Uveitis, PosteriorNCT06743906
Role of OCT & OCT Angiography in Patients With Posterior at the Uveitis Clinic of Assiut University Hospital.
An observational study of Uveitis, Posterior, run by Assiut University.
Trial summary
OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area. So combined structural and function image can be obtained by OCT angiography. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Uveitis, Posterior
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- 1 May 2025to 1 May 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: participants will be recruited from the ophthalmology outpatient clinic of Assiut University Hospitals.- Patient with posterior uveitis (infectious or non-infectious posterior uveitis).
Who may be able to join
- - Patient age of greater than 18 years old.
- Patient can offer viable consent.
- Patient with posterior uveitis (infectious or non-infectious posterior uveitis).
Who cannot join
- - Patient unable to offer viable consent.
- Patient unwilling to participate.
- Any coexistence retinal pathology: diabetic retinopathy, other causes of retinal vascular occlusion, traumatic retinopathy, traumatic maculopathy, other peripheral ischemic retinopathy e.g. sickles cell retinopathy.
- Presence of media opacity hindering appropriate scan.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area. So combined structural and function image can be obtained by OCT angiography.
Defferent type of uveitis often have specific OCT \& OCT angiography findingwhich deffer according to the involved ocular tissue and according to the type of inflammatory / infectious process that characterize them.
The aim of study is to determine the role of OCT \& OCT angiography in assessment of retinal and choroidal architectural and vascular changes in patients with posterior uveitis.
Read the detailed description
Uveitis is a challenging disease. It represents a major cause of ocular morbidity worldwide. More than half of all patients with uveitis develop sight threatening complications related to their disease, and up to 35% of patients suffer severe visual impairment.
Uveitis and its complications are responsible for 5% to 10% of all causes of legal blindness in developed countries .
The causes of uveitis are numerous, and include infectious conditions, autoimmune diseases, trauma and tumors (masquerade syndrome). To develop an accurate differential diagnosis, clinicians must consider all available information, including the patient history, anatomic location of the inflammation (anterior or posterior), character (granulomatous vs. non granulomatous), laterality, and chronicity of inflammation. Moreover, diagnostic tools, such as fluorescein angiography (FA), indocyanine green angiography (ICG), optical coherence tomography (OCT) and ultrasound, play an important role in the diagnosis and in the management of the uveitis.
OCT \& OCT angiography are now proven to be an effective noninvasive method in detecting pathologic features in uveitis and are rapidly gaining popularity as an ancillary exam. It may be used to assist in the diagnosis of uveitis and may be repeated safely during follow-up to monitor response to any intervention.
OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area. So combined structural and function image can be obtained by OCT angiography.
Defferent type of uveitis often have specific OCT \& OCT angiography findingwhich deffer according to the involved ocular tissue and according to the type of inflammatory / infectious process that characterize them.
- Conditions
- Uveitis, Posterior
- Keywords
- OCT & OCT angiography
- Medical subject headings
- Uveitis, Posterior, Ornithine Carbamoyltransferase Deficiency Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| uveitis patient | participants will be recruited from the ophthalmology outpatient clinic of Assiut University Hospitals.- Patient with posterior uveitis (infectious or non-infectious posterior uveitis). |
What is being measured
The primary outcome is the main question the study is designed to answer.
the choroidal thickness (CT) measurements
The choroidal thickness (CT) measurements will be obtained from manual segmentation of OCT B-scans at the fovea for case numbers 1, 2, 4 and 5 and at the location of the choroiditis lesion
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Dec 2024
- Study start1 May 2025 (estimated)
- Primary completion1 Mar 2026 (estimated)
- Study completion1 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Uveitis, PosteriorStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Lotfy Mahmoud Mohamed, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06743906
- Sponsor's protocol ID
- OCT & OCT posterior uveitis
- Status last verified
- Dec 2024
- First submitted
- 17 Dec 2024
- Last updated
- 21 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Gupta V, Gupta P, Singh R, Dogra MR, Gupta A. Spectral-domain Cirrus high-definition optical coherence tomography is better than time-domain Stratus optical coherence tomography for evaluation of macular pathologic features in uveitis. Am J Ophthalmol. 2008 Jun;145(6):1018-1022. doi: 10.1016/j.ajo.2008.01.021. Epub 2008 Mar 17.
PubMed 18343349Diniz B, Regatieri C, Andrade R, Maia A. Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis. Clin Ophthalmol. 2011;5:645-50. doi: 10.2147/OPTH.S20033. Epub 2011 May 17.
PubMed 21629569
Study at a glance
From the registry record, last updated by the sponsor on 21 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of OCT & OCT Angiography in Patients With Posterior at the Uveitis Clinic of Assiut University Hospital.
- ClinicalTrials.gov ID
- NCT06743906
- Acronym / sponsor ID
- OCT & OCT posterior uveitis
- Conditions
- Uveitis, Posterior
- Keywords
- OCT & OCT angiography
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 May 2025 (estimated)
- Primary completion
- 1 Mar 2026 (estimated)
- Study completion
- 1 May 2026 (estimated)
- First posted
- 20 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area. So combined structural and function image can be obtained by OCT angiography.
Defferent type of uveitis often have specific OCT \& OCT angiography findingwhich deffer according to the involved ocular tissue and according to the type of inflammatory / infectious process that characterize them.
The aim of study is to determine the role of OCT \& OCT angiography in assessment of retinal and choroidal architectural and vascular changes in patients with posterior uveitis.
Detailed description
Uveitis is a challenging disease. It represents a major cause of ocular morbidity worldwide. More than half of all patients with uveitis develop sight threatening complications related to their disease, and up to 35% of patients suffer severe visual impairment.
Uveitis and its complications are responsible for 5% to 10% of all causes of legal blindness in developed countries .
The causes of uveitis are numerous, and include infectious conditions, autoimmune diseases, trauma and tumors (masquerade syndrome). To develop an accurate differential diagnosis, clinicians must consider all available information, including the patient history, anatomic location of the inflammation (anterior or posterior), character (granulomatous vs. non granulomatous), laterality, and chronicity of inflammation. Moreover, diagnostic tools, such as fluorescein angiography (FA), indocyanine green angiography (ICG), optical coherence tomography (OCT) and ultrasound, play an important role in the diagnosis and in the management of the uveitis.
OCT \& OCT angiography are now proven to be an effective noninvasive method in detecting pathologic features in uveitis and are rapidly gaining popularity as an ancillary exam. It may be used to assist in the diagnosis of uveitis and may be repeated safely during follow-up to monitor response to any intervention.
OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area. So combined structural and function image can be obtained by OCT angiography.
Defferent type of uveitis often have specific OCT \& OCT angiography findingwhich deffer according to the involved ocular tissue and according to the type of inflammatory / infectious process that characterize them.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| uveitis patient | – | –participants will be recruited from the ophthalmology outpatient clinic of Assiut University Hospitals.- Patient with posterior uveitis (infectious or non-infectious posterior uveitis). |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- participants will be recruited from the ophthalmology outpatient clinic of Assiut University Hospitals.- Patient with posterior uveitis (infectious or non-infectious posterior uveitis).
Key inclusion criteria (3 listed)
- - Patient age of greater than 18 years old.
- Patient can offer viable consent.
- Patient with posterior uveitis (infectious or non-infectious posterior uveitis).
Key exclusion criteria (4 listed)
- - Patient unable to offer viable consent.
- Patient unwilling to participate.
- Any coexistence retinal pathology: diabetic retinopathy, other causes of retinal vascular occlusion, traumatic retinopathy, traumatic maculopathy, other peripheral ischemic retinopathy e.g. sickles cell retinopathy.
- Presence of media opacity hindering appropriate scan.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
the choroidal thickness (CT) measurements
Time frame: baseline
The choroidal thickness (CT) measurements will be obtained from manual segmentation of OCT B-scans at the fovea for case numbers 1, 2, 4 and 5 and at the location of the choroiditis lesion
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Apr 2025.
- Results publication: PubMed 18343349Gupta V, Gupta P, Singh R, Dogra MR, Gupta A. Spectral-domain Cirrus high-definition optical coherence tomography is better than time-domain Stratus optical coherence tomography for evaluation of macular pathologic features in uveitis. Am J Ophthalmol. 2008 Jun;145(6):1018-1022. doi: 10.1016/j.ajo.2008.01.021. Epub 2008 Mar 17.
- Results publication: PubMed 21629569Diniz B, Regatieri C, Andrade R, Maia A. Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis. Clin Ophthalmol. 2011;5:645-50. doi: 10.2147/OPTH.S20033. Epub 2011 May 17.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Uveitis, Posterior, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Lotfy Mahmoud, resident doctor (+20 11 00571623, me7rek@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
the choroidal thickness (CT) measurements (time frame: baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06743906, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Apr 2025.