Acute Respiratory InfectionsVITD-ARINCT06547749
Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections
An observational study of Acute Respiratory Infections and Critical Illness in Children, run by Assiut University at 1 site in Egypt.
Trial summary
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs). Read more about this study
- Who is it for?
- Ages 1 month to 16 years
- Conditions the study is for
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency
- What is being tested?
- Serum 25-Hydroxyvitamin D Assessment
- How many people
- 63 participants
- Where
- 1 siteEgypt
- Study dates
- Jun 2026to Apr 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 month to 16 years
- All sexes
- No healthy volunteers
- Child
Study population: The study involves pediatric patients admitted to the Pediatric Intensive Care Unit (PICU) at a tertiary care hospital who meet the diagnostic criteria for acute respiratory infections.
Who may be able to join
- Children aged between 1 month and 12 years.
- Admitted to the PICU with a primary diagnosis of acute respiratory infection.
- Diagnosis confirmed by clinical symptoms and radiological evidence.
Who cannot join
- Children with known chronic bone diseases or metabolic disorders.
- Patients receiving vitamin D supplementation prior to admission.
- Patients with chronic renal or hepatic failure.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Assessment of Serum Vitamin D Status and Its Association With Disease Severity and Mortality Risk Among Critically Ill Children With Acute Respiratory Infections: A Cross-Sectional Study
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs). Vitamin D has an important role not only in bone metabolism but also in regulation of innate and adaptive immune responses, especially within the respiratory tract. Recent evidence suggests that vitamin D deficiency may be associated with increased susceptibility to respiratory infections, greater disease severity, prolonged hospitalization, and higher mortality rates in critically ill children.
This observational cross-sectional study aims to assess serum vitamin D status among critically ill children admitted to the PICU with acute respiratory infections and to evaluate the relationship between vitamin D levels, severity of respiratory illness, and risk of mortality. The study will include pediatric patients aged 1 month to 16 years admitted to the Pediatric Intensive Care Unit of Assiut University Children's Hospital.
Read more
Clinical evaluation and laboratory investigations, including serum 25-hydroxyvitamin D levels, serum calcium, and alkaline phosphatase, will be performed within the first 24 hours of admission. Severity of respiratory distress will be assessed using the Pediatric Respiratory Severity Score (PRESS), while mortality risk will be evaluated using the Pediatric Risk of Mortality Score (PRISM III).
The findings of this study may contribute to better understanding of the role of vitamin D in critically ill children with respiratory infections and may support future strategies for early risk assessment and improved clinical management in pediatric intensive care settings.
Read the detailed description
Acute respiratory infections remain a major global health problem and are a leading cause of morbidity and mortality among pediatric populations, particularly in low- and middle-income countries. Critically ill children admitted to pediatric intensive care units (PICUs) with severe respiratory infections are at increased risk of complications, prolonged hospitalization, and mortality. Identifying modifiable risk factors associated with disease severity and poor outcomes is therefore of significant clinical importance.
Vitamin D is a fat-soluble steroid hormone traditionally recognized for its role in calcium and phosphorus homeostasis and skeletal development. However, increasing evidence has demonstrated that vitamin D also has immunomodulatory functions through its effects on innate and adaptive immunity. Vitamin D receptors are expressed in immune cells, including macrophages and respiratory epithelial cells, supporting its role in host defense against respiratory pathogens.
Recent studies have suggested an association between vitamin D deficiency and increased susceptibility to acute respiratory infections, sepsis, and adverse outcomes in critically ill children. Nevertheless, available evidence remains inconsistent, and data from pediatric intensive care populations in Egypt and similar settings are limited.
This cross-sectional observational study will be conducted at the Pediatric Intensive Care Unit of Assiut University Children's Hospital. The study will include children aged 1 month to 16 years admitted with acute respiratory infections. Patients with chronic illnesses affecting vitamin D metabolism, severe immunodeficiency, congenital heart disease, malnutrition, rickets, or recent vitamin D supplementation will be excluded.
At PICU admission, all eligible participants will undergo detailed history taking, complete clinical examination, and laboratory investigations. Serum 25-hydroxyvitamin D [25(OH)D] levels will be measured within the first 24 hours of admission as the standard indicator of vitamin D status. Vitamin D levels will be categorized according to international clinical practice guidelines into deficiency, insufficiency, sufficiency, and toxicity.
Severity of respiratory illness will be evaluated using the Pediatric Respiratory Severity Score (PRESS), a validated clinical scoring system for respiratory distress in children. Mortality risk will be assessed using the Pediatric Risk of Mortality Score (PRISM III), which incorporates physiological and laboratory parameters obtained during the first 24 hours of PICU admission.
The primary outcome of the study is the prevalence of vitamin D deficiency among critically ill children with acute respiratory infections. Secondary outcomes include the association between serum vitamin D levels and both respiratory disease severity and mortality risk.
Data will be statistically analyzed using SPSS software. Appropriate statistical tests will be selected according to the type and distribution of data, and statistical significance will be considered at p < 0.05.
This study may provide important insights into the clinical significance of vitamin D deficiency in critically ill pediatric patients and may support future preventive and therapeutic strategies aimed at improving outcomes in children with severe respiratory infections.
- Conditions
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency, Pediatric Respiratory Infections, Respiratory Distress
- Being tested
- Serum 25-Hydroxyvitamin D Assessment
- Keywords
- 25-hydroxyvitamin D, Vitamin D, Pediatric intensive care unit, PICU, Acute respiratory infection, Critically ill children, Pediatric respiratory severity score, Respiratory infection severity, Pediatric critical care, Mortality risk
- Medical subject headings
- Vitamin D Deficiency, Dyspnea
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Serum 25-Hydroxyvitamin D AssessmentDiagnostic test
Also called Serum Vitamin D Measurement, 25(OH)D Testing
Blood samples will be collected within the first 24 hours of admission to the Pediatric Intensive Care Unit (PICU) to measure serum 25-hydroxyvitamin D [25(OH)D] levels, which is the standard biomarker used to assess vitamin D status. The measured vitamin D levels will be analyzed in relation to the severity of acute respiratory infections using the Pediatric Respiratory Severity Score (PRESS) and the risk of mortality using the Pediatric Risk of Mortality Score (PRISM III). No therapeutic intervention or vitamin D supplementation will be administered as part of the study protocol.
| Study group | Role | What they receive |
|---|---|---|
| Critically Ill Children With Acute Respiratory Infections | This cohort includes pediatric patients aged 1 month to 16 years admitted to the Pediatric Intensive Care Unit (PICU) with acute respiratory infections. Participants will undergo clinical evaluation and laboratory assessment, including measurement of serum 25-hydroxyvitamin D levels within the first 24 hours of admission. Disease severity will be assessed using the Pediatric Respiratory Severity Score (PRESS), and mortality risk will be evaluated using the Pediatric Risk of Mortality Score (PRISM III). No interventions will be assigned as part of the study protocol. Receives: Diagnostic Test: Serum 25-Hydroxyvitamin D Assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of Vitamin D Deficiency among critically ill children with acute respiratory infections.
This measure evaluates the baseline vitamin D status of pediatric patients admitted to the PICU with acute respiratory infections. Vitamin D status is determined by measuring serum 25-hydroxyvitamin D [25(OH)D] levels. According to the Endocrine Society guidelines, deficiency is defined as levels <20 ng/mL.
Measured: Within the first 24 hours of admission to the Pediatric Intensive Care Unit (PICU).
Secondary outcomes (2)
Association between Vitamin D and Severity of ARI
Analysis of the relationship between serum vitamin D levels and the severity of acute respiratory infections (ARI) as measured by the Pediatric Respiratory Severity Score (PRESS). The PRESS score (0-5) categorizes distress as mild, moderate, or severe.
Measured: Within the first 24 hours of PICU admission.
Association between Vitamin D and Risk of Mortality
Analysis of the relationship between serum vitamin D levels and the risk of mortality as assessed by the Pediatric Risk of Mortality score (PRISM III). This score is based on 17 physiological variables.
Measured: Within the first 24 hours of PICU admission.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Aug 2024
- Study startJun 2026 (estimated)
- Primary completionMar 2027 (estimated)
- Study completionApr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (10)Papers the sponsor has linked to this study.
- Other trials for Acute Respiratory InfectionsStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 63 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Ali Hassan Mohamed, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06547749
- Sponsor's protocol ID
- VITD01
- Acronym
- VITD-ARI
- Status last verified
- May 2026
- First submitted
- 2 Aug 2024
- Last updated
- 8 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Thokngaen J, Karoonboonyanan W. Pediatric respiratory severity score evaluates disease severity of respiratory tract infection in children. Chulalongkorn Med J. 2019;63(1):Article 7. doi: 10.58837/CHULA.CMJ.63.1.6
Kangel D, Kıral A. The effect of vitamin D level on the clinical course of the disease in patients with lower respiratory tract infection. Cam Sakura Med J. 2025;5(1):17-24. doi: 10.58519/csmedj.galenos.2025.2025-3-2
Gunes N, Cam H. An observational study of serum vitamin D status in critically ill children admitted to the pediatric intensive care unit. Arch Med Sci. 2022 Oct 6;21(2):471-477. doi: 10.5114/aoms/155137. eCollection 2025.
PubMed 40395895Chandana HNG, Jyotirmanju CS, Jeniffer NV. Association of vitamin D levels and mortality in critically ill children: a prospective observational study. Lex Localis Journal of Local Self-Government. 2025;23(S6). Available from: https://lexlocalis.org/index.php/LexLocalis/article/view/802821/2956
Zhang C, Wang D, Zhu C, Lei X, Meng L, Shen C. Halogen-Engineered Copper-Based Materials with Multicolor Emission for Dual-Functional Anticounterfeiting and LED Applications. ACS Appl Mater Interfaces. 2025 Jul 30;17(30):43298-43306. doi: 10.1021/acsami.5c11245. Epub 2025 Jul 22.
PubMed 40693518Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med. 1996 May;24(5):743-52. doi: 10.1097/00003246-199605000-00004.
PubMed 8706448Pludowski P, Takacs I, Boyanov M, Belaya Z, Diaconu CC, Mokhort T, Zherdova N, Rasa I, Payer J, Pilz S. Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients. 2022 Apr 2;14(7):1483. doi: 10.3390/nu14071483.
PubMed 35406098Petkova GS, Mineva EN, Botsova VT. Clinical Study of Vitamin D Levels in Hospitalized Children with Acute Respiratory Infections. Pediatr Rep. 2024 Nov 22;16(4):1034-1041. doi: 10.3390/pediatric16040088.
PubMed 39585042Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6.
PubMed 21646368Gulla KM, Sachdev A. Illness severity and organ dysfunction scoring in Pediatric Intensive Care Unit. Indian J Crit Care Med. 2016 Jan;20(1):27-35. doi: 10.4103/0972-5229.173685.
PubMed 26955214
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Serum Vitamin D Status and Its Association With Disease Severity and Mortality Risk Among Critically Ill Children With Acute Respiratory Infections: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT06547749
- Acronym / sponsor ID
- VITD-ARI / VITD01
- Conditions
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency, Pediatric Respiratory Infections, Respiratory Distress
- Keywords
- 25-hydroxyvitamin D, Vitamin D, Pediatric intensive care unit, PICU, Acute respiratory infection, Critically ill children, Pediatric respiratory severity score, Respiratory infection severity
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 63 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Jun 2026 (estimated)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Apr 2027 (estimated)
- First posted
- 9 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs). Vitamin D has an important role not only in bone metabolism but also in regulation of innate and adaptive immune responses, especially within the respiratory tract. Recent evidence suggests that vitamin D deficiency may be associated with increased susceptibility to respiratory infections, greater disease severity, prolonged hospitalization, and higher mortality rates in critically ill children.
This observational cross-sectional study aims to assess serum vitamin D status among critically ill children admitted to the PICU with acute respiratory infections and to evaluate the relationship between vitamin D levels, severity of respiratory illness, and risk of mortality. The study will include pediatric patients aged 1 month to 16 years admitted to the Pediatric Intensive Care Unit of Assiut University Children's Hospital.
Clinical evaluation and laboratory investigations, including serum 25-hydroxyvitamin D levels, serum calcium, and alkaline phosphatase, will be performed within the first 24 hours of admission. Severity of respiratory distress will be assessed using the Pediatric Respiratory Severity Score (PRESS), while mortality risk will be evaluated using the Pediatric Risk of Mortality Score (PRISM III).
The findings of this study may contribute to better understanding of the role of vitamin D in critically ill children with respiratory infections and may support future strategies for early risk assessment and improved clinical management in pediatric intensive care settings.
Detailed description
Acute respiratory infections remain a major global health problem and are a leading cause of morbidity and mortality among pediatric populations, particularly in low- and middle-income countries. Critically ill children admitted to pediatric intensive care units (PICUs) with severe respiratory infections are at increased risk of complications, prolonged hospitalization, and mortality. Identifying modifiable risk factors associated with disease severity and poor outcomes is therefore of significant clinical importance.
Vitamin D is a fat-soluble steroid hormone traditionally recognized for its role in calcium and phosphorus homeostasis and skeletal development. However, increasing evidence has demonstrated that vitamin D also has immunomodulatory functions through its effects on innate and adaptive immunity. Vitamin D receptors are expressed in immune cells, including macrophages and respiratory epithelial cells, supporting its role in host defense against respiratory pathogens.
Recent studies have suggested an association between vitamin D deficiency and increased susceptibility to acute respiratory infections, sepsis, and adverse outcomes in critically ill children. Nevertheless, available evidence remains inconsistent, and data from pediatric intensive care populations in Egypt and similar settings are limited.
This cross-sectional observational study will be conducted at the Pediatric Intensive Care Unit of Assiut University Children's Hospital. The study will include children aged 1 month to 16 years admitted with acute respiratory infections. Patients with chronic illnesses affecting vitamin D metabolism, severe immunodeficiency, congenital heart disease, malnutrition, rickets, or recent vitamin D supplementation will be excluded.
At PICU admission, all eligible participants will undergo detailed history taking, complete clinical examination, and laboratory investigations. Serum 25-hydroxyvitamin D [25(OH)D] levels will be measured within the first 24 hours of admission as the standard indicator of vitamin D status. Vitamin D levels will be categorized according to international clinical practice guidelines into deficiency, insufficiency, sufficiency, and toxicity.
Severity of respiratory illness will be evaluated using the Pediatric Respiratory Severity Score (PRESS), a validated clinical scoring system for respiratory distress in children. Mortality risk will be assessed using the Pediatric Risk of Mortality Score (PRISM III), which incorporates physiological and laboratory parameters obtained during the first 24 hours of PICU admission.
The primary outcome of the study is the prevalence of vitamin D deficiency among critically ill children with acute respiratory infections. Secondary outcomes include the association between serum vitamin D levels and both respiratory disease severity and mortality risk.
Data will be statistically analyzed using SPSS software. Appropriate statistical tests will be selected according to the type and distribution of data, and statistical significance will be considered at p < 0.05.
This study may provide important insights into the clinical significance of vitamin D deficiency in critically ill pediatric patients and may support future preventive and therapeutic strategies aimed at improving outcomes in children with severe respiratory infections.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Critically Ill Children With Acute Respiratory Infections | – | Diagnostic Test: Serum 25-Hydroxyvitamin D AssessmentThis cohort includes pediatric patients aged 1 month to 16 years admitted to the Pediatric Intensive Care Unit (PICU) with acute respiratory infections. Participants will undergo clinical evaluation and laboratory assessment, including measurement of serum 25-hydroxyvitamin D levels within the first 24 hours of admission. Disease severity will be assessed using the Pediatric Respiratory Severity Score (PRESS), and mortality risk will be evaluated using the Pediatric Risk of Mortality Score (PRISM III). No interventions will be assigned as part of the study protocol. |
Who may qualify
- Ages
- 1 month to 16 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
- Study population
- The study involves pediatric patients admitted to the Pediatric Intensive Care Unit (PICU) at a tertiary care hospital who meet the diagnostic criteria for acute respiratory infections.
Key inclusion criteria (3 listed)
- Children aged between 1 month and 12 years.
- Admitted to the PICU with a primary diagnosis of acute respiratory infection.
- Diagnosis confirmed by clinical symptoms and radiological evidence.
Key exclusion criteria (3 listed)
- Children with known chronic bone diseases or metabolic disorders.
- Patients receiving vitamin D supplementation prior to admission.
- Patients with chronic renal or hepatic failure.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Serum 25-Hydroxyvitamin D AssessmentAlso: Serum Vitamin D Measurement, 25(OH)D TestingBlood samples will be collected within the first 24 hours of admission to the Pediatric Intensive Care Unit (PICU) to measure serum 25-hydroxyvitamin D [25(OH)D] levels, which is the standard biomarker used to assess vitamin D status. The measured vitamin D levels will be analyzed in relation to the severity of acute respiratory infections using the Pediatric Respiratory Severity Score (PRESS) and the risk of mortality using the Pediatric Risk of Mortality Score (PRISM III). No therapeutic intervention or vitamin D supplementation will be administered as part of the study protocol. | Diagnostic test | Critically Ill Children With Acute Respiratory Infections |
Primary outcome
Prevalence of Vitamin D Deficiency among critically ill children with acute respiratory infections.
Time frame: Within the first 24 hours of admission to the Pediatric Intensive Care Unit (PICU).
This measure evaluates the baseline vitamin D status of pediatric patients admitted to the PICU with acute respiratory infections. Vitamin D status is determined by measuring serum 25-hydroxyvitamin D [25(OH)D] levels. According to the Endocrine Society guidelines, deficiency is defined as levels <20 ng/mL.
2 secondary outcomes
Association between Vitamin D and Severity of ARI
Time frame: Within the first 24 hours of PICU admission.
Association between Vitamin D and Risk of Mortality
Time frame: Within the first 24 hours of PICU admission.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2026.
- BackgroundThokngaen J, Karoonboonyanan W. Pediatric respiratory severity score evaluates disease severity of respiratory tract infection in children. Chulalongkorn Med J. 2019;63(1):Article 7. doi: 10.58837/CHULA.CMJ.63.1.6
- BackgroundKangel D, Kıral A. The effect of vitamin D level on the clinical course of the disease in patients with lower respiratory tract infection. Cam Sakura Med J. 2025;5(1):17-24. doi: 10.58519/csmedj.galenos.2025.2025-3-2
- Background: PubMed 40395895Gunes N, Cam H. An observational study of serum vitamin D status in critically ill children admitted to the pediatric intensive care unit. Arch Med Sci. 2022 Oct 6;21(2):471-477. doi: 10.5114/aoms/155137. eCollection 2025.
- BackgroundChandana HNG, Jyotirmanju CS, Jeniffer NV. Association of vitamin D levels and mortality in critically ill children: a prospective observational study. Lex Localis Journal of Local Self-Government. 2025;23(S6). Available from: https://lexlocalis.org/index.php/LexLocalis/article/view/802821/2956
- Background: PubMed 40693518Zhang C, Wang D, Zhu C, Lei X, Meng L, Shen C. Halogen-Engineered Copper-Based Materials with Multicolor Emission for Dual-Functional Anticounterfeiting and LED Applications. ACS Appl Mater Interfaces. 2025 Jul 30;17(30):43298-43306. doi: 10.1021/acsami.5c11245. Epub 2025 Jul 22.
- Background: PubMed 8706448Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med. 1996 May;24(5):743-52. doi: 10.1097/00003246-199605000-00004.
- Background: PubMed 35406098Pludowski P, Takacs I, Boyanov M, Belaya Z, Diaconu CC, Mokhort T, Zherdova N, Rasa I, Payer J, Pilz S. Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients. 2022 Apr 2;14(7):1483. doi: 10.3390/nu14071483.
- Background: PubMed 39585042Petkova GS, Mineva EN, Botsova VT. Clinical Study of Vitamin D Levels in Hospitalized Children with Acute Respiratory Infections. Pediatr Rep. 2024 Nov 22;16(4):1034-1041. doi: 10.3390/pediatric16040088.
- Background: PubMed 21646368Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6.
- Background: PubMed 26955214Gulla KM, Sachdev A. Illness severity and organ dysfunction scoring in Pediatric Intensive Care Unit. Indian J Crit Care Med. 2016 Jan;20(1):27-35. doi: 10.4103/0972-5229.173685.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Respiratory Infections and Critical Illness in Children, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mohamed Ali (01284871896, abo.alimai.123@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of Vitamin D Deficiency among critically ill children with acute respiratory infections. (time frame: Within the first 24 hours of admission to the Pediatric Intensive Care Unit (PICU).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06547749, which also lists 10 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2026.