Cerebral PalsyNCT06292416
Mirror Therapy With Sensory Motor Training in Children With CP
A study testing Experimental: Mirror therapy with sensory motor training., Experimental: Mirror Therapy with motor training and Experimental: Motor Training in people with Cerebral Palsy, run by Riphah International University at 1 site in Pakistan.
Trial summary
The study compares two interventions in CP children: mirror therapy with sensory motor training versus mirror therapy with motor training. Mirror therapy works by manipulating the brain out of pain, ultimately improving movement in patients with one-sided paralysis. Read more about this study
- Who is it for?
- Ages 6 to 12 years
- Conditions the study is for
- Cerebral Palsy
- What is being tested?
- Experimental: Mirror therapy with sensory motor training., Experimental: Mirror Therapy with motor training and Experimental: Motor Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 sitePakistan
- Study dates
- 30 Dec 2023to 14 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 12 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Aged between 6 and 12 years
- Lack of use of the affected upper limb
- Level I-III of the Manual Ability Classification System (MACS)
- Level I-III in the Gross Motor Function Classification System (GMFCS)
Who cannot join
- Disease not associated with congenital hemiplegia
- Presence of contractures in the affected upper limb affecting the functional movement
- Surgery in the six months previously to the treatment
- Botulinum toxin in the two months previously to or during the intervention
- Pharmacologically uncontrolled epilepsy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Mirror Therapy With Sensory Motor Training on Upper Limb Functions and Quality of Movement in Children With Hemiplegic Cerebral Palsy
The study compares two interventions in CP children: mirror therapy with sensory motor training versus mirror therapy with motor training. Mirror therapy works by manipulating the brain out of pain, ultimately improving movement in patients with one-sided paralysis. It can be used in combination with other therapies to assist patients with cerebral palsy in retraining the brains, restoring function, and enhancing the overall quality of life. The purpose of this study is to use a combination of Mirror therapy with sensory motor training and motor training and observe which one of these combinations has the most desirable effects in improving movement and quality of life in CP Children
Read the detailed description
The neurodevelopmental disorder known as cerebral palsy (CP) is caused by damage to the developing brain and is characterized by abnormalities of muscle tone, mobility, and motor skills. A person with cerebral palsy can be classified according to how it affects movement, the area of the body that is affected, and how severe the effects are. Children with hemiplegic cerebral palsy have a variety of motor and sensory deficits in the upper limb, which makes it more difficult to perform everyday tasks including reaching, gripping, releasing, and manipulating things. The movement produced by constraints on the less-affected hand and extensive training on the more-affected hand aims to enhance upper limb function in hemiparetic youngsters. One such intervention to improve the motor function of these patients is the use of mirror therapy. Mirror therapy is one of the more recent approaches to helping the more severely afflicted upper extremities regain function after stroke. During mirror therapy, a mirror is held in the patient's midsagittal plane, reflecting the less-affected side as though it were the more-affected side. In this arrangement, the motions of the less affected extremity give the impression that the more affected extremity is moving normally. Mirror treatment is easy to use, reasonably priced, and non-intrusive. This makes it a promising and secure complement to hemiparesis therapy for children. Sensorimotor training involves proprioceptive and balance exercises that were developed to help individuals suffering from chronic musculoskeletal pain syndromes. Repetitive sensorimotor training may increase the responsiveness of nociceptive-evoked potentials. Motor training, on the other hand, focuses on skill acquisition through repetition. Through this study, the investigator wants to use a combination of techniques to improve upper limb function and quality of movement in patients with CP
- Conditions
- Cerebral Palsy
- Being tested
- Experimental: Mirror therapy with sensory motor training., Experimental: Mirror Therapy with motor training, Experimental: Motor Training
- Keywords
- Cerebral palsy, Hemiplegic, Mirror Therapy, Strength training
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Experimental: Mirror therapy with sensory motor training.Other
Block design, finding shapes in pictures, puzzles, matching geometric shapes and letters, numbers, and classification.
Pointing to the body parts, life-size drawing, turning left and right side and awareness of the body parts through touch.
feeling various textures, touching boards, and feeling shapes. Ocular-pursuit training, moving ball and pegboard activities During the sessions, subjects were asked to try and do the same movement with the paretic hand simultaneously The patients will be asked to repeat each movement 20 times per set for three sets, with a 2-minute break between sets.
Session will last for 45 mins
Experimental: Mirror Therapy with motor trainingOther
the participant is asked to perform a forearm movement sting on the paretic side while the subjects look into the mirror, watching the image of their non-involved hand and thus seeing the reflection of the hand movement projected over the involved hand. During the sessions subjects were asked to try and do the same movement with the paretic hand simultaneously. movement was repeated 20 times per set for three sets, with a 2-minute break between sets
Experimental: Motor TrainingOther
- Holding object with two hands, clapping, banging objects together.
- Stabilize objects with one hand while the other is manipulating (holding paper while coloring, holding a container while putting objects in)
- manipulate objects with both hands simultaneously (stringing beads, tying a knot),
- ask child to padlock in which a key can be put into, markers with caps to put on, a box with a lid and objects to put inside the box
- hold a cup with one hand while putting object in with other hand
- Buttoning with both hands, tying a bow. doing craft project, fitting blocks together
| Study group | Role | What they receive |
|---|---|---|
| Mirror therapy with sensory motor training. | Experimental | 1. Visual perception activities
2. Body awareness
3. Tactile perception.
4. Visual-motor coordination training
The child will be seated on a chair and a 30*30 cm mirror will set up on a table in front of them. The affected hand will be placed behind the mirror so that the image of a healthy hand can be seen clearly Receives: Other: Experimental: Mirror therapy with sensory motor training. |
| Mirror Therapy with motor training. | Experimental | supination-pronation, wrist flexion-extension, finger flexion-extension, abduction, adduction, opposition Receives: Other: Experimental: Mirror Therapy with motor training |
| Motor Training | Other | 1. Holding objects
2. Stabilize objects
3. manipulate objects Receives: Other: Experimental: Motor Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Melbourne Assessment of Unilateral Upper Limb Function (Melbourne Assessment)
It is an evaluation tool that objectively measures upper-extremity function in children with cerebral palsy. The total score is 122, which is the maximum, whereas the minimum score is 0. It is Reported as a percentage, with higher scores reflecting greater quality of upper-limb movement
Measured: Assessment will be done at 6th week by outcome measuring tool
Jebsen Taylor Hand dysfunction test
It measures the fine and gross motor function of the hands. The results are measured by timing the time taken to accomplish each task.
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Mar 2024
- Study start30 Dec 2023
- Primary completion14 May 2024
- Study completion14 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Assignment
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Huma Saleem, MS NMPT*, Principal investigator, Riphah International UniverisityAmmara Abbas, tDPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06292416
- Sponsor's protocol ID
- REC/0257Huma Saleem
- Status last verified
- Apr 2025
- First submitted
- 26 Dec 2023
- Last updated
- 8 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Mirror Therapy With Sensory Motor Training on Upper Limb Functions and Quality of Movement in Children With Hemiplegic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT06292416
- Acronym / sponsor ID
- REC/0257Huma Saleem
- Conditions
- Cerebral Palsy
- Keywords
- Cerebral palsy, Hemiplegic, Mirror Therapy, Strength training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 30 Dec 2023 (actual)
- Primary completion
- 14 May 2024 (actual)
- Study completion
- 14 May 2024 (actual)
- First posted
- 5 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study compares two interventions in CP children: mirror therapy with sensory motor training versus mirror therapy with motor training. Mirror therapy works by manipulating the brain out of pain, ultimately improving movement in patients with one-sided paralysis. It can be used in combination with other therapies to assist patients with cerebral palsy in retraining the brains, restoring function, and enhancing the overall quality of life. The purpose of this study is to use a combination of Mirror therapy with sensory motor training and motor training and observe which one of these combinations has the most desirable effects in improving movement and quality of life in CP Children
Detailed description
The neurodevelopmental disorder known as cerebral palsy (CP) is caused by damage to the developing brain and is characterized by abnormalities of muscle tone, mobility, and motor skills. A person with cerebral palsy can be classified according to how it affects movement, the area of the body that is affected, and how severe the effects are. Children with hemiplegic cerebral palsy have a variety of motor and sensory deficits in the upper limb, which makes it more difficult to perform everyday tasks including reaching, gripping, releasing, and manipulating things. The movement produced by constraints on the less-affected hand and extensive training on the more-affected hand aims to enhance upper limb function in hemiparetic youngsters. One such intervention to improve the motor function of these patients is the use of mirror therapy. Mirror therapy is one of the more recent approaches to helping the more severely afflicted upper extremities regain function after stroke. During mirror therapy, a mirror is held in the patient's midsagittal plane, reflecting the less-affected side as though it were the more-affected side. In this arrangement, the motions of the less affected extremity give the impression that the more affected extremity is moving normally. Mirror treatment is easy to use, reasonably priced, and non-intrusive. This makes it a promising and secure complement to hemiparesis therapy for children. Sensorimotor training involves proprioceptive and balance exercises that were developed to help individuals suffering from chronic musculoskeletal pain syndromes. Repetitive sensorimotor training may increase the responsiveness of nociceptive-evoked potentials. Motor training, on the other hand, focuses on skill acquisition through repetition. Through this study, the investigator wants to use a combination of techniques to improve upper limb function and quality of movement in patients with CP
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
- Model description
- Assignment
| Arm | Type | Receives |
|---|---|---|
| Mirror therapy with sensory motor training. | Experimental | Other: Experimental: Mirror therapy with sensory motor training.1. Visual perception activities 2. Body awareness 3. Tactile perception. 4. Visual-motor coordination training The child will be seated on a chair and a 30*30 cm mirror will set up on a table in front of them. The affected hand will be placed behind the mirror so that the image of a healthy hand can be seen clearly |
| Mirror Therapy with motor training. | Experimental | Other: Experimental: Mirror Therapy with motor trainingsupination-pronation, wrist flexion-extension, finger flexion-extension, abduction, adduction, opposition |
| Motor Training | Other | Other: Experimental: Motor Training1. Holding objects 2. Stabilize objects 3. manipulate objects |
Who may qualify
- Ages
- 6 to 12 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (4 listed)
- Aged between 6 and 12 years
- Lack of use of the affected upper limb
- Level I-III of the Manual Ability Classification System (MACS)
- Level I-III in the Gross Motor Function Classification System (GMFCS)
Key exclusion criteria (5 listed)
- Disease not associated with congenital hemiplegia
- Presence of contractures in the affected upper limb affecting the functional movement
- Surgery in the six months previously to the treatment
- Botulinum toxin in the two months previously to or during the intervention
- Pharmacologically uncontrolled epilepsy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Experimental: Mirror therapy with sensory motor training.Block design, finding shapes in pictures, puzzles, matching geometric shapes and letters, numbers, and classification. Pointing to the body parts, life-size drawing, turning left and right side and awareness of the body parts through touch. feeling various textures, touching boards, and feeling shapes. Ocular-pursuit training, moving ball and pegboard activities During the sessions, subjects were asked to try and do the same movement with the paretic hand simultaneously The patients will be asked to repeat each movement 20 times per set for three sets, with a 2-minute break between sets. Session will last for 45 mins | Other | Mirror therapy with sensory motor training. |
| Experimental: Mirror Therapy with motor trainingthe participant is asked to perform a forearm movement sting on the paretic side while the subjects look into the mirror, watching the image of their non-involved hand and thus seeing the reflection of the hand movement projected over the involved hand. During the sessions subjects were asked to try and do the same movement with the paretic hand simultaneously. movement was repeated 20 times per set for three sets, with a 2-minute break between sets | Other | Mirror Therapy with motor training. |
| Experimental: Motor Training1. Holding object with two hands, clapping, banging objects together. 2. Stabilize objects with one hand while the other is manipulating (holding paper while coloring, holding a container while putting objects in) 3. manipulate objects with both hands simultaneously (stringing beads, tying a knot), 4. ask child to padlock in which a key can be put into, markers with caps to put on, a box with a lid and objects to put inside the box 5. hold a cup with one hand while putting object in with other hand 6. Buttoning with both hands, tying a bow. doing craft project, fitting blocks together | Other | Motor Training |
Primary outcome
The Melbourne Assessment of Unilateral Upper Limb Function (Melbourne Assessment)
Time frame: Assessment will be done at 6th week by outcome measuring tool
It is an evaluation tool that objectively measures upper-extremity function in children with cerebral palsy. The total score is 122, which is the maximum, whereas the minimum score is 0. It is Reported as a percentage, with higher scores reflecting greater quality of upper-limb movement
Jebsen Taylor Hand dysfunction test
Time frame: 6 weeks
It measures the fine and gross motor function of the hands. The results are measured by timing the time taken to accomplish each task.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Huma Saleem, MS NMPT* principal investigator
Riphah International Univerisity
Ammara Abbas, tDPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Experimental: Mirror therapy with sensory motor training., Experimental: Mirror Therapy with motor training and Experimental: Motor Training in people with Cerebral Palsy, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Melbourne Assessment of Unilateral Upper Limb Function (Melbourne Assessment) (time frame: Assessment will be done at 6th week by outcome measuring tool). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2025.