Dream, DayNCT06609538
The Impact of Preoperative Suggestion on Dreaming
A study testing Suggestion Group in people with Dream, Day and Ketamine Adverse Reaction, run by Wonkwang University Hospital at 1 site in South Korea.
Trial summary
Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol. Read more about this study
- Who is it for?
- Ages 20 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Dream, Day, Ketamine Adverse Reaction, Propofol Adverse Reaction
- What is being tested?
- Suggestion Group
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 250 participants
- Where
- 1 siteSouth Korea
- Study dates
- 19 Sep 2024to 30 Jan 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adult patients aged 20-65 years.
- ASA physical status I-III.
- Scheduled for elective spinal anesthesia or brachial plexus block.
- Fluent in Korean.
Who cannot join
- Use of any medication, including premedication, within 12 hours before surgery.
- Cognitive impairments or psychiatric disorders (including a history of unpleasant dreams or nightmares).
- Current use of sedatives or hypnotics.
- History of severe or recurrent nightmares.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Impact of Preoperative Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial.
Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.
Read the detailed description
Cheong et al. demonstrated that a simple positive suggestion before ketamine administration could reduce unpleasant dreams, while Kim et al. found that propofol, compared to midazolam, led to more vivid and memorable dreams, along with similar satisfaction levels in patients. This study aims to extend these findings by comparing the effects of propofol and ketamine sedation on dreaming during anesthesia, with a focus on how preoperative suggestions might influence dream content, emotional tone, and patient satisfaction.
- Being tested
- Control Group, Suggestion Group
- Keywords
- Suggestion, dream incidence, dream contents, emotional tone, patient satisfaction
- Medical subject headings
- Patient Satisfaction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Control GroupOther
Also called Propofol, Ketamine
Receives standard preoperative instructions and propofol or ketamine infusion.
Suggestion GroupOther
Also called Propofol, Ketamine
Receives positive preoperative suggestions and propofol or ketamine infusion.
| Study group | Role | What they receive |
|---|---|---|
| Control Group with Propofol | Active comparator | Receives standard preoperative instructions and propofol infusion. Receives: Other: Control Group |
| Suggestion Group with Propofol | Experimental | Receives positive preoperative suggestions and propofol infusion. Receives: Other: Suggestion Group |
| Control Group with Ketamine | Active comparator | Receives standard preoperative instructions and ketamine infusion. Receives: Other: Control Group |
| Suggestion Group with Ketamine | Experimental | Receives positive preoperative suggestions and ketamine infusion. Receives: Other: Suggestion Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of Dreaming
The "Dreaming and Cognition Evaluation Questionnaire" will be used.questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance.
Measured: Dreaming will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU).
Quality of Dreaming
The "Dreaming and Cognition Evaluation Questionnaire" will be used. This questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance.
Measured: Dreaming will be assessed immediately in the Post-Anesthesia Care Unit (PACU).
Secondary outcomes (2)
Satisfaction with Care
A 101-point numerical rating scale included in the "Dreaming and Cognition Evaluation Questionnaire" will be used to measure patient satisfaction with the overall care and sedation experience.
Measured: Satisfaction will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU)
Adverse events
Any complications such as hypotension,or bradycardia, will be recorded systematically.
Measured: Monitoring will be continuous with regular vital signs recorded every 5 minutes during surgery and every 15 minutes in the PACU.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Sep 2024
- Study start19 Sep 2024
- Primary completion25 Nov 2024
- Study completion30 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Dream, DayStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- 1. Control Group with Propofol: Receives standard preoperative instructions and propofol infusion. 2. Suggestion Group with Propofol: Receives positive preoperative suggestions and propofol infusion. 3. Control Group with Ketamine: Receives standard preoperative instructions and ketamine infusion. 4. Suggestion Group with Ketamine: Receives positive preoperative suggestions and ketamine infusion.
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 250 participants (actual)
Sponsor and investigators
- Lead sponsor
- Wonkwang University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cheol Lee,MD,PhD,, Wonkwang University Hospital
- Investigators
- Cheol Lee, M.D.,Ph.D, Study director, Wonkwang University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06609538
- Sponsor's protocol ID
- Wonkwang UH15
- Status last verified
- Feb 2025
- First submitted
- 22 Sep 2024
- Last updated
- 25 Feb 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Lee D, Lee H, Lee C, Lee C. The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial. Anesth Analg. 2026 Jul 1;143(1):156-162. doi: 10.1213/ANE.0000000000007818. Epub 2025 Nov 24.
PubMed 41319686
Study at a glance
From the registry record, last updated by the sponsor on 25 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Preoperative Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial.
- ClinicalTrials.gov ID
- NCT06609538
- Acronym / sponsor ID
- Wonkwang UH15
- Keywords
- Suggestion, dream incidence, dream contents, emotional tone, patient satisfaction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 250 participants (actual)
- Lead sponsor
- Wonkwang University HospitalUniversity, hospital or other
- Study start
- 19 Sep 2024 (actual)
- Primary completion
- 25 Nov 2024 (actual)
- Study completion
- 30 Jan 2025 (actual)
- First posted
- 24 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.
Detailed description
Cheong et al. demonstrated that a simple positive suggestion before ketamine administration could reduce unpleasant dreams, while Kim et al. found that propofol, compared to midazolam, led to more vivid and memorable dreams, along with similar satisfaction levels in patients. This study aims to extend these findings by comparing the effects of propofol and ketamine sedation on dreaming during anesthesia, with a focus on how preoperative suggestions might influence dream content, emotional tone, and patient satisfaction.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 4
- Model description
- 1. Control Group with Propofol: Receives standard preoperative instructions and propofol infusion. 2. Suggestion Group with Propofol: Receives positive preoperative suggestions and propofol infusion. 3. Control Group with Ketamine: Receives standard preoperative instructions and ketamine infusion. 4. Suggestion Group with Ketamine: Receives positive preoperative suggestions and ketamine infusion.
| Arm | Type | Receives |
|---|---|---|
| Control Group with Propofol | Active comparator | Other: Control GroupReceives standard preoperative instructions and propofol infusion. |
| Suggestion Group with Propofol | Experimental | Other: Suggestion GroupReceives positive preoperative suggestions and propofol infusion. |
| Control Group with Ketamine | Active comparator | Other: Control GroupReceives standard preoperative instructions and ketamine infusion. |
| Suggestion Group with Ketamine | Experimental | Other: Suggestion GroupReceives positive preoperative suggestions and ketamine infusion. |
Who may qualify
- Ages
- 20 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adult patients aged 20-65 years.
- ASA physical status I-III.
- Scheduled for elective spinal anesthesia or brachial plexus block.
- Fluent in Korean.
Key exclusion criteria (4 listed)
- Use of any medication, including premedication, within 12 hours before surgery.
- Cognitive impairments or psychiatric disorders (including a history of unpleasant dreams or nightmares).
- Current use of sedatives or hypnotics.
- History of severe or recurrent nightmares.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Control GroupAlso: Propofol, KetamineReceives standard preoperative instructions and propofol or ketamine infusion. | Other | Control Group with Ketamine, Control Group with Propofol |
| Suggestion GroupAlso: Propofol, KetamineReceives positive preoperative suggestions and propofol or ketamine infusion. | Other | Suggestion Group with Ketamine, Suggestion Group with Propofol |
Primary outcome
Incidence of Dreaming
Time frame: Dreaming will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU).
The "Dreaming and Cognition Evaluation Questionnaire" will be used.questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance.
Quality of Dreaming
Time frame: Dreaming will be assessed immediately in the Post-Anesthesia Care Unit (PACU).
The "Dreaming and Cognition Evaluation Questionnaire" will be used. This questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance.
2 secondary outcomes
Satisfaction with Care
Time frame: Satisfaction will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU)
Adverse events
Time frame: Monitoring will be continuous with regular vital signs recorded every 5 minutes during surgery and every 15 minutes in the PACU.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Feb 2025.
- Derived from this study: PubMed 41319686Lee D, Lee H, Lee C, Lee C. The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial. Anesth Analg. 2026 Jul 1;143(1):156-162. doi: 10.1213/ANE.0000000000007818. Epub 2025 Nov 24.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Cheol Lee, M.D.,Ph.D study director
Wonkwang University Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Suggestion Group in people with Dream, Day and Ketamine Adverse Reaction, run by Wonkwang University Hospital at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of Dreaming (time frame: Dreaming will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06609538, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2025.