Multiple SclerosisREMINDNCT06450977
Remote Evaluation of MIND Diet
A study testing MIND Diet in people with Multiple Sclerosis and Cognitive Change, run by University of Illinois at Urbana-Champaign at 1 site in United States.
Trial summary
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). Read more about this study
- Who is it for?
- Ages 18 to 64 years
- Conditions the study is for
- Multiple Sclerosis, Cognitive Change, Nutrition, Healthy
- What is being tested?
- MIND Diet
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 7 Jun 2024to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 64 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Individuals aged 18-64 years old
- Self-reported diagnosis of Multiple sclerosis (MS)
- 20/20 or corrected vision
- No other neurodegenerative disease diagnosis
- Stable disease-modifying therapy (DMT) within 6 months
- Not Pregnant or lactating
Show all 10Show fewer
- No food allergies or intolerances
- Able to consume study meals
- Not enrolled in another dietary, exercise, or medication study during the study
- Access to a computer/laptop with internet
Who cannot join
- Individuals younger than 18 or older than 64 years old
- No self-reported diagnosis of Multiple sclerosis (MS)
- Not 20/20 or uncorrected vision
- Other neurodegenerative disease diagnosis
- Disease modifying therapy (DMT) less than 6 months
- Pregnant or lactating
Show all 10Show fewer
- Food allergies or intolerances
- Not able to consume study meals
- Enrolled in another dietary, exercise, or medication study during the study
- No access to a computer/laptop with internet
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Illinois Urbana-Champaign
Urbana, Illinois, 61801
Naiman Khan, PhD/RD
About this study
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is:
Does the MIND diet improve cognitive performance relative to a control diet in persons with MS?
Participants will:
Consume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.
Read the detailed description
The purpose of this study is to understand how a healthy diet is related to thinking ability and memory in people with multiple sclerosis (MS). This study is fully remote consisting of meals being delivered to participant homes using Daily Harvest meal delivery service. Participants will be asked to consume a microwaveable study meal or prepackaged smoothie every day for 12 weeks. The study meals and smoothies will follow either a dietary pattern thought to improve brain health (Mediterranean-DASH Intervention for Neurodegenerative Delay; MIND), or a control diet, and will include foods commonly found in grocery stores. Participants will not know which diet they are assigned to (active or control). Participants will also be asked to follow simple dietary guidance on a healthy diet in addition to the meals provided. Participants will complete a series of online forms or surveys. Additionally, participants will complete an online cognitive battery from Cambridge Neuropsychological Test Automated Battery (CANTAB) at the beginning and end of the study.
- Conditions
- Multiple Sclerosis, Cognitive Change, Nutrition, Healthy
- Being tested
- MIND Diet, Control Diet
- Keywords
- Executive Function, MIND, Dietary Pattern, Telehealth
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MIND DietOther
Daily meals designed to increase adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern.
Control DietOther
Daily meals designed to increase fruit, vegetable, and whole grain intake consistent with a healthy American diet.
| Study group | Role | What they receive |
|---|---|---|
| MIND Diet | Experimental | Participants in the active MIND diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The treatment meals will follow MIND diet guidelines and include leafy green vegetables, nuts, legumes, whole grains, berries, and extra virgin olive oil. Receives: Other: MIND Diet |
| Control Diet | Active comparator | Participants in the control diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The Control group will receive daily meals that are isocaloric with the active/experimental meals but will follow a general diet based on the average American diet and Dietary Guidelines for Americans (i.e., vegetables, fruits, nuts, whole grains, and unsaturated fats). Receives: Other: Control Diet |
What is being measured
The primary outcome is the main question the study is designed to answer.
Information Processing
Rapid Visual Information Processing Task from CANTAB online battery
Measured: 12 weeks (Baseline vs. Follow Up)
Visual Processing
Match to Sample Visual Search from CANTAB online battery
Measured: 12 weeks (Baseline vs. Follow Up)
Processing Speed
Digit Span from CANTAB online battery
Measured: 12 weeks (Baseline vs. Follow Up)
Learning
Paired Associates Learning Task from CANTAB online battery
Measured: 12 weeks (Baseline vs. Follow Up)
Memory
Spatial Working Memory from CANTAB online battery
Measured: 12 weeks (Baseline vs. Follow Up)
MIND Scores
MIND dietary pattern scores calculated from diet records/surveys. Validated score to determine how someone adheres to the dietary pattern, scale of 0 to 14 with a higher score indicating greater adherence to the pattern.
Measured: 12 weeks (Baseline vs. Follow Up)
Secondary outcomes (6)
Recruitment Rates
Measure the number of participants contacted and interested in participating in the study
Measured: Throughout the recruitment process
Refusal Rates
Measure the number of participants that refused to participate in the intervention. Data on refusal factors will be collected through emails and calls and summarized.
Measured: Throughout the recruitment process.
Retention rates
Retention will be described as the proportion of enrolled participants who complete the intervention
Measured: Throughout the intervention (weeks 1-12)
Attrition rates
Attrition is the proportion of the participants who did not complete the intervention.
Measured: Throughout the intervention (weeks 1-12)
Adherence/Compliance Rates
Adherence rates are the proportion of intervention meals and guidelines the participants followed. These will be tracked through tracking surveys throughout the intervention.
Measured: Throughout the intervention (weeks 1-12)
Participant Experience and Burden
Participants will report feedback on the intervention through video chats. Descriptives of participant experience and burden of intervention will be reported
Measured: Throughout the intervention (weeks 1-12)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jun 2024
- Study start7 Jun 2024
- Primary completion1 Jan 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Illinois at Urbana-Champaign
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Naiman Khan, University of Illinois at Urbana-Champaign
- Investigators
- Naiman Khan, PhD, Principal investigator, University of Illinois Urbana-Champaign
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06450977
- Sponsor's protocol ID
- REMIND
- Acronym
- REMIND
- Status last verified
- Jun 2024
- First submitted
- 4 Jun 2024
- Last updated
- 27 Jun 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Martell SG, Holthaus TA, Verma S, Adamson B, Motl RW, Khan NA. Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet intervention in persons with multiple sclerosis: A feasibility, randomized controlled trial. Nutr Res. 2026 Aug;152:11-25. doi: 10.1016/j.nutres.2026.05.006. Epub 2026 May 28.
PubMed 42314522
Study at a glance
From the registry record, last updated by the sponsor on 27 Jun 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Remote Evaluation of MIND Diet
- ClinicalTrials.gov ID
- NCT06450977
- Acronym / sponsor ID
- REMIND / REMIND
- Conditions
- Multiple Sclerosis, Cognitive Change, Nutrition, Healthy
- Keywords
- Executive Function, MIND, Dietary Pattern, Telehealth
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- University of Illinois at Urbana-ChampaignUniversity, hospital or other
- Study start
- 7 Jun 2024 (actual)
- Primary completion
- 1 Jan 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 10 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is:
Does the MIND diet improve cognitive performance relative to a control diet in persons with MS?
Participants will:
Consume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.
Detailed description
The purpose of this study is to understand how a healthy diet is related to thinking ability and memory in people with multiple sclerosis (MS). This study is fully remote consisting of meals being delivered to participant homes using Daily Harvest meal delivery service. Participants will be asked to consume a microwaveable study meal or prepackaged smoothie every day for 12 weeks. The study meals and smoothies will follow either a dietary pattern thought to improve brain health (Mediterranean-DASH Intervention for Neurodegenerative Delay; MIND), or a control diet, and will include foods commonly found in grocery stores. Participants will not know which diet they are assigned to (active or control). Participants will also be asked to follow simple dietary guidance on a healthy diet in addition to the meals provided. Participants will complete a series of online forms or surveys. Additionally, participants will complete an online cognitive battery from Cambridge Neuropsychological Test Automated Battery (CANTAB) at the beginning and end of the study.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| MIND Diet | Experimental | Other: MIND DietParticipants in the active MIND diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The treatment meals will follow MIND diet guidelines and include leafy green vegetables, nuts, legumes, whole grains, berries, and extra virgin olive oil. |
| Control Diet | Active comparator | Other: Control DietParticipants in the control diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The Control group will receive daily meals that are isocaloric with the active/experimental meals but will follow a general diet based on the average American diet and Dietary Guidelines for Americans (i.e., vegetables, fruits, nuts, whole grains, and unsaturated fats). |
Who may qualify
- Ages
- 18 to 64 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (10 listed)
- Individuals aged 18-64 years old
- Self-reported diagnosis of Multiple sclerosis (MS)
- 20/20 or corrected vision
- No other neurodegenerative disease diagnosis
- Stable disease-modifying therapy (DMT) within 6 months
Key exclusion criteria (10 listed)
- Individuals younger than 18 or older than 64 years old
- No self-reported diagnosis of Multiple sclerosis (MS)
- Not 20/20 or uncorrected vision
- Other neurodegenerative disease diagnosis
- Disease modifying therapy (DMT) less than 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MIND DietDaily meals designed to increase adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern. | Other | MIND Diet |
| Control DietDaily meals designed to increase fruit, vegetable, and whole grain intake consistent with a healthy American diet. | Other | Control Diet |
Primary outcome
Information Processing
Time frame: 12 weeks (Baseline vs. Follow Up)
Rapid Visual Information Processing Task from CANTAB online battery
Visual Processing
Time frame: 12 weeks (Baseline vs. Follow Up)
Match to Sample Visual Search from CANTAB online battery
Processing Speed
Time frame: 12 weeks (Baseline vs. Follow Up)
Digit Span from CANTAB online battery
Learning
Time frame: 12 weeks (Baseline vs. Follow Up)
Paired Associates Learning Task from CANTAB online battery
Memory
Time frame: 12 weeks (Baseline vs. Follow Up)
Spatial Working Memory from CANTAB online battery
MIND Scores
Time frame: 12 weeks (Baseline vs. Follow Up)
MIND dietary pattern scores calculated from diet records/surveys. Validated score to determine how someone adheres to the dietary pattern, scale of 0 to 14 with a higher score indicating greater adherence to the pattern.
6 secondary outcomes
Recruitment Rates
Time frame: Throughout the recruitment process
Refusal Rates
Time frame: Throughout the recruitment process.
Retention rates
Time frame: Throughout the intervention (weeks 1-12)
Attrition rates
Time frame: Throughout the intervention (weeks 1-12)
Adherence/Compliance Rates
Time frame: Throughout the intervention (weeks 1-12)
Participant Experience and Burden
Time frame: Throughout the intervention (weeks 1-12)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jun 2024.
- Derived from this study: PubMed 42314522Martell SG, Holthaus TA, Verma S, Adamson B, Motl RW, Khan NA. Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet intervention in persons with multiple sclerosis: A feasibility, randomized controlled trial. Nutr Res. 2026 Aug;152:11-25. doi: 10.1016/j.nutres.2026.05.006. Epub 2026 May 28.
- Individual participant dataSharing planned: No
Related trials for Multiple Sclerosis
RecruitingObservational study
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Multiple Sclerosis
RecruitingObservational study
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
Progressive Multifocal Leukoencephalopathy
Recruiting
Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis
Multiple Sclerosis, Clinically Isolated Syndrome
Active, not recruitingObservational study
A Study to Evaluate Long-Term Safety of Vumerity and Tecfidera in Participants With Multiple Sclerosis (MS)
Multiple Sclerosis
RecruitingPhase 3
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Relapsing Multiple Sclerosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Naiman Khan, PhD principal investigator
University of Illinois Urbana-Champaign
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MIND Diet in people with Multiple Sclerosis and Cognitive Change, run by University of Illinois at Urbana-Champaign at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Jun 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Naiman Khan, PhD (2173001667, nakhan2@illinois.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Information Processing (time frame: 12 weeks (Baseline vs. Follow Up)). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06450977, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jun 2024; AzTrials last refreshed its copy on 26 Oct 2026.