Dietary ExposureNCT06526169
Assessment of Human Exposure to Chemical Hazards
An observational study of Dietary Exposure, run by National University of Singapore at 2 sites in Singapore.
Trial summary
The aim of this study is to evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption. Read more about this study
- Who is it for?
- Ages 21 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Dietary Exposure
- What is being tested?
- Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection
- How many people
- 300 participants
- Where
- 2 sitesSingapore
- Study dates
- 21 Aug 2024to 31 Jul 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Healthy adults in the Singapore population
Who may be able to join
- Must be English-literate and able to give informed consent in English
- 21 to 60 years of age (inclusive) at screening
- Healthy adults
- Race must be Chinese or Indian or Malay
- Reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures
Who cannot join
- Known or ongoing psychiatric disorders within 3 years
- Being diagnosed with cancer, heart disease, stroke, renal failure, serious mental or physical illnesses at the time of recruitment
- Have donated blood of more than 500 mL within 4 weeks of study enrolment
Trial locations and contacts
2 sites in 1 country.
Singapore2 sites
National University of Singapore
Singapore, 118177
National University of Singapore, Department of Food Science & Technology
Singapore
About this study
Official title: Assessment of Human Exposure to Chemical Hazards and Their Association With Food Consumption in the Singapore Population
The aim of this study is to evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.
Read the detailed description
Human biomonitoring is an exposure assessment approach with the potential value-add supplementation to existing sources of information for regulatory risk assessments and for supporting food safety policies. The collaboration involving academic partners from the sciences and public health disciplines to quantify the in vivo chemical exposure of chemicals will take reference from the findings in the Singapore's total diet study on the prioritised chemical hazards of interest for a more precise assessment of the distribution of risk in the population. Direct measurement of chemicals and/or metabolites in biological specimens obtained from study subjects will be conducted to provide a more comprehensive understanding on the baseline dietary chemical exposure in the local population. Dietary assessment using food frequency questionnaire will be administered to the same group of study subjects to associate human exposure to chemical hazards with food consumption across the different population groups in Singapore.
- Conditions
- Dietary Exposure
- Being tested
- Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood CollectionOther
Questionnaires on food frequency, social, lifestyle, and demographics will be administered to participants and will be correlated with the presence of chemical hazards in the blood. The chemical hazards analyzed will be referenced from Singapore's Total Diet Study, based on the prioritized chemical hazards of interest to investigate the distribution of risk in the population.
| Study group | Role | What they receive |
|---|---|---|
| Ethnicity: Chinese | Not described Receives: Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection | |
| Ethnicity: Malay | Not described Receives: Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection | |
| Ethnicity: Indian | Not described Receives: Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Chemical hazards occurrence
To evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.
Measured: 3 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jul 2024
- Study start21 Aug 2024
- Primary completion31 Jul 2027 (estimated)
- Study completion31 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dietary ExposureStudies of the same condition, open and under way.
- More trials run by National University of SingaporeThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 300 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National University of Singapore
- Sponsor type
- University, hospital or other
- Collaborators
- Singapore Food Agency
- Responsible party
- Principal investigator, Mei Hui Liu, National University of Singapore
- Investigators
- Mei Hui Liu, Principal investigator, National University of Singapore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06526169
- Sponsor's protocol ID
- NUS-IRB-2024-128
- Status last verified
- Sep 2025
- First submitted
- 24 Jul 2024
- Last updated
- 9 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Human Exposure to Chemical Hazards and Their Association With Food Consumption in the Singapore Population
- ClinicalTrials.gov ID
- NCT06526169
- Acronym / sponsor ID
- NUS-IRB-2024-128
- Conditions
- Dietary Exposure
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- National University of SingaporeUniversity, hospital or other
- Collaborators
- Singapore Food Agency
- Study start
- 21 Aug 2024 (actual)
- Primary completion
- 31 Jul 2027 (estimated)
- Study completion
- 31 Jul 2027 (estimated)
- First posted
- 29 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.
Detailed description
Human biomonitoring is an exposure assessment approach with the potential value-add supplementation to existing sources of information for regulatory risk assessments and for supporting food safety policies. The collaboration involving academic partners from the sciences and public health disciplines to quantify the in vivo chemical exposure of chemicals will take reference from the findings in the Singapore's total diet study on the prioritised chemical hazards of interest for a more precise assessment of the distribution of risk in the population. Direct measurement of chemicals and/or metabolites in biological specimens obtained from study subjects will be conducted to provide a more comprehensive understanding on the baseline dietary chemical exposure in the local population. Dietary assessment using food frequency questionnaire will be administered to the same group of study subjects to associate human exposure to chemical hazards with food consumption across the different population groups in Singapore.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Ethnicity: Chinese | – | Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection |
| Ethnicity: Malay | – | Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection |
| Ethnicity: Indian | – | Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection |
Who may qualify
- Ages
- 21 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Healthy adults in the Singapore population
Key inclusion criteria (5 listed)
- Must be English-literate and able to give informed consent in English
- 21 to 60 years of age (inclusive) at screening
- Healthy adults
- Race must be Chinese or Indian or Malay
- Reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures
Key exclusion criteria (3 listed)
- Known or ongoing psychiatric disorders within 3 years
- Being diagnosed with cancer, heart disease, stroke, renal failure, serious mental or physical illnesses at the time of recruitment
- Have donated blood of more than 500 mL within 4 weeks of study enrolment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood CollectionQuestionnaires on food frequency, social, lifestyle, and demographics will be administered to participants and will be correlated with the presence of chemical hazards in the blood. The chemical hazards analyzed will be referenced from Singapore's Total Diet Study, based on the prioritized chemical hazards of interest to investigate the distribution of risk in the population. | Other | Ethnicity: Chinese, Ethnicity: Indian, Ethnicity: Malay |
Primary outcome
Chemical hazards occurrence
Time frame: 3 years
To evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mei Hui Liu principal investigator
National University of Singapore
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Dietary Exposure, run by National University of Singapore at 2 sites in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Chemical hazards occurrence (time frame: 3 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2025.