

    West Haven, Connecticut, 06516

    Study Coordinator, 203-932-5711

    Recruiting

  • Great Lakes Cancer Care ( Site 0047)

    Williamsville, New York, 14221

    Study Coordinator, 716-884-3000

    Recruiting

Other trials in United States

China34 sites, 34 recruiting

  • Peking University First Hospital ( Site 1434)

    Beijing, Beijing Municipality, 100034

    Study Coordinator, 010-83572505

    Recruiting

  • Shanghai General Hospital ( Site 1449)

    Beijing, Beijing Municipality, 200080

    Study Coordinator, 021-36126255

    Recruiting

  • Jilin Province People's Hospital ( Site 1461)

    Changchun, Jilin, 130021

    Study Coordinator, 0431-8595238

    Recruiting

  • Hunan Cancer Hospital ( Site 1411)

    Changsha, Hunan, 410013

    Study Coordinator, 0731-89762271

    Recruiting

  • West China Hospital of Sichuan University ( Site 1451)

    Chengdu, Sichuan, 610041

    Study Coordinator, +8618980606710

    Recruiting

  • West China Hospital, Sichuan University ( Site 1468)

    Chengdu, Sichuan, 610041

    Study Coordinator, 028-85422114

    Recruiting

  • The First Affiliated Hospital of Chonqing Medical University ( Site 1406)

    Chongqing, Chongqing Municipality, 400016

    Study Coordinator, 02389012012

    Recruiting

  • Chongqing University Three Gorges Hospital ( Site 1405)

    Chongqing, Chongqing Municipality, 404199

    Study Coordinator, 02358104650

    Recruiting

  • The First Affiliated Hospital Of Fujian Medical University ( Site 1452)

    Fuzhou, Fujian, 350005

    Study Coordinator, 0591-87981262

    Recruiting

  • Guangzhou First People's Hospital ( Site 1410)

    Guangzhou, Guangdong, 510000

    Study Coordinator, 020-81048888

    Recruiting

  • Sun Yat-Sen University Cancer Center ( Site 1467)

    Guangzhou, Guangdong, 510060

    Study Coordinator, 020-87343565

    Recruiting

  • Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 1402)

    Guangzhou, Guangdong, 510220

    Study Coordinator, 020-81332199

    Recruiting

  • Sun Yat-sen University Cancer Center ( Site 1409)

    Guangzhou, Guangdong, 510300

    Study Coordinator, +862066673666

    Recruiting

  • Zhejiang Cancer Hospital ( Site 1447)

    Hangzhou, Zhejiang, 310022

    Study Coordinator, 0571-88122222

    Recruiting

  • The First Hospital of Jiaxing ( Site 1416)

    Jiaxing, Zhejiang, 314001

    Study Coordinator, 0573-82519999

    Recruiting

  • Shandong Cancer Hospital ( Site 1421)

    Jinan, Shandong, 250117

    Study Coordinator, 0531-67626986

    Recruiting

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 1425)

    Nanjing, Jiangsu, 210008

    Study Coordinator, 02583106666

    Recruiting

  • Jiangsu Province Hospital ( Site 1426)

    Nanjing, Jiangsu, 210029

    Study Coordinator, 025-68306259

    Recruiting

  • Zhongda Hospital Southeast University ( Site 1427)

    Nanjing, Jiangsu, 214023

    Study Coordinator, 025-83272084

    Recruiting

  • Guangxi Medical University Cancer Hospital ( Site 1414)

    Nanning, Guangxi, 530201

    Study Coordinator, 0771-5331955

    Recruiting

  • The First Affiliated Hospital of Ningbo University ( Site 1419)

    Ningbo, Zhejiang, 315010

    Study Coordinator, 86057487085146

    Recruiting

  • Shanghai Tenth People's Hospital ( Site 1441)

    Shanghai, Shanghai Municipality, 200000

    Study Coordinator, 021-66300588

    Recruiting

  • Fudan University Shanghai Cancer Center ( Site 1400)

    Shanghai, Shanghai Municipality, 200032

    Study Coordinator, 021-64175590

    Recruiting

  • Zhongshan Hospital Fudan University ( Site 1430)

    Shanghai, Shanghai Municipality, 200032

    Study Coordinator, 8602131587861

    Recruiting

  • Shanghai Tongji Hospital ( Site 1412)

    Shanghai, Shanghai Municipality, 200065

    Study Coordinator, 021-56051080

    Recruiting

  • Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 1457)

    Shanghai, Shanghai Municipality, 200127

    Study Coordinator, 021-58752345

    Recruiting

  • First Affiliated Hospital Of Shanxi Medical University ( Site 1460)

    Taiyuan, Shanxi, 030001

    Study Coordinator, +86 0351-4639766

    Recruiting

  • The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 1469)

    Ürümqi, Xinjiang, 830000

    Study Coordinator, 0991-7968088

    Recruiting

  • The First Affiliated Hospital of Wenzhou Medical University ( Site 1437)

    Wenzhou, Zhejiang, 325000

    Study Coordinator, 057755579999

    Recruiting

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1424)

    Wuhan, Hubei, 430022

    Study Coordinator, 027-85726114

    Recruiting

  • The first affiliated Hospital of Xi an Jiaotong University ( Site 1408)

    Xi'an, Shaanxi, 710061

    Study Coordinator, 029-85323112

    Recruiting

  • The Affiliated Hospital of Xuzhou Medical University ( Site 1438)

    Xuzhou, Jiangsu, 221002

    Study Coordinator, 0516-85806507

    Recruiting

  • Henan Cancer Hospital ( Site 1472)

    Zhengzhou, Henan, 450008

    Study Coordinator, 400-0371-818

    Recruiting

  • The Fifth Affiliated Hospital of Sun Yat-Sen University ( Site 1459)

    Zhuhai, Guangdong, 51900

    Study Coordinator, +8607562528188

    Recruiting

Other trials in China

Japan31 sites, 28 recruiting

  • University of Yamanashi Hospital ( Site 1506)

    Chūō, Yamanashi, 409-3898

    Study Coordinator, +81-55-273-9325

    Recruiting

  • Harasanshin Hospital ( Site 1517)

    Fukuoka, 812-0033

    Study Coordinator, +81-92-291-3434

    Recruiting

  • Kyushu University Hospital ( Site 1515)

    Fukuoka, 812-8582

    Study Coordinator, +81926425774

    Recruiting

  • Gifu University Hospital ( Site 1527)

    Gifu, 501-1194

    Study Coordinator, +81-58-230-6000

    Recruiting

  • University of the Ryukyus Hospital ( Site 1519)

    Ginowan, Okinawa, 901-2725

    Study Coordinator, +81-98-894-1455

    Recruiting

  • Hamamatsu University Hospital ( Site 1520)

    Hamamatsu, Shizuoka, 431-3192

    Study Coordinator, +81-53-435-2111

    Recruiting

  • Hiroshima University Hospital ( Site 1512)

    Hiroshima, 734-8551

    Study Coordinator, +81-82-257-5555

    Recruiting

  • Kagoshima University Hospital ( Site 1518)

    Kagoshima, 890-8520

    Completed

  • Kagoshima City Hospital ( Site 1528)

    Kagoshima, 890-8760

    Completed

  • Kanazawa Medical University Hospital ( Site 1507)

    Kahoku-gun, Ishikawa-ken, 920-0293

    Study Coordinator, +81-76-286-3511

    Recruiting

  • Shonan Kamakura General Hospital ( Site 1530)

    Kamakura, Kanagawa, 247-8533

    Study Coordinator, +81-467-46-1717

    Recruiting

  • Hospital of the University of Occupational and Environmental Health, Japan ( Site 1510)

    Kitakyushu, Fukuoka, 807-8556

    Study Coordinator, +81-93-691-7503

    Recruiting

  • Kobe University Hospital ( Site 1511)

    Kobe, Hyōgo, 650-0017

    Study Coordinator, +81-78-382-5111

    Recruiting

  • Dokkyo Medical University Saitama Medical Center ( Site 1502)

    Koshigaya, Saitama, 343-8555

    Study Coordinator, +81-48-965-1111

    Recruiting

  • National Hospital Organization Kumamoto Medical Center ( Site 1524)

    Kumamoto, 860-0008

    Study Coordinator, +81-96-353-6501

    Recruiting

  • Kurume University Hospital ( Site 1516)

    Kurume, Fukuoka, 830-0011

    Study Coordinator, +81-942-35-3311

    Recruiting

  • University Hospital,Kyoto Prefectural University of Medicine ( Site 1525)

    Kyoto, 602-8566

    Study Coordinator, +81-75-251-5111

    Recruiting

  • The Jikei University Hospital ( Site 1504)

    Minato, Tokyo, 105-8471

    Study Coordinator, +81-3-3433-1111

    Recruiting

  • Nagano Municipal Hospital ( Site 1526)

    Nagano, 381-8551

    Study Coordinator, +81-26-295-1199

    Recruiting

  • Nagasaki University Hospital ( Site 1523)

    Nagasaki, 852-8501

    Study Coordinator, +81-958-19-7200

    Recruiting

  • Nagoya University Hospital ( Site 1508)

    Nagoya, Aichi-ken, 466-8560

    Study Coordinator, +81-52-741-2111

    Recruiting

  • Niigata Cancer Center Hospital ( Site 1529)

    Niigata, 951-8566

    Study Coordinator, +81-25-266-5111

    Recruiting

  • Bell Land General Hospital ( Site 1509)

    Sakai, Osaka, 599-8247

    Study Coordinator, +81-72-234-2001

    Recruiting

  • Toho University Sakura Medical Center ( Site 1503)

    Sakura, Chiba, 285-8741

    Study Coordinator, +81-43-462-8811

    Recruiting

  • Sapporo Medical University Hospital ( Site 1501)

    Sapporo, Hokkaido, 060-8543

    Study Coordinator, +81-11-611-2111

    Recruiting

  • Hokkaido University Hospital ( Site 1500)

    Sapporo, Hokkaido, 060-8648

    Study Coordinator, +81-11-716-1161

    Recruiting

  • Tokyo Women's Medical University ( Site 1505)

    Shinjuku, Tokyo, 162-8666

    Active, not recruiting

  • Tokushima University Hospital ( Site 1513)

    Tokushima, 770-8503

    Study Coordinator, +81-88-633-9294

    Recruiting

  • Ehime University Hospital ( Site 1514)

    Tōon, Ehime, 791-0295

    Study Coordinator, +81-89-964-5111

    Recruiting

  • Yamaguchi University Hospital ( Site 1522)

    Ube, Yamaguchi, 755-8505

    Study Coordinator, +81-836-22-2111

    Recruiting

  • Oita University Hospital ( Site 1521)

    Yufu, Oita Prefecture, 879-5593

    Study Coordinator, +81-97-549-4411

    Recruiting

Other trials in Japan

Germany13 sites, 13 recruiting

  • Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0352)

    Berlin, 10117

    Study Coordinator, 4930450615285

    Recruiting

  • Studienzentrum Bayenthal Urologische Partnerschaft Koln ( Site 0365)

    Cologne, North Rhine-Westphalia, 50968

    Study Coordinator, +4917642771450

    Recruiting

  • Urologicum Duisburg ( Site 0361)

    Duisburg, North Rhine-Westphalia, 47169

    Study Coordinator, +4920360012919

    Recruiting

  • Universitätsklinikum Frankfurt Goethe-Universität ( Site 0354)

    Frankfurt am Main, Hesse, 60590

    Study Coordinator, +4969630180072

    Recruiting

  • Universitaetsklinik Hamburg-Eppendorf ( Site 0351)

    Hamburg, 20246

    Study Coordinator, +4915222815585

    Recruiting

  • Universitaetsklinikum Schleswig Holstein ( Site 0360)

    Lübeck, Schleswig-Holstein, 23538

    Study Coordinator, +49 451 500 43601

    Recruiting

  • Universitätsmedizin Johannes Gutenberg Universität Mainz ( Site 0362)

    Mainz, Rhineland-Palatinate, 55131

    Study Coordinator, +49 6131 170

    Recruiting

  • Klinikum der Universität München Großhadern ( Site 0366)

    Munich, Bavaria, 81377

    Study Coordinator, 08944000

    Recruiting

  • klinikum rechts der isar der technischen universität münchen ( Site 0350)

    Munich, Bavaria, 81675

    Study Coordinator, 49 89 4140 2522

    Recruiting

  • Klinikum Nuernberg Nord ( Site 0353)

    Nuremberg, Bavaria, 90419

    Study Coordinator, +49 911 398 3085

    Recruiting

  • Studienpraxis Urologie ( Site 0358)

    Nürtingen, Baden-Wurttemberg, 72622

    Study Coordinator, 0049 15201622246

    Recruiting

  • LOGICURO GmbH ( Site 0364)

    Potsdam, Brandenburg, 14482

    Study Coordinator, +4933188769587

    Recruiting

  • Klinikum Stuttgart - Katharinenhospital ( Site 0355)

    Stuttgart, Baden-Wurttemberg, 70174

    Study Coordinator, +4971127854720

    Recruiting

Other trials in Germany

Netherlands13 sites, 13 recruiting

  • Meander Medisch Centrum ( Site 0604)

    Amersfoort, Utrecht, 3813 TZ

    Study Coordinator, +3133850 7278

    Recruiting

  • Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0602)

    Amsterdam, North Holland, 1066 CX

    Study Coordinator, 003120512 9111

    Recruiting

  • Martini Ziekenhuis ( Site 0621)

    Groningen, 9728 NT

    Study Coordinator, 050-5246311

    Recruiting

  • Ziekenhuisgroep Twente, locatie Almelo ( Site 0615)

    Hengelo, Overijssel, 7555 DL

    Study Coordinator, +31887083782

    Recruiting

  • Tergooiziekenhuizen, locatie Hilversum ( Site 0619)

    Hilversum, North Holland, 1212 VG

    Study Coordinator, +31887535153

    Recruiting

  • Spaarne Gasthuis - Hoofddorp ( Site 0608)

    Hoofddorp, North Holland, 2134 TM

    Study Coordinator, +31232245802

    Recruiting

  • Maastricht UMC+ ( Site 0612)

    Maastricht, Limburg, 6229 HX

    Study Coordinator, 043-3877025

    Recruiting

  • UMC St. Radboud ( Site 0601)

    Nijmegen, Gelderland, 6525 GA

    Study Coordinator, 0031243610353

    Recruiting

  • Erasmus Medisch Centrum ( Site 0611)

    Rotterdam, South Holland, 3015 GD

    Study Coordinator, 0031107041906

    Recruiting

  • Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 0600)

    Schiedam, South Holland, 3118 JH

    Study Coordinator, +31108931441

    Recruiting

  • Haga Ziekenhuis locatie Leyweg ( Site 0607)

    The Hague, South Holland, 2545 AA

    Study Coordinator, 070-210 2143

    Recruiting

  • St. Antonius Ziekenhuis, locatie Utrecht ( Site 0620)

    Utrecht, 3543 AZ

    Study Coordinator, +31883205148

    Recruiting

  • VieCuri Medisch Centrum, locatie Venlo ( Site 0610)

    Venlo, Limburg, 5912 BL

    Study Coordinator, 077-3205634

    Recruiting

Other trials in Netherlands

Spain11 sites, 11 recruiting

  • Hospital del Mar ( Site 0822)

    Barcelona, 08003

    Study Coordinator, 34932483860

    Recruiting

  • Hospital Vall D Hebron ( Site 0814)

    Barcelona, 08035

    Study Coordinator, +34 93 4894374

    Recruiting

  • Hospital Universitario Reina Sofia ( Site 0816)

    Córdoba, 14004

    Study Coordinator, +34 957011464

    Recruiting

  • Hospital Lucus Augusti ( Site 0813)

    Lugo, 27003

    Study Coordinator, +343982296459

    Recruiting

  • Hospital General Universitario Gregorio Marañón ( Site 0812)

    Madrid, Madrid, Comunidad de, 28009

    Study Coordinator, +34 914269393

    Recruiting

  • Hospital Universitario Quiron Madrid ( Site 0823)

    Madrid, 28223

    Study Coordinator, +34914521987

    Recruiting

  • HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 0811)

    Majadahonda Madrid, Madrid, 28220

    Study Coordinator, +34911917418

    Recruiting

  • Hospital Universitario Marqués de Valdecilla ( Site 0810)

    Santander, Cantabria, 39008

    Study Coordinator, +34 +349422025155 25

    Recruiting

  • CHUS - Hospital Clinico Universitario ( Site 0815)

    Santiago de Compostela, La Coruna, 15706

    Study Coordinator, +34 663 609 134

    Recruiting

  • Hospital Universitario Virgen de Valme ( Site 0819)

    Seville, 41014

    Study Coordinator, +34955015273

    Recruiting

  • Fundación Instituto Valenciano de Oncología ( Site 0821)

    Valencia, 46009

    Study Coordinator, +34 96 111 42 29

    Recruiting

Other trials in Spain

France10 sites, 9 recruiting

  • CHU Besançon ( Site 0305)

    Besançon, Doubs, 25000

    Completed

  • Centre François Baclesse ( Site 0311)

    Caen, Calvados, 14076

    Study Coordinator, +33231455002

    Recruiting

  • Clinique Francois Chenieux ( Site 0312)

    Limoges, Haute-Vienne, 87039

    Study Coordinator, +33555454800

    Recruiting

  • Hôpital Privé Clairval ( Site 0303)

    Marseille, Bouches-du-Rhone, 13273

    Study Coordinator, +33496196230

    Recruiting

  • Centre Hospitalier Universitaire de Nîmes - Institut de Canc-Medical Oncology ( Site 0313)

    Nîmes, Gard, 30029

    Study Coordinator, +330466282491

    Recruiting

  • Hôpital Saint-Louis ( Site 0310)

    Paris, Île-de-France Region, 75010

    Study Coordinator, +33142494212

    Recruiting

  • CHU de Rouen ( Site 0301)

    Rouen, Seine-Maritime, 76031

    Study Coordinator, +33232881315

    Recruiting

  • Hopitaux Universitaires de Strasbourg- Hopital de Hautepierre ( Site 0314)

    Strasbourg, Bas-Rhin, 67200

    Study Coordinator, +33388116768

    Recruiting

  • Hôpital Foch ( Site 0309)

    Suresnes, Ain, 92150

    Study Coordinator, +33146253581

    Recruiting

  • Institut de Cancérologie de Lorraine Alexis Vautrin ( Site 0307)

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54519

    Study Coordinator, +33383598551

    Recruiting

Other trials in France

Argentina9 sites, 9 recruiting

  • Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0136)

    Berazategui, Buenos Aires, B1884BBF

    Study Coordinator, +541142262013

    Recruiting

  • Centro Medico Dra De Salvo ( Site 0132)

    CABA, C1426ABP

    Study Coordinator, +5491151082017

    Recruiting

  • Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0131)

    La Rioja, F5300COE

    Study Coordinator, +543804693919

    Recruiting

  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0129)

    Mar del Plata, Buenos Aires, B7600FZO

    Study Coordinator, +5491132661847

    Recruiting

  • Instituto Alexander Fleming ( Site 0125)

    Mar del Plata, Buenos Aires, C1426ANZ

    Study Coordinator, +541132218900

    Recruiting

  • Centro Oncologico de Integracion Regional. COIR ( Site 0130)

    Mendoza, M5500AYB

    Study Coordinator, +542614252575

    Recruiting

  • Sanatorio Parque ( Site 0126)

    Rosario, Santa Fe Province, S2000DSV

    Study Coordinator, +543414200222

    Recruiting

  • Centro de Diagnostico Investigación y Tratamiento Oncológico (CeDIT) ( Site 0135)

    Salta, A4400AWG

    Study Coordinator, +5403874227282

    Recruiting

  • Instituto San Marcos ( Site 0137)

    San Juan, J5400EBB

    Study Coordinator, +5492645836798

    Recruiting

Other trials in Argentina

Italy9 sites, 8 recruiting

  • Azienda USL 8 di Arezzo ( Site 0503)

    Arezzo, 52100

    Study Coordinator, 0575255446

    Recruiting

  • Humanitas Gavazzeni ( Site 0508)

    Bergamo, 24125

    Completed

  • Azienda Ospedaliero Universitaria Policlinico Riuniti di Foggia ( Site 0510)

    Foggia, 71122

    Study Coordinator, 0881-736426

    Recruiting

  • Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0500)

    Milan, Lombardy, 20133

    Study Coordinator, (+39) 0223903028

    Recruiting

  • Istituto Nazionale Tumori Regina Elena ( Site 0507)

    Rome, Roma, 00128

    Study Coordinator, +390652666271

    Recruiting

  • Istituto Clinico Humanitas ( Site 0504)

    Rozzano, Milano, 20089

    Study Coordinator, (+39) 0282244061

    Recruiting

  • Azienda Ospedaliero Universitaria Senese ( Site 0505)

    Siena, Tuscany, 53100

    Study Coordinator, (+39) 0577586335

    Recruiting

  • Azienda Ospedaliera Santa Maria Terni ( Site 0509)

    Terni, 05100

    Study Coordinator, (+39) 0744205410

    Recruiting

  • Centro Ricerche Cliniche di Verona ( Site 0506)

    Verona, 37134

    Study Coordinator, 0458128120

    Recruiting

Other trials in Italy

United Kingdom8 sites, 7 recruiting

  • Queen Elizabeth Hospital Birmingham ( Site 0923)

    Birmingham, England, B15 2TH

    Study Coordinator, +441216272000

    Recruiting

  • Addenbrooke's Hospital ( Site 0915)

    Cambridge, Cambridgeshire, CB2 2QQ

    Study Coordinator, +441223805000

    Recruiting

  • Torbay Hospital ( Site 0918)

    Devon, United Kingdom, TQ2 7AA

    Study Coordinator, +441803656615

    Recruiting

  • Royal Devon & Exeter Hospital ( Site 0924)

    Exeter, Devon, EX2 5DW

    Active, not recruiting

  • University College London Hospital ( Site 0920)

    London, Camden, NW1 2PG

    Study Coordinator, +442034477729

    Recruiting

  • St Bartholomew s Hospital ( Site 0925)

    London, London, City of, EC1A 7BE

    Study Coordinator, 020 7377 7000

    Recruiting

  • Mount Vernon Hospital ( Site 0921)

    Northwood, Hillingdon, HA6 2RN

    Study Coordinator, 0203 826 2020

    Recruiting

  • Royal Marsden Hospital (Sutton) ( Site 0922)

    Sutton, London, City of, SM2 5PT

    Study Coordinator, +4402087224191

    Recruiting

Other trials in United Kingdom

Colombia7 sites, 7 recruiting

  • Centro Cancerológico del Caribe (CECAC) ( Site 0227)

    Barranquilla, Atlántico, 080002

    Study Coordinator, +573003263183

    Recruiting

  • FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0230)

    Bogota, Cundinamarca, 110111

    Study Coordinator, +57 3219198898

    Recruiting

  • Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0229)

    Bogotá, Bogota D.C., 111321

    Study Coordinator, +57 3103469453

    Recruiting

  • Instituto Nacional De Cancerologia ( Site 0237)

    Bogotá, Bogota D.C., 111511

    Study Coordinator, +57 311 8083188

    Recruiting

  • Promotora Medica Las Americas S.A ( Site 0234)

    Medellín, Antioquia, 050025

    Study Coordinator, +573332779092

    Recruiting

  • Oncologos Del Occidente ( Site 0231)

    Pereira, Risaralda Department, 660001

    Study Coordinator, +576063310712

    Recruiting

  • Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0228)

    Valledupar, Cesar Department, 200001

    Study Coordinator, +57 315 8505190

    Recruiting

Other trials in Colombia

Israel7 sites, 7 recruiting

  • Rambam Health Care Campus ( Site 0462)

    Haifa, 3109601

    Study Coordinator, 04-7776234

    Recruiting

  • Shaare Zedek Medical Center ( Site 0468)

    Jerusalem, 9103102

    Study Coordinator, +97226555999

    Recruiting

  • Meir Medical Center ( Site 0464)

    Kfar Saba, 4428164

    Study Coordinator, 972-50-3745684

    Recruiting

  • Rabin Medical Center ( Site 0461)

    Petah Tikva, 4941492

    Study Coordinator, 972-3-9378074

    Recruiting

  • Sheba Medical Center ( Site 0460)

    Ramat Gan, 5265601

    Study Coordinator, 0544557539

    Recruiting

  • Sourasky Medical Center ( Site 0463)

    Tel Aviv, 6423906

    Study Coordinator, 03-6974907

    Recruiting

  • Yitzhak Shamir Medical Center. ( Site 0466)

    Ẕerifin, 7033001

    Study Coordinator, 972-8-9542196

    Recruiting

Other trials in Israel

Turkey (Türkiye)7 sites, 7 recruiting

  • Adana Medical Park Seyhan Hastanesi ( Site 0906)

    Adana, 01140

    Study Coordinator, +905434352540

    Recruiting

  • Sakarya Egitim ve Arastırma Hastanesi ( Site 0897)

    Adapazarı, Sakarya, 54290

    Study Coordinator, 05523552411

    Recruiting

  • Hacettepe Universitesi Tip Fakultesi ( Site 0895)

    Ankara, 06230

    Study Coordinator, +90 5447363405

    Recruiting

  • Gazi University Health Research and Application Center Gazi Hospital ( Site 0903)

    Ankara, 06560

    Study Coordinator, 5064450149

    Recruiting

  • Ankara Universitesi Tıp Fakultesi Hastanesi ( Site 0901)

    Ankara, 06590

    Study Coordinator, +905076255017

    Recruiting

  • Istanbul Universitesi Cerrahpasa ( Site 0896)

    Istanbul, 34098

    Study Coordinator, +9005348874207

    Recruiting

  • Konya Necmettin Erbakan Universitesi ( Site 0905)

    Konya, 42080

    Study Coordinator, +905340537685

    Recruiting

Other trials in Turkey (Türkiye)

Brazil6 sites, 6 recruiting

  • Hospital Mario Penna ( Site 0179)

    Belo Horizonte, Minas Gerais, 30380-472

    Study Coordinator, +55 31 98803-2851

    Recruiting

  • Hospital Universitário Evangélico Mackenzie ( Site 0181)

    Curitiba, Paraná, 80730-150

    Study Coordinator, +5541991681411

    Recruiting

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0184)

    Porto Alegre, Rio Grande do Sul, 90020-090

    Study Coordinator, +55 51 32148107

    Recruiting

  • Hospital de Base de São José do Rio Preto ( Site 0176)

    São José do Rio Preto, São Paulo, 15090-000

    Study Coordinator, +5517988053335

    Recruiting

  • IPITEC ( Site 0189)

    São Paulo, 01221-020

    Study Coordinator, +55 14 99776-3115

    Recruiting

  • IBCC - Núcleo de Pesquisa e Ensino ( Site 0183)

    São Paulo, 04014-012

    Study Coordinator, +551144500300

    Recruiting

Other trials in Brazil

Mexico6 sites, 6 recruiting

  • CIO - Centro de Inmuno-Oncología de Occidente ( Site 0541)

    Guadalajara, Jalisco, 44630

    Study Coordinator, +52 3313587270

    Recruiting

  • Higiea Oncologia ( Site 0542)

    Mexico City, Mexico City, 11810

    Study Coordinator, 55 5273 1712

    Recruiting

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 0545)

    Mexico City, Mexico City, 14080

    Study Coordinator, +52 5554870900 2255

    Recruiting

  • Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 0540)

    Monterrey, Nuevo León, 64460

    Study Coordinator, 81 83338111 ext 1100

    Recruiting

  • Centro de Investigacion Clinica de Oaxaca ( Site 0543)

    Oaxaca City, Oaxaca, 68020

    Study Coordinator, 9516035559

    Recruiting

  • Grupo Ollin Care ( Site 0544)

    Pachuca, Hidalgo, 42000

    Study Coordinator, +52771715 752

    Recruiting

Other trials in Mexico

Poland6 sites, 5 recruiting

  • Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 0696)

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796

    Study Coordinator, +48523743589

    Recruiting

  • Pratia Onkologia Katowice ( Site 0693)

    Katowice, Silesian Voivodeship, 40-519

    Study Coordinator, +48327462500

    Recruiting

  • Pratia MCM Krakow ( Site 0692)

    Krakow, Lesser Poland Voivodeship, 30-727

    Study Coordinator, +48122954100

    Recruiting

  • Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k ( Site 0688)

    Poznan, Greater Poland Voivodeship, 61-731

    Completed

  • Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 0686)

    Siedlce, Masovian Voivodeship, 08-110

    Study Coordinator, +48256403300

    Recruiting

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej Curie ( Site 0685)

    Warsaw, Masovian Voivodeship, 02-781

    Study Coordinator, +48225462331

    Recruiting

Other trials in Poland

South Korea6 sites, 6 recruiting

  • Ulsan University Hospital ( Site 0793)

    Donggu, Ulsan-Kwangyokshi, 44033

    Study Coordinator, 82-52-230-1413

    Recruiting

  • Chonnam National University Hwasun Hospital ( Site 0794)

    Hwasun Gun, Jeonranamdo, 58128

    Study Coordinator, 82-61-379-7623

    Recruiting

  • The Catholic University of Korea St. Mary s Hospital ( Site 0795)

    Seocho-gu, Seoul, 06591

    Study Coordinator, 82-2-2258-6806

    Recruiting

  • Severance Hospital Yonsei University Health System ( Site 0790)

    Seoul, 03722

    Study Coordinator, 82-2-2228-8138

    Recruiting

  • Samsung Medical Center ( Site 0792)

    Seoul, 06351

    Study Coordinator, 82-2-3410-1767

    Recruiting

  • Asan Medical Center ( Site 0791)

    Songpagu, Seoul, 05505

    Study Coordinator, 82-2-3010-6961

    Recruiting

Other trials in South Korea

Australia5 sites, 4 recruiting

  • Blacktown Hospital ( Site 0154)

    Blacktown, New South Wales, 2148

    Study Coordinator, 61298818000

    Recruiting

  • Gallipoli Medical Research Ltd ( Site 0153)

    Greenslopes, Queensland, 4120

    Study Coordinator, +61402240196

    Recruiting

  • Macquarie University-MQ Health Clinical Trials Unit ( Site 0151)

    Macquarie University, New South Wales, 2109

    Completed

  • Peter MacCallum Cancer Centre ( Site 0152)

    Melbourne, Victoria, 3000

    Study Coordinator, +61385595000

    Recruiting

  • Fiona Stanley Hospital ( Site 0155)

    Murdock, Western Australia, 6150

    Study Coordinator, +61861525886

    Recruiting

Other trials in Australia

Czechia5 sites, 5 recruiting

  • Fakultni nemocnice u sv. Anny v Brne ( Site 0264)

    Brno, Brno-mesto, 602 00

    Study Coordinator, +420543182181

    Recruiting

  • Masarykuv onkologicky ustav ( Site 0260)

    Brno, Brno-mesto, 656 53

    Study Coordinator, +420543131111

    Recruiting

  • Fakultni nemocnice Olomouc ( Site 0262)

    Olomouc, 779 00

    Study Coordinator, +420585851111

    Recruiting

  • Fakultni nemocnice Ostrava ( Site 0263)

    Ostrava - Poruba, Moravian-Silesian Region, 708 52

    Study Coordinator, +420597371111

    Recruiting

  • Fakultni Nemocnice v Motole ( Site 0261)

    Prague, Praha 5, 150 06

    Study Coordinator, +420224431111

    Recruiting

Other trials in Czechia

Greece5 sites, 4 recruiting

  • Henry Dunant Hospital ( Site 0385)

    Athens, Attica, 115 26

    Completed

  • Metropolitan General Hospital ( Site 0382)

    Athens, Attica, 155 62

    Study Coordinator, 0030 2106502831

    Recruiting

  • University General Hospital Attikon ( Site 0381)

    Chaidari Athens, Attica, 124 62

    Study Coordinator, +302105831000

    Recruiting

  • General Oncology Hospital of Kifisia "Agioi Anargyroi" ( Site 0384)

    Kifissia, Attica, 145 64

    Study Coordinator, +302103501500

    Recruiting

  • Athens Medical Center ( Site 0383)

    Marousi, Attica, 151 25

    Study Coordinator, +302106198100

    Recruiting

Other trials in Greece

Peru5 sites, 5 recruiting

  • Unidad de Investigacion Oncologia Clínica Piura ( Site 0669)

    Castilla, Piura, 20001

    Study Coordinator, 51969618109

    Recruiting

  • Hospital Cayetano Heredia ( Site 0667)

    Lima, 15012

    Study Coordinator, 5112136000

    Recruiting

  • IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0666)

    Lima, 15036

    Study Coordinator, +5112241598

    Recruiting

  • Instituto Nacional de Enfermedades Neoplásicas ( Site 0665)

    Lima, 15038

    Study Coordinator, +5112016500

    Recruiting

  • Instituto Neuro Cardiovascular de las Americas ( Site 0668)

    Lima, 15047

    Study Coordinator, 51991366612

    Recruiting

Other trials in Peru

South Africa5 sites, 5 recruiting

  • Cancercare Rondebosch Oncology ( Site 0771)

    Cape Town, Gauteng, 7700

    Study Coordinator, +27219443700

    Recruiting

  • Wits Clinical Research ( Site 0776)

    Johannesburg, Gauteng, 2193

    Study Coordinator, +27113390600

    Recruiting

  • Wilgers Oncology Centre ( Site 0775)

    Pretoria, Gauteng, 0081

    Study Coordinator, +27 83 441 4889

    Recruiting

  • Curo Oncology Centre ( Site 0779)

    Pretoria, Gauteng, 0084

    Study Coordinator, +27123356771

    Recruiting

  • LIFE GROENKLOOF ( Site 0777)

    Pretoria, Gauteng, 0181

    Study Coordinator, +27123466701

    Recruiting

Other trials in South Africa

Switzerland5 sites, 5 recruiting

  • Kantonspital Aarau ( Site 0857)

    Aarau, Canton of Aargau, 5001

    Study Coordinator, +41628386050

    Recruiting

  • University Hospital Basel ( Site 0859)

    Basel, Canton of Basel-City, 4031

    Study Coordinator, +41612655074

    Recruiting

  • HFR Fribourg - Hôpital Cantonal ( Site 0858)

    Fribourg, 1708

    Study Coordinator, +41263062260

    Recruiting

  • Hopitaux Universitaires de Geneve HUG. ( Site 0856)

    Geneva, Canton of Geneva, 1211

    Study Coordinator, +41223722901

    Recruiting

  • Stadtspital Zürich Triemli ( Site 0855)

    Zurich, 8063

    Study Coordinator, +41444163505

    Recruiting

Other trials in Switzerland

Denmark4 sites, 4 recruiting

  • Aalborg Universitetshospital, Syd ( Site 0293)

    Aalborg, North Denmark, 9000

    Study Coordinator, 97661400

    Recruiting

  • Herlev and Gentofte Hospital ( Site 0290)

    Herlev, Capital Region, 2370

    Study Coordinator, +4538683868

    Recruiting

  • Odense Universitetshospital ( Site 0294)

    Odense, Region Syddanmark, 5000

    Study Coordinator, +4566113333

    Recruiting

  • Vejle Sygehus ( Site 0291)

    Vejle, Region Syddanmark, 7100

    Study Coordinator, 79406060

    Recruiting

Other trials in Denmark

Norway4 sites, 4 recruiting

  • Sykehuset Innlandet HF Gjøvik ( Site 0652)

    Gjøvik, Oppland, 2819

    Study Coordinator, 004791506200

    Recruiting

  • Akershus Universitetssykehus-Onkologisk avdeling ( Site 0650)

    Lorenskog, Akershus, 1474

    Study Coordinator, 004767960000

    Recruiting

  • Oslo universitetssykehus, Radiumhospitalet ( Site 0653)

    Oslo, 0379

    Study Coordinator, +4722934000

    Recruiting

  • St. Olavs Hospital-Kreftklinikken ( Site 0651)

    Trondheim, Sor-Trondelag, 7030

    Study Coordinator, +4772825810

    Recruiting

Other trials in Norway

Sweden4 sites, 4 recruiting

  • Skånes Universitetssjukhus Malmö ( Site 0841)

    Malmö, Skåne County, 20502

    Study Coordinator, 040331000

    Recruiting

  • Södersjukhuset ( Site 0844)

    Stockholm, Stockholm County, 11883

    Study Coordinator, +46812361000

    Recruiting

  • Karolinska Universitetssjukhuset Solna ( Site 0843)

    Stockholm, Stockholm County, 171 64

    Study Coordinator, 46812370000

    Recruiting

  • Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 0840)

    Uppsala, Östergötland County, 751 85

    Study Coordinator, +46186110000

    Recruiting

Other trials in Sweden

Taiwan4 sites, 4 recruiting

  • Chang Gung Medical Foundation - Kaohsiung ( Site 0872)

    Kaohsiung City, 83301

    Study Coordinator, +88677317123x2270

    Recruiting

  • Taichung Veterans General Hospital ( Site 0873)

    Taichung, 40705

    Study Coordinator, +886423592525x5121

    Recruiting

  • Taipei Veterans General Hospital ( Site 0875)

    Taipei, 11217

    Study Coordinator, +88622871 2121

    Recruiting

  • National Taiwan University Hospital ( Site 0870)

    Taiwan, Taipei, 10002

    Study Coordinator, +88623123456

    Recruiting

Other trials in Taiwan

Austria3 sites, 3 recruiting

  • Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0170)

    Linz, Upper Austria, 4020

    Study Coordinator, +4373276774724

    Recruiting

  • Uniklinikum Salzburg Universitaetsklinik für Innere Medizin III ( Site 0172)

    Salzburg, 5020

    Study Coordinator, +435725558858

    Recruiting

  • Klinikum Wels-Grieskirchen GmbH ( Site 0171)

    Wels, Upper Austria, 4600

    Study Coordinator, +4372424153452

    Recruiting

Other trials in Austria

Guatemala3 sites, 3 recruiting

  • MEDI-K ( Site 0401)

    Guatemala City, 01009

    Study Coordinator, +502 22912323

    Recruiting

  • Med Clinic ( Site 0403)

    Guatemala City, 01010

    Study Coordinator, +502 41040976

    Recruiting

  • Onco Go ( Site 0402)

    Guatemala City, 01010

    Study Coordinator, +502 42140711

    Recruiting

Other trials in Guatemala

Ireland3 sites, 3 recruiting

  • Cork University Hospital ( Site 0442)

    Cork, T12 E8YV

    Study Coordinator, +350214922687

    Recruiting

  • St Vincent's University Hospital ( Site 0441)

    Dublin, Dublin, D04 T6F4

    Study Coordinator, +4412214000

    Recruiting

  • Tallaght University Hospital ( Site 0440)

    Dublin, D24 NR0A

    Study Coordinator, +35314144299

    Recruiting

Other trials in Ireland

Chile2 sites, 2 recruiting

  • Fundación Arturo López Pérez ( Site 0201)

    Santiago, Region M. de Santiago, 7500921

    Study Coordinator, 56224457398

    Recruiting

  • Bradfordhill ( Site 0200)

    Santiago, Region M. de Santiago, 8420383

    Study Coordinator, +56229490970

    Recruiting

Other trials in Chile

Hong Kong2 sites, 2 recruiting

  • Queen Mary Hospital ( Site 0415)

    Hong Kong

    Study Coordinator, +852 2255 3838

    Recruiting

  • Tuen Mun Hospital ( Site 0416)

    New Territories

    Study Coordinator, +852 2468 5111

    Recruiting

Other trials in Hong Kong

Malaysia2 sites, 2 recruiting

  • Sarawak General Hospital ( Site 0526)

    Kuching, Sarawak, 93586

    Study Coordinator, +6082276666

    Recruiting

  • Sunway Medical Centre ( Site 0529)

    Petaling Jaya, Selangor, 47500

    Study Coordinator, +60374919191

    Recruiting

Other trials in Malaysia

Singapore2 sites, 2 recruiting

  • National Cancer Centre Singapore ( Site 0760)

    Singapore, Central Singapore, 168583

    Study Coordinator, +6564368000

    Recruiting

  • Tan Tock Seng Hospital ( Site 0761)

    Singapore, Central Singapore, 308433

    Study Coordinator, +6562566011

    Recruiting

Other trials in Singapore

Thailand2 sites, 2 recruiting

  • Faculty of Medicine Siriraj Hospital ( Site 0885)

    Bangkoknoi, Bangkok, 10700

    Study Coordinator, +6624194488

    Recruiting

  • Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 0887)

    Dusit, Bangkok, 10300

    Study Coordinator, +6622443461

    Recruiting

Other trials in Thailand

About this study

Official title: A Phase 3, Open-label Study of Ifinatamab Deruxtecan Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (IDeate-Prostate01)

Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if people who receive I-DXd live longer overall and live longer without the cancer growing or spreading than people who receive chemotherapy.

Being tested
Ifinatamab deruxtecan, Docetaxel, Prednisone, Rescue Medication
Medical subject headings
Prostatic Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Ifinatamab deruxtecanDrug

    Also called I-DXd, MK-2400, DS-7300a

    Administered via intravenous (IV) infusion every 3 weeks (q3w) until disease progression, unacceptable adverse events (AEs), or other cessation of treatment

  • DocetaxelDrug

    Administered via IV infusion q3W until disease progression, unacceptable adverse events (AEs), or other cessation of treatment

  • PrednisoneDrug

    Also called Prednisone acetate, Prednisolone, Prednisolone acetate

    Oral tablet administered once per day or per approved product label

  • Rescue MedicationDrug

    Also called 5-HT3 receptor antagonist, NK-1 receptor antagonist, Corticosteroid

    Before administering each dose of I-DXd, premedication is required for prevention of nausea and vomiting with a 2 or 3 drug combination regimen (eg, corticosteroids with either a 5-HT3 receptor antagonist or an NK-1 receptor antagonist and other drugs as indicated) per approved product label

Study groups in NCT06925737
Study groupRoleWhat they receive
I-DXdExperimentalParticipants receive I-DXd 12mg/kg every 3 weeks (q3w)
Receives: Drug: Ifinatamab deruxtecan; Drug: Rescue Medication
DocetaxelActive comparatorParticipants receive docetaxel 75 mg/m^2 q3w and prednisone 10 mg/day or per approved product label
Receives: Drug: Docetaxel; Drug: Prednisone

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall Survival (OS)

    OS is defined as the time from randomization to death due to any cause.

    Measured: Up to approximately 36 months

  2. Radiographic Progression Free Survival (rPFS)

    rPFS is defined as the time from randomization to the first documented disease progression per prostate cancer working group (PCWG)-modifed Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 by blinded independent central review (BICR) or death due to any cause, whichever occurs first.

    Measured: Up to approximately 36 months

Secondary outcomes (9)

  1. Time to First Subsequent Therapy (TFST)

    TFST is defined as the time from randomization to initiation of the first subsequent anticancer therapy or death, whichever occurs first.

    Measured: Up to approximately 36 months

  2. Objective Response Rate (ORR)

    The ORR is defined as a confirmed complete response (CR) or partial response (PR) per PCWG-modified RECIST 1.1 as assessed by BICR.

    Measured: Up to approximately 36 months

  3. Duration of Response (DOR)

    For participants who demonstrate confirmed CR or PR, DOR is defined as the time from the first documented evidence of CR or PR until disease progression per PCWG-modified RECIST 1.1 as assessed by BICR or death due to any cause, whichever occurs first.

    Measured: Up to approximately 36 months

  4. Time to Pain Progression (TTPP)

    TTPP is defined as the time from randomization to pain progression based on the brief pain inventory-short form (BPI-SF) Item 3 "worst pain in 24 hours" and opiate analgesic use (AQA score).

    Measured: Up to approximately 36 months

  5. Time to Prostate-specific Antigen (PSA) Progression

    Time to PSA progression is defined as the time from randomization to PSA progression. The PSA progression date is defined as the first date that 1) ≥25% increase and ≥2 ng/mL above the nadir which is confirmed by a second value≥3 weeks later if there is PSA decline from baseline, 2) ≥25% increase and ≥2 ng/mL increase from baseline beyond 12 weeks if there is no PSA decline from baseline.

    Measured: Up to approximately 36 months

  6. PSA Response Rate

    PSA response rate is defined as the proportion of participants in the analysis population who have a PSA reduction of ≥50% from baseline with a consecutive confirmation assessment at least 3 weeks later per PCWG criteria.

    Measured: Up to approximately 36 months

  7. Time to First Symptomatic Skeletal-Related Event (SSRE)

    Time to first SSRE is defined as the time from randomization to the first occurrence of any of the following symptomatic skeletal-related events:

    1. use of EBRT to prevent or relieve skeletal symptoms,
    2. new symptomatic pathologic bone fracture (vertebral or non-vertebral),
    3. spinal cord compression,
    4. a tumor-related orthopedic surgical intervention.

    Measured: Up to approximately 36 months

  8. Number of Participants Who Experienced at Least One Adverse Event (AE)

    An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.

    An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention.

    Measured: Up to approximately 36 months

  9. Number of Participants Who Discontinue Study Treatment Due to an Adverse Event (AE)

    An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.

    An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention.

    Measured: Up to approximately 36 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Apr 2025
  2. Study start13 May 2025
  3. Primary completion26 Jun 2028 (estimated)
  4. Study completion6 Jan 2031 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
1,440 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06925737
Sponsor's protocol ID
2400-001
Other IDs
U1111-1312-2498, 2024-517423-40-00, MK-2400-001
Status last verified
Oct 2026
First submitted
7 Apr 2025
Last updated
15 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

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