Skeletal Muscle EnduranceBFRCLNCT06724458
Resistance Exercise Blood Flow Restriction
A study testing Resistance exercise in people with Skeletal Muscle Endurance, run by University of British Columbia at 1 site in Canada.
Trial summary
The number of repetitions able to be performed during resistance exercise is impacted by the load an individual is working against. Heavier loads lead to less repetitions being performed and lighter loads lead to more repetitions being performed. Read more about this study
- Who is it for?
- Ages 19 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Skeletal Muscle Endurance
- What is being tested?
- Resistance exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 29 participants
- Where
- 1 siteCanada
- Study dates
- 28 Jan 2023to 21 Nov 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Able to understand and communicate in English
- 19-30 years of age
- All "No" answers on the Canadian Society for Exercise Physiology Get Active questionnaire or doctors' approval to participate
- Untrained participants: no structured resistance and/or endurance training over the past 12-months (i.e., >2 hours per week of structured/periodized training)
- Resistance trained participants: structured resistance training over the past 12-months (i.e., >2 hours per week of structured/periodized resistance training)
- Endurance trained participants: structured resistance training over the past 12-months (i.e., >2 hours per week of structured/periodized endurance training)
Who cannot join
- BMI lower than 18 or greater than 30
- Current use of cigarettes or other nicotine devices
- Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
- Any medical condition impacting the ability to participate in maximal exercise
- Type one or type two diabetes
- Diagnosis of cancer or undergoing cancer treatment in the past 12 months
Show all 9Show fewer
- Taking blood-thinning medication or the presence of a bleeding disorder
- Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)
- Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment (i.e., 36 pounds for the knee extension, and/or 33 pounds for the barbell curl)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Skeletal Muscle Endurance Responses to Various Relative Loads of Dynamic Resistance Exercise with and Without Peripheral Blood Flow Occlusion
The number of repetitions able to be performed during resistance exercise is impacted by the load an individual is working against. Heavier loads lead to less repetitions being performed and lighter loads lead to more repetitions being performed. As the load gets progressively lighter, it is hypothesized that oxygen availability becomes an important factor for performance of maximum repetitions. Peripheral blood flow occlusion using exercise specific blood flow occlusion cuffs can allow for oxygen availability to be controlled by altering the amount of blood able to get to working muscles. To date, no study has examined the effect of varying exercise loads, from heavy to light, on maximum repetitions able to be performed with and without blood flow occlusion.
Read the detailed description
The study aims to assess the difference in maximum repetitions performed at varying percentages of participants maximum strength and the impact peripheral blood flow occlusion has on performance
The study will take three weeks to complete with a total of six visits. The entire time commitment will be seven hours. During week 1 participants will visit the lab twice to perform baseline assessments of strength, endurance, muscle size and will also receive a resting thighs muscle biopsy. During weeks 2 and 3 participants will visit the lab twice per week to complete three out of twelve randomized exercise interventions per visit. The interventions are maximum repetitions at 80/40/30/25/20/15% of knee-extension one-repetition maximum as well as 90/70/60/55/50/45% of barbell curl one-repetition maximum; all of the listed conditions will be tested in a free-flow and blood flow occluded state (i.e., 12 total exercise interventions for the knee extension and 12 total exercise interventions for the barbell curl).
- Conditions
- Skeletal Muscle Endurance
- Being tested
- Resistance exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance exerciseOther
All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition
| Study group | Role | What they receive |
|---|---|---|
| 80% knee extension/80% barbell curl 1RM | Experimental | The load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl Receives: Other: Resistance exercise |
| 40% knee extension/70% barbell curl 1RM | Experimental | The load will be set to 40% of 1RM for the knee extension and 70% 1RM for the barbell curl Receives: Other: Resistance exercise |
| 30% knee extension/60% barbell curl 1RM | Experimental | The load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl Receives: Other: Resistance exercise |
| 25% knee extension/55% barbell curl 1RM | Experimental | The load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl Receives: Other: Resistance exercise |
| 20% knee extension/50% barbell curl 1RM | Experimental | The load will be set to 25% of 1RM for the knee extension and 50% 1RM for the barbell curl Receives: Other: Resistance exercise |
| 15% knee extension/45% barbell curl 1RM | Experimental | The load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl Receives: Other: Resistance exercise |
| 80% knee extension/80% barbell curl 1RM both with blood flow occlusion | Experimental | The load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl with both being under peripheral blood flow occlusion Receives: Other: Resistance exercise |
| 40% knee extension/60% barbell curl 1RM both with blood flow occlusion | Experimental | The load will be set to 40% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion Receives: Other: Resistance exercise |
| 30% knee extension/60% barbell curl 1RM both with blood flow occlusion | Experimental | The load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion Receives: Other: Resistance exercise |
| 25% knee extension/55% barbell curl 1RM both with blood flow occlusion | Experimental | The load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl with both being under peripheral blood flow occlusion Receives: Other: Resistance exercise |
| 20% knee extension/50% barbell curl 1RM both with blood flow occlusion | Experimental | The load will be set to 20% of 1RM for the knee extension and 50% 1RM for the barbell curl with both being under peripheral blood flow occlusion Receives: Other: Resistance exercise |
| 15% knee extension/45% barbell curl 1RM both with blood flow occlusion | Experimental | The load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl with both being under peripheral blood flow occlusion Receives: Other: Resistance exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximum knee extension repetitions
total repetitions completed for each load condition
Measured: From weeks two to three in the study
Secondary outcomes (20)
Maximum barbell curl repetitions
total repetitions completed for each load condition
Measured: From weeks two to three in the study
Change in vastus lateralis oxygen saturation
The change in vastus lateralis oxygen saturation across each load condition
Measured: From weeks two to three in the study
Correlation of muscle fiber size/type/distribution to maximum knee extension repetitions at 20% 1RM
Measured: From weeks two to three in the study
Correlation of mitochondrial content to maximum knee extension repetitions at 20% 1RM
Measured: From weeks two to three in the study
Correlation of capillary density to maximum knee extension repetitions at 20% 1RM
Measured: From weeks two to three in the study
Comparison of muscle fiber size/type/distribution, mitochondrial function, mitochondrial density, capillary density, absolute muscle size ,and VO2 max between participants of different training statuses
Measured: Week 3
Correlation of absolute muscle size to maximum knee extension repetitions at 20% 1RM/barbell curl repetitions at 45% 1RM
Measured: Weeks 1, 2, and 3
Correlation of absolute muscle size to maximum knee extension repetitions at 20% 1RM/barbell curl repetitions at 45% 1RM
Measured: Week 1
Correlation of absolute muscle size to maximum knee extension repetitions at 20% 1RM/barbell curl repetitions at 45% 1RM
Measured: Week 2
Comparison of absolute muscle size between sexes
Measured: Week 3
Comparison of capillary density between sexes
Measured: Week 3
Comparison of mitochondrial density between sexes
Measured: Week 3
Comparison of muscle fiber distribution between sexes
Measured: Week 3
Comparison of muscle fiber size between sexes
Measured: Week 3
Comparison of muscle fiber type between sexes
Measured: Week 3
Comparison of mitochondrial function between sexes
Measured: Week 3
Comparison of VO2 max between sexes
Measured: Week 3
Correlation of VO2 max to maximum knee extension repetitions at 20% 1RM
Measured: Week 1
Correlation of VO2 max to maximum knee extension repetitions at 20% 1RM
Measured: Week 2
Correlation of VO2 max to maximum knee extension repetitions at 20% 1RM
Measured: Week 3
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Dec 2024
- Study start28 Jan 2023
- Primary completion21 Nov 2023
- Study completion21 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skeletal Muscle EnduranceStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Enrolment
- 29 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cameron Mitchell, University of British Columbia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06724458
- Sponsor's protocol ID
- BFRCL
- Acronym
- BFRCL
- Status last verified
- Jun 2023
- First submitted
- 9 Jun 2023
- Last updated
- 9 Dec 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: A plan has not yet been made to make individual participant data available to other researchers
Study at a glance
From the registry record, last updated by the sponsor on 9 Dec 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Skeletal Muscle Endurance Responses to Various Relative Loads of Dynamic Resistance Exercise with and Without Peripheral Blood Flow Occlusion
- ClinicalTrials.gov ID
- NCT06724458
- Acronym / sponsor ID
- BFRCL / BFRCL
- Conditions
- Skeletal Muscle Endurance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 29 participants (actual)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Study start
- 28 Jan 2023 (actual)
- Primary completion
- 21 Nov 2023 (actual)
- Study completion
- 21 Nov 2023 (actual)
- First posted
- 9 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The number of repetitions able to be performed during resistance exercise is impacted by the load an individual is working against. Heavier loads lead to less repetitions being performed and lighter loads lead to more repetitions being performed. As the load gets progressively lighter, it is hypothesized that oxygen availability becomes an important factor for performance of maximum repetitions. Peripheral blood flow occlusion using exercise specific blood flow occlusion cuffs can allow for oxygen availability to be controlled by altering the amount of blood able to get to working muscles. To date, no study has examined the effect of varying exercise loads, from heavy to light, on maximum repetitions able to be performed with and without blood flow occlusion.
Detailed description
The study aims to assess the difference in maximum repetitions performed at varying percentages of participants maximum strength and the impact peripheral blood flow occlusion has on performance
The study will take three weeks to complete with a total of six visits. The entire time commitment will be seven hours. During week 1 participants will visit the lab twice to perform baseline assessments of strength, endurance, muscle size and will also receive a resting thighs muscle biopsy. During weeks 2 and 3 participants will visit the lab twice per week to complete three out of twelve randomized exercise interventions per visit. The interventions are maximum repetitions at 80/40/30/25/20/15% of knee-extension one-repetition maximum as well as 90/70/60/55/50/45% of barbell curl one-repetition maximum; all of the listed conditions will be tested in a free-flow and blood flow occluded state (i.e., 12 total exercise interventions for the knee extension and 12 total exercise interventions for the barbell curl).
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Number of arms
- 12
| Arm | Type | Receives |
|---|---|---|
| 80% knee extension/80% barbell curl 1RM | Experimental | Other: Resistance exerciseThe load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl |
| 40% knee extension/70% barbell curl 1RM | Experimental | Other: Resistance exerciseThe load will be set to 40% of 1RM for the knee extension and 70% 1RM for the barbell curl |
| 30% knee extension/60% barbell curl 1RM | Experimental | Other: Resistance exerciseThe load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl |
| 25% knee extension/55% barbell curl 1RM | Experimental | Other: Resistance exerciseThe load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl |
| 20% knee extension/50% barbell curl 1RM | Experimental | Other: Resistance exerciseThe load will be set to 25% of 1RM for the knee extension and 50% 1RM for the barbell curl |
| 15% knee extension/45% barbell curl 1RM | Experimental | Other: Resistance exerciseThe load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl |
| 80% knee extension/80% barbell curl 1RM both with blood flow occlusion | Experimental | Other: Resistance exerciseThe load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl with both being under peripheral blood flow occlusion |
| 40% knee extension/60% barbell curl 1RM both with blood flow occlusion | Experimental | Other: Resistance exerciseThe load will be set to 40% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion |
| 30% knee extension/60% barbell curl 1RM both with blood flow occlusion | Experimental | Other: Resistance exerciseThe load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion |
| 25% knee extension/55% barbell curl 1RM both with blood flow occlusion | Experimental | Other: Resistance exerciseThe load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl with both being under peripheral blood flow occlusion |
| 20% knee extension/50% barbell curl 1RM both with blood flow occlusion | Experimental | Other: Resistance exerciseThe load will be set to 20% of 1RM for the knee extension and 50% 1RM for the barbell curl with both being under peripheral blood flow occlusion |
| 15% knee extension/45% barbell curl 1RM both with blood flow occlusion | Experimental | Other: Resistance exerciseThe load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl with both being under peripheral blood flow occlusion |
Who may qualify
- Ages
- 19 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Able to understand and communicate in English
- 19-30 years of age
- All "No" answers on the Canadian Society for Exercise Physiology Get Active questionnaire or doctors' approval to participate
- Untrained participants: no structured resistance and/or endurance training over the past 12-months (i.e., >2 hours per week of structured/periodized training)
- Resistance trained participants: structured resistance training over the past 12-months (i.e., >2 hours per week of structured/periodized resistance training)
Key exclusion criteria (9 listed)
- BMI lower than 18 or greater than 30
- Current use of cigarettes or other nicotine devices
- Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
- Any medical condition impacting the ability to participate in maximal exercise
- Type one or type two diabetes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance exerciseAll arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition | Other | 15% knee extension/45% barbell curl 1RM, 15% knee extension/45% barbell curl 1RM both with blood flow occlusion, 20% knee extension/50% barbell curl 1RM, 20% knee extension/50% barbell curl 1RM both with blood flow occlusion, 25% knee extension/55% barbell curl 1RM, 25% knee extension/55% barbell curl 1RM both with blood flow occlusion, 30% knee extension/60% barbell curl 1RM, 30% knee extension/60% barbell curl 1RM both with blood flow occlusion, 40% knee extension/60% barbell curl 1RM both with blood flow occlusion, 40% knee extension/70% barbell curl 1RM, 80% knee extension/80% barbell curl 1RM, 80% knee extension/80% barbell curl 1RM both with blood flow occlusion |
Primary outcome
Maximum knee extension repetitions
Time frame: From weeks two to three in the study
total repetitions completed for each load condition
20 secondary outcomes
Maximum barbell curl repetitions
Time frame: From weeks two to three in the study
Change in vastus lateralis oxygen saturation
Time frame: From weeks two to three in the study
Correlation of muscle fiber size/type/distribution to maximum knee extension repetitions at 20% 1RM
Time frame: From weeks two to three in the study
Correlation of mitochondrial content to maximum knee extension repetitions at 20% 1RM
Time frame: From weeks two to three in the study
Correlation of capillary density to maximum knee extension repetitions at 20% 1RM
Time frame: From weeks two to three in the study
Comparison of muscle fiber size/type/distribution, mitochondrial function, mitochondrial density, capillary density, absolute muscle size ,and VO2 max between participants of different training statuses
Time frame: Week 3
Correlation of absolute muscle size to maximum knee extension repetitions at 20% 1RM/barbell curl repetitions at 45% 1RM
Time frame: Weeks 1, 2, and 3
Correlation of absolute muscle size to maximum knee extension repetitions at 20% 1RM/barbell curl repetitions at 45% 1RM
Time frame: Week 1
Correlation of absolute muscle size to maximum knee extension repetitions at 20% 1RM/barbell curl repetitions at 45% 1RM
Time frame: Week 2
Comparison of absolute muscle size between sexes
Time frame: Week 3
Comparison of capillary density between sexes
Time frame: Week 3
Comparison of mitochondrial density between sexes
Time frame: Week 3
Comparison of muscle fiber distribution between sexes
Time frame: Week 3
Comparison of muscle fiber size between sexes
Time frame: Week 3
Comparison of muscle fiber type between sexes
Time frame: Week 3
Comparison of mitochondrial function between sexes
Time frame: Week 3
Comparison of VO2 max between sexes
Time frame: Week 3
Correlation of VO2 max to maximum knee extension repetitions at 20% 1RM
Time frame: Week 1
Correlation of VO2 max to maximum knee extension repetitions at 20% 1RM
Time frame: Week 2
Correlation of VO2 max to maximum knee extension repetitions at 20% 1RM
Time frame: Week 3
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Dec 2024.
- Individual participant dataSharing planned: No. A plan has not yet been made to make individual participant data available to other researchers
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance exercise in people with Skeletal Muscle Endurance, run by University of British Columbia at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Dec 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximum knee extension repetitions (time frame: From weeks two to three in the study). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Dec 2024.