Lung DiseasesHEALTHeNCT06925373
Housing, Environment, And Living Conditions for Transformed Health
A study testing Indoor Air Purification, Neighborhood Improvements and Housing Improvements in people with Lung Diseases and Chronic Disease, run by University of Alabama at Birmingham at 1 site in United States.
Trial summary
This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach. Read more about this study
- Who is it for?
- Ages 18 to 89 yearsHealthy volunteers can take part
- Conditions the study is for
- Lung Diseases, Chronic Disease
- What is being tested?
- Indoor Air Purification, Neighborhood Improvements and Housing Improvements
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 460 participants
- Where
- 1 siteUnited States
- Study dates
- 18 Jun 2025to Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 89 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults age 18 years and older
- English speaking
- Residents of one of 4 public housing site in Birmingham, Alabama
Who cannot join
- Individuals who are not 18 years or older
- Do not speak English
- Do not meet the residency criteria
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Housing, Environment, And Living Conditions for Transformed Health (HEALTHe Birmingham)
This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach.
STUDY 1: The study will assess the effects of public housing and neighborhood environment (built and social) improvements on health-related behaviors, psychosocial and physiologic stress, and self-reported and physiological markers of lung health and chronic disease.
STUDY 2: The study will determine whether indoor air purification can positively impact lung health in public housing sites not undergoing housing renovation, comparing a site near industrial pollution vs one less contaminated.
Read the detailed description
Participants will complete surveys, physical exam, lung function tests, and blood draw. An indoor air purifier with a usage tracker and an indoor air quality monitor will be provided, and used filters will be analyzed.
- Conditions
- Lung Diseases, Chronic Disease
- Being tested
- Indoor Air Purification, Neighborhood Improvements, Housing Improvements
- Keywords
- Lung Health, Chronic Disease
- Medical subject headings
- Lung Diseases, Chronic Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Indoor Air PurificationOther
Also called Coway Airmega 400
An indoor air purifier with a dual HEPA/activated carbon filter, a usage tracker, and an indoor air quality monitor will be installed in public housing residences.
Neighborhood ImprovementsOther
Improved built environment (green space, sidewalks, street lights) and social environment (educational and workforce development programs, wrap-around social services, Internet access).
Housing ImprovementsOther
High-quality public housing
| Study group | Role | What they receive |
|---|---|---|
| Elyton Village Community | Active comparator | Participants will receive improved neighborhood environment (built and social) and indoor air purification. Receives: Other: Indoor Air Purification; Other: Neighborhood Improvements |
| Southtown Court Community | Active comparator | Participants will receive new public housing. Receives: Other: Housing Improvements |
| Smithfield Court Community | Active comparator | Participants will receive new public housing and improved neighborhood environment (built and social). Receives: Other: Neighborhood Improvements; Other: Housing Improvements |
| Collegeville Community | Active comparator | Participants will receive indoor air purification. Receives: Other: Indoor Air Purification |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health
A self-reported measure of physical, mental, and social health. 10 item questionnaire T-score metric from zero to 100 where higher T-scores indicate better health.
Measured: Baseline, 12 months, 24 months
Change in Allostatic load
Measure of cumulative stress burden as the number of 10 indicators above a threshold: (1) serum albumin <3.8 g/dL, (2) C Reactive Protein (CRP) >3 mg/L, (3) High-Density Lipoprotein (HDL) <40 mg/dL, (4) total cholesterol ≥240 mg/dL, (5) heart rate ≥90 beats/min, (6) systolic Blood Pressure (BP) ≥140 mmHg, (7) diastolic BP ≥90 mmHg, (8) serum creatinine ≥1.3 mg/dL, (9) Blood Urea Nitrogen (BUN) ≥18 mg/dL, and (10) waist circumference >88 cm in women, >102 cm in men.
Measured: Baseline, 12 months
Change in Indoor Air Quality
Particulate matter (PM2.5). Measures particles in the air that are 2.5 micrometers or smaller in diameter.
Measured: Baseline, 6 months, 12 months (Study 2 only)
Secondary outcomes (1)
The percentage change in FEV1/FVC
FEV1/FVC. A measure of lung funtion that compares the amount of air exhaled in the first second (FEV1) to the total amount of air exhaled in a forced breath (FVC).
Measured: Baseline, 6 months, 12 months (Study 2 only)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2025
- Study start18 Jun 2025
- Primary completionJul 2028 (estimated)
- Study completionJul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lung DiseasesStudies of the same condition, open and under way.
- More trials run by University of Alabama at BirminghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 460 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Alabama at Birmingham
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute of Nursing Research (NINR)
- Responsible party
- Principal investigator, Gabriela R Oates, University of Alabama at Birmingham
- Investigators
- Gabriela R Oates, PhD, Principal investigator, University of Alabama at Birmingham (UAB)
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06925373
- Sponsor's protocol ID
- IRB-300013400
- Other IDs
- 1U01NR021591
- Acronym
- HEALTHe
- Status last verified
- Oct 2026
- First submitted
- 11 Mar 2025
- Last updated
- 22 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Individual participant data that underlie the reported results, after de-identification.
Study at a glance
From the registry record, last updated by the sponsor on 22 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Housing, Environment, And Living Conditions for Transformed Health (HEALTHe Birmingham)
- ClinicalTrials.gov ID
- NCT06925373
- Acronym / sponsor ID
- HEALTHe / IRB-300013400
- Conditions
- Lung Diseases, Chronic Disease
- Keywords
- Lung Health, Chronic Disease
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 460 participants (estimated)
- Lead sponsor
- University of Alabama at BirminghamUniversity, hospital or other
- Collaborators
- National Institute of Nursing Research (NINR)
- Study start
- 18 Jun 2025 (actual)
- Primary completion
- Jul 2028 (estimated)
- Study completion
- Jul 2028 (estimated)
- First posted
- 13 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach.
STUDY 1: The study will assess the effects of public housing and neighborhood environment (built and social) improvements on health-related behaviors, psychosocial and physiologic stress, and self-reported and physiological markers of lung health and chronic disease.
STUDY 2: The study will determine whether indoor air purification can positively impact lung health in public housing sites not undergoing housing renovation, comparing a site near industrial pollution vs one less contaminated.
Detailed description
Participants will complete surveys, physical exam, lung function tests, and blood draw. An indoor air purifier with a usage tracker and an indoor air quality monitor will be provided, and used filters will be analyzed.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Elyton Village Community | Active comparator | Other: Indoor Air Purification, Other: Neighborhood ImprovementsParticipants will receive improved neighborhood environment (built and social) and indoor air purification. |
| Southtown Court Community | Active comparator | Other: Housing ImprovementsParticipants will receive new public housing. |
| Smithfield Court Community | Active comparator | Other: Neighborhood Improvements, Other: Housing ImprovementsParticipants will receive new public housing and improved neighborhood environment (built and social). |
| Collegeville Community | Active comparator | Other: Indoor Air PurificationParticipants will receive indoor air purification. |
Who may qualify
- Ages
- 18 to 89 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults age 18 years and older
- English speaking
- Residents of one of 4 public housing site in Birmingham, Alabama
Key exclusion criteria (3 listed)
- Individuals who are not 18 years or older
- Do not speak English
- Do not meet the residency criteria
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Indoor Air PurificationAlso: Coway Airmega 400An indoor air purifier with a dual HEPA/activated carbon filter, a usage tracker, and an indoor air quality monitor will be installed in public housing residences. | Other | Collegeville Community, Elyton Village Community |
| Neighborhood ImprovementsImproved built environment (green space, sidewalks, street lights) and social environment (educational and workforce development programs, wrap-around social services, Internet access). | Other | Elyton Village Community, Smithfield Court Community |
| Housing ImprovementsHigh-quality public housing | Other | Smithfield Court Community, Southtown Court Community |
Primary outcome
Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health
Time frame: Baseline, 12 months, 24 months
A self-reported measure of physical, mental, and social health. 10 item questionnaire T-score metric from zero to 100 where higher T-scores indicate better health.
Change in Allostatic load
Time frame: Baseline, 12 months
Measure of cumulative stress burden as the number of 10 indicators above a threshold: (1) serum albumin <3.8 g/dL, (2) C Reactive Protein (CRP) >3 mg/L, (3) High-Density Lipoprotein (HDL) <40 mg/dL, (4) total cholesterol ≥240 mg/dL, (5) heart rate ≥90 beats/min, (6) systolic Blood Pressure (BP) ≥140 mmHg, (7) diastolic BP ≥90 mmHg, (8) serum creatinine ≥1.3 mg/dL, (9) Blood Urea Nitrogen (BUN) ≥18 mg/dL, and (10) waist circumference >88 cm in women, >102 cm in men.
Change in Indoor Air Quality
Time frame: Baseline, 6 months, 12 months (Study 2 only)
Particulate matter (PM2.5). Measures particles in the air that are 2.5 micrometers or smaller in diameter.
1 secondary outcome
The percentage change in FEV1/FVC
Time frame: Baseline, 6 months, 12 months (Study 2 only)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Oct 2026.
- Individual participant dataSharing planned: Yes. Individual participant data that underlie the reported results, after de-identification.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gabriela R Oates, PhD principal investigator
University of Alabama at Birmingham (UAB)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Indoor Air Purification, Neighborhood Improvements and Housing Improvements in people with Lung Diseases and Chronic Disease, run by University of Alabama at Birmingham at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health (time frame: Baseline, 12 months, 24 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026.