E-Cig UseNCT06860698
The Impact of Chronic E-Cigarette Usage on Microvascular Health
An observational study of E-Cig Use, run by Virginia Commonwealth University at 1 site in United States.
Trial summary
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. Read more about this study
- Who is it for?
- Ages 18 to 29 yearsHealthy volunteers can take part
- Conditions the study is for
- E-Cig Use
- What is being tested?
- E-cig use
- How many people
- 41 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Jul 2023to 2 Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 29 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Chronic e-cigs users and never users that are between 18 and 29 years of age.
Who may be able to join
- Between 18 and 29 years of age
- Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)
- Between 18 and 29 years of age
Who cannot join
- 17 years old and younger or 30 years old or older.
- Former combustible tobacco user/ former smoker
- Use of cigarettes for 15 days or more in the past 60 days
- Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
- Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
- Disorder or use of medication that affects cardiopulmonary health
Show all 13Show fewer
- Evidence of pregnancy or current nursing
- Non e-Cig using arm
- 17 years old and younger or 30 years old and older
- Use of cigarettes or other tobacco products more than 50 times in their lifetime.
- Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
- Disorder or use of medication that affects cardiopulmonary health
- Evidence of pregnancy or current nursing
Trial locations and contacts
1 site in 1 country.
United States1 site
Virginia Commonwealth University
Richmond, Virginia, 23298
About this study
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.
Read the detailed description
Electronic cigarettes or e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes. However, there are large discrepancies of knowledge in understanding how these e-cigarettes affect the subjects health and the way their body uses oxygen. The overall goal of this study is to evaluate e-cigarettes usage on subjects health.
- Conditions
- E-Cig Use
- Being tested
- E-cig use
- Keywords
- Microvascular Health
- Medical subject headings
- Vaping
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
E-cig useOther
Based on e-cigarette usage, participants will be divided into those who used e-cigarettes and those who did not use e-cigarettes
| Study group | Role | What they receive |
|---|---|---|
| Chronic e-cigs users | Used e-cigarettes with nicotine (≥3 times/week for ≥6 months) Receives: Other: E-cig use | |
| Never Users | Use of cigarettes or other tobacco products less than 50 times in their lifetime. Receives: Other: E-cig use |
What is being measured
The primary outcome is the main question the study is designed to answer.
Endothelial dependent dilation
Endothelial-dependent dilation will be assessed using laser doppler speckle contrast in both groups through the intervention
Measured: Participation is one week
Neurogenic response
Neurogenic response will be assessed using axon reflex in both groups through the intervention
Measured: Participation is one week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2025
- Study start14 Jul 2023
- Primary completion2 Jun 2025
- Study completion2 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for E-Cig UseStudies of the same condition, open and under way.
- More trials run by Virginia Commonwealth UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 41 participants (actual)
Sponsor and investigators
- Lead sponsor
- Virginia Commonwealth University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Paula Rodriguez Miguelez, Principal investigator, Virginia Commonwealth University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06860698
- Sponsor's protocol ID
- HM20029023
- Status last verified
- Sep 2026
- First submitted
- 24 Feb 2025
- Last updated
- 14 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Chronic E-Cigarette Usage on Microvascular Health
- ClinicalTrials.gov ID
- NCT06860698
- Acronym / sponsor ID
- HM20029023
- Conditions
- E-Cig Use
- Keywords
- Microvascular Health
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 41 participants (actual)
- Lead sponsor
- Virginia Commonwealth UniversityUniversity, hospital or other
- Study start
- 14 Jul 2023 (actual)
- Primary completion
- 2 Jun 2025 (actual)
- Study completion
- 2 Jun 2025 (actual)
- First posted
- 6 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.
Detailed description
Electronic cigarettes or e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes. However, there are large discrepancies of knowledge in understanding how these e-cigarettes affect the subjects health and the way their body uses oxygen. The overall goal of this study is to evaluate e-cigarettes usage on subjects health.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Chronic e-cigs users | – | Other: E-cig useUsed e-cigarettes with nicotine (≥3 times/week for ≥6 months) |
| Never Users | – | Other: E-cig useUse of cigarettes or other tobacco products less than 50 times in their lifetime. |
Who may qualify
- Ages
- 18 to 29 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Chronic e-cigs users and never users that are between 18 and 29 years of age.
Key inclusion criteria (3 listed)
- Between 18 and 29 years of age
- Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)
- Between 18 and 29 years of age
Key exclusion criteria (13 listed)
- 17 years old and younger or 30 years old or older.
- Former combustible tobacco user/ former smoker
- Use of cigarettes for 15 days or more in the past 60 days
- Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
- Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| E-cig useBased on e-cigarette usage, participants will be divided into those who used e-cigarettes and those who did not use e-cigarettes | Other | Chronic e-cigs users, Never Users |
Primary outcome
Endothelial dependent dilation
Time frame: Participation is one week
Endothelial-dependent dilation will be assessed using laser doppler speckle contrast in both groups through the intervention
Neurogenic response
Time frame: Participation is one week
Neurogenic response will be assessed using axon reflex in both groups through the intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Paula Rodriguez Miguelez principal investigator
Virginia Commonwealth University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of E-Cig Use, run by Virginia Commonwealth University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Endothelial dependent dilation (time frame: Participation is one week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.