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Alveolar Bone LossLMPONCT06887595

Linear Micro-Perforation Osteotomy Ridge Split Approach

A study testing Free-hand linear micro perforation osteotomy and ridge splitting and AI-assisted/computer-guided linear micro perforation osteotomy and ridge splitting in people with Alveolar Bone Loss and Dental Implant Failed, run by Kafrelsheikh University at 1 site in Egypt.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The traditional ridge split technique might be performed simultaneously with implant placement, resulting in a shortened treatment time. However, this approach has the potential for serious complications, including buccal bone fracture, prolonged pain or paresthesia, and loss of bone height. Read more about this study

Who is it for?
Ages 18 to 40 yearsHealthy volunteers can take part
Conditions the study is for
Alveolar Bone Loss, Dental Implant Failed
What is being tested?
Free-hand linear micro perforation osteotomy and ridge splitting and AI-assisted/computer-guided linear micro perforation osteotomy and ridge splitting
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
22 participants
Where
1 siteEgypt
Study dates
18 Mar 2025to 5 May 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 40 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Patients presenting with narrow alveolar ridge that requires dental implantation.
  • Minimum bone width of 3 mm
  • Ridge width of not less than 3 mm in CBCT image
  • Minimum bone height of 10 mm
  • Proper inter-occlusal space
  • Perioperative cone beam CT scan image of the atrophic ridge

Who cannot join

  • • Uncontrolled diabetes.
  • Heavy smokers.
  • Current chemotherapy or radiotherapy.
  • Alcohol or drug abuse.
  • Pregnant women.
  • Active infection.
  • Inter-occlusal space not less than 7-8 mm.

Trial locations and contacts

1 site in 1 country.

Egypt1 site
  • faculty of dentistry, kafrelsheikh University

    Kafr ash Shaykh, Kafrelsheikh, 214312

Other trials in Egypt

About this study

Official title: A Comparative Study of AI-Powered/Computer-Guided Versus Conventional Linear Micro-Perforation Split Approach for Treatment of Horizontal Mandibular Ridge Atrophy (A Randomized Clinical Trial)

The traditional ridge split technique might be performed simultaneously with implant placement, resulting in a shortened treatment time. However, this approach has the potential for serious complications, including buccal bone fracture, prolonged pain or paresthesia, and loss of bone height. Linear Micro-Perforation Osteotomy (LMPO) has emerged as a less invasive alternative, promoting natural bone expansion through controlled micro-perforations in the cortical bone, allowing for ridge widening without extensive grafting. However, the precision required for LMPO can be difficult to achieve manually, especially in anatomically complex or narrow ridge areas, leading to variability in outcomes and potential risks such as bone fractures or inadequate expansion.Our study aims to evaluate the efficacy, clinical, and radiological outcomes of the flapless AI-powered/computer-guided LMPO ridge split/expansion technique compared to the traditional LMPO ridge split/expansion method for lateral ridge reconstruction of mandibular horizontal ridge deficiencies.

Read the detailed description

In contemporary dentistry, the aim is to replace missing teeth with prosthetics or to remove diseased teeth from the patient and return them to normal in terms of shape, function, comfort, appearance, speech, and health. Why implant dentistry is different is the capacity to fulfill this objective despite atrophy, illness, or harm to the stomatognathic apparatus.

Implant-based dental rehabilitation of partly or completely edentulous areas has become a frequent procedure with consistent long-term outcomes in recent decades. Nevertheless, alveolar ridges are frequently impaired with horizontal inadequacy as a result of bone resorption, which has an impact on implant application.

The resorption of alveolar bone is a common sequelae of tooth loss and presents a clinical problem for implant placement. Implants must be placed with at least 1 mm of bone on the buccal and lingual aspects to maintain crestal bone levels.

Narrow edentulous ridges less than 5 mm wide present a challenge to the clinician for implant placement. Hence, lateral bone augmentation procedures are necessary to overcome maxillary and mandibular bone deficiencies. These procedures involve the use of bone augmentation, such as guided bone regeneration (GBR), bone block (autogenous or non-autogenous), and conventional onlay/inlay graft. Those procedures have many drawbacks such as longer healing time (6-9 months) for adequate bone regeneration before implant placement, the possibility of membrane exposure, an increased risk of infection, high cost, and rapid graft resorption; thus leading to inadequate bone regeneration or loss of the newly formed bone.

Based on previous knowledge, ridge split/expansion was introduced as an alternative to treat the width insufficiency of alveolar ridges with specific indications. The basic procedure includes a sagittal osteotomy in the center of the edentulous ridge, where the two cortical plates are expanded to increase the width and thereby simultaneous implant insertion with an appropriate diameter could be achieved.

Due to double cellularity and double vascularity gained from the lateral bony plate, bone healing, and regeneration tendency were significantly improved without the need for bone graft or membrane. A shorter treatment period, no need for donor sites, and the possibility of simultaneous implant placement are among the merits of ridge splitting over different augmentation techniques.

For successful ridge split with simultaneous implantation, the alveolar ridge width should be 3 mm or more with at least 1 mm trabecular bone between the cortical plates.

The splitting could be performed using the chisel and mallet, the surgical disc, ultra-fine fissure burs, and recently the piezoelectric surgical devices and the electromagnetic mallet. Osteotomes, chisels, bone spreaders, and engine-driven expanders were utilized for Ridge expansion.

The traditional ridge split technique might be performed simultaneously with implant placement, resulting in a shortened treatment time. However, this approach has the potential for serious complications, including buccal bone fracture, prolonged pain or paresthesia, and loss of bone height. On the other hand, the staged approach has been proposed with splitting and expansion performed followed by implant placement after a 3-week healing interval to allow re-establishment of the blood supply to the surgical site.

Linear Micro-Perforation Osteotomy (LMPO) has emerged as a less invasive alternative, promoting natural bone expansion through controlled micro-perforations in the cortical bone, allowing for ridge widening without extensive grafting. However, the precision required for LMPO can be difficult to achieve manually, especially in anatomically complex or narrow ridge areas, leading to variability in outcomes and potential risks such as bone fractures or inadequate expansion.

Computer-guided technology presents an opportunity to enhance LMPO by providing a structured, pre-planned guide for split-osteotomy and expansion. Utilizing 3D imaging data, a computer-guided splint can be custom-fabricated to fit each patient's unique anatomy, offering unparalleled accuracy in osteotomy execution and minimizing the risk of error. Additionally, performing LMPO without flap elevation with the assistance of this guided splint further reduces surgical trauma, preserves periosteal blood supply, and promotes faster healing, making it a more patient-friendly option.

Limited clinical data are available about LMPO. Our study aims to evaluate the efficacy, clinical, and radiological outcomes of the flapless AI-powered/computer-guided LMPO ridge split/expansion technique compared to the traditional LMPO ridge split/expansion method for lateral ridge reconstruction of mandibular horizontal ridge deficiencies.

Being tested
Free-hand linear micro perforation osteotomy and ridge splitting, AI-assisted/computer-guided linear micro perforation osteotomy and ridge splitting
Medical subject headings
Alveolar Bone Loss

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Free-hand linear micro perforation osteotomy and ridge splittingProcedure or surgery

    Also called Free-hand crestal ridge splitting expansion after linear micro perforation osteotomy will be performed using electromagnetic mallet

    AI-assisted/computer-guided linear micro perforation osteotomy and ridge splitting

  • AI-assisted/computer-guided linear micro perforation osteotomy and ridge splittingProcedure or surgery

    AI-assisted/computer-guided crestal ridge splitting expansion after linear micro perforation osteotomy will be performed using electromagnetic mallet

Study groups in NCT06887595
Study groupRoleWhat they receive
study group IExperimentalridge split and expansion with free-hand linear micro perforation osteotomy approach with simultaneous implant placement
Receives: Procedure: Free-hand linear micro perforation osteotomy and ridge splitting
study group IIExperimentalridge split and expansion with AI-assisted/computer-guided (linear micro perforation osteotomy approach with simultaneous implant placement)
Receives: Procedure: AI-assisted/computer-guided linear micro perforation osteotomy and ridge splitting

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. ridge width

    The width of the alveolar bone will be measured again using CBCT

    Measured: 12-months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted20 Mar 2025
  2. Study start18 Mar 2025
  3. Primary completion20 Apr 2026
  4. Study completion5 May 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
22 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06887595
Sponsor's protocol ID
KFSIRB200-467
Acronym
LMPO
Status last verified
Jul 2026
First submitted
16 Mar 2025
Last updated
7 Jul 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided: sharing upon request

Questions about this trial

What is this clinical trial studying?

A study testing Free-hand linear micro perforation osteotomy and ridge splitting and AI-assisted/computer-guided linear micro perforation osteotomy and ridge splitting in people with Alveolar Bone Loss and Dental Implant Failed, run by Kafrelsheikh University at 1 site in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

ridge width (time frame: 12-months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.

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