Alcohol IntoxicationREACTNCT06579521
Real-world Experiences of Alcohol and Cognitions Over Time
A study testing Alcohol in people with Alcohol Intoxication, run by University of Washington at 1 site in United States.
Trial summary
The goal of this clinical trial is to examine how alcohol affects young adults' attention in both laboratory and real-world settings through phone-based cognitive tasks. The main questions this trial is designed to answer are: How well do the phone-based cognitive tasks capture alcohol's effects on attention? Does the… Read more about this study
- Who is it for?
- Ages 21 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Alcohol Intoxication
- What is being tested?
- Alcohol
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 92 participants
- Where
- 1 siteUnited States
- Study dates
- 18 Aug 2024to 31 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- aged 21-25
- drink at least 2x/week in the past month
- at least 1 past-month heavy episodic drinking event (4+/5+ standard drinks in a day for females/males)
- have an iPhone
- able to read and understand English
- willing to complete all study procedures
Who cannot join
- history of alcohol-related treatment or hospitalization
- medical contraindications for alcohol consumption (e.g., contraindicated medication, major psychiatric illness, history of seizure, gastric bypass surgery, cardiac pacemaker, major illness such as liver cirrhosis or hepatitis, past traumatic brain injury, asthma exacerbated by alcohol use, consistent flushing response to alcohol use) or pregnancy, nursing an infant, or plans to become pregnant in the next 8 weeks (i.e., during the EMA monitoring period)
- substantial visual impairment or color blindness (given that cognitive tasks rely on visual cues)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Connecting Alcohol Myopia to Real-World Risk Behaviors Through Cognitive Ecological Momentary Assessment (REACT Phase II: Lab and EMA)
The goal of this clinical trial is to examine how alcohol affects young adults' attention in both laboratory and real-world settings through phone-based cognitive tasks. The main questions this trial is designed to answer are:
- How well do the phone-based cognitive tasks capture alcohol's effects on attention?
- Does the effect of alcohol on attention contribute to risk-taking?
Participants will complete cognitive tasks to assess attention before and after consuming a standard amount of alcohol in the laboratory, and during surveys completed through a phone app for eight weekends.
Read the detailed description
The goal of this study is to develop cognitive tasks that assess alcohol-related attentional narrowing (i.e., alcohol myopia) for smartphone-based ecological momentary assessment (EMA). In Phase I, tasks were adapted from computer to smartphone format and refined through interviews with young adults who provided feedback on mock-ups. In Phase II (the current trial), feasibility, acceptability, reliability, and validity of the adapted tasks will be tested in lab and EMA. Young adults who pass an online pre-screening and phone screening will complete an initial lab session involving self-report questionnaires, alcohol consumption (target breath alcohol concentration [BrAC] = .08%), and general cognitive and myopia-specific tasks. All participants in Phase II will be assigned to receive a dose of alcohol in the lab session; task performance will be compared within individuals from before to after they are intoxicated. Participants will remain in the lab until their BrAC reduces to a level of .03% and they can pass a field sobriety test. These same participants will then complete EMA while wearing transdermal alcohol biosensors for 8 consecutive weekends, including one morning survey and at least two evening surveys per day. Then, participants will return to the lab for a follow-up session involving self-report questions and an interview eliciting additional feedback. Findings will help to clarify the role of alcohol myopia as a mechanism linking intoxication to real-world risk behaviors.
- Conditions
- Alcohol Intoxication
- Being tested
- Alcohol
- Medical subject headings
- Alcoholic Intoxication
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AlcoholOther
A standard dose of alcohol will be administered (volume calculated with regard to age, sex assigned at birth, height, and weight) in the form of vodka and combined with mixer at a 1:4 ratio to reach a target breath alcohol concentration of .08%.
| Study group | Role | What they receive |
|---|---|---|
| Alcohol | Experimental | Not described Receives: Other: Alcohol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Central Counting Task (phone)
On a phone, participants will count the number of times a crosshair flashes in the center of the screen. Each trial will include between 1 and 4 flashes. There will be 6 trials per block. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated.
Measured: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Peripheral Probe Identification Task (phone)
While counting the number of times a crosshair flashes in the center of a phone screen (central counting task), participants will also be asked to monitor a cued corner (if possible), and shown an array of four colored stimuli. In each trial, they will be asked to identify whether the color of a probe matches the cued stimulus, with a 50% likelihood of matching. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated.
Measured: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Visual Categorization Task (phone)
On a phone, participants will be presented with one of two visual stimuli (shapes) in a random sequence with equal probability, and asked to categorize each stimuli as quickly as possible (e.g., "Is this a square or circle?") with placement of response buttons (right or left side of screen) randomized. Each trial consists of a shape categorization. There are 12 trials per block. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Differences in response time will be evaluated for one-back stimuli (change vs. no change) and two-back stimuli (change vs. no change).
Measured: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Secondary outcomes (3)
Central Counting Task (desktop)
On a phone, participants will count the number of times a crosshair flashes in the center of the screen. Each trial will include between 1 and 4 flashes. A training block of 12 trials will be administered while sober. After alcohol consumption, two blocks of 120 trials each will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated.
Measured: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Peripheral Probe Identification Task (desktop)
While counting the number of times a crosshair flashes in the center of a desktop screen (central counting task), participants will also be asked to monitor a cued corner (if possible), and shown an array of four colored stimuli. In each trial, they will be asked to identify whether the color of a probe matches the cued stimulus, with a 50% likelihood of matching. A training block of 12 trials will be administered while sober. After alcohol consumption, two blocks of 120 trials each will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated.
Measured: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Auditory Categorization Task (desktop)
On a desktop, participants will be presented with one of two auditory stimuli (high and low tones) in a random sequence with equal probability, and asked to categorize each stimuli as quickly as possible with placement of response options (shown on right or left side of screen) randomized. Each trial consists of a shape categorization. A training block of 12 trials will be administered while sober. After alcohol consumption, five blocks of 100 trials each will be administered on the ascending limb of the BrAC curve. Differences in response time will be evaluated for one-back stimuli (change vs. no change) and two-back stimuli (change vs. no change).
Measured: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Aug 2024
- Study start18 Aug 2024
- Primary completion31 Aug 2025
- Study completion31 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alcohol IntoxicationStudies of the same condition, open and under way.
- More trials run by University of WashingtonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 92 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Washington
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Responsible party
- Principal investigator, Anna Jaffe, University of Washington
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06579521
- Sponsor's protocol ID
- STUDY00018677
- Other IDs
- R21AA029489
- Acronym
- REACT
- Status last verified
- Nov 2025
- First submitted
- 15 Aug 2024
- Last updated
- 17 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The investigators plan to share limited, de-identified datasets for the purposes of data analysis and dissemination.
Study at a glance
From the registry record, last updated by the sponsor on 17 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Connecting Alcohol Myopia to Real-World Risk Behaviors Through Cognitive Ecological Momentary Assessment (REACT Phase II: Lab and EMA)
- ClinicalTrials.gov ID
- NCT06579521
- Acronym / sponsor ID
- REACT / STUDY00018677
- Conditions
- Alcohol Intoxication
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 92 participants (actual)
- Lead sponsor
- University of WashingtonUniversity, hospital or other
- Collaborators
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Study start
- 18 Aug 2024 (actual)
- Primary completion
- 31 Aug 2025 (actual)
- Study completion
- 31 Aug 2025 (actual)
- First posted
- 30 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to examine how alcohol affects young adults' attention in both laboratory and real-world settings through phone-based cognitive tasks. The main questions this trial is designed to answer are:
- How well do the phone-based cognitive tasks capture alcohol's effects on attention?
- Does the effect of alcohol on attention contribute to risk-taking?
Participants will complete cognitive tasks to assess attention before and after consuming a standard amount of alcohol in the laboratory, and during surveys completed through a phone app for eight weekends.
Detailed description
The goal of this study is to develop cognitive tasks that assess alcohol-related attentional narrowing (i.e., alcohol myopia) for smartphone-based ecological momentary assessment (EMA). In Phase I, tasks were adapted from computer to smartphone format and refined through interviews with young adults who provided feedback on mock-ups. In Phase II (the current trial), feasibility, acceptability, reliability, and validity of the adapted tasks will be tested in lab and EMA. Young adults who pass an online pre-screening and phone screening will complete an initial lab session involving self-report questionnaires, alcohol consumption (target breath alcohol concentration [BrAC] = .08%), and general cognitive and myopia-specific tasks. All participants in Phase II will be assigned to receive a dose of alcohol in the lab session; task performance will be compared within individuals from before to after they are intoxicated. Participants will remain in the lab until their BrAC reduces to a level of .03% and they can pass a field sobriety test. These same participants will then complete EMA while wearing transdermal alcohol biosensors for 8 consecutive weekends, including one morning survey and at least two evening surveys per day. Then, participants will return to the lab for a follow-up session involving self-report questions and an interview eliciting additional feedback. Findings will help to clarify the role of alcohol myopia as a mechanism linking intoxication to real-world risk behaviors.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Alcohol | Experimental | Other: Alcohol |
Who may qualify
- Ages
- 21 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- aged 21-25
- drink at least 2x/week in the past month
- at least 1 past-month heavy episodic drinking event (4+/5+ standard drinks in a day for females/males)
- have an iPhone
- able to read and understand English
Key exclusion criteria (3 listed)
- history of alcohol-related treatment or hospitalization
- medical contraindications for alcohol consumption (e.g., contraindicated medication, major psychiatric illness, history of seizure, gastric bypass surgery, cardiac pacemaker, major illness such as liver cirrhosis or hepatitis, past traumatic brain injury, asthma exacerbated by alcohol use, consistent flushing response to alcohol use) or pregnancy, nursing an infant, or plans to become pregnant in the next 8 weeks (i.e., during the EMA monitoring period)
- substantial visual impairment or color blindness (given that cognitive tasks rely on visual cues)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AlcoholA standard dose of alcohol will be administered (volume calculated with regard to age, sex assigned at birth, height, and weight) in the form of vodka and combined with mixer at a 1:4 ratio to reach a target breath alcohol concentration of .08%. | Other | Alcohol |
Primary outcome
Central Counting Task (phone)
Time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
On a phone, participants will count the number of times a crosshair flashes in the center of the screen. Each trial will include between 1 and 4 flashes. There will be 6 trials per block. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated.
Peripheral Probe Identification Task (phone)
Time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
While counting the number of times a crosshair flashes in the center of a phone screen (central counting task), participants will also be asked to monitor a cued corner (if possible), and shown an array of four colored stimuli. In each trial, they will be asked to identify whether the color of a probe matches the cued stimulus, with a 50% likelihood of matching. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated.
Visual Categorization Task (phone)
Time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
On a phone, participants will be presented with one of two visual stimuli (shapes) in a random sequence with equal probability, and asked to categorize each stimuli as quickly as possible (e.g., "Is this a square or circle?") with placement of response buttons (right or left side of screen) randomized. Each trial consists of a shape categorization. There are 12 trials per block. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Differences in response time will be evaluated for one-back stimuli (change vs. no change) and two-back stimuli (change vs. no change).
3 secondary outcomes
Central Counting Task (desktop)
Time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Peripheral Probe Identification Task (desktop)
Time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Auditory Categorization Task (desktop)
Time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Dec 2025.
- Individual participant dataSharing planned: Yes. The investigators plan to share limited, de-identified datasets for the purposes of data analysis and dissemination.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Alcohol in people with Alcohol Intoxication, run by University of Washington at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Central Counting Task (phone) (time frame: Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Dec 2025.