InfertilityNCT06475690
the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients
A study testing Psychological interventions in people with Infertility and in Vitro Fertilization, run by First Affiliated Hospital of Chongqing Medical University at 1 site in China.
Trial summary
The goal of this clinical trial is to learn if psychological interventions alleviate the anxious emotion of women undergoing oocyte retrieval operation with general anesthesia. The main questions it aims to answer are: If psychological interventions reduced participants' anxiety scores before the oocyte retrieval… Read more about this study
- Who is it for?
- Ages 20 to 50 years, women only
- Conditions the study is for
- Infertility, in Vitro Fertilization, Mental Health
- What is being tested?
- Psychological interventions
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 180 participants
- Where
- 1 siteChina
- Study dates
- 8 Sep 2024to 10 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- underwent oocyte retrieval operation with general anesthesia
- able to use smartphone to complete questionnaire
Who cannot join
- had major psychological trauma, schizophrenia
- morbid obesity (BMI greater than 40.0 kg/m2.)
- serious disease of cardiovascular system including uncontrolled hypertension
- serious endocrine system disease including uncontrolled hypothyroidism
- history of severe adverse events related to anesthesia
- history of substance abuse or severe allergy
- refusal to provide written consent
Trial locations and contacts
1 site in 1 country.
China1 site
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400016
About this study
The goal of this clinical trial is to learn if psychological interventions alleviate the anxious emotion of women undergoing oocyte retrieval operation with general anesthesia.
The main questions it aims to answer are:
If psychological interventions reduced participants' anxiety scores before the oocyte retrieval operation. Researchers will compare psychological interventions to no interventions to see if psychological interventions work to alleviate anxious emotion. Questionnaires related anxiety were completed online before surgery by participants.
- Being tested
- Psychological interventions
- Keywords
- oocyte retrieval, Anxiety symptoms, depression symptoms, psychological intervention, intravenous anesthesia
- Medical subject headings
- Infertility, Psychological Well-Being, Anxiety Disorders, Depression
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Psychological interventionsOther
Psychological interventions is used for intervention group
| Study group | Role | What they receive |
|---|---|---|
| AC group | Experimental | AC group (active communication group): Prior to oocyte retrieval 24h, anesthesiologist and patient sign an informed consent form for anesthesia, then anxiety and depressive symptoms are assessed by scales including APAIS, GAD-7, PHQ-9 and HAD. This is the first score for all questionnaire. Subsequently, active communication will be performed, including addressing surgical procedures, anesthesia processes, and potential complications. No matter whether the patient asks the anesthesiologist about surgery and anesthesia or not, the active communication will be provided. One hour before surgery, patients' anxiety will be reassessed using APAIS. This is the second score for APAIS. Anxiety and depressive symptoms will be evaluated by GAD-7, PHQ-9 and HAD between 24 to 48 hours after oocyte retrieval operation. This is the second score for GAD-7, PHQ-9 and HAD. Receives: Other: Psychological interventions |
| CON group | No intervention | CON group (control group): Prior to oocyte retrieval 24h, anesthesiologist and patient sign an informed consent form for anesthesia, then anxiety and depressive symptoms are assessed by scales including APAIS, GAD-7, PHQ-9 and HAD. This is the first score for all questionnaire. If a patient doesn't ask any question about surgery or anesthesia, no interpretation will be provided. That is to say, the anesthesiologist will not actively communicate with the patient about surgical and anesthesia issues. One hour before surgery, patients' anxiety will be reassessed using APAIS. This is the second score for APAIS. Anxiety and depressive symptoms will be evaluated by GAD-7, PHQ-9 and HAD between 24 to 48 hours after oocyte retrieval operation. This is the second score for GAD-7, PHQ-9 and HAD. |
What is being measured
The primary outcome is the main question the study is designed to answer.
The difference in incidence of anxiety 1 hour before operation between the two groups
The degree of anxiety was measured by the Amsterdam Preoperative Anxiety and Information Scale and it is abbreviated as APAIS in the Primary Outcome. This is a six-item questionnaire. Every item is graded on a five-point scale from 1(meaning not at all) to 5 (meaning extremely). The scoring range of this scale is from 6 to 30 points, with a cutoff point of 11. Specifically, a score of ≤10 indicates no anxiety, while a score of ≥11 indicates anxiety. Each patient received two APAIS assessments, 24 hours before and 1 hour before surgery respectively. After the second assessment, the number of anxious patients in each group was calculated based on the APAIS scores. Then, the number of anxious patients divided by the total number of patients in the group is the incidence of anxiety. Finally, a statistical comparison was made to determine if there is a significant difference in incidence of anxiety between the two groups of patients.
Measured: Each patient is assessed by APAIS for two times. The first time is 24 hours before surgery, and the second time is 1 hour before surgery.
Secondary outcomes (6)
the comparison of APAIS score in two group 1h before operation
The degree of anxiety is measured by the Amsterdam Preoperative Anxiety and Information Scale and it is abbreviated as APAIS in the outcome. This is a six-item questionnaire. Every item is graded on a five-point scale from 1( not at all) to 5 (extremely). The score range of this scale is from 6 to 30 points, with a cutoff point of 11. Specifically, a score of ≤10 indicates no anxiety, while a score of ≥11 indicates anxiety. Each patient received two APAIS assessments, 24 hours before and 1 hour before surgery respectively. After the second evaluation about APAIS, the comparison of APAIS scores is fulfilled to determine if there is a significant difference among the two groups.
Measured: Each patient is assessed by APAIS for two times. The first time is 24 hours before surgery, and the second time is 1 hour before surgery.
the comparison of incidence of postoperative anxiety between two groups
The anxiety is measured by the Generalized anxiety disorder 7- item scale, a seven-item questionnaire, which is abbreviated as GAD-7. Every item is graded on a 4-point scale from 0 to 3. 0,1,2 and 3 stand for not at all, several days, more than half the days and nearly every day respectively. The total score ranges from 0 to 21 and 0-4, 5-9, 10-14, and 15-21 represent minimal, mild, moderate, and severe levels of anxiety respectively. A score of ≤4 represents no anxiety, while a score of ≥5 indicates the presence of anxiety. Each patient is assessed by GAD-7 twice, 24 hours before and 24~48 hours after surgery respectively. After the second GAD-7 rating, the number of anxious people and incidence of postoperative anxiety are calculated in each group and according to the GAD-7 score. Finally, a statistical comparison is made to determine whether there is a significant difference in incidence of postoperative anxiety between the two groups of patients.
Measured: Each patient is assessed by GAD-7 twice.The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of postoperative GAD-7 scores between two groups
The degree of anxiety was measured by the Generalized anxiety disorder 7- item scale and it is abbreviated as GAD-7 in this outcome. This is a seven-item questionnaire. Every item is graded on a 4-point scale from 0 to 3. 0,1,2 and 3 stand for not at all, several days, more than half the days and nearly every day respectively. The total score of this scale ranges from 0 to 21, where 0-4, 5-9, 10-14, and 15-21 represent minimal, mild, moderate, and severe levels of anxiety respectively. That means a score of ≤4 represents no anxiety, while a score of ≥5 indicates the presence of mild anxiety or higher-level anxiety. After the second GAD-7 rating, GAD-7 scores between the two groups of patients are compared to determine whether there is a statistical difference.
Measured: Each patient is assessed by GAD-7 twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of incidence of postoperative depression in two groups
The depression is measured by the Patient Health Questionnaire 9-item scale, a nine-item questionnaire, which is abbreviated as PHQ-9. Every item is graded on a 4-point scale from 0 to 3. 0,1,2 and 3 stand for not at all, several days, more than half the days and nearly every day respectively. The total score of this scale ranges from 0 to 27, where 0-4, 5-9, 10-14, 15-20 and 21-27 represent minimal, mild, moderate, moderately severe and severe levels of depression respectively. That means a score of ≤4 represents no depression, and a score of ≥5 indicates the presence of depression. Each patient is assessed by PHQ-9 twice, 24 hours before and 24~48 hours after surgery respectively. After the second PHQ-9 rating, the incidence of depression is calculated in each group according to the PHQ-9 score. Finally, a statistical comparison is made to determine whether there is a significant difference in the incidence of postoperative depression between the two groups of patients.
Measured: Each patient is assessed by PHQ-9 twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of postoperative PHQ-9 scores between two groups
The degree of depression is measured by the Patient Health Questionnaire 9-item scale and it is abbreviated as PHQ-9 in this outcome. This is a nine-item questionnaire. Every item is graded on a 4-point scale from 0 to 3. 0,1,2 and 3 stand for not at all, several days, more than half the days and nearly every day respectively. The total score of this scale ranges from 0 to 27, where 0-4, 5-9, 10-14, 15-20 and 21-27 represent minimal, mild, moderate, moderately severe and severe levels of depression respectively. That means a score of ≤4 represents no anxiety, while a score of ≥5 indicates the presence of mild depression or higher-level depression. Each patient is assessed by PHQ-9 two times, 24 hours before surgery and 24~48 hours after surgery respectively. After the second PHQ-9 rating, PHQ-9 scores between the two groups of patients are compared to determine whether there was a statistical difference.
Measured: Each patient is assessed by PHQ-9 twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of postoperative HADS scores between two groups
The Hospital Anxiety and Depression Scale can be used to measure anxiety and depression and it is abbreviated as HADS in this outcome. This is a 14-item questionnaire. Assessment of the overall severity of anxiety and depression are both rated on four-point (0-3) scales by the researchers. HADS includes two subscales the depression subscale and the anxiety subscale. The total score of this scale ranges from 0 to 21 for each subscale. For the depression subscale it is found that a score of 7 or less for no depressive cases, scores of 8-10 for doubtful cases and scores of 11 or more for definite cases combined with depression. The scoring range of anxiety subscale is the same as that of depression subscale. Each patient is assessed by HADS two times, 24 hours before surgery and 24~48 hours after surgery respectively. After the second HADS rating, HADS scores between the two groups of patients are compared to determine whether there was a statistical difference.
Measured: Each patient is assessed by HADS twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jun 2024
- Study start8 Sep 2024
- Primary completion24 Jun 2025
- Study completion10 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for InfertilityStudies of the same condition, open and under way.
- More trials run by First Affiliated Hospital of Chongqing Medical UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 180 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Qibin Chen, First Affiliated Hospital of Chongqing Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06475690
- Sponsor's protocol ID
- CQB2
- Status last verified
- Mar 2026
- First submitted
- 1 Jun 2024
- Last updated
- 25 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Liu YF, Fu Z, Chen SW, He XP, Fan LY. The Analysis of Anxiety and Depression in Different Stages of in vitro Fertilization-Embryo Transfer in Couples in China. Neuropsychiatr Dis Treat. 2021 Feb 25;17:649-657. doi: 10.2147/NDT.S287198. eCollection 2021.
PubMed 33658786Li G, Jiang Z, Kang X, Ma L, Han X, Fang M. Trajectories and predictors of anxiety and depression amongst infertile women during their first IVF/ICSI treatment cycle. J Psychosom Res. 2021 Mar;142:110357. doi: 10.1016/j.jpsychores.2021.110357. Epub 2021 Jan 16.
PubMed 33508704Braverman AM, Davoudian T, Levin IK, Bocage A, Wodoslawsky S. Depression, anxiety, quality of life, and infertility: a global lens on the last decade of research. Fertil Steril. 2024 Mar;121(3):379-383. doi: 10.1016/j.fertnstert.2024.01.013. Epub 2024 Jan 13.
PubMed 38224730Moerman N, van Dam FS, Muller MJ, Oosting H. The Amsterdam Preoperative Anxiety and Information Scale (APAIS). Anesth Analg. 1996 Mar;82(3):445-51. doi: 10.1097/00000539-199603000-00002.
PubMed 8623940Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. doi: 10.1001/archinte.166.10.1092.
PubMed 16717171Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.
PubMed 11556941Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. doi: 10.1111/j.1600-0447.1983.tb09716.x.
PubMed 6880820
Study at a glance
From the registry record, last updated by the sponsor on 25 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients
- ClinicalTrials.gov ID
- NCT06475690
- Acronym / sponsor ID
- CQB2
- Keywords
- oocyte retrieval, Anxiety symptoms, depression symptoms, psychological intervention, intravenous anesthesia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 180 participants (actual)
- Lead sponsor
- First Affiliated Hospital of Chongqing Medical UniversityUniversity, hospital or other
- Study start
- 8 Sep 2024 (actual)
- Primary completion
- 24 Jun 2025 (actual)
- Study completion
- 10 Jul 2025 (actual)
- First posted
- 26 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if psychological interventions alleviate the anxious emotion of women undergoing oocyte retrieval operation with general anesthesia.
The main questions it aims to answer are:
If psychological interventions reduced participants' anxiety scores before the oocyte retrieval operation. Researchers will compare psychological interventions to no interventions to see if psychological interventions work to alleviate anxious emotion. Questionnaires related anxiety were completed online before surgery by participants.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| AC group | Experimental | Other: Psychological interventionsAC group (active communication group): Prior to oocyte retrieval 24h, anesthesiologist and patient sign an informed consent form for anesthesia, then anxiety and depressive symptoms are assessed by scales including APAIS, GAD-7, PHQ-9 and HAD. This is the first score for all questionnaire. Subsequently, active communication will be performed, including addressing surgical procedures, anesthesia processes, and potential complications. No matter whether the patient asks the anesthesiologist about surgery and anesthesia or not, the active communication will be provided. One hour before surgery, patients' anxiety will be reassessed using APAIS. This is the second score for APAIS. Anxiety and depressive symptoms will be evaluated by GAD-7, PHQ-9 and HAD between 24 to 48 hours after oocyte retrieval operation. This is the second score for GAD-7, PHQ-9 and HAD. |
| CON group | No intervention | –CON group (control group): Prior to oocyte retrieval 24h, anesthesiologist and patient sign an informed consent form for anesthesia, then anxiety and depressive symptoms are assessed by scales including APAIS, GAD-7, PHQ-9 and HAD. This is the first score for all questionnaire. If a patient doesn't ask any question about surgery or anesthesia, no interpretation will be provided. That is to say, the anesthesiologist will not actively communicate with the patient about surgical and anesthesia issues. One hour before surgery, patients' anxiety will be reassessed using APAIS. This is the second score for APAIS. Anxiety and depressive symptoms will be evaluated by GAD-7, PHQ-9 and HAD between 24 to 48 hours after oocyte retrieval operation. This is the second score for GAD-7, PHQ-9 and HAD. |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- underwent oocyte retrieval operation with general anesthesia
- able to use smartphone to complete questionnaire
Key exclusion criteria (7 listed)
- had major psychological trauma, schizophrenia
- morbid obesity (BMI greater than 40.0 kg/m2.)
- serious disease of cardiovascular system including uncontrolled hypertension
- serious endocrine system disease including uncontrolled hypothyroidism
- history of severe adverse events related to anesthesia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Psychological interventionsPsychological interventions is used for intervention group | Other | AC group |
Primary outcome
The difference in incidence of anxiety 1 hour before operation between the two groups
Time frame: Each patient is assessed by APAIS for two times. The first time is 24 hours before surgery, and the second time is 1 hour before surgery.
The degree of anxiety was measured by the Amsterdam Preoperative Anxiety and Information Scale and it is abbreviated as APAIS in the Primary Outcome. This is a six-item questionnaire. Every item is graded on a five-point scale from 1(meaning not at all) to 5 (meaning extremely). The scoring range of this scale is from 6 to 30 points, with a cutoff point of 11. Specifically, a score of ≤10 indicates no anxiety, while a score of ≥11 indicates anxiety. Each patient received two APAIS assessments, 24 hours before and 1 hour before surgery respectively. After the second assessment, the number of anxious patients in each group was calculated based on the APAIS scores. Then, the number of anxious patients divided by the total number of patients in the group is the incidence of anxiety. Finally, a statistical comparison was made to determine if there is a significant difference in incidence of anxiety between the two groups of patients.
6 secondary outcomes
the comparison of APAIS score in two group 1h before operation
Time frame: Each patient is assessed by APAIS for two times. The first time is 24 hours before surgery, and the second time is 1 hour before surgery.
the comparison of incidence of postoperative anxiety between two groups
Time frame: Each patient is assessed by GAD-7 twice.The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of postoperative GAD-7 scores between two groups
Time frame: Each patient is assessed by GAD-7 twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of incidence of postoperative depression in two groups
Time frame: Each patient is assessed by PHQ-9 twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of postoperative PHQ-9 scores between two groups
Time frame: Each patient is assessed by PHQ-9 twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
the comparison of postoperative HADS scores between two groups
Time frame: Each patient is assessed by HADS twice. The first time is 24 hours before surgery, and the second time is 24~48 hours after surgery.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Mar 2026.
- Background: PubMed 33658786Liu YF, Fu Z, Chen SW, He XP, Fan LY. The Analysis of Anxiety and Depression in Different Stages of in vitro Fertilization-Embryo Transfer in Couples in China. Neuropsychiatr Dis Treat. 2021 Feb 25;17:649-657. doi: 10.2147/NDT.S287198. eCollection 2021.
- Background: PubMed 33508704Li G, Jiang Z, Kang X, Ma L, Han X, Fang M. Trajectories and predictors of anxiety and depression amongst infertile women during their first IVF/ICSI treatment cycle. J Psychosom Res. 2021 Mar;142:110357. doi: 10.1016/j.jpsychores.2021.110357. Epub 2021 Jan 16.
- Background: PubMed 38224730Braverman AM, Davoudian T, Levin IK, Bocage A, Wodoslawsky S. Depression, anxiety, quality of life, and infertility: a global lens on the last decade of research. Fertil Steril. 2024 Mar;121(3):379-383. doi: 10.1016/j.fertnstert.2024.01.013. Epub 2024 Jan 13.
- Background: PubMed 8623940Moerman N, van Dam FS, Muller MJ, Oosting H. The Amsterdam Preoperative Anxiety and Information Scale (APAIS). Anesth Analg. 1996 Mar;82(3):445-51. doi: 10.1097/00000539-199603000-00002.
- Background: PubMed 16717171Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. doi: 10.1001/archinte.166.10.1092.
- Background: PubMed 11556941Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.
- Background: PubMed 6880820Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. doi: 10.1111/j.1600-0447.1983.tb09716.x.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Psychological interventions in people with Infertility and in Vitro Fertilization, run by First Affiliated Hospital of Chongqing Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The difference in incidence of anxiety 1 hour before operation between the two groups (time frame: Each patient is assessed by APAIS for two times. The first time is 24 hours before surgery, and the second time is 1 hour before surgery.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06475690, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Mar 2026.