OsteopeniaFeDeBoMaNCT06813092
Effects of Resistance Exercise Compared to Whole-body Electromyostimulation in Young Female Dentists.
A study testing Whole-Body Electromyostimulation and Resistance exercise in people with Osteopenia and Cardiometabolic Conditions, run by University of Erlangen-Nürnberg Medical School at 2 sites in Germany.
Trial summary
Due to their high workload and unfavorable working position, young female dentists are particularly at risk of cardiometabolic diseases and an early reduction in bone mineral density (BMD). Read more about this study
- Who is it for?
- Ages 18 to 30 years, women only
- Conditions the study is for
- Osteopenia, Cardiometabolic Conditions
- What is being tested?
- Whole-Body Electromyostimulation and Resistance exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 2 sitesGermany
- Study dates
- 15 Mar 2025to 30 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- female dental students (>3rd semester) or licensed dentists
- no competitive sports background for >2 years
- normal body mass (BMI>18,5 and <25 kg/m2)
Who cannot join
- more than one resistance exercise session per week (last 12 month)
- whole-body electromyostimulation during the last 12 month
- amenorrhea, oligomenorrhea
Trial locations and contacts
2 sites in 1 country.
Germany2 sites
Institute of Radiology
Erlangen, 91052
Institute of Radiology, University Hospital NErlangen
Erlangen, 91054
About this study
Official title: Effects of a Single Bout of High Intensity, High Velocity Resistance Exercise Compared to Whole-body Electromyostimulation on Cardiometabolic Risk Factors and Markers of Bone Formation and -Resorption in Young Female Dentists.
Due to their high workload and unfavorable working position, young female dentists are particularly at risk of cardiometabolic diseases and an early reduction in bone mineral density (BMD). With focus on the latter issue, short bouts of resistance exercise with high strain magnitude and velocity are commonly considered to be a feasible option to prevent bone loss in the early years of young adulthood. In parallel, whole-body electromyostimulation (WB-EMS) a trainings technology able address all main muscle groups simultaneously, however with dedicated exercise intensity might be a time-effective, joint friendly and safe option to maintain BMD in people unable or unmotivated to exercise conventionally. In the present study, we aim to compare the effects of a single session of WB-EMS versus high intensity, high velocity resistance exercise on biomarkers of bone formation (Procollagen type 1 N propeptide, P1NP) and resorption (C-terminal telopeptide of type I collagen, CTX-I). We hypothesize that no clinically relevant different effects on P1NP and CTX-I were determined.
- Conditions
- Osteopenia, Cardiometabolic Conditions
- Being tested
- Whole-Body Electromyostimulation, Resistance exercise
- Keywords
- biomarkers, bone metabolism, exercise, whole-body electromyostimulation, female dentists
- Medical subject headings
- Bone Diseases, Metabolic, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Whole-Body ElectromyostimulationOther
20 min of WB-EMS (bipolar, 85 Hz, 350 µs, 6s impulse - 4s impulse break)
Resistance exerciseOther
High-intensity/high velocity multiple set resistance exercise
| Study group | Role | What they receive |
|---|---|---|
| Whole-Body Electromyostimulation | Experimental | One single bout of whole-body electromyostimulation (20 min, bipolar, 85 Hz, 350 µs, rectangular, 6s of impulse, 4s of rest) Receives: Other: Whole-Body Electromyostimulation |
| Resistance exercise | Active comparator | High intensity, high velocity resistance exercise (30 min, 5-6 exercises, 3 sets at 60-85% 1RM) Receives: Other: Resistance exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes for C-terminal telopeptide of type I collagen from pre- to 15 min post-exercise
Changes for C-terminal telopeptide of type I collagen (CTX-I) serum levels from pre- to 15 min post-exercise as determined by blood samples
Measured: Immediately pre-exercise to 15 min post exercise of a single exercise session
Secondary outcomes (3)
Changes for Procollagen type 1 N propeptide from pre- to 15 min post-exercise
Changes for Procollagen type 1 N propeptide (P1NP) serum levels from pre- to 15 min post-exercise as determined by blood samples
Measured: Immediately pre-exercise to 15 min post exercise of a single exercise session
Changes for resting glucose from pre- to 15 min post-exercise
Changes for resting glucose serum levels from pre- to 15 min post-exercise as determined by blood samples
Measured: Immediately pr to 15 min post-exercise of a single exercise session
Changes for hemoglobin A1c from pre- to 15 min post-exercise
Changes for hemoglobin A1c (HBA1C) serum levels from pre- to 15 min post-exercise as determined by blood samples
Measured: Immediately pre- to 15 min post-exercise of a single exercise session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Feb 2025
- Study start15 Mar 2025
- Primary completion15 Jul 2025
- Study completion30 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for OsteopeniaStudies of the same condition, open and under way.
- More trials run by University of Erlangen-Nürnberg Medical SchoolThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Randomized two-arm cross-over design
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Erlangen-Nürnberg Medical School
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Wolfgang Kemmler, PhD, Principal investigator, University Hospital Erlangen
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06813092
- Sponsor's protocol ID
- FeDeBoMa02
- Other IDs
- UKER
- Acronym
- FeDeBoMa
- Status last verified
- Jun 2025
- First submitted
- 3 Feb 2025
- Last updated
- 30 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Kemmler W, Bebenek M, von Stengel S, Bauer J. Peak-bone-mass development in young adults: effects of study program related levels of occupational and leisure time physical activity and exercise. A prospective 5-year study. Osteoporos Int. 2015 Feb;26(2):653-62. doi: 10.1007/s00198-014-2918-8. Epub 2014 Oct 7.
PubMed 25288444
Study at a glance
From the registry record, last updated by the sponsor on 30 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of a Single Bout of High Intensity, High Velocity Resistance Exercise Compared to Whole-body Electromyostimulation on Cardiometabolic Risk Factors and Markers of Bone Formation and -Resorption in Young Female Dentists.
- ClinicalTrials.gov ID
- NCT06813092
- Acronym / sponsor ID
- FeDeBoMa / FeDeBoMa02
- Conditions
- Osteopenia, Cardiometabolic Conditions
- Keywords
- biomarkers, bone metabolism, exercise, whole-body electromyostimulation, female dentists
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- University of Erlangen-Nürnberg Medical SchoolUniversity, hospital or other
- Study start
- 15 Mar 2025 (actual)
- Primary completion
- 15 Jul 2025 (actual)
- Study completion
- 30 Aug 2025 (actual)
- First posted
- 6 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Due to their high workload and unfavorable working position, young female dentists are particularly at risk of cardiometabolic diseases and an early reduction in bone mineral density (BMD). With focus on the latter issue, short bouts of resistance exercise with high strain magnitude and velocity are commonly considered to be a feasible option to prevent bone loss in the early years of young adulthood. In parallel, whole-body electromyostimulation (WB-EMS) a trainings technology able address all main muscle groups simultaneously, however with dedicated exercise intensity might be a time-effective, joint friendly and safe option to maintain BMD in people unable or unmotivated to exercise conventionally. In the present study, we aim to compare the effects of a single session of WB-EMS versus high intensity, high velocity resistance exercise on biomarkers of bone formation (Procollagen type 1 N propeptide, P1NP) and resorption (C-terminal telopeptide of type I collagen, CTX-I). We hypothesize that no clinically relevant different effects on P1NP and CTX-I were determined.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Randomized two-arm cross-over design
| Arm | Type | Receives |
|---|---|---|
| Whole-Body Electromyostimulation | Experimental | Other: Whole-Body ElectromyostimulationOne single bout of whole-body electromyostimulation (20 min, bipolar, 85 Hz, 350 µs, rectangular, 6s of impulse, 4s of rest) |
| Resistance exercise | Active comparator | Other: Resistance exerciseHigh intensity, high velocity resistance exercise (30 min, 5-6 exercises, 3 sets at 60-85% 1RM) |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- female dental students (>3rd semester) or licensed dentists
- no competitive sports background for >2 years
- normal body mass (BMI>18,5 and <25 kg/m2)
Key exclusion criteria (3 listed)
- more than one resistance exercise session per week (last 12 month)
- whole-body electromyostimulation during the last 12 month
- amenorrhea, oligomenorrhea
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Whole-Body Electromyostimulation20 min of WB-EMS (bipolar, 85 Hz, 350 µs, 6s impulse - 4s impulse break) | Other | Whole-Body Electromyostimulation |
| Resistance exerciseHigh-intensity/high velocity multiple set resistance exercise | Other | Resistance exercise |
Primary outcome
Changes for C-terminal telopeptide of type I collagen from pre- to 15 min post-exercise
Time frame: Immediately pre-exercise to 15 min post exercise of a single exercise session
Changes for C-terminal telopeptide of type I collagen (CTX-I) serum levels from pre- to 15 min post-exercise as determined by blood samples
3 secondary outcomes
Changes for Procollagen type 1 N propeptide from pre- to 15 min post-exercise
Time frame: Immediately pre-exercise to 15 min post exercise of a single exercise session
Changes for resting glucose from pre- to 15 min post-exercise
Time frame: Immediately pr to 15 min post-exercise of a single exercise session
Changes for hemoglobin A1c from pre- to 15 min post-exercise
Time frame: Immediately pre- to 15 min post-exercise of a single exercise session
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jan 2026.
- Background: PubMed 25288444Kemmler W, Bebenek M, von Stengel S, Bauer J. Peak-bone-mass development in young adults: effects of study program related levels of occupational and leisure time physical activity and exercise. A prospective 5-year study. Osteoporos Int. 2015 Feb;26(2):653-62. doi: 10.1007/s00198-014-2918-8. Epub 2014 Oct 7.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Wolfgang Kemmler, PhD principal investigator
University Hospital Erlangen
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Whole-Body Electromyostimulation and Resistance exercise in people with Osteopenia and Cardiometabolic Conditions, run by University of Erlangen-Nürnberg Medical School at 2 sites in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes for C-terminal telopeptide of type I collagen from pre- to 15 min post-exercise (time frame: Immediately pre-exercise to 15 min post exercise of a single exercise session). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06813092, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jan 2026.