Aquagenic Wrinkling of PalmsNCT06831110
Aquagenic Wrinkling Prediction
An observational study of Aquagenic Wrinkling of Palms and Carrier State, run by University of Iowa at 1 site in United States.
Trial summary
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status. Read more about this study
- Who is it for?
- Ages 18 to 24 yearsHealthy volunteers can take part
- Conditions the study is for
- Aquagenic Wrinkling of Palms, Carrier State
- What is being tested?
- Aquagenic Wrinkling
- Type of treatment
- Surgery or procedure
- How many people
- 2,000 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Mar 2025to Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 24 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: University students
Who may be able to join
- Interested in participating in other CF Carrier-related research studies.
Who cannot join
- CF patient status
- Unable to speak English
- Unable to provide written informed consent
- Prisoner status
- An open wound on either hand
- A tattoo on either hand
Show all 12Show fewer
- Missing any portion of either hand
- Diagnosis of Diabetes
- Diagnosis of Hyperhidrosis
- Diagnosis of Raynaud's Disease
- Diagnosis of Atopic Dermatitis
- Regularly taking ACE inhibitors or angiotensin receptor blockers
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Iowa
Iowa City, Iowa, 52242
Shelby Francis, PhD, 319-678-8037, shelby-francis@uiowa.edu
About this study
Official title: Using Aquagenic Wrinkling to Predict CF Carrier State
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.
Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.
- Conditions
- Aquagenic Wrinkling of Palms, Carrier State
- Being tested
- Aquagenic Wrinkling
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aquagenic WrinklingProcedure or surgery
Participants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water.
| Study group | Role | What they receive |
|---|---|---|
| Potential Cystic Fibrosis Carriers | Participants that are identified as potential cystic fibrosis carriers based on aquagenic wrinkling results. Receives: Procedure: Aquagenic Wrinkling | |
| Potential Controls | Participants that are identified as potential controls based on aquagenic wrinkling results. Receives: Procedure: Aquagenic Wrinkling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Human Observation of Wrinkling
Photos of hands will be scored on a scale of 0 (no wrinkling) to 4 (severe wrinkling) at each minute by human observers.
Measured: Up to 20 minutes
Machine-Learning Observation of Wrinkling
Photos of hands will be scored by a machine-learning algorithm at each minute.
Measured: Up to 20 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2025
- Study start6 Mar 2025
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aquagenic Wrinkling of PalmsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Iowa
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Philip Polgreen, University of Iowa
- Investigators
- Philip M Polgreen, MD, Principal investigator, University of Iowa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06831110
- Sponsor's protocol ID
- 202410028
- Status last verified
- Jun 2026
- First submitted
- 5 Feb 2025
- Last updated
- 4 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Using Aquagenic Wrinkling to Predict CF Carrier State
- ClinicalTrials.gov ID
- NCT06831110
- Acronym / sponsor ID
- 202410028
- Conditions
- Aquagenic Wrinkling of Palms, Carrier State
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- University of IowaUniversity, hospital or other
- Study start
- 6 Mar 2025 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 17 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.
Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Potential Cystic Fibrosis Carriers | – | Procedure: Aquagenic WrinklingParticipants that are identified as potential cystic fibrosis carriers based on aquagenic wrinkling results. |
| Potential Controls | – | Procedure: Aquagenic WrinklingParticipants that are identified as potential controls based on aquagenic wrinkling results. |
Who may qualify
- Ages
- 18 to 24 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- University students
Key inclusion criteria (1 listed)
- Interested in participating in other CF Carrier-related research studies.
Key exclusion criteria (12 listed)
- CF patient status
- Unable to speak English
- Unable to provide written informed consent
- Prisoner status
- An open wound on either hand
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aquagenic WrinklingParticipants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water. | Procedure or surgery | Potential Controls, Potential Cystic Fibrosis Carriers |
Primary outcome
Human Observation of Wrinkling
Time frame: Up to 20 minutes
Photos of hands will be scored on a scale of 0 (no wrinkling) to 4 (severe wrinkling) at each minute by human observers.
Machine-Learning Observation of Wrinkling
Time frame: Up to 20 minutes
Photos of hands will be scored by a machine-learning algorithm at each minute.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Jun 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Philip M Polgreen, MD principal investigator
University of Iowa
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aquagenic Wrinkling of Palms and Carrier State, run by University of Iowa at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Philip M Polgreen, MD (319-384-6194, philip-polgreen@uiowa.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Human Observation of Wrinkling (time frame: Up to 20 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jun 2026; AzTrials last refreshed its copy on 26 Oct 2026.