MyopiaViPCD3NCT06475053
Visual Performance of Center Distance Daily Disposable Multifocal Lenses
A study testing NaturalVue Enhanced Multifocal 1 Day contact lens and MiSight 1 Day contact lens in people with Myopia, run by Visioneering Technologies, Inc at 1 site in United States.
Trial summary
The purpose of this study is to compare visual performance (high and low contrast acuity, reading acuity, contrast sensitivity, stereoacuity, accommodative response, eye hand coordination, far near vision, and dynamic vision) between Visioneering Technologies, Inc. NaturalVue Multifocal and CooperVivion MiSight. Read more about this study
- Who is it for?
- Ages 9 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Myopia
- What is being tested?
- NaturalVue Enhanced Multifocal 1 Day contact lens and MiSight 1 Day contact lens
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 31 Jul 2024to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 9 to 30 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Participants must satisfy the following conditions for inclusion in the trial:
- Be between 9 and 30 years of age
- Sign written Informed Consent/Assent.
- Spherical Equivalent glasses prescription: -0.50 to -7.00 diopters (D), Astigmatism: ≤ -0.75D, Anisometropia: ≤ 1.00D
- 20/20 vision in each eye
- Existing contact lens wearer
Show all 11Show fewer
- An eye exam in last 9 months, normal stereoacuity on prior chart (or test if not available)
- No known ocular disease - anterior or posterior (posterior determined by history/chart)
- Have an acceptable or optimal fit with test lenses and be willing to wear these lenses as directed for the duration of the study.
- On examination, have ocular findings considered to be within normal limits.
- Be willing and able to follow instructions and attend the schedule of follow-up visits.
Who cannot join
- Any of the following will exclude a participant from this trial:
- Current hard lens wearers
- Using eye medication contraindicating lens wear such as daily use of artificial tears.
- Eye injury or surgery within twelve weeks immediately prior to enrollment for this trial.
- History of corneal refractive surgery
- Currently enrolled in an ophthalmic clinical trial that could negatively impact corneal or conjunctival health in this trial.
Show all 12Show fewer
- Evidence of systemic or ocular abnormality, infection or disease likely to affect successful wear of contact lenses or use of their accessory solutions.
- Allergy or sensitivity to any product used in this trial.
- Pre-existing ocular condition that would contraindicate lens wear.
- Any systemic disease including autoimmune disease, immunocompromising diseases, connective tissue disease, clinically significant atopic diseases, insulin dependent diabetes, use of medications including corticosteroids and antimetabolites that may affect the eye or be exaggerated by wearing contact lenses.
- Lazy eye (Strabismus or amblyopia)
- Pupil size < 3.00 mm in either eye in dim light (measured at approximately 10 cd/m2 )
Trial locations and contacts
1 site in 1 country.
United States1 site
The Ohio State University College of Optometry
Columbus, Ohio, 43210
About this study
The purpose of this study is to compare visual performance (high and low contrast acuity, reading acuity, contrast sensitivity, stereoacuity, accommodative response, eye hand coordination, far near vision, and dynamic vision) between Visioneering Technologies, Inc. NaturalVue Multifocal and CooperVivion MiSight.
- Conditions
- Myopia
- Being tested
- NaturalVue Enhanced Multifocal 1 Day contact lens, MiSight 1 Day contact lens
- Keywords
- Contact lens, Multifocal
- Medical subject headings
- Myopia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NaturalVue Enhanced Multifocal 1 Day contact lensDevice
Daily disposable multifocal contact lens
MiSight 1 Day contact lensDevice
Daily disposable dual-focus contact lens
| Study group | Role | What they receive |
|---|---|---|
| NaturalVue | Active comparator | NaturalVue Enhanced Multifocal 1 Day contact lens Receives: Device: NaturalVue Enhanced Multifocal 1 Day contact lens |
| MiSight | Active comparator | MiSight 1 Day contact lens Receives: Device: MiSight 1 Day contact lens |
What is being measured
The primary outcome is the main question the study is designed to answer.
Comparison of visual performance (high and low contrast acuity) between VTI NaturalVue Enhanced Multifocal and CooperVision MiSight.
log MAR vision scale
Measured: 2 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jun 2024
- Study start31 Jul 2024
- Primary completion1 Dec 2025 (estimated)
- Study completion31 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MyopiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This will be a prospective, double-masked, crossover trial.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Visioneering Technologies, Inc
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Ohio State University
- Responsible party
- Sponsor
- Investigators
- Marjean T Kulp, OD, MS, Principal investigator, The Ohio State University College of Optometry
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06475053
- Sponsor's protocol ID
- VTI-2405
- Acronym
- ViPCD3
- Status last verified
- Sep 2025
- First submitted
- 4 Jun 2024
- Last updated
- 22 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Visual Performance of Center Distance Daily Disposable Multifocal Lenses
- ClinicalTrials.gov ID
- NCT06475053
- Acronym / sponsor ID
- ViPCD3 / VTI-2405
- Conditions
- Myopia
- Keywords
- Contact lens, Multifocal
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Visioneering Technologies, IncIndustry (pharma, biotech, devices)
- Collaborators
- Ohio State University
- Study start
- 31 Jul 2024 (actual)
- Primary completion
- 1 Dec 2025 (estimated)
- Study completion
- 31 Dec 2025 (estimated)
- First posted
- 26 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare visual performance (high and low contrast acuity, reading acuity, contrast sensitivity, stereoacuity, accommodative response, eye hand coordination, far near vision, and dynamic vision) between Visioneering Technologies, Inc. NaturalVue Multifocal and CooperVivion MiSight.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- This will be a prospective, double-masked, crossover trial.
| Arm | Type | Receives |
|---|---|---|
| NaturalVue | Active comparator | Device: NaturalVue Enhanced Multifocal 1 Day contact lensNaturalVue Enhanced Multifocal 1 Day contact lens |
| MiSight | Active comparator | Device: MiSight 1 Day contact lensMiSight 1 Day contact lens |
Who may qualify
- Ages
- 9 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (11 listed)
- Participants must satisfy the following conditions for inclusion in the trial:
Key exclusion criteria (12 listed)
- Any of the following will exclude a participant from this trial:
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NaturalVue Enhanced Multifocal 1 Day contact lensDaily disposable multifocal contact lens | Device | NaturalVue |
| MiSight 1 Day contact lensDaily disposable dual-focus contact lens | Device | MiSight |
Primary outcome
Comparison of visual performance (high and low contrast acuity) between VTI NaturalVue Enhanced Multifocal and CooperVision MiSight.
Time frame: 2 months
log MAR vision scale
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2025.
- Individual participant dataSharing planned: No
Related trials for Myopia
Recruiting
Managing Premyopia in Chinese Children Using Artificial Intelligence Assisted Defocus Incorporated Multiple Segments Based Spectacle Lens: a Randomized Controlled Clinical Trial
Pre-myopia, Myopia
Not yet recruiting
BRIGHT-LIGHT: Studying Red Light Therapy for Severe Short-Sightedness or Short-Sightedness That Worsens Despite Standard Treatment
Myopia, Myopia Progressing
Not yet recruiting
Clinical Performance and Outcomes After Toric Lens Transition
Astigmatism
Active, not recruiting
Effect of IOP Lowering on Progressive HM
High Myopia, Intraocular Pressure
Recruiting
Evaluation of a New Laser Refractive Vision Correction Using the TENEO™ 317 Model 2
Hyperopia and Myopia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marjean T Kulp, OD, MS principal investigator
The Ohio State University College of Optometry
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing NaturalVue Enhanced Multifocal 1 Day contact lens and MiSight 1 Day contact lens in people with Myopia, run by Visioneering Technologies, Inc at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 22 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Comparison of visual performance (high and low contrast acuity) between VTI NaturalVue Enhanced Multifocal and CooperVision MiSight. (time frame: 2 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2025.