Cardiac ArrestNCT06448156
Epidemiological Study of Out-of-hospital Cardiac Arrest in Guangzhou
An observational study of Cardiac Arrest and Sudden Cardiac Death, run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University at 1 site in China.
Trial summary
Aim This was a population-based retrospective cohort study of OHCA. This study intends to retrospectively analyze the data of pre-hospital emergency system in Guangzhou for 10 years, explore the incidence trend of OHCA in Guangzhou for 10 years; Through further analysis, we try to explore the time distribution… Read more about this study
- Who is it for?
- Ages 0 to 120 years
- Conditions the study is for
- Cardiac Arrest, Sudden Cardiac Death
- What is being tested?
- "cardiac arrest" and "sudden death"
- How many people
- 44,375 participants
- Where
- 1 siteChina
- Study dates
- 1 Jan 2021to 31 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 0 to 120 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Cases in the database with a secondary diagnosis containing the diagnostic keywords "cardiac arrest" and "sudden death".Data were collected from the GZ-EMS Command Centre's dispatch system database of pre-hospital data for the central urban districts of City.
Who may be able to join
- Cases in the database with a secondary diagnosis containing the diagnostic keywords "cardiac arrest" and "sudden death"
Who cannot join
- cases where the diagnosis of "cardiac arrest" and "sudden death" includes a diagnosis of a non-cardiac cause such as asphyxiation, suicide, drowning, advanced cancer, trauma, shock, poisoning, cerebral vascular accident, etc;
- cases with duplicate records of sex, age, time of call, pick-up address and initial diagnosis
Trial locations and contacts
1 site in 1 country.
About this study
Aim This was a population-based retrospective cohort study of OHCA. This study intends to retrospectively analyze the data of pre-hospital emergency system in Guangzhou for 10 years, explore the incidence trend of OHCA in Guangzhou for 10 years; Through further analysis, we try to explore the time distribution characteristics of OHCA in order to understand the epidemiological characteristics and rules of OHCA in super large cities in southern China.
Methods The pre-hospital traffic data in the main urban area of Guangzhou Emergency Medical Command Center database from 2011 to 2020 were collected. The cases diagnosed as "cardiac arrest" and "sudden death" were screened, and the cases with non-cardiac causes in the diagnosis were deleted. The crude incidence rate and age-standardized incidence rate of OHCA were calculated. Joinpoint software was used to calculate the changing nodes in the OHCA incidence trend, and the AnnualPercent Change (APC) and Average AnnualPercent Change (Average AnnualPercent Change, APC) of OHCA incidence were calculated. AAPC). The OHCA data were grouped according to the six main urban areas, and the crude incidence rate, ASIR and changing trend of the six main urban areas were calculated. The data of OHCA were grouped by age, and the crude incidence rate, ASIR and changing trend of each age group were calculated. The data information was divided into groups according to 24 hours a day, 7 days a week, and four seasons. The number of OHCA cases in different time periods was statistically described. The data were imported into SPSS 26.0 for analysis, and Mann-Kendall test was used to evaluate the statistical significance of the time trend. Time rhythm variability was tested for mean distribution using chi-square goodness of fit test.
- Conditions
- Cardiac Arrest, Sudden Cardiac Death
- Being tested
- "cardiac arrest" and "sudden death"
- Medical subject headings
- Heart Arrest, Death, Sudden, Cardiac
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
"cardiac arrest" and "sudden death"Diagnostic test
Selection of cases with a secondary diagnosis containing the diagnostic keywords "cardiac arrest" and "sudden death"."cardiac arrest" and "sudden death".The incidence rate is then calculated
| Study group | Role | What they receive |
|---|---|---|
| 0-19 years age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 20-29 years age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 30-39 years age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 40 to 49 age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 50 to 59 age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 60 to 69 age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 70 to 79 age group | Not described Receives: Diagnostic Test: "cardiac arrest" and "sudden death" | |
| 80+age group | Age group greater than or equal to 80 years Receives: Diagnostic Test: "cardiac arrest" and "sudden death" |
What is being measured
The primary outcome is the main question the study is designed to answer.
Crude incidence rate
The frequency of new cases of a disease in a given population over a given period of time.
Measured: 2011-01-01 to 2020-12-31
Age standardized incidence rate
Incidence rates after removing the influence of age, and incidence rates normalised by age. The rationale is that age is an important influence on cancer incidence, with higher incidence rates occurring at older ages, so that if the age structure of the population in two regions is very different, it is not possible to determine whether the high incidence of a disease in a particular region is due to a different age composition or to other influences if incidence rate comparisons are applied.
Measured: 2011-01-01 to 2020-12-31
Average annual percentage change
Calculated using the weighted average of the APC, it is an overall measure of trend.
Measured: 2011-01-01 to 2020-12-31
Annual percentage change
Indicates the change from one year to the next within a segment at a constant percentage on a log-linear model for evaluating trends within segments.
Measured: 2011-01-01 to 2020-12-31
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jun 2024
- Study start1 Jan 2021
- Primary completion31 Dec 2025 (estimated)
- Study completion31 Dec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac ArrestStudies of the same condition, open and under way.
- More trials run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 44,375 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Tao Yu, Study director, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06448156
- Sponsor's protocol ID
- MR-44-24-003181
- Status last verified
- Dec 2023
- First submitted
- 3 Jun 2024
- Last updated
- 7 Jun 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jun 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Epidemiological Study of Out-of-hospital Cardiac Arrest in Guangzhou
- ClinicalTrials.gov ID
- NCT06448156
- Acronym / sponsor ID
- MR-44-24-003181
- Conditions
- Cardiac Arrest, Sudden Cardiac Death
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 44,375 participants (actual)
- Lead sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityUniversity, hospital or other
- Study start
- 1 Jan 2021 (actual)
- Primary completion
- 31 Dec 2025 (estimated)
- Study completion
- 31 Dec 2025 (estimated)
- First posted
- 7 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aim This was a population-based retrospective cohort study of OHCA. This study intends to retrospectively analyze the data of pre-hospital emergency system in Guangzhou for 10 years, explore the incidence trend of OHCA in Guangzhou for 10 years; Through further analysis, we try to explore the time distribution characteristics of OHCA in order to understand the epidemiological characteristics and rules of OHCA in super large cities in southern China.
Methods The pre-hospital traffic data in the main urban area of Guangzhou Emergency Medical Command Center database from 2011 to 2020 were collected. The cases diagnosed as "cardiac arrest" and "sudden death" were screened, and the cases with non-cardiac causes in the diagnosis were deleted. The crude incidence rate and age-standardized incidence rate of OHCA were calculated. Joinpoint software was used to calculate the changing nodes in the OHCA incidence trend, and the AnnualPercent Change (APC) and Average AnnualPercent Change (Average AnnualPercent Change, APC) of OHCA incidence were calculated. AAPC). The OHCA data were grouped according to the six main urban areas, and the crude incidence rate, ASIR and changing trend of the six main urban areas were calculated. The data of OHCA were grouped by age, and the crude incidence rate, ASIR and changing trend of each age group were calculated. The data information was divided into groups according to 24 hours a day, 7 days a week, and four seasons. The number of OHCA cases in different time periods was statistically described. The data were imported into SPSS 26.0 for analysis, and Mann-Kendall test was used to evaluate the statistical significance of the time trend. Time rhythm variability was tested for mean distribution using chi-square goodness of fit test.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 8
| Arm | Type | Receives |
|---|---|---|
| 0-19 years age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 20-29 years age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 30-39 years age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 40 to 49 age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 50 to 59 age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 60 to 69 age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 70 to 79 age group | – | Diagnostic Test: "cardiac arrest" and "sudden death" |
| 80+age group | – | Diagnostic Test: "cardiac arrest" and "sudden death"Age group greater than or equal to 80 years |
Who may qualify
- Ages
- 0 to 120 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Cases in the database with a secondary diagnosis containing the diagnostic keywords "cardiac arrest" and "sudden death".Data were collected from the GZ-EMS Command Centre's dispatch system database of pre-hospital data for the central urban districts of City.
Key inclusion criteria (1 listed)
- Cases in the database with a secondary diagnosis containing the diagnostic keywords "cardiac arrest" and "sudden death"
Key exclusion criteria (2 listed)
- cases where the diagnosis of "cardiac arrest" and "sudden death" includes a diagnosis of a non-cardiac cause such as asphyxiation, suicide, drowning, advanced cancer, trauma, shock, poisoning, cerebral vascular accident, etc;
- cases with duplicate records of sex, age, time of call, pick-up address and initial diagnosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| "cardiac arrest" and "sudden death"Selection of cases with a secondary diagnosis containing the diagnostic keywords "cardiac arrest" and "sudden death"."cardiac arrest" and "sudden death".The incidence rate is then calculated | Diagnostic test | 0-19 years age group, 20-29 years age group, 30-39 years age group, 40 to 49 age group, 50 to 59 age group, 60 to 69 age group, 70 to 79 age group, 80+age group |
Primary outcome
Crude incidence rate
Time frame: 2011-01-01 to 2020-12-31
The frequency of new cases of a disease in a given population over a given period of time.
Age standardized incidence rate
Time frame: 2011-01-01 to 2020-12-31
Incidence rates after removing the influence of age, and incidence rates normalised by age. The rationale is that age is an important influence on cancer incidence, with higher incidence rates occurring at older ages, so that if the age structure of the population in two regions is very different, it is not possible to determine whether the high incidence of a disease in a particular region is due to a different age composition or to other influences if incidence rate comparisons are applied.
Average annual percentage change
Time frame: 2011-01-01 to 2020-12-31
Calculated using the weighted average of the APC, it is an overall measure of trend.
Annual percentage change
Time frame: 2011-01-01 to 2020-12-31
Indicates the change from one year to the next within a segment at a constant percentage on a log-linear model for evaluating trends within segments.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jun 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tao Yu study director
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, China
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest and Sudden Cardiac Death, run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 7 Jun 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Crude incidence rate (time frame: 2011-01-01 to 2020-12-31). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jun 2024.