Exercise OvertrainingHYDRO2EAUNCT06788015
Hydrogen-Infused Water for Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life
A study testing Hydrogen-infused water in people with Exercise Overtraining, run by University of Novi Sad, Faculty of Sport and Physical Education at 1 site in Serbia.
Trial summary
The study investigates the impact of 4-week hydrogen-infused water consumption on various health and performance outcomes. Conducted with healthy young adults, the trial assesses endurance performance, hydration biomarkers, and health-related quality of life. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise Overtraining
- What is being tested?
- Hydrogen-infused water
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 10 participants
- Where
- 1 siteSerbia
- Study dates
- 15 Nov 2024to 15 Apr 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18.0 - 29.9 years
- Body mass index 18.5 - 24.9 kg/m2
- Collegiate athletes with training experience >3 years
- Weekly exercise > 5 hours
- Given written informed consent
Who cannot join
- Major chronic diseases or acute disorders
- History of dietary supplement usage in the 4 weeks preceding the study initiation
- Unwillingness to return for a follow-up
- Participation in other clinical trials
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effects of Hydrogen-Infused Water on Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life in Healthy Young Men and Women (HYDRO2EAU): A Randomized-Controlled Clinical Trial
The study investigates the impact of 4-week hydrogen-infused water consumption on various health and performance outcomes. Conducted with healthy young adults, the trial assesses endurance performance, hydration biomarkers, and health-related quality of life. Participants are randomized into intervention and control groups, with outcomes measured over a specified period. The findings aim to elucidate whether hydrogen-infused water water provides significant benefits for physical performance, hydration status, and overall well-being compared to standard hydration methods.
- Conditions
- Exercise Overtraining
- Being tested
- Hydrogen-infused water, Placebo
- Keywords
- endurance
- Medical subject headings
- Overtraining Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hydrogen-infused waterDietary supplement
Water containing molecular hydrogen
PlaceboDietary supplement
Water containing no molecular hydrogen
| Study group | Role | What they receive |
|---|---|---|
| Hydrogen-infused water | Experimental | One can of hydrogen-infused water consumed before breakfast and dinner Receives: Dietary Supplement: Hydrogen-infused water |
| Placebo | Placebo comparator | One can of hydrogen-free water consumed before breakfast and dinner Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to exhaustion
Running time to exhaustion at treadmill
Measured: Change from baseline time to exhaustion at 4 weeks
Secondary outcomes (1)
Total body water
Level of total body water
Measured: Change from baseline total body water at 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2025
- Study start15 Nov 2024
- Primary completion28 Feb 2025
- Study completion15 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Exercise OvertrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06788015
- Sponsor's protocol ID
- THIC-1-24
- Acronym
- HYDRO2EAU
- Status last verified
- Dec 2025
- First submitted
- 16 Jan 2025
- Last updated
- 22 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Data obtained through this study may be provided to qualified researchers with academic interest in hydrogen research in biomedicine. Data will be coded, with no PHI included. Approval of the request and execution of all applicable agreements are prerequisites to the sharing of data with the requesting party.
Publications
Ostojic SM. Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities. Curr Pharm Des. 2021;27(5):723-730. doi: 10.2174/1381612826666200922155242.
PubMed 32962610
Study at a glance
From the registry record, last updated by the sponsor on 22 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Hydrogen-Infused Water on Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life in Healthy Young Men and Women (HYDRO2EAU): A Randomized-Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT06788015
- Acronym / sponsor ID
- HYDRO2EAU / THIC-1-24
- Conditions
- Exercise Overtraining
- Keywords
- endurance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- University of Novi Sad, Faculty of Sport and Physical EducationUniversity, hospital or other
- Study start
- 15 Nov 2024 (actual)
- Primary completion
- 28 Feb 2025 (actual)
- Study completion
- 15 Apr 2025 (actual)
- First posted
- 22 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study investigates the impact of 4-week hydrogen-infused water consumption on various health and performance outcomes. Conducted with healthy young adults, the trial assesses endurance performance, hydration biomarkers, and health-related quality of life. Participants are randomized into intervention and control groups, with outcomes measured over a specified period. The findings aim to elucidate whether hydrogen-infused water water provides significant benefits for physical performance, hydration status, and overall well-being compared to standard hydration methods.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Hydrogen-infused water | Experimental | Dietary Supplement: Hydrogen-infused waterOne can of hydrogen-infused water consumed before breakfast and dinner |
| Placebo | Placebo comparator | Dietary Supplement: PlaceboOne can of hydrogen-free water consumed before breakfast and dinner |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age 18.0 - 29.9 years
- Body mass index 18.5 - 24.9 kg/m2
- Collegiate athletes with training experience >3 years
- Weekly exercise > 5 hours
- Given written informed consent
Key exclusion criteria (4 listed)
- Major chronic diseases or acute disorders
- History of dietary supplement usage in the 4 weeks preceding the study initiation
- Unwillingness to return for a follow-up
- Participation in other clinical trials
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hydrogen-infused waterWater containing molecular hydrogen | Dietary supplement | Hydrogen-infused water |
| PlaceboWater containing no molecular hydrogen | Dietary supplement | Placebo |
Primary outcome
Time to exhaustion
Time frame: Change from baseline time to exhaustion at 4 weeks
Running time to exhaustion at treadmill
1 secondary outcome
Total body water
Time frame: Change from baseline total body water at 4 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Dec 2025.
- Background: PubMed 32962610Ostojic SM. Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities. Curr Pharm Des. 2021;27(5):723-730. doi: 10.2174/1381612826666200922155242.
- Individual participant dataSharing planned: Yes. Data obtained through this study may be provided to qualified researchers with academic interest in hydrogen research in biomedicine. Data will be coded, with no PHI included. Approval of the request and execution of all applicable agreements are prerequisites to the sharing of data with the requesting party.
Related trials for Exercise Overtraining
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hydrogen-infused water in people with Exercise Overtraining, run by University of Novi Sad, Faculty of Sport and Physical Education at 1 site in Serbia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Serbia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to exhaustion (time frame: Change from baseline time to exhaustion at 4 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06788015, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Dec 2025.