PneumoniaNCT06835842
Effect of Rib Mobilization on Weaning Parameters From Mechanical Ventilator in Patients With Pneumonia
A study testing rib mobilization technique and routine chest physiotherapy in people with Pneumonia, run by Cairo University at 1 site in Egypt.
Trial summary
this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters from mechanical ventilator in patients with pneumonia • HYPOTHESES: It will be hypothesized that there may be significant effect of rib mobilization on weaning parameters from mechanical… Read more about this study
- Who is it for?
- Ages 40 to 50 years
- Conditions the study is for
- Pneumonia
- What is being tested?
- rib mobilization technique and routine chest physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Mar 2025to 20 May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patient's age ranged from 40- 50 years old from both genders.
- Diagnosed with pneumonia and need invasive mechanical ventilation support.
- Stable oxygen saturation (SpO2 more than 85, (FiO2) 0.6 or less, PEEP less than 10 Cm H2O).
- mean arterial pressure > 75 mmHg and urine output > 1 mL/kg/h;
- Patients with Glasgow coma scale (GCS) > 8T
- Unconscious and semi-conscious patients. -
Who cannot join
- Unstable hemodynamics
- Unstable neurological problems e.g. (epileptic seizures -hyperthermia).
- Unstable chest wall e.g. (multiple rib or vertebral fractures)
- Increase intracranial pressure (>20 mmHg for >5 min).
- Undrained pneumothorax, recent pulmonary surgery
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
El Galaa Military Hospital
Cairo
Hoda gaber elsaid, M.Sc, +20 110 027 2020, huda.eaid68@gmail.com
About this study
this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters from mechanical ventilator in patients with pneumonia •
HYPOTHESES:
Read more
It will be hypothesized that there may be significant effect of rib mobilization on weaning parameters from mechanical ventilator in patients with pneumonia.
RESEARCH QUESTION:
Does rib mobilization have an effect on weaning parameters from mechanical ventilator in patients with pneumonia? measuring weaning parameters: on screen of mechanical ventilator : measuring respiratory rate, Tidal volume (TV), FiO2.
- Arterial blood gases (ABG) analyzer machine ABG is recorded daily (PH- PaO2 - PaCO2)
- Length of ICU stay: calculated by (admission date - discharge date
- Weaning success rate
Read the detailed description
Ventilator-associated pneumonia (VAP) represents a significant sub-set of (HAP) remains the most frequent intensive care unit (ICU)-acquired infection its incidence ranges from 9% to 27% of ventilated patients ,VAP is associated with an increased length of stay, mortality and health care costs, Pneumonia can result in chest wall stiffness, decreased mobility, limiting the range of motion during breathing and decreased lung compliance and impaired respiratory function , Rib mobilization: is an articular , non-invasive, passive technique that can be useful with acutely ill, hospitalized patients emphasizes the placement of a repetitive force to increase the range of motion of the posterior rib articulations and chest wall , lessening somatic dysfunction of the spine, stretches myofascial structures and improve respiratory mechanics So, this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters among intubated pneumonic patients on mechanical vent.
- Conditions
- Pneumonia
- Being tested
- rib mobilization technique, routine chest physiotherapy
- Medical subject headings
- Pneumonia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
rib mobilization techniqueOther
rib mobilization technique The patient in experimental group will be relaxed in semi- fowler position while connected to mechanical ventilator, therapist will seat at the patient "side, his fingers pads are placed at the position of the patient's rib angles , pulling upward and the lateral position the position is held while wait for the soft tissues to release this take from 15 seconds .Release of the diaphragm through manual contact with hypothenar region of therapist thumb inferior laterally xiphoid process and rest along Antero lateral costal margin below rib7 during exhalation the therapist thumb give pressure posteriorly repeat this steps for 3 to5 respiratory cycle • routine chest physiotherapy percussion on chest wall its frequency should be 3-7 beats per sec. vibration applying a light pressure with hand on affected segment for about 5 min modified postural drainage R. and L. side. U\&L limb passive ex. for R.10 x3 set
.this program for 30 minutes once daily for ten days
routine chest physiotherapyOther
routine chest physiotherapy the patient will be laid in half supine position connected to a ventilator applying
- percussion on chest wall its frequency should be 3-7 beats per second or 180-420 beats per minute
- vibration applying a light pressure with flattened hand on affected segment for about 5 minutes
- modified postural drainage (right and left sidling 10 min for each side
- upper and lower limb exercise for 4 limbs (3 sets and each set has 10 repetition
- this program for 30 minutes once daily
- for 10 consecutive days
| Study group | Role | What they receive |
|---|---|---|
| rib mobilization technique and routine chest physiotherapy group | Experimental | 1.rib mobilization technique and routine chest physio therapy group: the patients will receive rib mobilization technique in addition to their medical treatment and routine chest physiotherapy for at least 30 minutes once daily for ten consecutive days Receives: Other: rib mobilization technique; Other: routine chest physiotherapy |
| routine chest physiotherapy group | Active comparator | routine chest physiotherapy group : the patients in this group will receive routine chest physical therapy for at least 30 minutes once daily for 10 consecutive days Receives: Other: routine chest physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Arterial blood gases
- Arterial blood gases (ABG): (PH -PaO2 - PaCO2)
- PaO2/FiO2 ratio (P/F): One element of predicting successful weaning from mechanical ventilation is PaO2/FiO2 > 200
Measured: at least 10 consecutive days
Respiratory rate (RR)
It will be measured using a mechanical ventilator.
Measured: at least 10 consecutive days
Tidal volume (TV)
It will be measured using a mechanical ventilator.
Measured: at least 10 consecutive days
Secondary outcomes (1)
Length of hospital stay
;• Length of stay in intensive care unite can be defined as the number of days that an in-patient will remain in ICU during a single admission event, is calculated by subtracting the admission date (ADATE) from the discharge date (DDATE)
Measured: at least 10 consecutive days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Feb 2025
- Study start10 Mar 2025
- Primary completion10 Feb 2026 (estimated)
- Study completion20 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PneumoniaStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hoda Gaber, Cairo University
- Investigators
- Azza Abd El Aziz Abd El Hady, professor, Study chair, Cairo UniversityMohammed Abd Hakim El-Nadi, professor, Study director, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06835842
- Sponsor's protocol ID
- PT REC/012/005446
- Status last verified
- Jul 2025
- First submitted
- 9 Feb 2025
- Last updated
- 10 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Rib Mobilization on Weaning Parameters From Mechanical Ventilator in Patients With Pneumonia
- ClinicalTrials.gov ID
- NCT06835842
- Acronym / sponsor ID
- PT REC/012/005446
- Conditions
- Pneumonia
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 10 Mar 2025 (actual)
- Primary completion
- 10 Feb 2026 (estimated)
- Study completion
- 20 May 2026 (estimated)
- First posted
- 19 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters from mechanical ventilator in patients with pneumonia •
HYPOTHESES:
It will be hypothesized that there may be significant effect of rib mobilization on weaning parameters from mechanical ventilator in patients with pneumonia.
RESEARCH QUESTION:
Does rib mobilization have an effect on weaning parameters from mechanical ventilator in patients with pneumonia? measuring weaning parameters: on screen of mechanical ventilator : measuring respiratory rate, Tidal volume (TV), FiO2.
- Arterial blood gases (ABG) analyzer machine ABG is recorded daily (PH- PaO2 - PaCO2)
- Length of ICU stay: calculated by (admission date - discharge date
- Weaning success rate
Detailed description
Ventilator-associated pneumonia (VAP) represents a significant sub-set of (HAP) remains the most frequent intensive care unit (ICU)-acquired infection its incidence ranges from 9% to 27% of ventilated patients ,VAP is associated with an increased length of stay, mortality and health care costs, Pneumonia can result in chest wall stiffness, decreased mobility, limiting the range of motion during breathing and decreased lung compliance and impaired respiratory function , Rib mobilization: is an articular , non-invasive, passive technique that can be useful with acutely ill, hospitalized patients emphasizes the placement of a repetitive force to increase the range of motion of the posterior rib articulations and chest wall , lessening somatic dysfunction of the spine, stretches myofascial structures and improve respiratory mechanics So, this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters among intubated pneumonic patients on mechanical vent.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| rib mobilization technique and routine chest physiotherapy group | Experimental | Other: rib mobilization technique, Other: routine chest physiotherapy1.rib mobilization technique and routine chest physio therapy group: the patients will receive rib mobilization technique in addition to their medical treatment and routine chest physiotherapy for at least 30 minutes once daily for ten consecutive days |
| routine chest physiotherapy group | Active comparator | Other: routine chest physiotherapyroutine chest physiotherapy group : the patients in this group will receive routine chest physical therapy for at least 30 minutes once daily for 10 consecutive days |
Who may qualify
- Ages
- 40 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Patient's age ranged from 40- 50 years old from both genders.
- Diagnosed with pneumonia and need invasive mechanical ventilation support.
- Stable oxygen saturation (SpO2 more than 85, (FiO2) 0.6 or less, PEEP less than 10 Cm H2O).
- mean arterial pressure > 75 mmHg and urine output > 1 mL/kg/h;
- Patients with Glasgow coma scale (GCS) > 8T
Key exclusion criteria (5 listed)
- Unstable hemodynamics
- Unstable neurological problems e.g. (epileptic seizures -hyperthermia).
- Unstable chest wall e.g. (multiple rib or vertebral fractures)
- Increase intracranial pressure (>20 mmHg for >5 min).
- Undrained pneumothorax, recent pulmonary surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| rib mobilization techniquerib mobilization technique The patient in experimental group will be relaxed in semi- fowler position while connected to mechanical ventilator, therapist will seat at the patient "side, his fingers pads are placed at the position of the patient's rib angles , pulling upward and the lateral position the position is held while wait for the soft tissues to release this take from 15 seconds .Release of the diaphragm through manual contact with hypothenar region of therapist thumb inferior laterally xiphoid process and rest along Antero lateral costal margin below rib7 during exhalation the therapist thumb give pressure posteriorly repeat this steps for 3 to5 respiratory cycle • routine chest physiotherapy percussion on chest wall its frequency should be 3-7 beats per sec. vibration applying a light pressure with hand on affected segment for about 5 min modified postural drainage R. and L. side. U\&L limb passive ex. for R.10 x3 set .this program for 30 minutes once daily for ten days | Other | rib mobilization technique and routine chest physiotherapy group |
| routine chest physiotherapyroutine chest physiotherapy the patient will be laid in half supine position connected to a ventilator applying * percussion on chest wall its frequency should be 3-7 beats per second or 180-420 beats per minute * vibration applying a light pressure with flattened hand on affected segment for about 5 minutes * modified postural drainage (right and left sidling 10 min for each side * upper and lower limb exercise for 4 limbs (3 sets and each set has 10 repetition * this program for 30 minutes once daily * for 10 consecutive days | Other | rib mobilization technique and routine chest physiotherapy group, routine chest physiotherapy group |
Primary outcome
Arterial blood gases
Time frame: at least 10 consecutive days
• Arterial blood gases (ABG): (PH -PaO2 - PaCO2) • PaO2/FiO2 ratio (P/F): One element of predicting successful weaning from mechanical ventilation is PaO2/FiO2 > 200
Respiratory rate (RR)
Time frame: at least 10 consecutive days
It will be measured using a mechanical ventilator.
Tidal volume (TV)
Time frame: at least 10 consecutive days
It will be measured using a mechanical ventilator.
1 secondary outcome
Length of hospital stay
Time frame: at least 10 consecutive days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Azza Abd El Aziz Abd El Hady, professor study chair
Cairo University
Mohammed Abd Hakim El-Nadi, professor study director
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing rib mobilization technique and routine chest physiotherapy in people with Pneumonia, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact hoda gaber el said, master (01100272020, huda.eaid68@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Arterial blood gases (time frame: at least 10 consecutive days). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2025.