Rheumatoid ArthritisRAPD-MRNCT06603207
Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization
An observational study of Rheumatoid Arthritis and Periodontitis, run by Zhibin Xu.
Trial summary
This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Rheumatoid Arthritis, Periodontitis
- How many people
- 220,000 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2024to 1 Dec 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: This study utilizes genetic data from an East Asian population, sourced from publicly available genome-wide association studies (GWAS) focused on rheumatoid arthritis and periodontitis.
Who may be able to join
- Participants included in the genome-wide association study (GWAS) database.
- Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.
Who cannot join
- Individuals without complete genotypic data or those with missing critical phenotypic information.
About this study
Official title: Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study
This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.
Read the detailed description
The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.
- Conditions
- Rheumatoid Arthritis, Periodontitis
- Keywords
- Mendelian Randomization, Genome-Wide Association Study (GWAS), Inflammatory Diseases, Genetic Risk Factors, SNP (Single Nucleotide Polymorphism)
- Medical subject headings
- Arthritis, Rheumatoid, Periodontitis
What is being measured
The primary outcome is the main question the study is designed to answer.
Causal Association Between Rheumatoid Arthritis and Periodontitis
This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.
Measured: Data collected from 2023 to 2024.
Secondary outcomes (1)
Analysis of Genetic Pleiotropy and Confounders
Evaluation of the presence of genetic pleiotropy and its potential effect on the association between rheumatoid arthritis and periodontitis.
Measured: 2023 to 2024
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2024
- Study start1 Oct 2024 (estimated)
- Primary completion1 Nov 2024 (estimated)
- Study completion1 Dec 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Rheumatoid ArthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 220,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Zhibin Xu
- Sponsor type
- University, hospital or other
- Collaborators
- Zhongshan People's Hospital, Guangdong, China
- Responsible party
- Sponsor-investigator, Zhibin Xu, Guangzhou Institute of Respiratory Disease
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06603207
- Sponsor's protocol ID
- KY20240918-01
- Acronym
- RAPD-MR
- Status last verified
- Sep 2024
- First submitted
- 17 Sep 2024
- Last updated
- 20 Sep 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Li X, Ouyang Y, Liang L, Li Y. Causal association between rheumatoid arthritis and periodontitis: A Mendelian randomization study. Medicine (Baltimore). 2026 Jun 5;105(23):e49095. doi: 10.1097/MD.0000000000049095.
PubMed 42260828
Study at a glance
From the registry record, last updated by the sponsor on 20 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study
- ClinicalTrials.gov ID
- NCT06603207
- Acronym / sponsor ID
- RAPD-MR / KY20240918-01
- Conditions
- Rheumatoid Arthritis, Periodontitis
- Keywords
- Mendelian Randomization, Genome-Wide Association Study (GWAS), Inflammatory Diseases, Genetic Risk Factors, SNP (Single Nucleotide Polymorphism)
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 220,000 participants (estimated)
- Lead sponsor
- Zhibin XuUniversity, hospital or other
- Collaborators
- Zhongshan People's Hospital, Guangdong, China
- Study start
- 1 Oct 2024 (estimated)
- Primary completion
- 1 Nov 2024 (estimated)
- Study completion
- 1 Dec 2024 (estimated)
- First posted
- 19 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.
Detailed description
The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- This study utilizes genetic data from an East Asian population, sourced from publicly available genome-wide association studies (GWAS) focused on rheumatoid arthritis and periodontitis.
Key inclusion criteria (2 listed)
- Participants included in the genome-wide association study (GWAS) database.
- Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.
Key exclusion criteria (1 listed)
- Individuals without complete genotypic data or those with missing critical phenotypic information.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Causal Association Between Rheumatoid Arthritis and Periodontitis
Time frame: Data collected from 2023 to 2024.
This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.
1 secondary outcome
Analysis of Genetic Pleiotropy and Confounders
Time frame: 2023 to 2024
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Sep 2024.
- Derived from this study: PubMed 42260828Li X, Ouyang Y, Liang L, Li Y. Causal association between rheumatoid arthritis and periodontitis: A Mendelian randomization study. Medicine (Baltimore). 2026 Jun 5;105(23):e49095. doi: 10.1097/MD.0000000000049095.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Rheumatoid Arthritis and Periodontitis, run by Zhibin Xu.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 20 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Causal Association Between Rheumatoid Arthritis and Periodontitis (time frame: Data collected from 2023 to 2024.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06603207, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Sep 2024.