Overweight and ObesityNCT06323070
Effects of Watermelon or Low-fat Cookie Consumption on Wellness
A study testing Low-fat cookies and Watermelon in people with Overweight and Obesity, run by San Diego State University at 1 site in United States.
Trial summary
The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Overweight and Obesity
- What is being tested?
- Low-fat cookies and Watermelon
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Mar 2024to Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Generally healthy subjects
- BMI 20-40 kg/m2
Who cannot join
- Smoker
- Pregnant woman
- Required antibiotics use
- Required dietary supplement use
- Required medication of metabolic disorders, mental health and sexual health
- Allergy to watermelon or wheat
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
School of Exercise and Nutritional Sciences
San Diego, California, 92182
Mee Young Hong, PhD, 619-594-2392, mhong2@sdsu.edu
About this study
The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults.
- Conditions
- Overweight and Obesity
- Being tested
- Low-fat cookies, Watermelon
- Medical subject headings
- Overweight, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low-fat cookiesOther
To determine the effects of low-fat cookie consumption on physiological indicators of wellness regarding sexual, skin, and gut health
WatermelonOther
To determine the effects of watermelon consumption on physiological indicators of wellness regarding sexual, skin, and gut health
| Study group | Role | What they receive |
|---|---|---|
| Low-fat cookies | Active comparator | Subjects consume 100 kcal of low-fat cookies daily for 4 weeks. Receives: Other: Low-fat cookies |
| Watermelon | Experimental | Subjects consume 100 kcal of watermelon daily for 4 weeks. Receives: Other: Watermelon |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change of sexual health questionnaire scores
Change of sexual health questionnaire scores will be determined to examine effects of watermelon consumption vs low-fat cookies.
Measured: Baseline and week 4
Change of skin hydration scores
Change of skin hydration scores will be determined to examine effects of watermelon consumption vs low-fat cookies.
Measured: Baseline, 1 min post application and week 4 consumption
Change of microbiome diversity
Change of microbiome diversity will be determined to examine effects of watermelon consumption vs low-fat cookies.
Measured: Baseline and week 4
Secondary outcomes (3)
Change of depression questionnaire scores
Change of depression questionnaire scores will be determined to examine effects of watermelon consumption vs low-fat cookies.
Measured: Baseline and week 4
Changes of trimethylamine N-oxide (TMAO) levels
Changes in trimethylamine N-oxide (TMAO) levels will be determined to examine the effects of watermelon consumption vs low-fat cookies.
Measured: Baseline and week 4
Changes of cholesterol levels
Changes in cholesterol levels will be determined to examine the effects of watermelon consumption vs low-fat cookies.
Measured: Baseline and week 4
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Mar 2024
- Study start1 Mar 2024
- Primary completionDec 2028 (estimated)
- Study completionDec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Overweight and ObesityStudies of the same condition, open and under way.
- More trials run by San Diego State UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- San Diego State University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Mee Young Hong, PhD, Principal investigator, San Diego State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06323070
- Sponsor's protocol ID
- HS-2023-0281
- Status last verified
- Aug 2026
- First submitted
- 14 Mar 2024
- Last updated
- 28 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Watermelon or Low-fat Cookie Consumption on Wellness
- ClinicalTrials.gov ID
- NCT06323070
- Acronym / sponsor ID
- HS-2023-0281
- Conditions
- Overweight and Obesity
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- San Diego State UniversityUniversity, hospital or other
- Study start
- 1 Mar 2024 (actual)
- Primary completion
- Dec 2028 (estimated)
- Study completion
- Dec 2028 (estimated)
- First posted
- 21 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Low-fat cookies | Active comparator | Other: Low-fat cookiesSubjects consume 100 kcal of low-fat cookies daily for 4 weeks. |
| Watermelon | Experimental | Other: WatermelonSubjects consume 100 kcal of watermelon daily for 4 weeks. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Generally healthy subjects
- BMI 20-40 kg/m2
Key exclusion criteria (6 listed)
- Smoker
- Pregnant woman
- Required antibiotics use
- Required dietary supplement use
- Required medication of metabolic disorders, mental health and sexual health
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low-fat cookiesTo determine the effects of low-fat cookie consumption on physiological indicators of wellness regarding sexual, skin, and gut health | Other | Low-fat cookies |
| WatermelonTo determine the effects of watermelon consumption on physiological indicators of wellness regarding sexual, skin, and gut health | Other | Watermelon |
Primary outcome
Change of sexual health questionnaire scores
Time frame: Baseline and week 4
Change of sexual health questionnaire scores will be determined to examine effects of watermelon consumption vs low-fat cookies.
Change of skin hydration scores
Time frame: Baseline, 1 min post application and week 4 consumption
Change of skin hydration scores will be determined to examine effects of watermelon consumption vs low-fat cookies.
Change of microbiome diversity
Time frame: Baseline and week 4
Change of microbiome diversity will be determined to examine effects of watermelon consumption vs low-fat cookies.
3 secondary outcomes
Change of depression questionnaire scores
Time frame: Baseline and week 4
Changes of trimethylamine N-oxide (TMAO) levels
Time frame: Baseline and week 4
Changes of cholesterol levels
Time frame: Baseline and week 4
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Aug 2026.
Related trials for Overweight and Obesity
RecruitingObservational study
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
Obesity
Active, not recruitingPhase 4
Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic Disorders
Metabolic Abnormalities, Obesity & Overweight
Recruiting
Exercise Training and Vitamin D Metabolism
Obesity & Overweight, Vitamin D
Recruiting
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Weight Loss, Bone Density
Active, not recruiting
Effect of Probiotics on Insulin Sensitivity in Overweight and Obese Pregnancy
Obesity & Overweight, Gestational Diabetes Mellitus (GDM)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mee Young Hong, PhD principal investigator
San Diego State University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low-fat cookies and Watermelon in people with Overweight and Obesity, run by San Diego State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mee Young Hong, PhD (619-594-2392, mhong2@sdsu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change of sexual health questionnaire scores (time frame: Baseline and week 4). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Aug 2026.