FerroptosisNCT06891820
Multifaceted Analysis of the Adaptation of Rowers in the Process of Sports Training
An observational study of Ferroptosis and Inflammation, run by Poznan University of Physical Education at 1 site in Poland.
Trial summary
This study aims to analyze in detail selected indicators of appetite regulation, metabolism, and iron balance in competitive rowers undergoing intense exercise. The project involves assessing dynamic hormonal and biochemical changes in the athletes' bodies, which will allow a better understanding of the body's… Read more about this study
- Who is it for?
- Ages 19 to 24 yearsHealthy volunteers can take part
- Conditions the study is for
- Ferroptosis, Inflammation, Muscle Damage
- What is being tested?
- Physical effort
- How many people
- 30 participants
- Where
- 1 sitePoland
- Study dates
- 29 Mar 2025to 29 Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 24 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: The Polish Youth Rowing Team
- Inclusion Criteria:
- consent to participate in the study,
- regular training regimen,
- current medical examination,
- no health contraindications (to be decided by a doctor).
- Exclusion Criteria:
- Lack of consent for blood draws,
- injuries,
- health problems,
- anti-inflammatory drugs,
- supportive substances, supplements in the last 3 months before the start of the study.
Trial locations and contacts
1 site in 1 country.
About this study
This study aims to analyze in detail selected indicators of appetite regulation, metabolism, and iron balance in competitive rowers undergoing intense exercise. The project involves assessing dynamic hormonal and biochemical changes in the athletes' bodies, which will allow a better understanding of the body's adaptive mechanisms to prolonged physical strain.
Research group: the research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified for the Polish Youth Rowing Team:
Read more
- aged 19 - 24, because the age group must be homogeneous,
- the size of the group is about thirty people, which in the case of a homogeneous group will enable statistical analyzes to be conducted.
Rowing performance test: At the beginning and end of the training camp, participants will perform a test on a rowing ergometer (Concept II, USA). Each subject will have to cover a distance of 2000 m in the shortest possible time, which is the distance starting in rowing competitions. The results of both tests will be considered in the selection for the championship team; therefore, athletes will be well motivated to perform both tests with maximum effort.
Blood samples will be taken from the cubital vein at three-time points: before each ergometer test (after overnight fasting), directly after the test, and after a 1-hour recovery period.
Read the detailed description
The study aims to conduct a detailed analysis of selected indicators of appetite regulation, metabolism, inflammation, and iron balance in competitive rowers undergoing intense exercise. The project involves assessing dynamic hormonal and biochemical changes in the athletes' bodies, which will allow for a better understanding of the body's adaptive mechanisms to prolonged physical strain.
Research group: The research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified for the Polish Youth. Rowing Team:
- aged 19 - 24, because the age group must be homogeneous,
- the size of the group is about thirty people, which in the case of a homogeneous group will enable statistical analyzes to be conducted.
Rowing performance test: at the beginning and at the end of the training camp, participants will perform a test on a rowing ergometer (Concept II, USA), each subject will have to cover a distance of 2000 m in the shortest possible time, which is the distance starting in rowing competitions. The results of both tests will be considered in the selection for the championship team; therefore, athletes will be well motivated to perform both tests with maximum effort.
Blood samples will be taken from the cubital vein at three-time points: before each ergometer test (after overnight fasting), directly after the test, and after a 1-hour recovery period.
Measurement: All determined parameters will be measured with the available equipment in the biochemical laboratory of Poznan University of Physical Education, Faculty of Sport Sciences in Gorzow Wlkp., using commercial assay kits. Measurements will be performed by the project contractors.
- Polyethylene tubes (4.9 ml) containing dipotassium ethylenediaminetetraacetic acid (EDTAK2) anticoagulant will be used for the following tests: (a) complete blood count (18 parameters) determined on the MYTHIC 18 hematology analyzer (Orphee Medical, Geneva, Switzerland). White blood cell indices: WBC (white blood cells), LYM (lymphocytes as a percentage), LYM (lymphocytes), MON (monocytes as a percentage), MON (monocytes), GRA (granulocytes as a percentage), GRA (granulocytes). Red blood cell indices: RBC (Red Blood Cells), HGB (Hemoglobin), HCT (Hematocrit), MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Hemoglobin), MCHC (Mean Corpuscular Hemoglobin Concentration), RDW (Red Blood cells Distribution Width). Platelet indices: PLT (Platelet), MPV (Mean Platelet Volume), PDW (Platelet Distribution Width), PCT (Thrombocrit) (b) gene expression.
- Polyethylene clotting activator tubes (9 ml) will be centrifuged to separate the morphotic elements from the serum using a centrifuge (3000 rpm for 10 min). The serum will be pipetted into several Eppendorf tubes, which will then be frozen (temp. -80°C). All the following biochemical parameters will be determined from the extracted serum: using the ELISA method by the test manufacturer's instructions. The designations include the flowing parameters:
- Analysis of leptin, ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide (PP) and cholecystokinin (CCK) levels will allow assessment of dynamic hormonal changes in rowers in relation to training intensity, energy availability and diet composition.
- Leptin (LEP) - a satiety hormone whose levels may be reduced in athletes with low levels of body fat.
- Ghrelin (GHRL) - a hunger hormone that increases in states of energy deficit and may affect the regulation of caloric intake.
- GLP-1, PYY, PP and CCK - intestinal peptides involved in appetite suppression and modulation of insulin secretion and fat metabolism.
- Biochemical and hormonal parameters Stress and recovery hormones:
- Cortisol - a marker of stress response and catabolism.
- Testosterone - a key anabolic hormone, whose ratio to cortisol (T/C) helps assess the balance between anabolism and catabolism. Neurotransmitters associated with fatigue resistance:
- Serotonin - important in regulating mood and central fatigue; its excess can contribute to lethargy and decreased motivation.
- Dopamine - crucial for motivation and mental performance; decreased levels may indicate neurotransmitter depletion. Sex hormones and metabolic balance:
- Estradiol
- Progesterone - in women indicators of menstrual cycle and hormonal balance,
- ferroptosis parameters
- antioxidants: glutathione (GSH), glutathione peroxidase 4 (GPX4),
- markers of oxidative stress: 4-Hydroxynonenal (4-HNE), Heme oxygenase 1 (HO-1)
- iron status parameters: soluble transferrin receptor, ferritin, erythroferrone, lactoferrin The iron and Total Iron Binding Capacity (TIBC) levels will be determined using the colorimetric method on the SPECTROstar Nano reader. Unsaturated Iron Binding Capacity (UIBC) will be calculated from the formula: UIBC = TIBC-iron in serum)
- Markers of energy metabolism:
- Glucose - a key energy source for working muscles, to assess how the body regulates carbohydrate metabolism during and after exercise.
- Glycogen - an important indicator of energy reserve utilization during high intensities, to determine the level of energy reserve utilization.
- Insulin - responsible for the transport of glucose into muscle cells and to assess how the body manages energy before, during and after exercise, and whether adaptation to load is effective,
- Lactic acid - an indicator of exercise intensity and the balance between aerobic and anaerobic metabolism. Markers of muscle damage:
- CK (creatine kinase), myoglobin - increases with muscle damage, especially after intense exercise, allows to assess the degree of fatigue and risk of overtraining.
- interleukin-6 (IL-6) - mediator of inflammatory response and marker of fatigue; rises after intense exercise, indicates fatigue and recovery processes. Markers of metabolic adaptation and recovery:
- fibroblast growth factor-21 (FGF-21) - , a protein, regulates metabolism and restoration of energy resources, allows assessment of the body's adaptation to intense exercise.
- Using a portable analyzer system for measuring blood gas, electrolytes and metabolites (epoc®), using dedicated epoc® test cards. Measured parameters: Direct: pH, partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), total plasma carbon dioxide (tCO2), sodium (Na+), potassium (K+), calcium (Ca++), chlorine (Cl-), hematocrit (Hct), glukose (glu), Lactic Acid (Lac), Crea, Urea, urea nitrogen (BUN). Calculated values: cHgb, bicarbonate level (cHCO3), cTCO2, excess base in extracellular fluid (BE ecf), BE(b), total blood saturation (cSO2), glomerular filtration rate (GFRmdr), GFRmdr-a, GFRckd, GFRckd-a, GFRswz, anion gap (AGAP), AGapK, BUN/Crea, Urea/Crea. It will be determined from capillary blood taken from the earlobe (90 µl). Lactic acid will be determined from capillary blood taken from the earlobe (10 µl). The determination will be performed with dedicated reagents, using a portable biochemical photometer Vario Photometer II (Diaglobal, Berlin, Germany).
- Conditions
- Ferroptosis, Inflammation, Muscle Damage, Nervous System Diseases
- Being tested
- Physical effort
- Medical subject headings
- Inflammation, Nervous System Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Physical effortOther
The examined athletes will be subjected to an effort on a rowing ergometer, covering a designated distance in the shortest possible time.
| Study group | Role | What they receive |
|---|---|---|
| Physical effort | Rowers will perform an intensive exercise test on a rowing ergometer (Concept II, USA), covering a distance of 2000 meters in the shortest time possible. The test on the rowing ergometer will be performed under the supervision of a physician. Receives: Other: Physical effort |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Blood morphology
Using MYTHIC18 hematology analyzer (Cormay Diagnostics, Geneva, Switzerland). Qualitative and quantitative evaluation of morphological elements of blood (determination in venous blood).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Glycogen level.
Concentration of glycogen [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline Insulin level.
Concentration of insulin [μIU/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baselineCreatine kinase activity (CK) level.
Concetration of CK [ng/ml]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline interleukin-6 (Il-6) level.
Concentration of Il-6 [pg/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in fibroblast growth factor 21 (FGF-21) level.
Concentration of FGF-21 [pg/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in lactic acid (LA) level.
Concetration of LA [mmol/l]. Using a portable biochemical photometer Vario Photometer II (Diaglobal, Berlin, Germany) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Gene expression
Genes studied: LEP, GHRL, AGRP, GOT1 and GPX4.
RNA isolation will be performed by the column method on the Direct-zol™ RNA MiniPrep Plus Kits, according to the test manufacturer's instructions. Gene expression analysis from cells isolated from blood will be performed by reverse transcription using TaqMan
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in testosterone level.
Concentration of testosterone [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in serotonin level.
Concentration of serotonin [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Changes from baseline in progesterone level.
Concentration of progesterone [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Changes from baseline in estradiol level.
Concentration of estradiol [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Changes from baseline in dopamine level.
Concentration of dopamine [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Measured: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Baseline Mood Profile of Athletes Before Exercise Test Using POMS Questionnaire.
The Profile of Mood States (POMS) questionnaire measures mood states and emotional well-being.
Measured: At rest (before the exercise test).
Baseline Mental Toughness in Sport measured using the Scale of Mental Toughness in Sport (SMTQ)
Scale of Mental Toughness in Sport (SMTQ) - to assess an athlete's ability to cope with training loads and stress
Measured: At rest (before the exercise test).
Baseline Eating Behavior and Attitudes of Athletes Before Exercise Test Using EDE-Q 6.0 Questionnaire.
The Eating Disorder Examination Questionnaire (EDE-Q) measures the severity of eating disorder behaviors and attitudes.
Measured: At rest (before the exercise test).
Baseline Appetite Assessment of Athletes Before Exercise Test Using Visual Analogue Scale (VAS).
The Visual Analogue Scale (VAS) measures subjective appetite sensations-linear scale from one to 10 where 10 is the strongest feeling.
Measured: At rest (before the exercise test).
Changes from baseline in leptin(LEP) level.
Satiety regulation marker. Concentration of leptin [pg/ml].ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in glucagon-like peptide-1 (GLP-1) level.
Satiety regulation marker. Concentration of GLP-1 [pg/ml]. ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in peptide YY (PYY) level.
Satiety regulation marker. Concentration of leptin [pg/ml]. ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in pancreatic polipeptide (PP) level.
Satiety regulation marker. Concentration of PP [pg/ml]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in ghrelin (GHRL) level.
Hunger regulation marker. Concentration of GHRL [pg/ml].ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in cholocystokinin (CCK) level.
Satiety regulation marker. Concentration of CCK [pg/ml].ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Soluble transferrin receptor level.
Concentration of Soluble transferrin receptor [μg/ml]. ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Ferritin level.
Concentration of ferritin [ng/mL]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in 4-Hydroxynonenal (4-HNE) level.
Concentration of 4-Hydroxynonenal (4-HNE) [pg/ml]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Glutathione Peroxidase 4 (GPX4) level.
Concentration of Human Glutathione Peroxidase 4 (GPX4) [ng/mL]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Glutathione level.
Concentration of Glutathione (GSH) [μg/mL]. ELISA method by the test manufacturer's instructions.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Heme Oxygenase 1(HO-1) level.
Concentration of Heme Oxygenase 1 (HO-1) [ng/mL]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Erythroferrone level.
Concentration of erythroferrone [ng/mL]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Lactoferrin level.
Concentration of lactoferrin [ng/mL]. ELISA method by the test manufacturer's instructions
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in Iron (Fe) level.
The iron level [µg/dL] will be determined using the colorimetric method on the SPECTROstar Nano reader.
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - urea nitrogen (BUN) level.
Concentration of BUN [ml/dl]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - anion gap (AGAP) level.
Concentration of AGAP [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - excess base in extracellular fluid (BE ecf) level.
Concentration of Be ecf [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - sodium (Na) level.
Concentration of Na [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - calcium (Ca) level.
Concentration of Ca [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - potassium (K) level.
Concentration of K [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - chlorine (Cl) level.
Concentration of Cl [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - bicarbonate level (cHCO3).
Concentration of cHCO3 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - total plasma CO2 (tCO2) level.
Concentration of tCO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - partial pressure of carbon dioxide (pCO2)
Concentration of pCO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - partial pressure of oxygen (pO2)
Concentration of pO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance -total blood saturation (cSO2) level.
Concentration of cSO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - urea level.
Concentration of urea [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - crea level.
Concentration of crea [mg/dl]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - hematocrit [hct] level.
Concentration of hct [%]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - hemoglobin [chgb] level.
Concentration of chgb [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Changes from baseline in acid-base balance - glukose [glu] level.
Concentration of glu [mg/dl]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Measured: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Secondary outcomes (11)
Antropometric characteristic - height
Prior to the exercise test, we measured the anthropometric parameters, including height (Seca 213 Hamburg, Deutschland) [cm]
Measured: Day 1 after overall fast
Antropometric characteristic - weight
Prior to the exercise test, we measured the anthropometric parameters, including weight (Tanita BC 418 MA, Tanita Corporation, Tokyo, Japan) [kg]
Measured: Day 1 after overall fast
Antropometric characteristic - LBM
Prior to the exercise test, we measured the anthropometric parameters, including lean body mas (Tanita BC 418 MA, Tanita Corporation, Tokyo, Japan) [kg]
Measured: Day 1 after overall fast
Antropometric characteristic - TBW
Prior to the exercise test, we measured the anthropometric parameters, including total body water (Tanita BC 418 MA, Tanita Corporation, Tokyo, Japan) [kg]
Measured: Day 1 after overall fast
Antropometric characteristic - Water%
Prior to the exercise test, we measured the anthropometric parameters, including water (Tanita BC 418 MA, Tanita Corporation, Tokyo, Japan) [%]
Measured: Day 1 after overall fast
Antropometric characteristic - FAT
Prior to the exercise test, we measured the anthropometric parameters, including fat (Tanita BC 418 MA, Tanita Corporation, Tokyo, Japan) [%]
Measured: Day 1 after overall fast
Food record - energy
Participants will prepare a food record. The results will be calculated using the dietetykpro program: energy [kcal]
Measured: Day before the Day 1, in the morning at Day 1
Food record - protein
Participants will prepare a food record. The results will be calculated using the dietetykpro program: protein [g]
Measured: Day before the Day 1, in the morning at Day 1
Food record - carobhydrates
Participants will prepare a food record. The results will be calculated using the dietetykpro program: carbohydrates [g]
Measured: Day before the Day 1, in the morning at Day 1
Food record - fiber
Participants will prepare a food record. The results will be calculated using the dietetykpro program: fiber [g]
Measured: Day before the Day 1, in the morning at Day 1
Food record - fat
Participants will prepare a food record. The results will be calculated using the dietetykpro program: fat [g]
Measured: Day before the Day 1, in the morning at Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Mar 2025
- Study start29 Mar 2025
- Primary completion28 Jun 2025
- Study completion29 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for FerroptosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Poznan University of Physical Education
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Anna Skarpańska-Stejborn, Professor, Study director, Poznań University of Physical Education, Faculty of Sport Sciences in Gorzów Wielkopolski, Poland;
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06891820
- Sponsor's protocol ID
- Rowers 2025
- Status last verified
- Feb 2025
- First submitted
- 3 Mar 2025
- Last updated
- 11 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Multifaceted Analysis of the Adaptation of Rowers in the Process of Sports Training
- ClinicalTrials.gov ID
- NCT06891820
- Acronym / sponsor ID
- Rowers 2025
- Conditions
- Ferroptosis, Inflammation, Muscle Damage, Nervous System Diseases
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Poznan University of Physical EducationUniversity, hospital or other
- Study start
- 29 Mar 2025 (actual)
- Primary completion
- 28 Jun 2025 (actual)
- Study completion
- 29 Jun 2025 (actual)
- First posted
- 24 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to analyze in detail selected indicators of appetite regulation, metabolism, and iron balance in competitive rowers undergoing intense exercise. The project involves assessing dynamic hormonal and biochemical changes in the athletes' bodies, which will allow a better understanding of the body's adaptive mechanisms to prolonged physical strain.
Research group: the research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified for the Polish Youth Rowing Team:
- aged 19 - 24, because the age group must be homogeneous,
- the size of the group is about thirty people, which in the case of a homogeneous group will enable statistical analyzes to be conducted.
Rowing performance test: At the beginning and end of the training camp, participants will perform a test on a rowing ergometer (Concept II, USA). Each subject will have to cover a distance of 2000 m in the shortest possible time, which is the distance starting in rowing competitions. The results of both tests will be considered in the selection for the championship team; therefore, athletes will be well motivated to perform both tests with maximum effort.
Blood samples will be taken from the cubital vein at three-time points: before each ergometer test (after overnight fasting), directly after the test, and after a 1-hour recovery period.
Detailed description
The study aims to conduct a detailed analysis of selected indicators of appetite regulation, metabolism, inflammation, and iron balance in competitive rowers undergoing intense exercise. The project involves assessing dynamic hormonal and biochemical changes in the athletes' bodies, which will allow for a better understanding of the body's adaptive mechanisms to prolonged physical strain.
Research group: The research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified for the Polish Youth. Rowing Team:
- aged 19 - 24, because the age group must be homogeneous,
- the size of the group is about thirty people, which in the case of a homogeneous group will enable statistical analyzes to be conducted.
Rowing performance test: at the beginning and at the end of the training camp, participants will perform a test on a rowing ergometer (Concept II, USA), each subject will have to cover a distance of 2000 m in the shortest possible time, which is the distance starting in rowing competitions. The results of both tests will be considered in the selection for the championship team; therefore, athletes will be well motivated to perform both tests with maximum effort.
Blood samples will be taken from the cubital vein at three-time points: before each ergometer test (after overnight fasting), directly after the test, and after a 1-hour recovery period.
Measurement: All determined parameters will be measured with the available equipment in the biochemical laboratory of Poznan University of Physical Education, Faculty of Sport Sciences in Gorzow Wlkp., using commercial assay kits. Measurements will be performed by the project contractors.
- Polyethylene tubes (4.9 ml) containing dipotassium ethylenediaminetetraacetic acid (EDTAK2) anticoagulant will be used for the following tests: (a) complete blood count (18 parameters) determined on the MYTHIC 18 hematology analyzer (Orphee Medical, Geneva, Switzerland). White blood cell indices: WBC (white blood cells), LYM (lymphocytes as a percentage), LYM (lymphocytes), MON (monocytes as a percentage), MON (monocytes), GRA (granulocytes as a percentage), GRA (granulocytes). Red blood cell indices: RBC (Red Blood Cells), HGB (Hemoglobin), HCT (Hematocrit), MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Hemoglobin), MCHC (Mean Corpuscular Hemoglobin Concentration), RDW (Red Blood cells Distribution Width). Platelet indices: PLT (Platelet), MPV (Mean Platelet Volume), PDW (Platelet Distribution Width), PCT (Thrombocrit) (b) gene expression.
- Polyethylene clotting activator tubes (9 ml) will be centrifuged to separate the morphotic elements from the serum using a centrifuge (3000 rpm for 10 min). The serum will be pipetted into several Eppendorf tubes, which will then be frozen (temp. -80°C). All the following biochemical parameters will be determined from the extracted serum: using the ELISA method by the test manufacturer's instructions. The designations include the flowing parameters:
- Analysis of leptin, ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide (PP) and cholecystokinin (CCK) levels will allow assessment of dynamic hormonal changes in rowers in relation to training intensity, energy availability and diet composition.
- Leptin (LEP) - a satiety hormone whose levels may be reduced in athletes with low levels of body fat.
- Ghrelin (GHRL) - a hunger hormone that increases in states of energy deficit and may affect the regulation of caloric intake.
- GLP-1, PYY, PP and CCK - intestinal peptides involved in appetite suppression and modulation of insulin secretion and fat metabolism.
- Biochemical and hormonal parameters Stress and recovery hormones:
- Cortisol - a marker of stress response and catabolism.
- Testosterone - a key anabolic hormone, whose ratio to cortisol (T/C) helps assess the balance between anabolism and catabolism. Neurotransmitters associated with fatigue resistance:
- Serotonin - important in regulating mood and central fatigue; its excess can contribute to lethargy and decreased motivation.
- Dopamine - crucial for motivation and mental performance; decreased levels may indicate neurotransmitter depletion. Sex hormones and metabolic balance:
- Estradiol
- Progesterone - in women indicators of menstrual cycle and hormonal balance,
- ferroptosis parameters
- antioxidants: glutathione (GSH), glutathione peroxidase 4 (GPX4),
- markers of oxidative stress: 4-Hydroxynonenal (4-HNE), Heme oxygenase 1 (HO-1)
- iron status parameters: soluble transferrin receptor, ferritin, erythroferrone, lactoferrin The iron and Total Iron Binding Capacity (TIBC) levels will be determined using the colorimetric method on the SPECTROstar Nano reader. Unsaturated Iron Binding Capacity (UIBC) will be calculated from the formula: UIBC = TIBC-iron in serum)
- Markers of energy metabolism:
- Glucose - a key energy source for working muscles, to assess how the body regulates carbohydrate metabolism during and after exercise.
- Glycogen - an important indicator of energy reserve utilization during high intensities, to determine the level of energy reserve utilization.
- Insulin - responsible for the transport of glucose into muscle cells and to assess how the body manages energy before, during and after exercise, and whether adaptation to load is effective,
- Lactic acid - an indicator of exercise intensity and the balance between aerobic and anaerobic metabolism. Markers of muscle damage:
- CK (creatine kinase), myoglobin - increases with muscle damage, especially after intense exercise, allows to assess the degree of fatigue and risk of overtraining.
- interleukin-6 (IL-6) - mediator of inflammatory response and marker of fatigue; rises after intense exercise, indicates fatigue and recovery processes. Markers of metabolic adaptation and recovery:
- fibroblast growth factor-21 (FGF-21) - , a protein, regulates metabolism and restoration of energy resources, allows assessment of the body's adaptation to intense exercise.
- Using a portable analyzer system for measuring blood gas, electrolytes and metabolites (epoc®), using dedicated epoc® test cards. Measured parameters: Direct: pH, partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), total plasma carbon dioxide (tCO2), sodium (Na+), potassium (K+), calcium (Ca++), chlorine (Cl-), hematocrit (Hct), glukose (glu), Lactic Acid (Lac), Crea, Urea, urea nitrogen (BUN). Calculated values: cHgb, bicarbonate level (cHCO3), cTCO2, excess base in extracellular fluid (BE ecf), BE(b), total blood saturation (cSO2), glomerular filtration rate (GFRmdr), GFRmdr-a, GFRckd, GFRckd-a, GFRswz, anion gap (AGAP), AGapK, BUN/Crea, Urea/Crea. It will be determined from capillary blood taken from the earlobe (90 µl). Lactic acid will be determined from capillary blood taken from the earlobe (10 µl). The determination will be performed with dedicated reagents, using a portable biochemical photometer Vario Photometer II (Diaglobal, Berlin, Germany).
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Physical effort | – | Other: Physical effortRowers will perform an intensive exercise test on a rowing ergometer (Concept II, USA), covering a distance of 2000 meters in the shortest time possible. The test on the rowing ergometer will be performed under the supervision of a physician. |
Who may qualify
- Ages
- 19 to 24 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- The Polish Youth Rowing Team
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Physical effortThe examined athletes will be subjected to an effort on a rowing ergometer, covering a designated distance in the shortest possible time. | Other | Physical effort |
Primary outcome
The Blood morphology
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Using MYTHIC18 hematology analyzer (Cormay Diagnostics, Geneva, Switzerland). Qualitative and quantitative evaluation of morphological elements of blood (determination in venous blood).
Changes from baseline in Glycogen level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of glycogen [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline Insulin level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of insulin [μIU/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baselineCreatine kinase activity (CK) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concetration of CK [ng/ml]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline interleukin-6 (Il-6) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Il-6 [pg/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline in fibroblast growth factor 21 (FGF-21) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of FGF-21 [pg/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline in lactic acid (LA) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concetration of LA [mmol/l]. Using a portable biochemical photometer Vario Photometer II (Diaglobal, Berlin, Germany) (capillary blood from the ear lobe).
Gene expression
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Genes studied: LEP, GHRL, AGRP, GOT1 and GPX4. RNA isolation will be performed by the column method on the Direct-zol™ RNA MiniPrep Plus Kits, according to the test manufacturer's instructions. Gene expression analysis from cells isolated from blood will be performed by reverse transcription using TaqMan
Changes from baseline in testosterone level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of testosterone [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline in serotonin level.
Time frame: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Concentration of serotonin [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline in progesterone level.
Time frame: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Concentration of progesterone [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline in estradiol level.
Time frame: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Concentration of estradiol [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Changes from baseline in dopamine level.
Time frame: At rest (before the exercise test), 1 minute after the end of the test, after 1 hour of recovery
Concentration of dopamine [ng/mL]. Immunoenzymatic assay method using a diagnostic ELISA Kit
Baseline Mood Profile of Athletes Before Exercise Test Using POMS Questionnaire.
Time frame: At rest (before the exercise test).
The Profile of Mood States (POMS) questionnaire measures mood states and emotional well-being.
Baseline Mental Toughness in Sport measured using the Scale of Mental Toughness in Sport (SMTQ)
Time frame: At rest (before the exercise test).
Scale of Mental Toughness in Sport (SMTQ) - to assess an athlete's ability to cope with training loads and stress
Baseline Eating Behavior and Attitudes of Athletes Before Exercise Test Using EDE-Q 6.0 Questionnaire.
Time frame: At rest (before the exercise test).
The Eating Disorder Examination Questionnaire (EDE-Q) measures the severity of eating disorder behaviors and attitudes.
Baseline Appetite Assessment of Athletes Before Exercise Test Using Visual Analogue Scale (VAS).
Time frame: At rest (before the exercise test).
The Visual Analogue Scale (VAS) measures subjective appetite sensations-linear scale from one to 10 where 10 is the strongest feeling.
Changes from baseline in leptin(LEP) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Satiety regulation marker. Concentration of leptin [pg/ml].ELISA method by the test manufacturer's instructions.
Changes from baseline in glucagon-like peptide-1 (GLP-1) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Satiety regulation marker. Concentration of GLP-1 [pg/ml]. ELISA method by the test manufacturer's instructions.
Changes from baseline in peptide YY (PYY) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Satiety regulation marker. Concentration of leptin [pg/ml]. ELISA method by the test manufacturer's instructions.
Changes from baseline in pancreatic polipeptide (PP) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Satiety regulation marker. Concentration of PP [pg/ml]. ELISA method by the test manufacturer's instructions
Changes from baseline in ghrelin (GHRL) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Hunger regulation marker. Concentration of GHRL [pg/ml].ELISA method by the test manufacturer's instructions.
Changes from baseline in cholocystokinin (CCK) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Satiety regulation marker. Concentration of CCK [pg/ml].ELISA method by the test manufacturer's instructions.
Changes from baseline in Soluble transferrin receptor level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Soluble transferrin receptor [μg/ml]. ELISA method by the test manufacturer's instructions.
Changes from baseline in Ferritin level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of ferritin [ng/mL]. ELISA method by the test manufacturer's instructions
Changes from baseline in 4-Hydroxynonenal (4-HNE) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of 4-Hydroxynonenal (4-HNE) [pg/ml]. ELISA method by the test manufacturer's instructions
Changes from baseline in Glutathione Peroxidase 4 (GPX4) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Human Glutathione Peroxidase 4 (GPX4) [ng/mL]. ELISA method by the test manufacturer's instructions
Changes from baseline in Glutathione level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Glutathione (GSH) [μg/mL]. ELISA method by the test manufacturer's instructions.
Changes from baseline in Heme Oxygenase 1(HO-1) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Heme Oxygenase 1 (HO-1) [ng/mL]. ELISA method by the test manufacturer's instructions
Changes from baseline in Erythroferrone level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of erythroferrone [ng/mL]. ELISA method by the test manufacturer's instructions
Changes from baseline in Lactoferrin level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of lactoferrin [ng/mL]. ELISA method by the test manufacturer's instructions
Changes from baseline in Iron (Fe) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
The iron level [µg/dL] will be determined using the colorimetric method on the SPECTROstar Nano reader.
Changes from baseline in acid-base balance - urea nitrogen (BUN) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of BUN [ml/dl]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - anion gap (AGAP) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of AGAP [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - excess base in extracellular fluid (BE ecf) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Be ecf [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - sodium (Na) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Na [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - calcium (Ca) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Ca [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - potassium (K) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of K [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - chlorine (Cl) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of Cl [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - bicarbonate level (cHCO3).
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of cHCO3 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - total plasma CO2 (tCO2) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of tCO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - partial pressure of carbon dioxide (pCO2)
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of pCO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - partial pressure of oxygen (pO2)
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of pO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance -total blood saturation (cSO2) level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of cSO2 [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - urea level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of urea [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - crea level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of crea [mg/dl]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - hematocrit [hct] level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of hct [%]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - hemoglobin [chgb] level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of chgb [mmol/l]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
Changes from baseline in acid-base balance - glukose [glu] level.
Time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.
Concentration of glu [mg/dl]. Using the portable blood gas, electrolyte, and metabolite analyzer (epoc®) (capillary blood from the ear lobe).
11 secondary outcomes
Antropometric characteristic - height
Time frame: Day 1 after overall fast
Antropometric characteristic - weight
Time frame: Day 1 after overall fast
Antropometric characteristic - LBM
Time frame: Day 1 after overall fast
Antropometric characteristic - TBW
Time frame: Day 1 after overall fast
Antropometric characteristic - Water%
Time frame: Day 1 after overall fast
Antropometric characteristic - FAT
Time frame: Day 1 after overall fast
Food record - energy
Time frame: Day before the Day 1, in the morning at Day 1
Food record - protein
Time frame: Day before the Day 1, in the morning at Day 1
Food record - carobhydrates
Time frame: Day before the Day 1, in the morning at Day 1
Food record - fiber
Time frame: Day before the Day 1, in the morning at Day 1
Food record - fat
Time frame: Day before the Day 1, in the morning at Day 1
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Sep 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anna Skarpańska-Stejborn, Professor study director
Poznań University of Physical Education, Faculty of Sport Sciences in Gorzów Wielkopolski, Poland;
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ferroptosis and Inflammation, run by Poznan University of Physical Education at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Blood morphology (time frame: At rest (before the test), directly after the test, and after a 1-hour recovery period.). The study lists 49 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Sep 2025.