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Moderate to Severe Rheumatoid ArthritisUP-RISINGNCT06712628

A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

An observational study of Moderate to Severe Rheumatoid Arthritis, run by AbbVie at 75 sites in Germany.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record

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Trial summary

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or… Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Moderate to Severe Rheumatoid Arthritis
How many people
678 participants
Where
75 sitesGermany
Study dates
7 Nov 2024to Dec 2028
Phase
Observational

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Participants with moderate to severe active Rheumatoid Arthritis receiving Upadcitinib or a Tumor necrosis factor inhibitor treatment.

Who may be able to join

  • Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician.
  • Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study
  • UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies

Who cannot join

  • Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug [whichever is longer] prior to baseline)
  • Prior treatment with Upadacitinib
  • Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study

Trial locations and contacts

75 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Medical Information Germany contact

49 611 1720 1520

medinfo.germany@abbvie.com

75 sites in 1 country

Germany75 sites, 74 recruiting

  • Private Practice - Dr. Thomas Kupka /ID# 273631

    Altenburg, Thuringia, 04600

    Recruiting

  • Dr. Med. Thomas Marycz /ID# 274646

    Amberg, Bavaria, 92224

    Recruiting

  • Rheumapraxis Am Webereck /ID# 274412

    Augsburg, Bavaria, 86157

    Recruiting

  • Rheumatism Center Mittelhessen /ID# 274641

    Bad Endenbach, Hesse, 35080

    Recruiting

  • MVZ Weserbergland /ID# 276009

    Bad Pyrmont, 31812

    Completed

  • Private Practice - Dr. Karin Manger /ID# 287347

    Bamberg, Bavaria, 96047

    Recruiting

  • Rheumapraxis Steglitz /ID# 280323

    Berlin, 10777

    Recruiting

  • Private Practice - Dr. Silke Zinke /ID# 276366

    Berlin, 13055

    Recruiting

  • Rheumapraxis am Schlachtensee /ID# 287793

    Berlin, 14129

    Recruiting

  • Klinikum Bielefeld Rosenhohe /ID# 283715

    Bielefeld, North Rhine-Westphalia, 33647

    Recruiting

  • Mvz Dr. Med. Mahdy and Kollegen - Braunschweig /ID# 284988

    Braunschweig, Lower Saxony, 38106

    Recruiting

  • Stadtisches Klinikum Braunschweig /ID# 282626

    Braunschweig, Lower Saxony, 38126

    Recruiting

  • MVZ Herzogin Elisabeth Hospital /ID# 272725

    Braunschweig, 38114

    Recruiting

  • Medizinischen Versorgungszentrums Agilomed /ID# 274887

    Chemnitz, Saxony, 09130

    Recruiting

  • Private Practice - Dr. Sebastian Schuh /ID# 272731

    Coburg, 96450

    Recruiting

  • MVZ-Medizinisches Versorgungszentrum Daun GmbH /ID# 285725

    Daun, 54550

    Recruiting

  • Schwerpunktpraxis Rheumatologie und Klinische Immunologie /ID# 282628

    Dresden, Saxony, 01097

    Recruiting

  • Rheumapraxis Düren /ID# 272726

    Düren, 52355

    Recruiting

  • Praxis Dilltal /ID# 272727

    Ehringshausen, 35630

    Recruiting

  • Medikomp Mvz /ID# 285898

    Elsterwerda, Brandenburg, 04910

    Recruiting

  • Private Practice - Dr. Daniel Bestler /ID# 272741

    Erfurt, 99096

    Recruiting

  • Praxisgemeinschaft Rheumatologie Nephrologie Erlangen /ID# 286648

    Erlangen, Bavaria, 91056

    Recruiting

  • Rheumatology Euskirchen /ID# 285419

    Euskirchen, North Rhine-Westphalia, 53879

    Recruiting

  • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291

    Frankfurt am Main, Hesse, 60329

    Recruiting

  • Dr. Mueller /ID# 273081

    Freiberg, Saxony, 09599

    Recruiting

  • Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584

    Freiburg im Breisgau, Baden-Wurttemberg, 79098

    Recruiting

  • Private Practice - Dr. Jorg Sensse /ID# 281907

    Gifhorn, Lower Saxony, 38518

    Recruiting

  • Praxis Fiene /ID# 279410

    Greifswald, 17493

    Recruiting

  • Rheumapraxis Dr. Liebhaber /ID# 274888

    Halle, Saxony-Anhalt, 06128

    Recruiting

  • Private Practice - Dr Hauke E Heintz /ID# 278081

    Hamburg, 22391

    Recruiting

  • Rheumatologische Facharztpraxis /ID# 286591

    Hanover, Lower Saxony, 30159

    Recruiting

  • Rheumapraxis Hannover-List /ID# 273735

    Hanover, Lower Saxony, 30161

    Recruiting

  • Praxis. F. Bigdeli-Wilshusen /ID# 273455

    Hanover, Lower Saxony, 30173

    Recruiting

  • Rheumapraxis Heidelberg /ID# 276475

    Heidelberg, Baden-Wurttemberg, 69120

    Recruiting

  • Rheumazentrum Ruhrgebiet /ID# 275518

    Herne, North Rhine-Westphalia, 44649

    Recruiting

  • Private Practice - Dr. Dirk Wernicke /ID# 276820

    Hohen Neuendorf, Brandenburg, 16540

    Recruiting

  • Rheumapraxis am Schlossberg /ID# 272728

    Homburg, Saarland, 66424

    Recruiting

  • Praxis K. Pagel /ID# 279121

    Hoppegarten, Brandenburg, 15366

    Recruiting

  • Praxis Dr. med. Florian Beyer /ID# 274293

    Kaiserslautern, Rhineland-Palatinate, 67657

    Recruiting

  • Rheumatologie Kassel /ID# 275916

    Kassel, Lower Saxony, 34125

    Recruiting

  • Rheumapraxis Kaufering /ID# 283852

    Kaufering, 86916

    Recruiting

  • Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358

    Leipzig, Saxony, 04109

    Recruiting

  • Private Practice - Dr. Ilka Schwarze /ID# 276981

    Leipzig, Saxony, 04129

    Recruiting

  • Dr. Ann-Dorthe Holst /ID# 285741

    Ludwigslust, Mecklenburg-Vorpommern, 19288

    Recruiting

  • Rheumatologische Facharztpraxis - Magdeburg /ID# 272866

    Magdeburg, Saxony-Anhalt, 39104

    Recruiting

  • Private Practice- Dr. Joerdis Gerigk /ID# 283747

    Magdeburg, Saxony-Anhalt, 39106

    Recruiting

  • Dr. Harmuth /ID# 273401

    Marktredwitz, Bavaria, 95615

    Recruiting

  • St.Elisabeth Hospital Meerbusch /ID# 275030

    Meerbusch, North Rhine-Westphalia, 40668

    Recruiting

  • Gesundheitscampus Monheim /ID# 283726

    Monheim am Rhein, North Rhine-Westphalia, 40789

    Recruiting

  • Praxiszentrum Dr. Med. Klaus Kruger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138

    Munich, Bavaria, 81541

    Recruiting

  • Prof-med-stud.de /ID# 285869

    Munich, 80935

    Recruiting

  • Rheumatologische Facharztpraxis - Naumburg (Saale) /ID# 272743

    Naumburg, Saxony-Anhalt, 06618

    Recruiting

  • Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367

    Neubrandenburg, Mecklenburg-Vorpommern, 17033

    Recruiting

  • Dr. Murawski /ID# 272724

    Neunkirchen, Saarland, 66538

    Recruiting

  • Rheumapraxis An Der Hase /ID# 276949

    Osnabrück, Lower Saxony, 49074

    Recruiting

  • Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 284221

    Pfarrkirchen, 84347

    Recruiting

  • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587

    Planegg, Bavaria, 82152

    Recruiting

  • Private Practice - Dr. Christine Baumann /ID# 275095

    Plauen, Saxony, 08523

    Recruiting

  • Rheumahaus Studien GbR /ID# 275917

    Potsdam, Brandenburg, 14467

    Recruiting

  • Knappschaftsklinikum Saar /ID# 279852

    Püttlingen, Saarland, 66346

    Recruiting

  • Rheumapraxis Dr. Prothmann /ID# 279851

    Püttlingen, Saarland, 66346

    Recruiting

  • Rheumazentrum Ratingen /ID# 275707

    Ratingen, North Rhine-Westphalia, 40882

    Recruiting

  • Private Practice - Dr. Jochen Walter /ID# 280069

    Rendsburg, Schleswig-Holstein, 24768

    Recruiting

  • Rheumatologische Facharztpraxis - Schwerin /ID# 284785

    Schwerin, Mecklenburg-Vorpommern, 19053

    Recruiting

  • Rheumatologisch Immunologisch /ID# 275830

    Templin, Brandenburg, 17268

    Recruiting

  • Rheumapraxis Haas Tubingen /ID# 275536

    Tübingen, Baden-Wurttemberg, 72072

    Recruiting

  • Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293

    Ulm, Baden-Wurttemberg, 89073

    Recruiting

  • Praxis F. Schattenberg /ID# 280322

    Waren, 17192

    Recruiting

  • Rheumapraxis Weimar /ID# 272740

    Weimar, Thuringia, 99427

    Recruiting

  • Fachpraxis fur Rheumatologie und Osteologie /ID# 275359

    Weyhe, Lower Saxony, 28844

    Recruiting

  • Private Practice - Dr. Alexander Lautwein /ID# 282328

    Wittlich, Rhineland-Palatinate, 54516

    Recruiting

  • Cellitinnen-Krankenhaus St. Josef /ID# 275926

    Wuppertal, 42105

    Recruiting

  • Praxis Barmen /ID# 277514

    Wuppertal, 42285

    Recruiting

  • Rheumapraxis Zweibruecken - Matar /ID# 282656

    Zweibrücken, Rhineland-Palatinate, 66482

    Recruiting

  • Praxis H. Fricke-Wagner /ID# 274467

    Zwickau, Saxony, 08056

    Recruiting

Other trials in Germany

About this study

Official title: Comparison of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care

This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany.

Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.

Keywords
Moderate to Severe Rheumatoid Arthritis, Rheumatoid Arthritis, Upadacitinib, Tumor Necrosis Factor Inhibitor Treatment
Medical subject headings
Arthritis, Rheumatoid

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT06712628
Study groupRoleWhat they receive
UpadacitinibParticipants will receive upadacitinib as prescribed by their physician according to local label.
Tumor Necrosis Factor Inhibitor-TreatmentParticipants will receive a tumor necrosis factor inhibitor treatment as prescribed by their physician according to local label.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Retention Rate of UPA vs TNFi

    Time to the discontinuation of Upadacitinib. Time to the discontinuation of Tumor Necrosis Factor Inhibitor treatment

    Measured: Up to approximately 24 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Dec 2024
  2. Study start7 Nov 2024
  3. Primary completionDec 2028 (estimated)
  4. Study completionDec 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
678 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06712628
Sponsor's protocol ID
P25-188
Acronym
UP-RISING
Status last verified
Oct 2026
First submitted
27 Nov 2024
Last updated
15 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

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