High Altitude Pulmonary HypertensionNCT06489704
High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)
A study testing Echocardiography in people with High Altitude Pulmonary Hypertension, run by University of Zurich at 1 site in Kyrgyzstan.
Trial summary
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP) Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- High Altitude Pulmonary Hypertension
- What is being tested?
- Echocardiography
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteKyrgyzstan
- Study dates
- 2 Jul 2024to 27 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Permanently living >2500 m
- HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m
- Written informed consent
Who cannot join
- Highlanders who cannot follow the study investigations,
- Patients with moderate to severe concomitant lung disease (FEV1<70% or forced vital capacity <70%), severe parenchymal lung disease, heavy smoking >20 cigarettes/day or >20 pack-years.
- Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months
- Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)
Trial locations and contacts
1 site in 1 country.
Kyrgyzstan1 site
Aksay Medical Center
Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan
About this study
Official title: Comparative Study of Pulmonary Artery Pressure (PAP) Assessed by Echocardiography in Patients With High Altitude Pulmonary Hypertension (HAPH) Permanently Residing Above 2500 Meters When Assessed Near Resident High Altitude (HA) at 3200 m vs. at Low Altitude (LA) at 760 m
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP)
Read the detailed description
This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA >30 mmHg who permanently live at HA >2500 m will have pulmonary arterial pressure (PAP) assessed by echocardiography near their living altitude in Aksay at 3200 m and at 760 m in Bishkek the day after the first and the seventh night after relocation.
- Conditions
- High Altitude Pulmonary Hypertension
- Being tested
- Echocardiography
- Keywords
- Pulmonary Hypertension, Hypoxia, High Altitude, Pulmonal Arterial Pressure
- Medical subject headings
- Pulmonary edema of mountaineers, Hypertension, Pulmonary, Hypoxia, Altitude Sickness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EchocardiographyOther
Echocardiography will be performed according to clinical standards
| Study group | Role | What they receive |
|---|---|---|
| Assessments at 3200 m and 760 m, respectively | Experimental | Participants will have a echocardiography near their resident altitude at 3200 m and after relocation to 760 m after 1 and 7 days Receives: Other: Echocardiography |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA)
Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m)
Measured: day 2 at 760 m vs. 3200 m
Secondary outcomes (11)
Change in Pulmonary artery Pressure (PAP) after seven nights at 760 m (LA) vs at 3200 m (HA)
Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m)
Measured: day 7 at 760 m vs. 3200 m
Cardiac output at 760 m (LA) vs at 3200 m (HA)
Change in cardiac output in l/min assessed by echocardiography between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
Tricuspid pressure gradient by echocardiography at 760 m (LA) vs at 3200 m (HA)
Tricuspid pressure gradient assessed by echocardiography between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
Tricupsid annular plane systolic excursion by echocardiography at 760 m (LA) vs at 3200 m (HA)
Tricupsid annular plane systolic excursion assessed by echocardiography between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
pH by arterial blood gases at 760 m (LA) vs at 3200 m (HA)
Change in pH by arterial blood gases assessed between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
partial pressure of oxygen (PaO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA)
Change in partial pressure of oxygen (PaO2) assessed by arterial blood gases between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
partial pressure of carbon dioxide (PaCO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA)
Change in partial pressure of carbon dioxide (PaCO2) assessed by arterial blood gases partial pressure of carbon dioxide (PaCO2) between LA (760 m) vs HA (3200 m)
Measured: after the first and seventh night at LA
Change in right to left heart diameter ratio at 760 m (LA) vs at 3200 m (HA)
Change in right to left heart diameter ratio assessed by echocardiography between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
Change in right atrial area at 760 m (LA) vs at 3200 m (HA)
Change in right atrial area by echocardiography between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
Change in right heart strain at 760 m (LA) vs at 3200 m (HA)
Change in right heart strain by echocardiography between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
Change in ECG morphology at 760 m (LA) vs at 3200 m (HA)
Change in ECG morphology and QT-interval by 12-lead ECG between LA (760 m) vs HA (3200 m)
Measured: day 2 and 7 at 760 m vs. 3200 m
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jul 2024
- Study start2 Jul 2024
- Primary completion27 Sep 2024
- Study completion27 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for High Altitude Pulmonary HypertensionStudies of the same condition, open and under way.
- More trials run by University of ZurichThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Each highlander with HAPH will perform a echocardiography at high altitude (HA, 3200 m) and day 2 and day 7 at low altitude (LA, 760 m) according to a prospective study design
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Talant M Sooronbaev, Prof. Dr., Principal investigator, National Center of Cardiology and Internal Medicine named after academician M.MirrakhimovSilvia Ulrich, Prof. Dr., Principal investigator, University Hospital Zurich, Department of Pulmonology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06489704
- Sponsor's protocol ID
- HAPH_HAvsLA_PAP
- Status last verified
- Jan 2026
- First submitted
- 28 Jun 2024
- Last updated
- 21 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study of Pulmonary Artery Pressure (PAP) Assessed by Echocardiography in Patients With High Altitude Pulmonary Hypertension (HAPH) Permanently Residing Above 2500 Meters When Assessed Near Resident High Altitude (HA) at 3200 m vs. at Low Altitude (LA) at 760 m
- ClinicalTrials.gov ID
- NCT06489704
- Acronym / sponsor ID
- HAPH_HAvsLA_PAP
- Conditions
- High Altitude Pulmonary Hypertension
- Keywords
- Pulmonary Hypertension, Hypoxia, High Altitude, Pulmonal Arterial Pressure
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- 2 Jul 2024 (actual)
- Primary completion
- 27 Sep 2024 (actual)
- Study completion
- 27 Sep 2024 (actual)
- First posted
- 8 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP)
Detailed description
This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA >30 mmHg who permanently live at HA >2500 m will have pulmonary arterial pressure (PAP) assessed by echocardiography near their living altitude in Aksay at 3200 m and at 760 m in Bishkek the day after the first and the seventh night after relocation.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Each highlander with HAPH will perform a echocardiography at high altitude (HA, 3200 m) and day 2 and day 7 at low altitude (LA, 760 m) according to a prospective study design
| Arm | Type | Receives |
|---|---|---|
| Assessments at 3200 m and 760 m, respectively | Experimental | Other: EchocardiographyParticipants will have a echocardiography near their resident altitude at 3200 m and after relocation to 760 m after 1 and 7 days |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Permanently living >2500 m
- HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m
- Written informed consent
Key exclusion criteria (4 listed)
- Highlanders who cannot follow the study investigations,
- Patients with moderate to severe concomitant lung disease (FEV1<70% or forced vital capacity <70%), severe parenchymal lung disease, heavy smoking >20 cigarettes/day or >20 pack-years.
- Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months
- Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EchocardiographyEchocardiography will be performed according to clinical standards | Other | Assessments at 3200 m and 760 m, respectively |
Primary outcome
Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 at 760 m vs. 3200 m
Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m)
11 secondary outcomes
Change in Pulmonary artery Pressure (PAP) after seven nights at 760 m (LA) vs at 3200 m (HA)
Time frame: day 7 at 760 m vs. 3200 m
Cardiac output at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
Tricuspid pressure gradient by echocardiography at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
Tricupsid annular plane systolic excursion by echocardiography at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
pH by arterial blood gases at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
partial pressure of oxygen (PaO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
partial pressure of carbon dioxide (PaCO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA)
Time frame: after the first and seventh night at LA
Change in right to left heart diameter ratio at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
Change in right atrial area at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
Change in right heart strain at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
Change in ECG morphology at 760 m (LA) vs at 3200 m (HA)
Time frame: day 2 and 7 at 760 m vs. 3200 m
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jan 2026.
Related trials for High Altitude Pulmonary Hypertension
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Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
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Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
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Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
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Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
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Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Talant M Sooronbaev, Prof. Dr. principal investigator
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Silvia Ulrich, Prof. Dr. principal investigator
University Hospital Zurich, Department of Pulmonology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Echocardiography in people with High Altitude Pulmonary Hypertension, run by University of Zurich at 1 site in Kyrgyzstan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Kyrgyzstan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA) (time frame: day 2 at 760 m vs. 3200 m). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jan 2026.