Alzheimer Disease, Early OnsetMUSENGAGENCT06688968
Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease
A study testing neuropsychologist interview and questionnaire in people with Alzheimer Disease, Early Onset and Parkinsons Disease with Dementia, run by University Hospital, Montpellier at 3 sites in France.
Trial summary
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects. The main questions it aims to answer are: 1. Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Non Pharmacological Intervention
- What is being tested?
- neuropsychologist interview and questionnaire
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 3 sitesFrance
- Study dates
- 4 Feb 2025to 1 Dec 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- General inclusion criteria:
- 60 years and older
- French-speaking and volunteering for the study
- Living at home with a relative
- Alzheimer's disease inclusion criteria:
- Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
Show all 9Show fewer
- MMSE greater than or equal to 20
- Diagnosis of Idiopathic Parkinson's disease
- MMSE greater than or equal to 20
Who cannot join
- No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
- Autistic disorders
- History of stroke or head trauma
- Unstable medical condition (cancer)
- Subject unable to read and/or write
- Hearing impairment without hearing aids
Show all 12Show fewer
- Refusal of consent after information
- Persons unable to give consent, research carried out in emergency situations, etc.)
- Non-affiliation with a social security scheme
- Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
- Person under legal protection (guardianship, curatorship, legal protection)
- Person participating in another research project with an exclusion period still in progress
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France3 sites, 3 recruiting
- Not yet recruiting
Montpellier Seniors' Association
Montpellier, Hérault, 34000
Mikaël Guenguelou, PhD, 06.04.45.37.94. ext. +33, mikael.genguelou@univ-montp3.fr
- Recruiting
CHU de Montpellier - CEPMo
Montpellier, Hérault, 34295
Mahmoud CHARIF, MD, 0467337413 ext. +33, m-charif@chu-montpellier.fr
- Not yet recruiting
CHU de Montpellier - CMRR
Montpellier, Hérault, 34295
Karim BENNYS, MD, 04.67.33.60.29 ext. +33, k-bennys@chu-montpellier.fr
About this study
Official title: Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.
The main questions it aims to answer are:
Read more
- The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
- The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.
Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :
- A semi-structured interview to check the participants eligibility and gather demographic data.
- Neuropsychological tests and questionnaires will then be administered.
- A relative of the study participant will help complete questionnaires.
Read the detailed description
Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies.
To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.
- Conditions
- Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Non Pharmacological Intervention
- Being tested
- neuropsychologist interview, questionnaire
- Keywords
- Non Pharmacological intervention, Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Music Therapy
- Medical subject headings
- Alzheimer Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
neuropsychologist interviewBehavioural
It will take place either at the hospital or at the participant's home.
This interview will consist of :
- socio-demographic data collection
- neuropsychological tests:
- MMSE test (Mini Mental State Examination) cognitive function
- RL-RI-16 test (16-item free recall/indexed recall test)
- BECS test (Semantic knowledge assessment battery )
- WCST test (Wisconsin Card Sorting Test )
- Musical Cognition Test
- Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire
questionnaireBehavioural
The participant answers questionnaires:
- Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire)
- Questionnaire BMRQ (Barcelona Reward Music Questionnaire)
- Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale)
- Questionnaire LARS (Lille's Apathy Rating Scale)
- Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)
| Study group | Role | What they receive |
|---|---|---|
| patient with early-onset Alzheimer's disease (AD) | Experimental | patients followed up at the Centre Mémoire de Ressources et de Recherche (CMRR) of Montpellier, over 60 with Alzheimer's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative Receives: Behavioral: neuropsychologist interview; Behavioral: questionnaire |
| patients with parkinson's disease (PD) | Active comparator | patients followed up at the Center Expert Parkinson of Montpellier (CEPMo), over 60 with Parkinson's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative Receives: Behavioral: neuropsychologist interview; Behavioral: questionnaire |
| Healthy control | Active comparator | Subjects aged over 60, with no known neurodegenerative disease, living at home with a relative in the Hérault département. Receives: Behavioral: neuropsychologist interview; Behavioral: questionnaire |
What is being measured
The primary outcome is the main question the study is designed to answer.
Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.
Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
Measured: Baseline
Secondary outcomes (26)
The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension
Compare the results of the self-reported and hetero-reported versions of the Musical Engagement Questionnaire.
Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
Measured: Baseline
Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups
Mini Mental State Examination (MMSE) scoring from 0 (minimum) to 30 (maximum), with higher scores indicating better semantic memory function.
Measured: Baseline
Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups
Wisconsin Card Sorting Test (WCST) which assesses executive functioning globally with a rule deduction task. (Scoring from 0 to 6 for the number of correct categories and 0 to 48 for the number of mistakes). The higher the number of categories, the higher the executive functioning. The higher the number of errors, the lower the executive functioning.
Measured: Baseline
Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups
Free and Cued Recall Test (RL/RI-16), a 16 items tests scoring from 0 (minimum) to 48 (maximum), with higher scores indicating better memory recall.
Measured: Baseline
Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups
Recognition subtest of the Battery for the Assessment of Semantic Knowledge (BECS) scoring from 0 to 40.
Higher scores indicate stronger semantic memory abilities, with lower scores reflecting potential deficits in semantic knowledge.
Measured: Baseline
Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups
Test of Orientation in Music Therapy (TOM), scoring from 0 to 34 Higher scores represent better musical cognition abilities, while lower scores may indicate reduced cognitive processing of musical information.
Measured: Baseline
Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups
The extension of the Test of Orientation in Music Therapy (TOM), scoring from 24 to 120.
Higher scores represent better musical cognition abilities, while lower scores may indicate reduced cognitive processing of musical information.
Measured: Baseline
Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups
Barcelona Reward Music Questionnaire BRMQ, (scoring 20 to 100, the lower the score the lower the sensitivity to musical reward). It contains 20 items scored on a 5-point Likert scale. It contains 5 dimensions: musical search, emotional evocation, mood regulation, social reward and sensorimotor.
Measured: Baseline
Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups
MusEQ-24, self-reported Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
Measured: Baseline
Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups
MusEQ-24 item 22, hetero-reported (scoring 0 to 5, the lower the score the lower memory recall)
Measured: Baseline
Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups
MusEQ-24 Emotion subscale, hetero-reported (scoring 0 to 5, the lower the score the lower the emotional experience)
Measured: Baseline
Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups
Snaith-Hamilton Pleasure Scale (SHAPS), a 14 items scale, Score Range: 0 (minimum) to 14 (maximum).
Higher scores suggest anhedonia, with lower scores indicating a greater capacity for experiencing pleasure.
Measured: Baseline
Comparison of Affective blunting between Alzheimer's, Parkinson's and healthy elderly groups
Emotional intensity subscale of Lille's Apathy Rating Scale (LARS) a 33 items scale. The LARS is divided into 9 subscales, each scoring -4 to +4.
Higher scores reflect greater affective blunting (reduced emotional intensity), while lower scores suggest a more typical range of emotional responses.
Measured: Baseline
Comparison of Depression symptoms
Patient Health Questionnaire 9 items (PHQ-9). Score Range: 0 (minimum) to 27 (maximum), each item is rated from 0 to 3 Score Interpretation: Higher scores indicate more severe depressive symptoms, with lower scores suggesting fewer depressive symptoms or none at all.
Measured: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Wisconsin Card Sorting Test (WCST) for each group
correlation coefficient R
Measured: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the 16-item free recall/indexed recall test (RL/RI- 16) for each group
correlation coefficient R
Measured: Baseline
Correlation between Barcelona Reward Music Questionnaire (BMRQ) and Lille's Apathy Rating Scale (LARS) subscale for each group
correlation coefficient R
Measured: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
correlation coefficient R
Measured: Baseline
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Wisconsin Card Sorting Test (WCST) for each group
correlation coefficient R
Measured: Baseline
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the 16-item free recall/indexed recall test (RL/RI- 16) for each group.
correlation coefficient R
Measured: Baseline
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group
correlation coefficient R
Measured: Baseline
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
correlation coefficient R
Measured: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and Wisconsin Card Sorting Test (WCST) for each group
correlation coefficient R
Measured: Baseline
Correlation between item 22 of the MusEQ-24 hetero-reported version with 16-item free recall/indexed recall test (RL/RI- 16) for each group
correlation coefficient R
Measured: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group
correlation coefficient R
Measured: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
correlation coefficient R
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2024
- Study start4 Feb 2025
- Primary completion1 Dec 2025 (estimated)
- Study completion1 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for Alzheimer Disease, Early OnsetStudies of the same condition, open and under way.
- More trials run by University Hospital, MontpellierThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Multicenter observational pilot study
- Masking
- None (open label)
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Montpellier
- Sponsor type
- University, hospital or other
- Collaborators
- Laboratoire EPSYLON
- Responsible party
- Sponsor
- Investigators
- KARIM BENNYS, MD, Principal investigator, University Hospital, Montpellier
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06688968
- Sponsor's protocol ID
- RECHMPL23_0427
- Acronym
- MUSENGAGE
- Status last verified
- Mar 2025
- First submitted
- 12 Nov 2024
- Last updated
- 19 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Bian X, Wang Y, Zhao X, Zhang Z, Ding C. Does music therapy affect the global cognitive function of patients with dementia? A meta-analysis. NeuroRehabilitation. 2021;48(4):553-562. doi: 10.3233/NRE-210018.
PubMed 33967069Zhang Y, Cai J, An L, Hui F, Ren T, Ma H, Zhao Q. Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis. Ageing Res Rev. 2017 May;35:1-11. doi: 10.1016/j.arr.2016.12.003. Epub 2016 Dec 23.
PubMed 28025173van der Steen JT, van Soest-Poortvliet MC, van der Wouden JC, Bruinsma MS, Scholten RJ, Vink AC. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev. 2017 May 2;5(5):CD003477. doi: 10.1002/14651858.CD003477.pub3.
PubMed 28462986Platel H, Eustache ML, Coppalle R, Viard A, Eustache F, Groussard M, Desgranges B. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops? Front Psychol. 2021 Feb 15;12:636028. doi: 10.3389/fpsyg.2021.636028. eCollection 2021.
PubMed 33679562Morris IB, Vasudevan E, Schedel M, Weymouth D, Loomis J, Pinkhasov T, Muratori LM. Music to One's Ears: Familiarity and Music Engagement in People With Parkinson's Disease. Front Neurosci. 2019 Jun 25;13:661. doi: 10.3389/fnins.2019.00661. eCollection 2019.
PubMed 31293379Machado Sotomayor MJ, Arufe-Giraldez V, Ruiz-Rico G, Navarro-Paton R. Music Therapy and Parkinson's Disease: A Systematic Review from 2015-2020. Int J Environ Res Public Health. 2021 Nov 4;18(21):11618. doi: 10.3390/ijerph182111618.
PubMed 34770129Loas G, Duru C, Godefroy O, Krystkowiak P. Hedonic deficits in Parkinson's disease: is consummatory anhedonia specific? Front Neurol. 2014 Mar 10;5:24. doi: 10.3389/fneur.2014.00024. eCollection 2014.
PubMed 24653714Groussard M, Chan TG, Coppalle R, Platel H. Preservation of Musical Memory Throughout the Progression of Alzheimer's Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence. J Alzheimers Dis. 2019;68(3):857-883. doi: 10.3233/JAD-180474.
PubMed 30883343Belfi AM, Moreno GL, Gugliano M, Neill C. Musical reward across the lifespan. Aging Ment Health. 2022 May;26(5):932-939. doi: 10.1080/13607863.2021.1871881. Epub 2021 Jan 14.
PubMed 33442987
Study at a glance
From the registry record, last updated by the sponsor on 19 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment
- ClinicalTrials.gov ID
- NCT06688968
- Acronym / sponsor ID
- MUSENGAGE / RECHMPL23_0427
- Conditions
- Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Non Pharmacological Intervention
- Keywords
- Non Pharmacological intervention, Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Music Therapy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- University Hospital, MontpellierUniversity, hospital or other
- Collaborators
- Laboratoire EPSYLON
- Study start
- 4 Feb 2025 (actual)
- Primary completion
- 1 Dec 2025 (estimated)
- Study completion
- 1 Dec 2025 (estimated)
- First posted
- 14 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.
The main questions it aims to answer are:
- The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
- The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.
Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :
- A semi-structured interview to check the participants eligibility and gather demographic data.
- Neuropsychological tests and questionnaires will then be administered.
- A relative of the study participant will help complete questionnaires.
Detailed description
Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies.
To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Multicenter observational pilot study
| Arm | Type | Receives |
|---|---|---|
| patient with early-onset Alzheimer's disease (AD) | Experimental | Behavioral: neuropsychologist interview, Behavioral: questionnairepatients followed up at the Centre Mémoire de Ressources et de Recherche (CMRR) of Montpellier, over 60 with Alzheimer's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative |
| patients with parkinson's disease (PD) | Active comparator | Behavioral: neuropsychologist interview, Behavioral: questionnairepatients followed up at the Center Expert Parkinson of Montpellier (CEPMo), over 60 with Parkinson's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative |
| Healthy control | Active comparator | Behavioral: neuropsychologist interview, Behavioral: questionnaireSubjects aged over 60, with no known neurodegenerative disease, living at home with a relative in the Hérault département. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- 60 years and older
- French-speaking and volunteering for the study
- Living at home with a relative
- Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
- MMSE greater than or equal to 20
Key exclusion criteria (12 listed)
- No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
- Autistic disorders
- History of stroke or head trauma
- Unstable medical condition (cancer)
- Subject unable to read and/or write
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| neuropsychologist interviewIt will take place either at the hospital or at the participant's home. This interview will consist of : * socio-demographic data collection * neuropsychological tests: * MMSE test (Mini Mental State Examination) cognitive function * RL-RI-16 test (16-item free recall/indexed recall test) * BECS test (Semantic knowledge assessment battery ) * WCST test (Wisconsin Card Sorting Test ) * Musical Cognition Test * Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire | Behavioural | Healthy control, patient with early-onset Alzheimer's disease (AD), patients with parkinson's disease (PD) |
| questionnaireThe participant answers questionnaires: * Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire) * Questionnaire BMRQ (Barcelona Reward Music Questionnaire) * Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale) * Questionnaire LARS (Lille's Apathy Rating Scale) * Questionnaire PHQ-9 (Patient Health Questionnaire 9 items) | Behavioural | Healthy control, patient with early-onset Alzheimer's disease (AD), patients with parkinson's disease (PD) |
Primary outcome
Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.
Time frame: Baseline
Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
26 secondary outcomes
The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension
Time frame: Baseline
Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Affective blunting between Alzheimer's, Parkinson's and healthy elderly groups
Time frame: Baseline
Comparison of Depression symptoms
Time frame: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Wisconsin Card Sorting Test (WCST) for each group
Time frame: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the 16-item free recall/indexed recall test (RL/RI- 16) for each group
Time frame: Baseline
Correlation between Barcelona Reward Music Questionnaire (BMRQ) and Lille's Apathy Rating Scale (LARS) subscale for each group
Time frame: Baseline
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
Time frame: Baseline
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Wisconsin Card Sorting Test (WCST) for each group
Time frame: Baseline
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the 16-item free recall/indexed recall test (RL/RI- 16) for each group.
Time frame: Baseline
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group
Time frame: Baseline
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
Time frame: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and Wisconsin Card Sorting Test (WCST) for each group
Time frame: Baseline
Correlation between item 22 of the MusEQ-24 hetero-reported version with 16-item free recall/indexed recall test (RL/RI- 16) for each group
Time frame: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group
Time frame: Baseline
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Mar 2025.
- Background: PubMed 33967069Bian X, Wang Y, Zhao X, Zhang Z, Ding C. Does music therapy affect the global cognitive function of patients with dementia? A meta-analysis. NeuroRehabilitation. 2021;48(4):553-562. doi: 10.3233/NRE-210018.
- Background: PubMed 28025173Zhang Y, Cai J, An L, Hui F, Ren T, Ma H, Zhao Q. Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis. Ageing Res Rev. 2017 May;35:1-11. doi: 10.1016/j.arr.2016.12.003. Epub 2016 Dec 23.
- Background: PubMed 28462986van der Steen JT, van Soest-Poortvliet MC, van der Wouden JC, Bruinsma MS, Scholten RJ, Vink AC. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev. 2017 May 2;5(5):CD003477. doi: 10.1002/14651858.CD003477.pub3.
- Background: PubMed 33679562Platel H, Eustache ML, Coppalle R, Viard A, Eustache F, Groussard M, Desgranges B. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops? Front Psychol. 2021 Feb 15;12:636028. doi: 10.3389/fpsyg.2021.636028. eCollection 2021.
- Background: PubMed 31293379Morris IB, Vasudevan E, Schedel M, Weymouth D, Loomis J, Pinkhasov T, Muratori LM. Music to One's Ears: Familiarity and Music Engagement in People With Parkinson's Disease. Front Neurosci. 2019 Jun 25;13:661. doi: 10.3389/fnins.2019.00661. eCollection 2019.
- Background: PubMed 34770129Machado Sotomayor MJ, Arufe-Giraldez V, Ruiz-Rico G, Navarro-Paton R. Music Therapy and Parkinson's Disease: A Systematic Review from 2015-2020. Int J Environ Res Public Health. 2021 Nov 4;18(21):11618. doi: 10.3390/ijerph182111618.
- Background: PubMed 24653714Loas G, Duru C, Godefroy O, Krystkowiak P. Hedonic deficits in Parkinson's disease: is consummatory anhedonia specific? Front Neurol. 2014 Mar 10;5:24. doi: 10.3389/fneur.2014.00024. eCollection 2014.
- Background: PubMed 30883343Groussard M, Chan TG, Coppalle R, Platel H. Preservation of Musical Memory Throughout the Progression of Alzheimer's Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence. J Alzheimers Dis. 2019;68(3):857-883. doi: 10.3233/JAD-180474.
- Background: PubMed 33442987Belfi AM, Moreno GL, Gugliano M, Neill C. Musical reward across the lifespan. Aging Ment Health. 2022 May;26(5):932-939. doi: 10.1080/13607863.2021.1871881. Epub 2021 Jan 14.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
KARIM BENNYS, MD principal investigator
University Hospital, Montpellier
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing neuropsychologist interview and questionnaire in people with Alzheimer Disease, Early Onset and Parkinsons Disease with Dementia, run by University Hospital, Montpellier at 3 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mikaël Genguelou, PhD (06.04.45.37.94. ext. +33, mikael.genguelou@univ-montp3.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults. (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06688968, which also lists 9 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Mar 2025.