Muscle RelaxantsNCT06899048
The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio
An observational study of Muscle Relaxants, run by Assiut University at 1 site in Egypt.
Trial summary
evaluate the degree of association, and the predictive accuracy of the REPS (as a predictive tool) compared with the TOFr as a quantitative assessment tool for (rNMB) in surgical patients in the early postoperative phase. The TOFr will be measured at 0, 15, 30, 45, and 60 min after extubation. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Muscle Relaxants
- What is being tested?
- residual neuromuscular block risk prediction score
- How many people
- 91 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Aug 2024to 1 Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients who will be scheduled to undergo elective surgical procedures requiring the use of neuromuscular blocking drugs.
Who may be able to join
- Age group 18-65 years old
- Both genders
- Patients with American Society of Anesthesiologist physical status classification of 1 or 2.
Who cannot join
- Patients who are less than 18 years old or more than 65 years old.
- Patients with planned scheduled recovery in the intensive care unit or if more than 10 minutes had elapsed since tracheal extubation until NMB monitoring at the PACU.
- Patients on medications that interfere with muscle activity.
- Known allergy to neuromuscular blocking agents.
- Pregnancy or suspected pregnancy.
- Neuro-muscular diseases.
- Patients refusing to participate in the study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Residual Paralysis in the Post Anesthesia Care Unit: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. A Prospective Single-Center Open-Label Cohort Study
evaluate the degree of association, and the predictive accuracy of the REPS (as a predictive tool) compared with the TOFr as a quantitative assessment tool for (rNMB) in surgical patients in the early postoperative phase. The TOFr will be measured at 0, 15, 30, 45, and 60 min after extubation.
- Conditions
- Muscle Relaxants
- Being tested
- residual neuromuscular block risk prediction score
- Medical subject headings
- Muscle Hypotonia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
residual neuromuscular block risk prediction scoreDiagnostic test
it is a clinical tool designed to estimate the likelihood of residual neuromuxcular blockade in postoperative patients
What is being measured
The primary outcome is the main question the study is designed to answer.
correlation between residual neuromuscular block risk prediction score and train of four
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2025
- Study start1 Aug 2024
- Primary completion1 Jan 2027 (estimated)
- Study completion1 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle RelaxantsStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 91 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Faisal, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06899048
- Sponsor's protocol ID
- 04-2025-201158
- Status last verified
- Oct 2026
- First submitted
- 21 Mar 2025
- Last updated
- 30 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Residual Paralysis in the Post Anesthesia Care Unit: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. A Prospective Single-Center Open-Label Cohort Study
- ClinicalTrials.gov ID
- NCT06899048
- Acronym / sponsor ID
- 04-2025-201158
- Conditions
- Muscle Relaxants
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 91 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Aug 2024 (actual)
- Primary completion
- 1 Jan 2027 (estimated)
- Study completion
- 1 Feb 2027 (estimated)
- First posted
- 27 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
evaluate the degree of association, and the predictive accuracy of the REPS (as a predictive tool) compared with the TOFr as a quantitative assessment tool for (rNMB) in surgical patients in the early postoperative phase. The TOFr will be measured at 0, 15, 30, 45, and 60 min after extubation.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients who will be scheduled to undergo elective surgical procedures requiring the use of neuromuscular blocking drugs.
Key inclusion criteria (3 listed)
- Age group 18-65 years old
- Both genders
- Patients with American Society of Anesthesiologist physical status classification of 1 or 2.
Key exclusion criteria (7 listed)
- Patients who are less than 18 years old or more than 65 years old.
- Patients with planned scheduled recovery in the intensive care unit or if more than 10 minutes had elapsed since tracheal extubation until NMB monitoring at the PACU.
- Patients on medications that interfere with muscle activity.
- Known allergy to neuromuscular blocking agents.
- Pregnancy or suspected pregnancy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| residual neuromuscular block risk prediction scoreit is a clinical tool designed to estimate the likelihood of residual neuromuxcular blockade in postoperative patients | Diagnostic test | – |
Primary outcome
correlation between residual neuromuscular block risk prediction score and train of four
Time frame: 1 hour
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2026.
- Individual participant dataSharing planned: No
Related trials for Muscle Relaxants
Recruiting
Small Doses Muscle Relaxant in General Anesthesia
Muscle Relaxant
Recruiting
Impact of Entropy Monitoring on Anesthetic Consumption and Recovery After Laparoscopic Cholecystectomy
Entropy Device and How Will Muscle Relaxants Affect it
RecruitingObservational study
Effect of Muscle Relaxants on Postoperative Sore Throat in Video Laryngeal Mask Airway(LMA) Use
Laryngeal Mask Airway
Enrolling by invitationPhase 3
Efficacy and Safety of HRS-9190 in General Anesthesia
Adult Participants Requiring Tracheal Intubation Under General Anesthesia for Elective Surgery
Not yet recruiting
The Impact of Ventilator Synchrony on Muscle Relaxant Consumption and Surgeon Satisfaction During Laparoscopic Cholecystectomy.
Muscle Relaxant Consumption, Mechanical Ventilation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Muscle Relaxants, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mahmoud A Faisal, Dr (01004391577 ext. 020, dr_mahmoudfaisal@aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
correlation between residual neuromuscular block risk prediction score and train of four (time frame: 1 hour). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2026.