Type 2 DiabetesNCT06382246
The Acute Effect of "Exercise Snacks" on Glycemic Responses in Individuals With Type 2 Diabetes.
A study testing Exercise snacks in people with Type 2 Diabetes, run by University of British Columbia at 1 site in Canada.
Trial summary
To conduct a randomized crossover trial to determine the acute impact of exercise snacks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring. Read more about this study
- Who is it for?
- Ages 30 to 75 years
- Conditions the study is for
- Type 2 Diabetes
- What is being tested?
- Exercise snacks
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteCanada
- Study dates
- 20 Apr 2024to 15 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 30-75 years old.
- Have physician-diagnosed type 2 diabetes.
- Currently participating in less than 150 minutes of moderate-to-vigorous intensity aerobic exercise per week.
- Have a body mass index between 18.5 and 40 kg/m2.
- Have had a stable medication dosage and no changes to the number of prescribed medications for at least 6 months.
- Able to maintain current medication doses during the study.
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- Able to maintain current physical activity patterns during the study.
- HbA1c is less than or equal to 8.5%.
- Have access to a computer, tablet, or smartphone for intervention delivery and tracking.
- Can travel to McMaster University for in-person laboratory testing visits.
- Can read, write, and understand English.
- Anticipate having access to the internet for the duration of the intervention (i.e., over the next 3-4 months).
- Cleared for exercise participation based on the CSEP Get Active Questionnaire and the Rose Angina Questionnaire.
Who cannot join
- Taking 4 or more glucose-lowering medications.
- Taking insulin.
- Taking beta-blockers.
- Taking 3 or more commonly prescribed medications for the prevention of cardiovascular disease (e.g., statins, antihypertensives).
- Have had an episode of severe hypoglycemia in the past 6 months (defined as having neurological symptoms consistent with neuroglycopenia and required assistance in treatment by a second party).
- Currently a cigarette smoker.
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- Have a chronic musculoskeletal condition that would prevent participation in exercise.
- Have had a recent (within the last 2 years) cardiovascular event that prevents participation in exercise.
- Experience angina upon exertion.
- Have uncontrolled high blood pressure (hypertension) or an atypical blood pressure or pulse rate at rest or during exercise as determined by a physician.
- Have a scheduled surgical procedure within the next 3-4 months that would prevent exercise participation.
- Currently diagnosed with a cardiac or pulmonary disease (e.g., angina, arrythmia, exercise-induced bronchospasm) that would prevent exercise participation.
- Have a psychiatric disorder that could prevent you from completing the study procedures or visits.
- Have donated more than 0.5 L of blood within the last 4 weeks.
- Currently following an extreme diet (e.g., very low carbohydrate/calorie, ketogenic) or taking dietary/nutritional supplements that impact glucose control (e.g., exogenous ketones).
- Currently have diabetic ulcers, peripheral vascular disease, or diabetic neuropathy that will prevent participation in exercise.
- Currently on dialysis.
- Currently participating in another clinical trial that interferes with the study procedures.
- Currently pregnant or planning on becoming pregnant during the intervention (i.e., within the next 3-4 months).
Trial locations and contacts
1 site in 1 country.
Canada1 site, 1 recruiting
- Recruiting
University of British Columbia Okanagan
Kelowna, British Columbia, V1V 3G1
Jonathan Little, PhD, 2508079876, jonathan.little@ubc.ca
2508079876, jonathan.little@ubc.ca
About this study
Official title: The Acute Effect of "Exercise Snacks" on Glycemic Responses in Individuals With Type 2 Diabetes: a Randomized Controlled Crossover Trial
To conduct a randomized crossover trial to determine the acute impact of exercise snacks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring.
Read the detailed description
Participants will perform two, 48-hour experimental conditions separated by 24 hours while wearing a continuous glucose monitor to measure glycemic responses. The order of the trials will be randomized for each participant. The two trials will include an exercise condition (EX) and a control, non-exercise condition (CON). During the EX trial, participants will perform four exercise snacks per day on two consecutive days (i.e., Monday and Tuesday). Each exercise snack will be 1-minute in duration and consist of bodyweight style exercise performed with vigorous effort. During the CON trial, participants will be asked to refrain from any structured exercise during two consecutive days (i.e., Thursday and Friday). All meals will be provided to participants during the two 48-hour trials and will be standardized for a given participant. There will be a one-day wash out period in between the completion of both trials for all participants.
- Conditions
- Type 2 Diabetes
- Being tested
- Exercise snacks
- Medical subject headings
- Diabetes Mellitus, Type 2
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise snacksOther
Bodyweight-style exercise snacks lasting 1-minute each performed with vigorous effort 4 times per day on two consecutive days.
| Study group | Role | What they receive |
|---|---|---|
| Exercise (EX): exercise snacks condition | Experimental | Bodyweight-style exercise snacks lasting 1-minute each performed with vigorous effort 4 times per day on two consecutive days. Receives: Other: Exercise snacks |
| Control (CON): Non-exercise condition | No intervention | No structured exercise on two consecutive days. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean 24-h glucose concentration assessed using continuous glucose monitoring
The mean 24-h glucose per trial will be determined as the average of the two 24-h periods during that specific trial.
Measured: 48-hour EX trial versus the 48-hour CON trial
Secondary outcomes (5)
Time in range determined using continuous glucose monitoring
Percentage of time in range (3.9-10 mmol/L)
Measured: 48-hour EX trial versus the 48-hour CON trial
Time above range determined using continuous glucose monitoring
Percentage of time above range (>10 mmol/L)
Measured: 48-hour EX trial versus the 48-hour CON trial
Time below range determined using continuous glucose monitoring
Percentage of time above range (<3.9 mmol/L)
Measured: 48-hour EX trial versus the 48-hour CON trial
Glycemic variability determined using continuous glucose monitoring
Glycemic variability will be assess using the Standard Deviation (SD), mean amplitude of glycemic excursions (MAGE), and the coefficient of variation (CV)
Measured: 48-hour EX trial versus the 48-hour CON trial
Two-hour glucose area under the curve following standardized breakfast, lunch and dinner meals
The incremental area under the curve following breakfast, lunch and dinner (2 h post meal)
Measured: 48-hour EX trial versus the 48-hour CON trial
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Apr 2024
- Study start20 Apr 2024
- Primary completion15 Jul 2025 (estimated)
- Study completion15 Jul 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Type 2 DiabetesStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Randomized controlled crossover design
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Collaborators
- McMaster University
- Responsible party
- Principal investigator, Jonathan Little, University of British Columbia
- Investigators
- Jonathan Little, PhD, Principal investigator, University of British Columbia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06382246
- Sponsor's protocol ID
- H24-Acute-ExSnacks
- Status last verified
- May 2024
- First submitted
- 19 Apr 2024
- Last updated
- 8 May 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Babir FJ, Marcotte-Chenard A, Sandilands RE, D'Amico A, Falkenhain K, Mulkewich N, Islam H, Richards DL, Madden K, Singer J, Riddell M, Gibala MJ, Little JP. Exercise snacks performed in real-world settings reduce postprandial hyperglycaemia and glycaemic variability in individuals living with type 2 diabetes: a randomised crossover study. Diabetologia. 2026 Aug;69(8):2200-2211. doi: 10.1007/s00125-026-06741-2. Epub 2026 Apr 24.
PubMed 42029706
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Acute Effect of "Exercise Snacks" on Glycemic Responses in Individuals With Type 2 Diabetes: a Randomized Controlled Crossover Trial
- ClinicalTrials.gov ID
- NCT06382246
- Acronym / sponsor ID
- H24-Acute-ExSnacks
- Conditions
- Type 2 Diabetes
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Collaborators
- McMaster University
- Study start
- 20 Apr 2024 (actual)
- Primary completion
- 15 Jul 2025 (estimated)
- Study completion
- 15 Jul 2025 (estimated)
- First posted
- 24 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To conduct a randomized crossover trial to determine the acute impact of exercise snacks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring.
Detailed description
Participants will perform two, 48-hour experimental conditions separated by 24 hours while wearing a continuous glucose monitor to measure glycemic responses. The order of the trials will be randomized for each participant. The two trials will include an exercise condition (EX) and a control, non-exercise condition (CON). During the EX trial, participants will perform four exercise snacks per day on two consecutive days (i.e., Monday and Tuesday). Each exercise snack will be 1-minute in duration and consist of bodyweight style exercise performed with vigorous effort. During the CON trial, participants will be asked to refrain from any structured exercise during two consecutive days (i.e., Thursday and Friday). All meals will be provided to participants during the two 48-hour trials and will be standardized for a given participant. There will be a one-day wash out period in between the completion of both trials for all participants.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Randomized controlled crossover design
| Arm | Type | Receives |
|---|---|---|
| Exercise (EX): exercise snacks condition | Experimental | Other: Exercise snacksBodyweight-style exercise snacks lasting 1-minute each performed with vigorous effort 4 times per day on two consecutive days. |
| Control (CON): Non-exercise condition | No intervention | –No structured exercise on two consecutive days. |
Who may qualify
- Ages
- 30 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- Aged 30-75 years old.
- Have physician-diagnosed type 2 diabetes.
- Currently participating in less than 150 minutes of moderate-to-vigorous intensity aerobic exercise per week.
- Have a body mass index between 18.5 and 40 kg/m2.
- Have had a stable medication dosage and no changes to the number of prescribed medications for at least 6 months.
Key exclusion criteria (19 listed)
- Taking 4 or more glucose-lowering medications.
- Taking insulin.
- Taking beta-blockers.
- Taking 3 or more commonly prescribed medications for the prevention of cardiovascular disease (e.g., statins, antihypertensives).
- Have had an episode of severe hypoglycemia in the past 6 months (defined as having neurological symptoms consistent with neuroglycopenia and required assistance in treatment by a second party).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise snacksBodyweight-style exercise snacks lasting 1-minute each performed with vigorous effort 4 times per day on two consecutive days. | Other | Exercise (EX): exercise snacks condition |
Primary outcome
Mean 24-h glucose concentration assessed using continuous glucose monitoring
Time frame: 48-hour EX trial versus the 48-hour CON trial
The mean 24-h glucose per trial will be determined as the average of the two 24-h periods during that specific trial.
5 secondary outcomes
Time in range determined using continuous glucose monitoring
Time frame: 48-hour EX trial versus the 48-hour CON trial
Time above range determined using continuous glucose monitoring
Time frame: 48-hour EX trial versus the 48-hour CON trial
Time below range determined using continuous glucose monitoring
Time frame: 48-hour EX trial versus the 48-hour CON trial
Glycemic variability determined using continuous glucose monitoring
Time frame: 48-hour EX trial versus the 48-hour CON trial
Two-hour glucose area under the curve following standardized breakfast, lunch and dinner meals
Time frame: 48-hour EX trial versus the 48-hour CON trial
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2024.
- Derived from this study: PubMed 42029706Babir FJ, Marcotte-Chenard A, Sandilands RE, D'Amico A, Falkenhain K, Mulkewich N, Islam H, Richards DL, Madden K, Singer J, Riddell M, Gibala MJ, Little JP. Exercise snacks performed in real-world settings reduce postprandial hyperglycaemia and glycaemic variability in individuals living with type 2 diabetes: a randomised crossover study. Diabetologia. 2026 Aug;69(8):2200-2211. doi: 10.1007/s00125-026-06741-2. Epub 2026 Apr 24.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jonathan Little, PhD principal investigator
University of British Columbia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise snacks in people with Type 2 Diabetes, run by University of British Columbia at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 19 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 8 May 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Jonathan P Little, PhD (250.807.9876, jonathan.little@ubc.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean 24-h glucose concentration assessed using continuous glucose monitoring (time frame: 48-hour EX trial versus the 48-hour CON trial). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06382246, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2024.