Multiple SclerosisNCT06704464
Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis
An observational study of Multiple Sclerosis, run by Gazi University at 1 site in Turkey (Türkiye).
Trial summary
Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Multiple Sclerosis
- What is being tested?
- Manual Dexterity, Manual Dexterity (only MMDT) and disability level
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 28 Nov 2024to 25 Jan 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients with Multiple Sclerosis who apply to Sivas Cumhuriyet University, Department of Physiotherapy and Rehabilitation will be invited to this study.
Who may be able to join
- Age at least 18 years,
- Neurologist-diagnosed Multiple Sclerosis,
- Expanded Disability Status Scale (EDSS) score between 0-6.5
- No MS exacerbation within the last 3 months,
- Use of stable medication in the last 3 months.
Who cannot join
- Having any vision, hearing or perception problems that may affect the research results,
- Having an orthopedic problem that may affect manual skills in the upper extremity,
- Having a cardiovascular, pulmonary disorder
Trial locations and contacts
1 site in 1 country.
About this study
Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. On the other hand, most daily life activities require the coordinated use of both hands. In MS patients, bilateral impairments in hand functions can also be observed. Therefore, there is a need for bilateral assessment tools.
Unlike many other assessment tools, the Minnesota Manual Dexterity Test (MMDT) allows for simultaneous evaluation of both hands. In addition to manual dexterity, it also assesses hand-eye coordination and gross motor skills. The MMDT consists of five subtests: placing, turning, displacing, single-hand turning and placing, and two-hand turning and placing. The validity of the MMDT has also been examined in MS patients.
Our study aims to evaluate the reliability and validity of the MMDT in MS patients. The cutoff times that best distinguish individuals with MS from healthy individuals will also be examined. The study aims to systematically and thoroughly evaluate the MMDT, establish it as a valid and reliable method for MS patients, and provide a new perspective on assessing hand functions.
Read the detailed description
At baseline, the MMDT, EDSS, 9-hole peg test (9-HPT), ABILHAND survey, and Jebsen-Taylor Hand Function Test (JTHFT) will be applied to the MS group. The MMDT will be repeated seven days after the first application in MS. Healthy controls are going to perform only the MMDT.
- Conditions
- Multiple Sclerosis
- Being tested
- Manual Dexterity, Manual Dexterity (only MMDT), disability level
- Keywords
- Minnesota manual dexterity, reliability, validity, multiple sclerosis, hand function
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Manual DexterityOther
Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT, 9-HPT, ABILHAND, and JTHFT.
Manual Dexterity (only MMDT)Other
Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT on a predetermined day.
disability levelOther
Individuals who meet the inclusion criteria will be evaluated for disability level using EDSS
| Study group | Role | What they receive |
|---|---|---|
| Test Group | Patients with Multiple Sclerosis Receives: Other: Manual Dexterity; Other: disability level | |
| Control Group | healthy controls Receives: Other: Manual Dexterity (only MMDT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Minnesota Manual Dexterity Test
The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.
Measured: baseline (on the predetermined assessment day)
Minnesota Manual Dexterity Test-second
The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.
Measured: the second assessment will be conducted after the seven days
Secondary outcomes (4)
9-Hole Peg Test
The 9-Hole Peg Test (9-HPT) evaluates hand dexterity based on performance, higher scores mean a worse outcome.
Measured: baseline (on the predetermined assessment day)
ABILHAND
to assess for performance of activity. score range 0-46 point, higher scores mean a better outcome.
Measured: baseline (on the predetermined assessment day)
The Jebsen Hand Function Test
The Jebsen Hand Function Test (JHFT) is one of the objective and standardized tests that assesses fine motor skills and functional hand use by simulating daily living activities, higher scores mean a worse outcome.
Measured: baseline (on the predetermined assessment day)
The Expanded Disability Status Scale
The Expanded Disability Status Scale (EDSS) is a scale used to determine the degree of disability resulting from multiple sclerosis (MS). It evaluates eight functional domains: pyramidal, cerebellar, brainstem, sensory, bowel/bladder, visual, mental, and other functions.Score range 0-10, higher scores mean a worse outcome.
Measured: baseline (on the predetermined assessment day)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Nov 2024
- Study start28 Nov 2024
- Primary completion25 Jan 2025
- Study completion25 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- More trials run by Gazi UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gazi University
- Sponsor type
- University, hospital or other
- Collaborators
- Cumhuriyet University
- Responsible party
- Principal investigator, Kader Eldemir, Cumhuriyet University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06704464
- Sponsor's protocol ID
- 1-MS-minnesota-reliability
- Status last verified
- Mar 2025
- First submitted
- 18 Nov 2024
- Last updated
- 18 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Celik RGG. Upper Extremity Capability Tests in Multiple Sclerosis. Noro Psikiyatr Ars. 2018;55(Suppl 1):S54-S57. doi: 10.29399/npa.23338.
PubMed 30692857Hervault M, Balto JM, Hubbard EA, Motl RW. Reliability, precision, and clinically important change of the Nine-Hole Peg Test in individuals with multiple sclerosis. Int J Rehabil Res. 2017 Mar;40(1):91-93. doi: 10.1097/MRR.0000000000000209.
PubMed 28059944Eldemir K, Eldemir S, Gokce SF. Psychometric properties of the Minnesota manual dexterity test in people with multiple sclerosis. Clin Rehabil. 2026 May 25:2692155261454955. doi: 10.1177/02692155261454955. Online ahead of print.
PubMed 42183667
Study at a glance
From the registry record, last updated by the sponsor on 18 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of Validity and Reliability of the Minnesota Manual Dexterity Test in Patients With Multiple Sclerosis
- ClinicalTrials.gov ID
- NCT06704464
- Acronym / sponsor ID
- 1-MS-minnesota-reliability
- Conditions
- Multiple Sclerosis
- Keywords
- Minnesota manual dexterity, reliability, validity, multiple sclerosis, hand function
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Gazi UniversityUniversity, hospital or other
- Collaborators
- Cumhuriyet University
- Study start
- 28 Nov 2024 (actual)
- Primary completion
- 25 Jan 2025 (actual)
- Study completion
- 25 Jan 2025 (actual)
- First posted
- 26 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Many assessment tools have been developed and used to evaluate upper extremity functions in multiple sclerosis (MS) patients. While each test has its strengths and weaknesses, the most significant limitation of these tests is that only a limited number assess both hands simultaneously. On the other hand, most daily life activities require the coordinated use of both hands. In MS patients, bilateral impairments in hand functions can also be observed. Therefore, there is a need for bilateral assessment tools.
Unlike many other assessment tools, the Minnesota Manual Dexterity Test (MMDT) allows for simultaneous evaluation of both hands. In addition to manual dexterity, it also assesses hand-eye coordination and gross motor skills. The MMDT consists of five subtests: placing, turning, displacing, single-hand turning and placing, and two-hand turning and placing. The validity of the MMDT has also been examined in MS patients.
Our study aims to evaluate the reliability and validity of the MMDT in MS patients. The cutoff times that best distinguish individuals with MS from healthy individuals will also be examined. The study aims to systematically and thoroughly evaluate the MMDT, establish it as a valid and reliable method for MS patients, and provide a new perspective on assessing hand functions.
Detailed description
At baseline, the MMDT, EDSS, 9-hole peg test (9-HPT), ABILHAND survey, and Jebsen-Taylor Hand Function Test (JTHFT) will be applied to the MS group. The MMDT will be repeated seven days after the first application in MS. Healthy controls are going to perform only the MMDT.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Test Group | – | Other: Manual Dexterity, Other: disability levelPatients with Multiple Sclerosis |
| Control Group | – | Other: Manual Dexterity (only MMDT)healthy controls |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with Multiple Sclerosis who apply to Sivas Cumhuriyet University, Department of Physiotherapy and Rehabilitation will be invited to this study.
Key inclusion criteria (5 listed)
- Age at least 18 years,
- Neurologist-diagnosed Multiple Sclerosis,
- Expanded Disability Status Scale (EDSS) score between 0-6.5
- No MS exacerbation within the last 3 months,
- Use of stable medication in the last 3 months.
Key exclusion criteria (3 listed)
- Having any vision, hearing or perception problems that may affect the research results,
- Having an orthopedic problem that may affect manual skills in the upper extremity,
- Having a cardiovascular, pulmonary disorder
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Manual DexterityIndividuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT, 9-HPT, ABILHAND, and JTHFT. | Other | Test Group |
| Manual Dexterity (only MMDT)Individuals who meet the inclusion criteria will be evaluated for manual dexterity using MMDT on a predetermined day. | Other | Control Group |
| disability levelIndividuals who meet the inclusion criteria will be evaluated for disability level using EDSS | Other | Test Group |
Primary outcome
Minnesota Manual Dexterity Test
Time frame: baseline (on the predetermined assessment day)
The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.
Minnesota Manual Dexterity Test-second
Time frame: the second assessment will be conducted after the seven days
The Minnesota Manual Dexterity Test (MMDT) is a performance test designed to evaluate hand functions and hand-eye coordination both unilaterally and bilaterally, higher scores mean a worse outcome.
4 secondary outcomes
9-Hole Peg Test
Time frame: baseline (on the predetermined assessment day)
ABILHAND
Time frame: baseline (on the predetermined assessment day)
The Jebsen Hand Function Test
Time frame: baseline (on the predetermined assessment day)
The Expanded Disability Status Scale
Time frame: baseline (on the predetermined assessment day)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Mar 2025.
- Results publication: PubMed 30692857Celik RGG. Upper Extremity Capability Tests in Multiple Sclerosis. Noro Psikiyatr Ars. 2018;55(Suppl 1):S54-S57. doi: 10.29399/npa.23338.
- Results publication: PubMed 28059944Hervault M, Balto JM, Hubbard EA, Motl RW. Reliability, precision, and clinically important change of the Nine-Hole Peg Test in individuals with multiple sclerosis. Int J Rehabil Res. 2017 Mar;40(1):91-93. doi: 10.1097/MRR.0000000000000209.
- Derived from this study: PubMed 42183667Eldemir K, Eldemir S, Gokce SF. Psychometric properties of the Minnesota manual dexterity test in people with multiple sclerosis. Clin Rehabil. 2026 May 25:2692155261454955. doi: 10.1177/02692155261454955. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Multiple Sclerosis, run by Gazi University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Minnesota Manual Dexterity Test (time frame: baseline (on the predetermined assessment day)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06704464, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Mar 2025.