HealthyNCT06627491
Influence of Fast and Slow Imagined Muscle Contractions on Muscle Function or Central Nervous System Properties
A study testing Imagined muscle contractions in people with Healthy, run by Kennesaw State University at 1 site in United States.
Trial summary
The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Imagined muscle contractions
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteUnited States
- Study dates
- Oct 2024to May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Be between the ages of 18 - 30
- Healthy (no medical conditions)
- If female, must be taking the same monophasic oral contraceptive for the past 6 months
- Have a body mass index between 18.5 - 30 kg/m2
- Have not performed structured cardiovascular or resistance exercise in past 3 years
- Be right-handed
- Not currently taking stimulants, antipsychotic, anxiety, or depression medications
- Have not suffered an upper extremity musculoskeletal injury within the past year
Who cannot join
- If transcranial magnetic stimulation (TMS) is not deemed appropriate depending on your responses to the TMS-specific questionnaire
- Being ambidextrous
- Although rare, you will be excluded if discernable muscle activation responses are not possible via TMS
Trial locations and contacts
1 site in 1 country.
United States1 site, 1 recruiting
- Recruiting
Kennesaw State University
Kennesaw, Georgia, 30144
Garrett Hester, Ph.D., 470-578-4267, ghester4@kennesaw.edu
Garrett Hester, Ph.D.
About this study
Official title: Does the Speed of Imagined Muscle Contractions Affect Muscle Function and Central Nervous System Excitability?
The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are:
Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions?
Read more
Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions?
A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response.
Participants will:
- Attend 4 laboratory visits
- Perform 50 imagined contractions fast or slow, but with no physical movement
- Physical muscle contractions and non-invasive brain stimulation would be completed before and after each condition.
Read the detailed description
Participants will complete 4 laboratory visits in a randomized order, including a familiarization session, a control condition, and 2 conditions involving imaginary muscle contractions. During visits involving imaginary muscle contractions, participants will complete 2 sets of 25 repetitions of either fast (i.e., less than 1 second to peak torque increase torque as fast as possible) or slow (i.e., 3 seconds to peak torque) isometric elbow flexions. Before and after each condition, single-pulse transcranial magnetic stimulation will be delivered to the primary motor cortex to measure the amplitude of motor-evoked potentials and the duration of the resulting silent periods in the bicep brachii to quantify changes in corticospinal excitability and inhibition, respectively. Rapid maximal voluntary isometric contractions will be used to measure changes in rate of torque development, peak torque, and rate of muscle activation.
- Conditions
- Healthy
- Being tested
- Imagined muscle contractions
- Keywords
- Muscle strength, Nervous System, Motor Imagery
- Medical subject headings
- Neurologic Manifestations
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Imagined muscle contractionsBehavioural
The intervention involved imagining, with no physical movement, of muscle contractions.
| Study group | Role | What they receive |
|---|---|---|
| Control | No intervention | Participants will rest quietly with eyes closed during the control condition. |
| Fast | Experimental | Participants will imagine 2 blocks of 25 fast muscle contractions separated by 30 sec Receives: Behavioral: Imagined muscle contractions |
| Slow | Experimental | Participants will imagine 2 blocks of 25 slow muscle contractions separated by 30 sec Receives: Behavioral: Imagined muscle contractions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in rate of torque development as measured by newton-meters per second
A measure of the capacity to increase muscle torque rapidly as determined by the slope of the torque-time curve
Measured: Baseline, minute 20
Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation
A measure of excitability for the corticospinal tract
Measured: Baseline, minute 20
Secondary outcomes (5)
Change in isometric bicep strength as measured by newton-meters of torque
Isometric strength of a muscle
Measured: Baseline, minute 20
Change in agonist muscle activation as measured by electromyography amplitude
A measure of the capacity at which the muscle is activated by the nervous system
Measured: Baseline, minute 20
Change in antagonist co-activation as measured by electromyography amplitude
A measure of the capacity at which the antagonist muscle is activated by the nervous system
Measured: Baseline, minute 20
Change in rate of agonist muscle activation as measured by electromyography amplitude
A measure of how quickly the nervous system activates the muscle
Measured: Baseline, minute 20
Change in nervous system inhibition as measured by electromyographic waveform aplitude following motor cortex stimulation
A measure of inhibition for the corticospinal tract
Measured: Baseline, minute 20
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Oct 2024
- Study startOct 2024 (estimated)
- Primary completionMay 2025 (estimated)
- Study completionMay 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 18 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kennesaw State University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Garrett Hester, Kennesaw State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06627491
- Sponsor's protocol ID
- MI_KA
- Status last verified
- Oct 2024
- First submitted
- 2 Oct 2024
- Last updated
- 9 Oct 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Non-identifying IPD will be provided upon a reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 9 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does the Speed of Imagined Muscle Contractions Affect Muscle Function and Central Nervous System Excitability?
- ClinicalTrials.gov ID
- NCT06627491
- Acronym / sponsor ID
- MI_KA
- Conditions
- Healthy
- Keywords
- Muscle strength, Nervous System, Motor Imagery
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 18 participants (estimated)
- Lead sponsor
- Kennesaw State UniversityUniversity, hospital or other
- Study start
- Oct 2024 (estimated)
- Primary completion
- May 2025 (estimated)
- Study completion
- May 2025 (estimated)
- First posted
- 4 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are:
Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions?
Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions?
A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response.
Participants will:
- Attend 4 laboratory visits
- Perform 50 imagined contractions fast or slow, but with no physical movement
- Physical muscle contractions and non-invasive brain stimulation would be completed before and after each condition.
Detailed description
Participants will complete 4 laboratory visits in a randomized order, including a familiarization session, a control condition, and 2 conditions involving imaginary muscle contractions. During visits involving imaginary muscle contractions, participants will complete 2 sets of 25 repetitions of either fast (i.e., less than 1 second to peak torque increase torque as fast as possible) or slow (i.e., 3 seconds to peak torque) isometric elbow flexions. Before and after each condition, single-pulse transcranial magnetic stimulation will be delivered to the primary motor cortex to measure the amplitude of motor-evoked potentials and the duration of the resulting silent periods in the bicep brachii to quantify changes in corticospinal excitability and inhibition, respectively. Rapid maximal voluntary isometric contractions will be used to measure changes in rate of torque development, peak torque, and rate of muscle activation.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Control | No intervention | –Participants will rest quietly with eyes closed during the control condition. |
| Fast | Experimental | Behavioral: Imagined muscle contractionsParticipants will imagine 2 blocks of 25 fast muscle contractions separated by 30 sec |
| Slow | Experimental | Behavioral: Imagined muscle contractionsParticipants will imagine 2 blocks of 25 slow muscle contractions separated by 30 sec |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Be between the ages of 18 - 30
- Healthy (no medical conditions)
- If female, must be taking the same monophasic oral contraceptive for the past 6 months
- Have a body mass index between 18.5 - 30 kg/m2
- Have not performed structured cardiovascular or resistance exercise in past 3 years
Key exclusion criteria (3 listed)
- If transcranial magnetic stimulation (TMS) is not deemed appropriate depending on your responses to the TMS-specific questionnaire
- Being ambidextrous
- Although rare, you will be excluded if discernable muscle activation responses are not possible via TMS
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Imagined muscle contractionsThe intervention involved imagining, with no physical movement, of muscle contractions. | Behavioural | Fast, Slow |
Primary outcome
Change in rate of torque development as measured by newton-meters per second
Time frame: Baseline, minute 20
A measure of the capacity to increase muscle torque rapidly as determined by the slope of the torque-time curve
Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation
Time frame: Baseline, minute 20
A measure of excitability for the corticospinal tract
5 secondary outcomes
Change in isometric bicep strength as measured by newton-meters of torque
Time frame: Baseline, minute 20
Change in agonist muscle activation as measured by electromyography amplitude
Time frame: Baseline, minute 20
Change in antagonist co-activation as measured by electromyography amplitude
Time frame: Baseline, minute 20
Change in rate of agonist muscle activation as measured by electromyography amplitude
Time frame: Baseline, minute 20
Change in nervous system inhibition as measured by electromyographic waveform aplitude following motor cortex stimulation
Time frame: Baseline, minute 20
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2024.
- Individual participant dataSharing planned: Yes. Non-identifying IPD will be provided upon a reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Imagined muscle contractions in people with Healthy, run by Kennesaw State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 9 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Garrett Hester, Ph.D. (470-578-4267, ghester4@kennesaw.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in rate of torque development as measured by newton-meters per second (time frame: Baseline, minute 20). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2024.