AzTrials
AzTrials

Prostate Cancer (Adenocarcinoma)Phase 3TRIPLE-SWITCHNCT06592924

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

A Phase 3 study testing Abiraterone, Enzalutamide and Apalutamide in people with Prostate Cancer (Adenocarcinoma), run by Canadian Cancer Trials Group at 395 sites in 4 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record

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Trial summary

This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach is better or worse than the usual approach for prostate cancer. Read more about this study

Who is it for?
Ages 18 years and older, men only
Conditions the study is for
Prostate Cancer (Adenocarcinoma)
What is being tested?
Abiraterone, Enzalutamide and Apalutamide
Could I receive a placebo?
No, everyone receives an active treatment
How many people
830 participants
Where
395 sitesin 4 countries
Study dates
28 May 2025to 15 Apr 2031
Phase
Phase 3

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • Men only
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histologically/cytologically confirmed adenocarcinoma of the prostate or participants with a PSA >100 ng/ml (100 ug/L) and radiographic evidence of metastatic disease at diagnosis.
  • Metastatic disease by conventional imaging (bone scan or CT and/or MRI or PSMA-PET scan at the time of ADT initiation.
  • PSA of ≥ 2.0 ng/ml (2.0 ug/L) prior to commencement of ADT (this refers to patients who have histologically/cytologically confirmed adenocarcinoma of the prostate)
  • Patients will have recovered from any treatment-related toxicities prior to enrollment (unless ≤ grade 1, irreversible, or considered by investigator as not clinically significant).
  • Patients may enroll with persistent toxicities attributable to ADT, including hot flushes and fatigue, of any grade, provided these toxicities are clinically stable, not rapidly worsening, and not considered by the Investigator to pose a safety risk or impair the patient's ability to comply with study procedures. Such toxicities do not need to resolve to Grade ≤1 prior to study entry.
  • Receipt of ADT for mCSPC for at least 6 months and no greater than 12 months (+/- 3 weeks) at time of enrollment.
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  • Receipt of ARPI (e.g. abiraterone acetate, enzalutamide, apalutamide, or darolutamide) for at least 4 months (+/- 2 weeks) at time of enrollment
  • Patients may have had radiotherapy to prostatic bed and/or metastatic sites prior to enrollment. Potential trial participants should have recovered from radiotherapy-related toxicities prior to enrollment.
  • Serum testosterone <1.7 nmol/L or 50 ng/dL.
  • PSA ≥ 0.2 ng/ml (0.2 ug/L) within 28 days of enrollment.
  • Candidate for docetaxel chemotherapy
  • ECOG Performance Status (PS) 0 to 2.
  • Adequate organ and marrow function measured within 28 days prior to enrollment.
  • Participant consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each participant must sign a consent form prior to enrollment in the trial to document their willingness to participate.
  • Participants must be accessible for treatment and follow-up. Investigators must assure themselves the participants enrolled on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.
  • In accordance with CCTG policy, protocol treatment is to begin within 10 working days of participant enrollment.
  • If the participant and the participant's partner are of childbearing potential, they must agree to use medically accepted methods of contraception
  • HIV-infected participants on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
  • Participant access to all protocol therapies must be confirmed prior to enrollment

Who cannot join

  • Confirmed PSA progression, defined by an increase in PSA of 25% above the nadir since achieving castration on ADT, an absolute increase in PSA value of 2.0 ng/ml (ug/L) above nadir, and a subsequent increase in PSA of 25% further separated by 3 or more weeks.
  • Evidence of confirmed radiographic progression or clinical progression since start of ADT. Participants may be enrolled on the study if, in the opinion of the investigator, any new bone lesions on bone scan and CT represent flare or treatment effect.
  • Docetaxel criteria:
  • Prior treatment with taxane chemotherapy
  • Grade 2 or worse peripheral neuropathy
  • Severe hypersensitivity to drugs formulated with polysorbate 80
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  • Clinically significant cardiac disease including:
  • History of unstable angina pectoris, symptomatic pericarditis, or myocardial infarction within 6 months prior to study entry.
  • History of documented congestive heart failure (New York Heart Association functions classification III-IV).
  • Patients with uncontrolled intercurrent illness or any other significant condition(s) that would make this protocol unreasonably hazardous.
  • Patients with a prior or concurrent malignancy whose natural history of treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
  • Concurrent treatment with other anti-cancer systemic therapy other than ADT and ARPI.
  • Live attenuated vaccination administered within 30 days prior to enrollment/randomization.
  • For participants with a history of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
  • Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.
  • High-grade neuroendocrine prostate cancer or small cell features (except if a participant has no histological diagnosis but a PSA >100 ng/ml (>100 ug/L) at diagnosis and radiographic evidence of metastatic disease)

Trial locations and contacts

395 sites in 4 countries. Contact the study team or a site near you to ask about taking part.

Mariam Jafri contact

613-533-6430

mjafri@ctg.queensu.ca

Wendy Parulekar contact

613-533-6430

wparulekar@ctg.queensu.ca

321 sites in 4 countries

United States300 sites, 287 recruiting

  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii, 96701

    Site Public Contact, 808-539-2273, info@hawaiicancercare.com

    Jeffrey L. Berenberg

    Recruiting

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701

    Site Public Contact, 808-486-6000

    Jeffrey L. Berenberg

    Recruiting

  • Queen's Cancer Center - Pearlridge

    ‘Aiea, Hawaii, 96701

    Site Public Contact, 808-487-7447

    Jeffrey L. Berenberg

    Recruiting

  • Straub Pearlridge Clinic

    ‘Aiea, Hawaii, 96701

    Site Public Contact, 808-522-4333

    Jeffrey L. Berenberg

    Recruiting

  • The Cancer Center of Hawaii-Pali Momi

    ‘Aiea, Hawaii, 96701

    Suspended

  • The Queen's Medical Center - West Oahu

    ‘Ewa Beach, Hawaii, 96706

    Site Public Contact, rohta@queens.org

    Jeffrey L. Berenberg

    Recruiting

  • Providence Regional Cancer System-Aberdeen

    Aberdeen, Washington, 98520

    Site Public Contact, 360-412-8958, deidre.dillon@providence.org

    Charles W. Drescher

    Recruiting

  • Riverwood Healthcare Center

    Aitkin, Minnesota, 56431

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Cleveland Clinic Akron General

    Akron, Ohio, 44307

    Site Public Contact, 866-223-8100, CancerAnswer@ccf.org

    Shilpa Gupta

    Recruiting

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Kaiser Permanente-Anaheim

    Anaheim, California, 92806

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, 98508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Alaska Breast Care and Surgery LLC

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Katmai Oncology Group

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa, 50023

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Veteran's Administration Medical Center - Ann Arbor

    Ann Arbor, Michigan, 48105

    Site Public Contact, 800-361-8387

    Phoebe A. Tsao

    Recruiting

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109

    Site Public Contact, 800-865-1125, CancerAnswerLine@med.umich.edu

    Zachery R. Reichert

    Recruiting

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California, 93420

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Duluth Clinic Ashland

    Ashland, Wisconsin, 54806

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Northwest Wisconsin Cancer Center

    Ashland, Wisconsin, 54806

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Grady Health System

    Atlanta, Georgia, 30303

    Site Public Contact, 404-778-1868

    Bradley C. Carthon

    Recruiting

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308

    Site Public Contact, 888-946-7447

    Bradley C. Carthon

    Recruiting

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322

    Site Public Contact, 404-778-1868

    Bradley C. Carthon

    Recruiting

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342

    Site Public Contact, 404-851-7115

    Bradley C. Carthon

    Recruiting

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045

    Site Public Contact, 720-848-0650

    Laura Graham

    Recruiting

  • Mount Sinai Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180

    Site Public Contact, 305-674-2625, yenrique@msmc.com

    Bruno R. Bastos

    Recruiting

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio, 44011

    Site Public Contact, 800-641-2422

    Iris Y. Sheng

    Recruiting

  • Saint Alphonsus Cancer Care Center-Baker City

    Baker City, Oregon, 97814

    Suspended

  • Kaiser Permanente-Baldwin Park

    Baldwin Park, California, 91706

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287

    Site Public Contact, 410-955-8804, jhcccro@jhmi.edu

    Adel Mandl

    Recruiting

  • CommonSpirit Saint Joseph Hospital - Bardstown

    Bardstown, Kentucky, 40004

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Louisiana Hematology Oncology Associates LLC

    Baton Rouge, Louisiana, 70809

    Site Public Contact, 225-215-1353, clinicalresearch@marybird.com

    Scott E. Delacroix

    Recruiting

  • Essentia Health - Baxter Clinic

    Baxter, Minnesota, 56425

    Site Public Contact, 218-828-2880

    Bret E. Friday

    Recruiting

  • McLaren Cancer Institute-Bay City

    Bay City, Michigan, 48706

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Houston Methodist San Jacinto Hospital

    Baytown, Texas, 77521

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Patrick E. Prath

    Recruiting

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio, 44122

    Site Public Contact, 800-641-2422, CTUReferral@UHhospitals.org

    Iris Y. Sheng

    Recruiting

  • FHCC Overlake

    Bellevue, Washington, 98004

    Site Public Contact, 425-454-2148

    Mikhail G. Perlov

    Recruiting

  • Kaiser Permanente-Bellflower

    Bellflower, California, 90706

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • PeaceHealth Saint Joseph Medical Center

    Bellingham, Washington, 98225

    Site Public Contact, 360-788-8223, achapman1@peacehealth.org

    Charles W. Drescher

    Recruiting

  • Saint Charles Health System

    Bend, Oregon, 97701

    Site Public Contact, 541-706-2909, nosall@stcharleshealthcare.org

    Charles W. Drescher

    Recruiting

  • Tower Cancer Research Foundation

    Beverly Hills, California, 90211

    Site Public Contact, towercancerresearch@toweroncology.com

    Edwin M. Posadas

    Recruiting

  • Billings Clinic Cancer Center

    Billings, Montana, 59101

    Site Public Contact, 800-996-2663, research@billingsclinic.org

    John M. Schallenkamp

    Recruiting

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706

    Suspended

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota, 56401

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • University of Michigan - Brighton Center for Specialty Care

    Brighton, Michigan, 48116

    Site Public Contact, 800-865-1125

    Zachery R. Reichert

    Recruiting

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan, 48183

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Clara Hwang

    Recruiting

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California, 91505

    Site Public Contact, 818-847-4793, Najee.Boucher@providence.org

    Charles W. Drescher

    Recruiting

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605

    Suspended

  • Mercy Cancer Center - Carmichael

    Carmichael, California, 95608

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Mercy San Juan Medical Center

    Carmichael, California, 95608

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@commonspirit.org

    Shahzad Siddique

    Recruiting

  • Saint Anthony Regional Hospital

    Carroll, Iowa, 51401

    Site Public Contact, 515-689-7658, sbenson@iora.org

    Seema Harichand-Herdt

    Recruiting

  • Mercy Hospital

    Cedar Rapids, Iowa, 52403

    Site Public Contact, 319-365-4673

    Deborah W. Wilbur

    Recruiting

  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa, 52403

    Site Public Contact, 319-363-2690

    Deborah W. Wilbur

    Recruiting

  • Providence Regional Cancer System-Centralia

    Centralia, Washington, 98531

    Site Public Contact, 360-412-8958, deidre.dillon@providence.org

    Charles W. Drescher

    Recruiting

  • Christiana Care Health System-Concord Health Center

    Chadds Ford, Pennsylvania, 19317

    Site Public Contact, 302-623-4450, lbarone@christianacare.org

    Gregory A. Masters

    Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina, 29425

    Site Public Contact, 843-792-9321, hcc-clinical-trials@musc.edu

    Kevin Becker

    Recruiting

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Atrium Health University City/LCI-University

    Charlotte, North Carolina, 28262

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Levine Cancer Institute-Ballantyne

    Charlotte, North Carolina, 28277

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908

    Site Public Contact, 434-243-6303, uvacancertrials@hscmail.mcc.virginia.edu

    Paul V. Viscuse

    Recruiting

  • Memorial Hospital of Laramie County

    Cheyenne, Wyoming, 82001

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    John M. Schallenkamp

    Recruiting

  • University of Illinois

    Chicago, Illinois, 60612

    Site Public Contact, 312-355-3046

    Karine Tawagi

    Recruiting

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Bethesda North Hospital

    Cincinnati, Ohio, 45242

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • TriHealth Cancer Institute-Anderson

    Cincinnati, Ohio, 45255

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Melissa A. Reimers

    Recruiting

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon, 97015

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

  • McLaren Cancer Institute-Clarkston

    Clarkston, Michigan, 48346

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Wake Forest University at Clemmons

    Clemmons, North Carolina, 27012

    Site Public Contact, 888-716-9259

    Michael McCormack

    Recruiting

  • Case Western Reserve University

    Cleveland, Ohio, 44106

    Site Public Contact, 800-641-2422, CTUReferral@UHhospitals.org

    Iris Y. Sheng

    Recruiting

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109

    Site Public Contact, 216-778-7559, ababal@metrohealth.org

    Joseph Attallah

    Recruiting

  • Cleveland Clinic Cancer Center/Fairview Hospital

    Cleveland, Ohio, 44111

    Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

    Shilpa Gupta

    Recruiting

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195

    Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

    Shilpa Gupta

    Recruiting

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan, 48038

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Clara Hwang

    Recruiting

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325

    Site Public Contact, 515-241-3305

    Richard L. Deming

    Recruiting

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Billings Clinic-Cody

    Cody, Wyoming, 82414

    Site Public Contact, 800-996-2663, research@billingsclinic.org

    John M. Schallenkamp

    Recruiting

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho, 83814

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, 80907

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado, 80909

    Site Public Contact, 719-365-2406

    Laura Graham

    Recruiting

  • Memorial Hospital North

    Colorado Springs, Colorado, 80920

    Site Public Contact, 719-364-6700

    Laura Graham

    Recruiting

  • Saint Francis Cancer Center

    Colorado Springs, Colorado, 80923

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210

    Site Public Contact, 800-293-5066, Jamesline@osumc.edu

    Danielle E. Zimmerman

    Recruiting

  • Atrium Health Cabarrus/LCI-Concord

    Concord, North Carolina, 28025

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Bay Area Hospital

    Coos Bay, Oregon, 97420

    Site Public Contact, 541-269-8392, cherie.cox@bayareahospital.org

    Charles W. Drescher

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Coral Springs

    Coral Springs, Florida, 33065

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky, 40701

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Ochsner Hematology Oncology North Shore - Covington (West Region)

    Covington, Louisiana, 70433

    Suspended

  • Greater Regional Medical Center

    Creston, Iowa, 50801

    Site Public Contact, 515-241-3305

    Richard L. Deming

    Recruiting

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Melissa A. Reimers

    Recruiting

  • Essentia Health - Saint Joseph's Crosslake Clinic

    Crosslake, Minnesota, 56442

    Site Public Contact, 218-692-1010

    Bret E. Friday

    Recruiting

  • Houston Methodist Cypress Hospital

    Cypress, Texas, 77429

    Site Public Contact, 346-356-1413, irb@houstonmethodist.org

    Patrick E. Prath

    Recruiting

  • Dallas VA Medical Center

    Dallas, Texas, 75216

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Jonathan E. Dowell

    Recruiting

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822

    Site Public Contact, 570-271-5251, HemonCCTrials@geisinger.edu

    Rajiv Panikkar

    Recruiting

  • Henry Ford Medical Center-Fairlane

    Dearborn, Michigan, 48126

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Clara Hwang

    Recruiting

  • Atlanta VA Medical Center

    Decatur, Georgia, 30033

    Site Public Contact, 404-321-6111 ext. 7632

    Wayne B. Harris

    Recruiting

  • Emory Decatur Hospital

    Decatur, Georgia, 30033

    Site Public Contact, 440-778-1868, clinicaltrialsoncology@dekalbmedical.org

    Bradley C. Carthon

    Recruiting

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • UCHealth - Cherry Creek

    Denver, Colorado, 80206

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Laura Graham

    Recruiting

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309

    Site Public Contact, 515-241-6727

    Seema Harichand-Herdt

    Recruiting

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa, 50309

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Broadlawns Medical Center

    Des Moines, Iowa, 50314

    Site Public Contact, 515-282-2200

    Seema Harichand-Herdt

    Recruiting

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314

    Site Public Contact, 515-241-3305

    Richard L. Deming

    Recruiting

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201

    Site Public Contact, 800-527-6266, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Henry Ford Hospital

    Detroit, Michigan, 48202

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Clara Hwang

    Recruiting

  • Essentia Health Saint Mary's - Detroit Lakes Clinic

    Detroit Lakes, Minnesota, 56501

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Geisinger Cancer Center Dickson City

    Dickson City, Pennsylvania, 18519

    Site Public Contact, 877-204-6081, hemoncctrials@geisinger.edu

    Rajiv Panikkar

    Recruiting

  • Dillon Health Center/Shaw Cancer Center

    Dillon, Colorado, 80435

    Site Public Contact, 970-470-7170

    Erin Schwab

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Doral

    Doral, Florida, 33166

    Site Public Contact, kginnity@med.miami.edu

    Janaki N. Sharma

    Recruiting

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010

    Site Public Contact, 800-826-4673, becomingapatient@coh.org

    Tanya B. Dorff

    Recruiting

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Essentia Health Saint Mary's Medical Center

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Miller-Dwan Hospital

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • CommonSpirit Cancer Center Mercy

    Durango, Colorado, 81301

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Mercy Medical Center

    Durango, Colorado, 81301

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026

    Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org

    Charles W. Drescher

    Recruiting

  • Shaw Cancer Center

    Edwards, Colorado, 81632

    Site Public Contact, 970-569-7429

    Erin Schwab

    Recruiting

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California, 95758

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Christiana Care - Union Hospital

    Elkton, Maryland, 21921

    Site Public Contact, 410-443-1360, frank.crum@christianacare.org

    Gregory A. Masters

    Recruiting

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois, 60126

    Site Public Contact, 630-758-5460, Jrohde@emhc.org

    Matthew Siegel

    Recruiting

  • Essentia Health - Ely Clinic

    Ely, Minnesota, 55731

    Site Public Contact, 218-365-7900

    Bret E. Friday

    Recruiting

  • Stanford Cancer Center Emeryville

    Emeryville, California, 94608

    Site Public Contact, 650-498-7061, ccto-office@stanford.edu

    Ali R. Khaki

    Recruiting

  • Providence Regional Cancer Partnership

    Everett, Washington, 98201

    Site Public Contact, 425-261-3529, marilyn.birchman@providence.org

    Charles W. Drescher

    Recruiting

  • Fairbanks Memorial Hospital

    Fairbanks, Alaska, 99701

    Site Public Contact, 907-458-3043, Veronica.Stevenson@foundationhealth.org

    John M. Schallenkamp

    Recruiting

  • Essentia Health Cancer Center-South University Clinic

    Fargo, North Dakota, 58103

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Weisberg Cancer Treatment Center

    Farmington Hills, Michigan, 48334

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • McLaren Cancer Institute-Flint

    Flint, Michigan, 48532

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Kaiser Permanente-Fontana

    Fontana, California, 92335

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Levine Cancer Institute - Rutherford

    Forest City, North Carolina, 28043

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • Poudre Valley Hospital

    Fort Collins, Colorado, 80524

    Site Public Contact, 970-297-6150

    Laura Graham

    Recruiting

  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado, 80528

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Laura Graham

    Recruiting

  • UI Healthcare Mission Cancer and Blood - Fort Dodge

    Fort Dodge, Iowa, 50501

    Site Public Contact, 515-282-2921, trials@missioncancer.com

    Seema Harichand-Herdt

    Recruiting

  • Essentia Health - Fosston

    Fosston, Minnesota, 56542

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • Malcom Randall Veterans Administration Medical Center

    Gainesville, Florida, 32610

    Site Public Contact, 352-273-8675, trials@cancer.ufl.edu

    Jess DeLaune

    Recruiting

  • Levine Cancer Institute-Gaston

    Gastonia, North Carolina, 28054

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • CHI Health Saint Francis

    Grand Island, Nebraska, 68803

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, 59405

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Great Falls Clinic

    Great Falls, Montana, 59405

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • UCHealth Greeley Hospital

    Greeley, Colorado, 80631

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Laura Graham

    Recruiting

  • Kaiser Permanente South Bay

    Harbor City, California, 90710

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Hi-Line Sletten Cancer Center

    Havre, Montana, 59501

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    John M. Schallenkamp

    Recruiting

  • Essentia Health-Hayward Clinic

    Hayward, Wisconsin, 54843

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Tamarack Health Hayward Medical Center

    Hayward, Wisconsin, 54843

    Site Public Contact, 218-568-4416

    Bret E. Friday

    Recruiting

  • Geisinger Medical Center-Cancer Center Hazleton

    Hazleton, Pennsylvania, 18201

    Site Public Contact, 570-459-2901, HemonCCTrials@geisinger.edu

    Rajiv Panikkar

    Recruiting

  • Benefis Helena Specialty Center

    Helena, Montana, 59601

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota, 55746

    Site Public Contact, 218-786-3308

    Bret E. Friday

    Recruiting

  • UCHealth Highlands Ranch Hospital

    Highlands Ranch, Colorado, 80129

    Site Public Contact, 720-848-0650

    Laura Graham

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Hollywood

    Hollywood, Florida, 33021

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii, 96813

    Site Public Contact, 808-524-6115, i.webster@hawaiicancercare.com

    Jeffrey L. Berenberg

    Recruiting

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii, 96813

    Site Public Contact, 808-532-0315

    Jeffrey L. Berenberg

    Recruiting

  • Queen's Medical Center

    Honolulu, Hawaii, 96813

    Site Public Contact, 808-545-8548

    Jeffrey L. Berenberg

    Recruiting

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813

    Site Public Contact, 808-522-4333

    Jeffrey L. Berenberg

    Recruiting

  • University of Hawaii Cancer Center

    Honolulu, Hawaii, 96813

    Site Public Contact, 808-586-2979

    Jeffrey L. Berenberg

    Recruiting

  • Hawaii Diagnostic Radiology Services LLC

    Honolulu, Hawaii, 96817

    Site Public Contact, 808-792-7897, mmiyoshi@hawaiidrs.com

    Jeffrey L. Berenberg

    Recruiting

  • Kuakini Medical Center

    Honolulu, Hawaii, 96817

    Site Public Contact, 808-547-9816

    Jeffrey L. Berenberg

    Recruiting

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii, 96817

    Site Public Contact, 808-531-8521

    Jeffrey L. Berenberg

    Recruiting

  • The Cancer Center of Hawaii-Liliha

    Honolulu, Hawaii, 96817

    Suspended

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826

    Site Public Contact, 808-983-6090

    Jeffrey L. Berenberg

    Recruiting

  • Tripler Army Medical Center

    Honolulu, Hawaii, 96859

    Site Public Contact, 808-433-6336

    Karen J. Shou

    Recruiting

  • Providence Hood River Memorial Hospital

    Hood River, Oregon, 97031

    Site Public Contact, 503-215-1979, canrsrchstudies@provdience.org

    Charles W. Drescher

    Recruiting

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030

    Site Public Contact, 713-798-1354, burton@bcm.edu

    Aihua E. Yen

    Recruiting

  • Ben Taub General Hospital

    Houston, Texas, 77030

    Site Public Contact, 713-873-2000

    Aihua E. Yen

    Recruiting

  • Houston Methodist Hospital

    Houston, Texas, 77030

    Site Public Contact, 713-790-2700

    Patrick E. Prath

    Recruiting

  • Michael E DeBakey VA Medical Center

    Houston, Texas, 77030

    Site Public Contact, 800-553-2278

    Aihua E. Yen

    Recruiting

  • UT MD Anderson Cancer Center

    Houston, Texas, 77030

    Site Public Contact, 866-632-6789, askmdanderson@mdanderson.org

    Paul Corn

    Recruiting

  • Methodist Willowbrook Hospital

    Houston, Texas, 77070

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Patrick E. Prath

    Recruiting

  • Houston Methodist West Hospital

    Houston, Texas, 77094

    Site Public Contact, 832-522-2873

    Patrick E. Prath

    Recruiting

  • Essentia Health - International Falls Clinic

    International Falls, Minnesota, 56649

    Site Public Contact, 218-283-9431

    Bret E. Friday

    Recruiting

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    Irvine, California, 92612

    Site Public Contact, 877-827-8839, ucstudy@uci.edu

    Omid Yazdanpanah

    Recruiting

  • City of Hope at Irvine Lennar

    Irvine, California, 92618

    Site Public Contact, 877-467-3411

    Tanya B. Dorff

    Recruiting

  • Kaiser Permanente-Irvine

    Irvine, California, 92618

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington, 98029

    Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org

    Charles W. Drescher

    Recruiting

  • Allegiance Health

    Jackson, Michigan, 49201

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Clara Hwang

    Recruiting

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216

    Site Public Contact, 601-815-6700

    John C. Henegan

    Recruiting

  • Essentia Health - Jamestown Clinic

    Jamestown, North Dakota, 58401

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Emory Johns Creek Hospital

    Johns Creek, Georgia, 30097

    Site Public Contact, 404-778-5714, m.lisa.hwang@emory.edu

    Bradley C. Carthon

    Recruiting

  • Straub Medical Center - Kahului Clinic

    Kahului, Hawaii, 96732

    Site Public Contact, lori.kam@hawaiipacifichealth.org

    Jeffrey L. Berenberg

    Recruiting

  • Castle Medical Center

    Kailua, Hawaii, 96734

    Suspended

  • Logan Health Medical Center

    Kalispell, Montana, 59901

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington, 99336

    Site Public Contact, 509-783-4637, research@kadlecmed.org

    Charles W. Drescher

    Recruiting

  • FHCC at EvergreenHealth

    Kirkland, Washington, 98034

    Site Public Contact, 425-899-6000

    Eric W. Dean

    Recruiting

  • Providence Regional Cancer System-Lacey

    Lacey, Washington, 98503

    Site Public Contact, 360-412-8958, deidre.dillon@providence.org

    Charles W. Drescher

    Recruiting

  • CommonSpirit Saint Anthony Hospital Cancer Center

    Lakewood, Colorado, 80228

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • City of Hope Antelope Valley

    Lancaster, California, 93534

    Site Public Contact, 800-826-4673, becomingapatient@coh.org

    Tanya B. Dorff

    Recruiting

  • Karmanos Cancer Institute at McLaren Greater Lansing

    Lansing, Michigan, 48910

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • McLaren Cancer Institute-Lapeer Region

    Lapeer, Michigan, 48446

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Cancer Centers of Southwest Oklahoma Research

    Lawton, Oklahoma, 73505

    Site Public Contact, 877-231-4440

    Adanma Anji Ayanambakkam Attanathi

    Recruiting

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756

    Site Public Contact, 800-639-6918, cancer.research.nurse@dartmouth.edu

    Rodwell Mabaera

    Recruiting

  • Beebe Medical Center

    Lewes, Delaware, 19958

    Site Public Contact, 302-291-6730, research@beebehealthcare.org

    Gregory A. Masters

    Recruiting

  • Geisinger Medical Oncology-Lewisburg

    Lewisburg, Pennsylvania, 17837

    Site Public Contact, 570-374-8555, HemonCCTrials@geisinger.edu

    Rajiv Panikkar

    Recruiting

  • CommonSpirit Saint Joseph Hospital - Lexington

    Lexington, Kentucky, 40504

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • CommonSpirit Saint Joseph Medical Center - East Lexington

    Lexington, Kentucky, 40509

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536

    Site Public Contact, 859-257-3379

    Zin W. Myint

    Recruiting

  • Wilcox Memorial Hospital and Kauai Medical Clinic

    Lihue, Hawaii, 96766

    Site Public Contact, 808-535-7960

    Jeffrey L. Berenberg

    Recruiting

  • Atrium Health Lincoln/LCI-Lincolnton

    Lincolnton, North Carolina, 28092

    Site Public Contact, 800-804-9376

    Earle F. Burgess

    Recruiting

  • CommonSpirit Saint Joseph Hospital London

    London, Kentucky, 40741

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • UCHealth Lone Tree Health Center

    Lone Tree, Colorado, 80124

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Laura Graham

    Recruiting

  • City of Hope at Long Beach Elm

    Long Beach, California, 90813

    Site Public Contact, 877-467-3411

    Tanya B. Dorff

    Recruiting

  • Longmont United Hospital

    Longmont, Colorado, 80501

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • PeaceHealth Saint John Medical Center

    Longview, Washington, 98632

    Site Public Contact, 360-514-2016, kmakin-bond@peacehealth.org

    Charles W. Drescher

    Recruiting

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Los Angeles General Medical Center

    Los Angeles, California, 90033

    Site Public Contact, 323-865-0451, uscnorrisinfo@med.usc.edu

    Jacek Pinski

    Recruiting

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033

    Site Public Contact, 323-865-0451

    Jacek Pinski

    Recruiting

  • Kaiser Permanente West Los Angeles

    Los Angeles, California, 90034

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048

    Site Public Contact, 310-423-2133, Cancer.trial.info@cshs.org

    Edwin M. Posadas

    Recruiting

  • The James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky, 40202

    Site Public Contact, 502-562-3429

    Rohit Kumar

    Recruiting

  • Baptist Health Louisville

    Louisville, Kentucky, 40207

    Site Public Contact, 502-897-8592, Cbcresearch@bhsi.com

    Vikas K. Singh

    Recruiting

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245

    Site Public Contact, 502-852-2755, ctoinfo@louisville.edu

    Rohit Kumar

    Recruiting

  • Medical Center of the Rockies

    Loveland, Colorado, 80538

    Site Public Contact, 970-203-7083

    Laura Graham

    Recruiting

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin, 53718

    Site Public Contact, 800-622-8922, clinicaltrials@cancer.wisc.edu

    Amy K. Taylor

    Recruiting

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792

    Site Public Contact, 800-622-8922, clinicaltrials@cancer.wisc.edu

    Amy K. Taylor

    Recruiting

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Levine Cancer Institute - Union West

    Matthews, North Carolina, 28104

    Site Public Contact, 980-442-0600

    Earle F. Burgess

    Recruiting

  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio, 44124

    Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

    Shilpa Gupta

    Recruiting

  • Bon Secours Memorial Regional Medical Center

    Mechanicsville, Virginia, 23116

    Site Public Contact, 804-893-8978, anne_carmellat@bshsi.org

    Joseph D. Pennington

    Recruiting

  • Asante Rogue Regional Medical Center

    Medford, Oregon, 97504

    Site Public Contact, 541-789-4673, research@asante.org

    Alison D. Savage

    Recruiting

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio, 44060

    Site Public Contact, 800-641-2422, CTUReferral@UHhospitals.org

    Iris Y. Sheng

    Recruiting

  • Mercy Cancer Center

    Merced, California, 95340

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Idaho Urologic Institute-Meridian

    Meridian, Idaho, 83642

    Suspended

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • Mary Bird Perkins Cancer Center - Metairie

    Metairie, Louisiana, 70002

    Site Public Contact, 504-584-6990

    Scott E. Delacroix

    Recruiting

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, 33176

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • Mount Sinai Medical Center

    Miami Beach, Florida, 33140

    Site Public Contact, 305-674-2625, Yvonne.Enriquez@msmc.com

    Bruno R. Bastos

    Recruiting

  • Bon Secours Saint Francis Medical Center

    Midlothian, Virginia, 23114

    Site Public Contact, 804-893-8978, anne_carmellat@bshsi.org

    Joseph D. Pennington

    Recruiting

  • Beebe South Coastal Health Campus

    Millville, Delaware, 19967

    Site Public Contact, 302-291-6730, research@beebehealthcare.org

    Gregory A. Masters

    Recruiting

  • Saint Patrick Hospital - Community Hospital

    Missoula, Montana, 59802

    Site Public Contact, 406-327-3118, amy.hanneman@providence.org

    Charles W. Drescher

    Recruiting

  • Community Medical Center

    Missoula, Montana, 59804

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Atrium Health Union/LCI-Union

    Monroe, North Carolina, 28112

    Site Public Contact, 980-442-2000

    Earle F. Burgess

    Recruiting

  • Essentia Health - Moose Lake Clinic

    Moose Lake, Minnesota, 55767

    Site Public Contact, 218-485-4481

    Bret E. Friday

    Recruiting

  • McLaren Cancer Institute-Macomb

    Mount Clemens, Michigan, 48043

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • McLaren Cancer Institute-Central Michigan

    Mount Pleasant, Michigan, 48858

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • CommonSpirit Saint Joseph Hospital Mount Sterling

    Mount Sterling, Kentucky, 40353

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Skagit Regional Health Cancer Care Center

    Mount Vernon, Washington, 98274

    Site Public Contact, 360-814-2182, rcccclinicalresearch@skagitvalleyhospital.org

    Charles W. Drescher

    Recruiting

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin, 53149

    Active, not recruiting

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, 83687

    Suspended

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83687

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • Providence Queen of The Valley

    Napa, California, 94558

    Site Public Contact, 707-521-3830

    Charles W. Drescher

    Recruiting

  • Edward Hospital/Cancer Center

    Naperville, Illinois, 60540

    Site Public Contact, 630-646-6075

    Matthew Siegel

    Recruiting

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232

    Site Public Contact, 800-811-8480

    Kerry R. Schaffer

    Recruiting

  • Houston Methodist Saint John Hospital

    Nassau Bay, Texas, 77058

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Patrick E. Prath

    Recruiting

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112

    Site Public Contact, 504-210-3539, emede1@lsuhsc.edu

    Rajasree P. Chowdry

    Recruiting

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana, 70121

    Site Public Contact, 504-842-8084, Elisemarie.curry@ochsner.org

    Brian T. Halbert

    Recruiting

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713

    Site Public Contact, 302-623-4450, lbarone@christianacare.org

    Gregory A. Masters

    Recruiting

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware, 19713

    Site Public Contact, 302-623-4450, lbarone@christianacare.org

    Gregory A. Masters

    Recruiting

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware, 19718

    Site Public Contact, 302-623-4450, lbarone@christianacare.org

    Gregory A. Masters

    Recruiting

  • Providence Newberg Medical Center

    Newberg, Oregon, 97132

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

  • USC Norris Oncology/Hematology-Newport Beach

    Newport Beach, California, 92663

    Site Public Contact, 323-865-0451

    Jacek Pinski

    Recruiting

  • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

    North Miami, Florida, 33181

    Site Public Contact, kginnity@med.miami.edu

    Janaki N. Sharma

    Recruiting

  • Henry Ford Medical Center-Columbus

    Novi, Michigan, 48377

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Clara Hwang

    Recruiting

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin, 53066

    Active, not recruiting

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104

    Site Public Contact, 405-271-8777, ou-clinical-trials@ouhsc.edu

    Adanma Anji Ayanambakkam Attanathi

    Recruiting

  • Alegent Health Immanuel Medical Center

    Omaha, Nebraska, 68122

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Alegent Health Bergan Mercy Medical Center

    Omaha, Nebraska, 68124

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Alegent Health Lakeside Hospital

    Omaha, Nebraska, 68130

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Kaiser Permanente-Ontario

    Ontario, California, 91761

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon, 97914

    Suspended

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California, 92868

    Site Public Contact, 877-827-8839, ucstudy@uci.edu

    Omid Yazdanpanah

    Recruiting

  • Providence Willamette Falls Medical Center

    Oregon City, Oregon, 97045

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California, 94304

    Site Public Contact, 650-498-7061, ccto-office@stanford.edu

    Ali R. Khaki

    Recruiting

  • VA Palo Alto Health Care System

    Palo Alto, California, 94304

    Site Public Contact, 800-455-0057

    Divya A. Parikh

    Recruiting

  • Kaiser Permanente - Panorama City

    Panorama City, California, 91402

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Helen H. Moon

    Recruiting

  • Essentia Health - Park Rapids

    Park Rapids, Minnesota, 56470

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Keck Medical Center of USC Pasadena

    Pasadena, California, 91105

    Site Public Contact, 323-865-0451

    Jacek Pinski

    Recruiting

  • UI Healthcare Mission Cancer and Blood - Pella

    Pella, Iowa, 50219

    Site Public Contact, 515-282-2921, trials@missioncancer.com

    Seema Harichand-Herdt

    Recruiting

  • Essentia Health - Saint Joseph's Pequot Lakes Clinic

    Pequot Lakes, Minnesota, 56472

    Site Public Contact, 218-568-4416

    Bret E. Friday

    Recruiting

  • McLaren Cancer Institute-Northern Michigan

    Petoskey, Michigan, 49770

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Philadelphia Veterans Administration Medical Center

    Philadelphia, Pennsylvania, 19104

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Yu-Ning Wong

    Recruiting

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona, 85004

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Essentia Health - Saint Joseph's Pine River Clinic

    Pine River, Minnesota, 56474

    Site Public Contact, 218-587-4416

    Bret E. Friday

    Recruiting

  • FirstHealth of the Carolinas-Moore Regional Hospital

    Pinehurst, North Carolina, 28374

    Site Public Contact, 910-715-3500, jcwilliams@firsthealth.org

    Charles S. Kuzma

    Recruiting

  • Edward Hospital/Cancer Center?Plainfield

    Plainfield, Illinois, 60585

    Site Public Contact, 630-646-6075, Cancerresearch@edward.org

    Matthew Siegel

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida, 33324

    Site Public Contact, 305-243-2647

    Janaki N. Sharma

    Recruiting

  • McLaren-Port Huron

    Port Huron, Michigan, 48060

    Site Public Contact, 313-576-9790, ctoadmin@karmanos.org

    Frank C. Cackowski

    Recruiting

  • Providence Portland Medical Center

    Portland, Oregon, 97213

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

  • Providence Saint Vincent Medical Center

    Portland, Oregon, 97225

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

  • Oregon Health and Science University

    Portland, Oregon, 97239

    Site Public Contact, 503-494-1080, trials@ohsu.edu

    Alexandra O. Sokolova

    Recruiting

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho, 83854

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Geisinger Cancer Services-Pottsville

    Pottsville, Pennsylvania, 17901

    Site Public Contact, 800-275-6401, HemonCCTrials@geisinger.edu

    Rajiv Panikkar

    Recruiting

  • Rhode Island Hospital

    Providence, Rhode Island, 02903

    Site Public Contact, 401-444-1488

    Ariana Santopietro

    Recruiting

  • Miriam Hospital

    Providence, Rhode Island, 02906

    Suspended

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado, 81004

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Charles Health System-Redmond

    Redmond, Oregon, 97756

    Site Public Contact, 541-706-2909

    Charles W. Drescher

    Recruiting

  • Beebe Health Campus

    Rehoboth Beach, Delaware, 19971

    Site Public Contact, 302-291-6730, research@beebehealthcare.org

    Gregory A. Masters

    Recruiting

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Bon Secours Richmond Community Hospital

    Richmond, Virginia, 23223

    Site Public Contact, 804-893-8978, anne_carmellat@bshsi.org

    Joseph D. Pennington

    Recruiting

Other trials in United States

Canada19 sites, 19 recruiting

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2

    Site Public Contact, 780-432-8500

    Michael P. Kolinsky

    Recruiting

  • Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1

    Site Public Contact, 706-522-6237 ext. 2401, japaquette@hrsrh.on.ca

    Eoghan R. Malone

    Recruiting

  • CSSS Champlain-Charles Le Moyne

    Greenfield Park, Quebec, J4V 2H1

    Site Public Contact, 450-466-5065

    Trung N. Nguyen

    Recruiting

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, L8V 5C2

    Site Public Contact, 905-387-9495

    Sebastien J. Hotte

    Recruiting

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7

    Site Public Contact, 613-549-6666, cc-clinicaltrials@kgh.kari.net

    Martin Smoragiewicz

    Recruiting

  • Waterloo Regional Health Network

    Kitchener, Ontario, N2G 1G3

    Site Public Contact, 519-749-4370, research@wrhn.ca

    Anupam Batra

    Recruiting

  • London Regional Cancer Program

    London, Ontario, N6A 4L6

    Site Public Contact, 519-685-8600

    Lorin Dodbiba

    Recruiting

  • Trillium Health Partners - Credit Valley Hospital

    Mississauga, Ontario, L5M 2N1

    Site Public Contact, 905-813-4040

    Daniel Yokom

    Recruiting

  • CIUSSSEMTL-Hopital Maisonneuve-Rosemont

    Montreal, Quebec, H1T 2M4

    Site Public Contact, 514-252-3400 ext. 3329

    Caroline Letendre

    Recruiting

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2

    Site Public Contact, 514-340-8222 ext. 8248

    April Rose

    Recruiting

  • Ottawa Hospital and Cancer Center-General Campus

    Ottawa, Ontario, K1H 8L6

    Site Public Contact, 613-761-4395

    Michael Ong

    Recruiting

  • CHA Hopital L'Enfant-Jesus

    Québec, Quebec, G1J 1Z4

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Eric Levesque

    Recruiting

  • Niagara Health System-Saint Catharines General

    Saint Catharines, Ontario, L2S 0A9

    Site Public Contact, 905-682-6451

    David W. Wasserman

    Recruiting

  • Atlantic Health Sciences Corporation-Saint John Regional Hospital

    Saint John, New Brunswick, E2L 4L2

    Site Public Contact, 506-648-6890

    Samantha L. Gray

    Recruiting

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4

    Site Public Contact, 306-655-2914

    Nayyer Iqbal

    Recruiting

  • Odette Cancer Centre- Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5

    Site Public Contact, 416-480-5000

    Daniel J. Khalaf

    Recruiting

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9

    Site Public Contact, 416-946-4501, clinical.trials@uhn.on.ca

    Di Maria Jiang

    Recruiting

  • BCCA-Vancouver Cancer Centre

    Vancouver, British Columbia, V5Z 4E6

    Site Public Contact, 888-939-3333

    Corinne Maurice Dror

    Recruiting

  • CancerCare Manitoba

    Winnipeg, Manitoba, R3E 0V9

    Site Public Contact, 866-561-1026, ctu_web@cancercare.mb.ca

    Hanbo Zhang

    Recruiting

Other trials in Canada

Mexico1 site, 1 recruiting

  • Instituto Nacional De Cancerologia de Mexico

    Mexico City, Tlalpan, 14080

    Site Public Contact, (52) 5628-0400

    Nora Sobrevilla-Moreno

    Recruiting

Other trials in Mexico

Uruguay1 site, 1 recruiting

  • Hospital de Clinicas Dr Manuel Quintela

    Montevideo, 11600

    Site Public Contact, 598 2 4000101 X 1934, comunicaciones@msp.gub.uy

    Noelia Silveyra

    Recruiting

Other trials in Uruguay

About this study

Official title: A Randomized Phase III Clinical Trial for the Addition of Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs?

This study would like to find out if this approach is better or worse than the usual approach for prostate cancer.

The usual approach for patients who are not in a study is hormone treatment with Androgen Deprivation Therapy (ADT) and Androgen-Receptor Pathway Inhibitor (ARPI).

Read the detailed description

This is an international multi-centre, open-label, randomized phase III trial comparing Docetaxel chemotherapy added to standard of care Androgen Deprivation Therapy (ADT) + Androgen-Receptor Pathway Inhibitor (ARPI) versus standard of care Androgen Deprivation Therapy (ADT) + Androgen-Receptor Pathway Inhibitor (ARPI) in participants with metastatic castration sensitive prostate cancer (mCSPC) who have a suboptimal PSA response after 6-12 months of androgen-targeting therapy.

Being tested
Abiraterone, Enzalutamide, Apalutamide, Darolutamide (BAY 1841788), Docetaxel
Keywords
PR26, Castration sensitive
Medical subject headings
Prostatic Neoplasms, Adenocarcinoma

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • AbirateroneDrug

    Assigned prior to enrollment

  • EnzalutamideDrug

    Assigned prior to enrollment

  • ApalutamideDrug

    Assigned prior to enrollment

  • Darolutamide (BAY 1841788)Drug

    Assigned prior to enrollment

  • DocetaxelDrug

    Assigned at enrollment

  • ADTDrug

    Physician's choice. Assigned prior to enrollment

Study groups in NCT06592924
Study groupRoleWhat they receive
Standard ADT + ARPIActive comparatorNot described
Receives: Drug: Abiraterone; Drug: Enzalutamide; Drug: Apalutamide; Drug: Darolutamide (BAY 1841788); Drug: ADT
Docetaxel + Standard ADT + ARPIExperimentalNot described
Receives: Drug: Abiraterone; Drug: Enzalutamide; Drug: Apalutamide; Drug: Darolutamide (BAY 1841788); Drug: Docetaxel; Drug: ADT

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall Survival

    Measured: 39 months

Secondary outcomes (4)

  1. PSA Progression compared in both arms

    Measured: 39 months

  2. PSA Response comparison between arms

    PCWG3 criteria

    Measured: 39 months

  3. PSA Kinetics compared between both arms

    • 90% PSA decline
    • PSA <0.2ng/ml
    • PSA <0.02ng/ml

    Measured: 39 months

  4. Clinical progression-free survival between both arms

    Measured: 39 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted19 Sep 2024
  2. Study start28 May 2025
  3. Primary completion14 Mar 2031 (estimated)
  4. Study completion15 Apr 2031 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
830 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06592924
Sponsor's protocol ID
CCTG-PR26
Other IDs
CCTG-PR26, NCI-2024-07535
Acronym
TRIPLE-SWITCH
Status last verified
Jun 2026
First submitted
9 Sep 2024
Last updated
14 Jul 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No

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