Pulmonary Disease, Chronic ObstructiveNCT06283004
Investigation of Walking Training With Different Slope Types in COPD Patients
A study testing Downhill walking training, Level walking training and Uphill walking training in people with Pulmonary Disease, Chronic Obstructive, run by Acibadem University at 1 site in Turkey (Türkiye).
Trial summary
Chronic obstructive pulmonary disease (COPD) is a disease that continues to generate a great deal of research and this research must continue, both because it is not completely curable and because of the large patient population. The importance and benefits of exercise training in COPD patients are clear. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Pulmonary Disease, Chronic Obstructive
- What is being tested?
- Downhill walking training, Level walking training and Uphill walking training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 51 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 9 Apr 2025to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Being diagnosed with COPD (A, B, E groups according to GOLD assessment)
- Ambulate on your own
- Not having any contraindications for exercise
- To be mentally appropriate (score 24 points and above in the mini mental test)
Who cannot join
- Being in GOLD 4 stage in spirometric evaluation
- Presence of hypoxemia
- Participation in another pulmonary rehabilitation program within the last 6 months
- Having an exacerbation in the last 1 month
- Being diagnosed with additional respiratory disease (asthma, bronchiectasis, etc.)
- Having had pulmonary surgery
Show all 9Show fewer
- Having an orthopedic, neurological or cardiac disease that affects exercise
- Having uncontrolled hypertension or diabetes
- Presence of malignancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Alis Kostanoğlu, Assoc. Prof. contact
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Bezmialem Vakif University, Department of Physiotherapy and Rehabilitation
Istanbul, Eyüp Sultan
Alis Kostanoglu, +90 0543 493 1848, Akostanoglu@bezmialem.edu.tr
About this study
Official title: The Effect of Aerobic Exercise Training in Different Slope Types on Exercise Capacity, Respiratory Functions, Muscle Strength, and Functional Status in COPD Patients
Chronic obstructive pulmonary disease (COPD) is a disease that continues to generate a great deal of research and this research must continue, both because it is not completely curable and because of the large patient population. The importance and benefits of exercise training in COPD patients are clear. One of the most preferred types of exercise training is the so-called aerobic exercise training, which typically takes the form of walking. A typical walking training does not use a slope or may include an uphill slope. However, recently there have been publications about downhill walking and its benefits in COPD. Walking on a level, uphill, and downhill slope may have the potential to result in different gains by using different muscle groups more. Therefore, this study aimed to compare the effects of walking training on exercise capacity, respiratory functions, muscle strength, and functional status in COPD patients with three different slope types: level, uphill, and downhill.
Read the detailed description
The convenience sampling method will be used as the sampling method in the research.
In this study, sample size was calculated by a priori power analysis using G*Power 3.1.9.4 software. In the analysis for analysis of variance (ANOVA: repeated measures, between factors) with two factors and repeated measures; effect size f = 0.62 (based on data obtained from previous study, Borghi-Silva et al, 2009), significance level α = 0.05, statistical power (1 - β) = 0.80, number of groups 3, number of measures 2 and correlation coefficient between measures r = 0.5. According to the calculation, it was predicted that the study would reach sufficient statistical power with a total of 24 participants, 8 participants in each group.
There will be three groups in the study: downhill walking, uphill walking, and level walking. The downhill walking and uphill walking groups will be included as the study group and the level walking group will be included as the control group. Participants will be distributed equally to the three groups. Patients will be assigned to these groups by block randomization method using https://www.randomizer.org/ website.
All three groups will be administered a 6-minute walking test at baseline, and participants will be subjected to a common 8-week, twice-weekly treadmill walking training program in which the speed is determined and increased according to the average speed they walk in this test, and in addition to this, the duration is also increased. One session of the training program will consist of warming up, loading, and cooling down on the treadmill.
During the training, the slope of the treadmill will be adjusted to +10 degrees for uphill walking, -10 degrees for downhill walking, and 0 degrees for level walking and will be kept constant for 8 weeks. A special wooden wedge apparatus will be made under the normal treadmill to give -10 downhill slope.
Primary outcome measurements will be made at baseline and at the end of week 8.
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Being tested
- Downhill walking training, Level walking training, Uphill walking training
- Medical subject headings
- Pulmonary Disease, Chronic Obstructive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Downhill walking trainingOther
For 8 weeks, downhill walking training will be done 2 times a week at a slope of -10 degrees.
Level walking trainingOther
For 8 weeks, level walking training will be done 2 times a week at a slope of 0 degrees.
Uphill walking trainingOther
For 8 weeks, uphill walking training will be done 2 times a week at a slope of +10 degrees.
| Study group | Role | What they receive |
|---|---|---|
| Level walking | Active comparator | It will walk at a 0-degree slope (0) throughout the research. Receives: Other: Level walking training |
| Downhill walking | Experimental | It will walk at a 10-degree downhill slope (-10) throughout the research. Receives: Other: Downhill walking training |
| Uphill walking | Experimental | It will walk at a 10-degree uphill slope (+10) throughout the research. Receives: Other: Uphill walking training |
What is being measured
The primary outcome is the main question the study is designed to answer.
6 Minutes Walking Distance (6MWD)
6 MWD means the distance traveled in 6 MWT. Its unit is meters.
Measured: Up to 8 weeks.
Spirometric measurements (Forced vital capacity)
It is used to evaluate respiratory functions. It is evaluated with a spirometer. Forced vital capacity (FVC): the maximum amount of air that can be forcibly exhaled from the lungs after fully inhaling. It can be recorded in percentages or liters.
Measured: Up to 8 weeks.
Spirometric measurements (First second forced expiratory volume)
It is used to evaluate respiratory functions. It is evaluated with a spirometer. First-second forced expiratory volume (FEV1): the amount of air that can be exhaled with force in 1 second. It can be recorded in percentages or liters.
Measured: Up to 8 weeks.
Spirometric measurements (FEV1/FVC ratio)
It is used to evaluate respiratory functions. It is evaluated with a spirometer. It is calculated by dividing FEV1 by FVC. It is expressed as a percentage.
Measured: Up to 8 weeks.
Spirometric measurements (Peak Expiratory Flow)
It is used to evaluate respiratory functions. It is evaluated with a spirometer. Peak expiratory flow (PEF) is the maximum flow achieved during a forced expiration starting from the level of maximal lung inflation. It can be recorded in percentages or liters.
Measured: Up to 8 weeks.
Spirometric measurements (Maximum Intermediate Expiratory Flow)
It is used to evaluate respiratory functions. It is evaluated with a spirometer. Maximum Intermediate Expiratory Flow (FEF25-75) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. It can be recorded in percentages or liters.
Measured: Up to 8 weeks.
Muscle strength measurements (skeletal muscles)
Hip extension, knee extension, and ankle extension muscle strength will be measured with a handheld dynamometer. The results are recorded in Newtons.
Measured: Up to 8 weeks.
Muscle strength measurements (respiratory muscles)
The strength of the respiratory muscles will be assessed and recorded as maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) with a device that allows the measurement of intraoral pressures, which is an indirect indicator of the strength of these muscles. In this device, measurements are based on recording the highest average pressure sustained for one second during inspiration and expiration against a closed valve. Measurements are recorded in cmH2O.
Measured: Up to 8 weeks.
30-second sit and stand test
The result is the total number of stands within 30 seconds.
Measured: Up to 8 weeks.
Functional performance inventory
It is a valid and reliable measurement tool used to assess functional performance in COPD patients. It consists of 6 sub-dimensions (body care, household maintenance, physical exercise, recreation, spiritual activities, social activities) and a total of 65 items. The questions are answered by choosing from the following options: "I can do the activity easily without any difficulty (3 points), I can do it with some difficulty (2 points), I can do it with much difficulty (1 point), I can no longer do this activity due to my health reasons (0 points), I do not prefer it (0 points)" and are scored according to the specified scores. Each sub-dimension and total performance is calculated as an average. The lowest score is 0 and the highest score is 3. Higher score means better functional performance. Turkish validation study of the questionnaire in COPD patients was conducted.
Measured: Up to 8 weeks.
Secondary outcomes (3)
Dyspnea
It will be reported by the participant using the modified borg scale (between 0-10 points). On this scale, 0 is the lowest score and means absent, while 10 is the highest score and indicates that the condition is most severe.
Measured: Up to 8 weeks.
Fatigue
It will be reported by the participant using the modified borg scale (between 0-10 points).On this scale, 0 is the lowest score and means absent, while 10 is the highest score and indicates that the condition is most severe.
Measured: Up to 8 weeks.
Level of exertion
It will be reported by the participant using the modified borg scale (between 0-10 points). On this scale, 0 is the lowest score and means absent, while 10 is the highest score and indicates that the condition is most severe.
Measured: Up to 8 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Feb 2024
- Study start9 Apr 2025
- Primary completion1 Jun 2026 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for Pulmonary Disease, Chronic ObstructiveStudies of the same condition, open and under way.
- More trials run by Acibadem UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 51 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Acibadem University
- Sponsor type
- University, hospital or other
- Collaborators
- Bezmialem Vakif University
- Responsible party
- Principal investigator, Meryem BEKTAŞ KARAKUŞ, Acibadem University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06283004
- Sponsor's protocol ID
- 2024-1/30
- Status last verified
- Jun 2025
- First submitted
- 12 Feb 2024
- Last updated
- 13 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Borghi-Silva A, Arena R, Castello V, Simoes RP, Martins LE, Catai AM, Costa D. Aerobic exercise training improves autonomic nervous control in patients with COPD. Respir Med. 2009 Oct;103(10):1503-10. doi: 10.1016/j.rmed.2009.04.015. Epub 2009 May 22.
PubMed 19464865Franz JR, Kram R. The effects of grade and speed on leg muscle activations during walking. Gait Posture. 2012 Jan;35(1):143-7. doi: 10.1016/j.gaitpost.2011.08.025. Epub 2011 Oct 2.
PubMed 21962846Alexander N, Strutzenberger G, Ameshofer LM, Schwameder H. Lower limb joint work and joint work contribution during downhill and uphill walking at different inclinations. J Biomech. 2017 Aug 16;61:75-80. doi: 10.1016/j.jbiomech.2017.07.001. Epub 2017 Jul 11.
PubMed 28734544Moezy A, Erfani A, Mazaherinezhad A, Mousavi SAJ. Downhill walking influence on physical condition and quality of life in patients with COPD: A randomized controlled trial. Med J Islam Repub Iran. 2018 Jun 14;32:49. doi: 10.14196/mjiri.32.49. eCollection 2018.
PubMed 30159300Camillo CA, Burtin C, Hornikx M, Demeyer H, De Bent K, van Remoortel H, Osadnik CR, Janssens W, Troosters T. Physiological responses during downhill walking: A new exercise modality for subjects with chronic obstructive pulmonary disease? Chron Respir Dis. 2015 May;12(2):155-64. doi: 10.1177/1479972315575717. Epub 2015 Mar 10.
PubMed 25758676Erfani A, Moezy A, Mazaherinezhad A, Mousavi SA. Does Downhill Walking on Treadmill Improve Physical Status and Quality of Life of A Patient With COPD? Asian J Sports Med. 2015 Dec;6(4):e25821. doi: 10.5812/asjsm.25821. Epub 2015 Dec 1.
PubMed 26715973Camillo CA, Osadnik CR, Burtin C, Everaerts S, Hornikx M, Demeyer H, Loeckx M, Rodrigues FM, Maes K, Gayan-Ramirez G, Janssens W, Troosters T. Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial. Eur Respir J. 2020 Sep 17;56(3):2000639. doi: 10.1183/13993003.00639-2020. Print 2020 Sep.
PubMed 32444407Leidy NK. Psychometric properties of the functional performance inventory in patients with chronic obstructive pulmonary disease. Nurs Res. 1999 Jan-Feb;48(1):20-8. doi: 10.1097/00006199-199901000-00004.
PubMed 10029398
Study at a glance
From the registry record, last updated by the sponsor on 13 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Aerobic Exercise Training in Different Slope Types on Exercise Capacity, Respiratory Functions, Muscle Strength, and Functional Status in COPD Patients
- ClinicalTrials.gov ID
- NCT06283004
- Acronym / sponsor ID
- 2024-1/30
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 51 participants (estimated)
- Lead sponsor
- Acibadem UniversityUniversity, hospital or other
- Collaborators
- Bezmialem Vakif University
- Study start
- 9 Apr 2025 (actual)
- Primary completion
- 1 Jun 2026 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 28 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Chronic obstructive pulmonary disease (COPD) is a disease that continues to generate a great deal of research and this research must continue, both because it is not completely curable and because of the large patient population. The importance and benefits of exercise training in COPD patients are clear. One of the most preferred types of exercise training is the so-called aerobic exercise training, which typically takes the form of walking. A typical walking training does not use a slope or may include an uphill slope. However, recently there have been publications about downhill walking and its benefits in COPD. Walking on a level, uphill, and downhill slope may have the potential to result in different gains by using different muscle groups more. Therefore, this study aimed to compare the effects of walking training on exercise capacity, respiratory functions, muscle strength, and functional status in COPD patients with three different slope types: level, uphill, and downhill.
Detailed description
The convenience sampling method will be used as the sampling method in the research.
In this study, sample size was calculated by a priori power analysis using G*Power 3.1.9.4 software. In the analysis for analysis of variance (ANOVA: repeated measures, between factors) with two factors and repeated measures; effect size f = 0.62 (based on data obtained from previous study, Borghi-Silva et al, 2009), significance level α = 0.05, statistical power (1 - β) = 0.80, number of groups 3, number of measures 2 and correlation coefficient between measures r = 0.5. According to the calculation, it was predicted that the study would reach sufficient statistical power with a total of 24 participants, 8 participants in each group.
There will be three groups in the study: downhill walking, uphill walking, and level walking. The downhill walking and uphill walking groups will be included as the study group and the level walking group will be included as the control group. Participants will be distributed equally to the three groups. Patients will be assigned to these groups by block randomization method using https://www.randomizer.org/ website.
All three groups will be administered a 6-minute walking test at baseline, and participants will be subjected to a common 8-week, twice-weekly treadmill walking training program in which the speed is determined and increased according to the average speed they walk in this test, and in addition to this, the duration is also increased. One session of the training program will consist of warming up, loading, and cooling down on the treadmill.
During the training, the slope of the treadmill will be adjusted to +10 degrees for uphill walking, -10 degrees for downhill walking, and 0 degrees for level walking and will be kept constant for 8 weeks. A special wooden wedge apparatus will be made under the normal treadmill to give -10 downhill slope.
Primary outcome measurements will be made at baseline and at the end of week 8.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Level walking | Active comparator | Other: Level walking trainingIt will walk at a 0-degree slope (0) throughout the research. |
| Downhill walking | Experimental | Other: Downhill walking trainingIt will walk at a 10-degree downhill slope (-10) throughout the research. |
| Uphill walking | Experimental | Other: Uphill walking trainingIt will walk at a 10-degree uphill slope (+10) throughout the research. |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Being diagnosed with COPD (A, B, E groups according to GOLD assessment)
- Ambulate on your own
- Not having any contraindications for exercise
- To be mentally appropriate (score 24 points and above in the mini mental test)
Key exclusion criteria (9 listed)
- Being in GOLD 4 stage in spirometric evaluation
- Presence of hypoxemia
- Participation in another pulmonary rehabilitation program within the last 6 months
- Having an exacerbation in the last 1 month
- Being diagnosed with additional respiratory disease (asthma, bronchiectasis, etc.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Downhill walking trainingFor 8 weeks, downhill walking training will be done 2 times a week at a slope of -10 degrees. | Other | Downhill walking |
| Level walking trainingFor 8 weeks, level walking training will be done 2 times a week at a slope of 0 degrees. | Other | Level walking |
| Uphill walking trainingFor 8 weeks, uphill walking training will be done 2 times a week at a slope of +10 degrees. | Other | Uphill walking |
Primary outcome
6 Minutes Walking Distance (6MWD)
Time frame: Up to 8 weeks.
6 MWD means the distance traveled in 6 MWT. Its unit is meters.
Spirometric measurements (Forced vital capacity)
Time frame: Up to 8 weeks.
It is used to evaluate respiratory functions. It is evaluated with a spirometer. Forced vital capacity (FVC): the maximum amount of air that can be forcibly exhaled from the lungs after fully inhaling. It can be recorded in percentages or liters.
Spirometric measurements (First second forced expiratory volume)
Time frame: Up to 8 weeks.
It is used to evaluate respiratory functions. It is evaluated with a spirometer. First-second forced expiratory volume (FEV1): the amount of air that can be exhaled with force in 1 second. It can be recorded in percentages or liters.
Spirometric measurements (FEV1/FVC ratio)
Time frame: Up to 8 weeks.
It is used to evaluate respiratory functions. It is evaluated with a spirometer. It is calculated by dividing FEV1 by FVC. It is expressed as a percentage.
Spirometric measurements (Peak Expiratory Flow)
Time frame: Up to 8 weeks.
It is used to evaluate respiratory functions. It is evaluated with a spirometer. Peak expiratory flow (PEF) is the maximum flow achieved during a forced expiration starting from the level of maximal lung inflation. It can be recorded in percentages or liters.
Spirometric measurements (Maximum Intermediate Expiratory Flow)
Time frame: Up to 8 weeks.
It is used to evaluate respiratory functions. It is evaluated with a spirometer. Maximum Intermediate Expiratory Flow (FEF25-75) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. It can be recorded in percentages or liters.
Muscle strength measurements (skeletal muscles)
Time frame: Up to 8 weeks.
Hip extension, knee extension, and ankle extension muscle strength will be measured with a handheld dynamometer. The results are recorded in Newtons.
Muscle strength measurements (respiratory muscles)
Time frame: Up to 8 weeks.
The strength of the respiratory muscles will be assessed and recorded as maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) with a device that allows the measurement of intraoral pressures, which is an indirect indicator of the strength of these muscles. In this device, measurements are based on recording the highest average pressure sustained for one second during inspiration and expiration against a closed valve. Measurements are recorded in cmH2O.
30-second sit and stand test
Time frame: Up to 8 weeks.
The result is the total number of stands within 30 seconds.
Functional performance inventory
Time frame: Up to 8 weeks.
It is a valid and reliable measurement tool used to assess functional performance in COPD patients. It consists of 6 sub-dimensions (body care, household maintenance, physical exercise, recreation, spiritual activities, social activities) and a total of 65 items. The questions are answered by choosing from the following options: "I can do the activity easily without any difficulty (3 points), I can do it with some difficulty (2 points), I can do it with much difficulty (1 point), I can no longer do this activity due to my health reasons (0 points), I do not prefer it (0 points)" and are scored according to the specified scores. Each sub-dimension and total performance is calculated as an average. The lowest score is 0 and the highest score is 3. Higher score means better functional performance. Turkish validation study of the questionnaire in COPD patients was conducted.
3 secondary outcomes
Dyspnea
Time frame: Up to 8 weeks.
Fatigue
Time frame: Up to 8 weeks.
Level of exertion
Time frame: Up to 8 weeks.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jun 2025.
- Background: PubMed 19464865Borghi-Silva A, Arena R, Castello V, Simoes RP, Martins LE, Catai AM, Costa D. Aerobic exercise training improves autonomic nervous control in patients with COPD. Respir Med. 2009 Oct;103(10):1503-10. doi: 10.1016/j.rmed.2009.04.015. Epub 2009 May 22.
- Background: PubMed 21962846Franz JR, Kram R. The effects of grade and speed on leg muscle activations during walking. Gait Posture. 2012 Jan;35(1):143-7. doi: 10.1016/j.gaitpost.2011.08.025. Epub 2011 Oct 2.
- Background: PubMed 28734544Alexander N, Strutzenberger G, Ameshofer LM, Schwameder H. Lower limb joint work and joint work contribution during downhill and uphill walking at different inclinations. J Biomech. 2017 Aug 16;61:75-80. doi: 10.1016/j.jbiomech.2017.07.001. Epub 2017 Jul 11.
- Background: PubMed 30159300Moezy A, Erfani A, Mazaherinezhad A, Mousavi SAJ. Downhill walking influence on physical condition and quality of life in patients with COPD: A randomized controlled trial. Med J Islam Repub Iran. 2018 Jun 14;32:49. doi: 10.14196/mjiri.32.49. eCollection 2018.
- Background: PubMed 25758676Camillo CA, Burtin C, Hornikx M, Demeyer H, De Bent K, van Remoortel H, Osadnik CR, Janssens W, Troosters T. Physiological responses during downhill walking: A new exercise modality for subjects with chronic obstructive pulmonary disease? Chron Respir Dis. 2015 May;12(2):155-64. doi: 10.1177/1479972315575717. Epub 2015 Mar 10.
- Background: PubMed 26715973Erfani A, Moezy A, Mazaherinezhad A, Mousavi SA. Does Downhill Walking on Treadmill Improve Physical Status and Quality of Life of A Patient With COPD? Asian J Sports Med. 2015 Dec;6(4):e25821. doi: 10.5812/asjsm.25821. Epub 2015 Dec 1.
- Background: PubMed 32444407Camillo CA, Osadnik CR, Burtin C, Everaerts S, Hornikx M, Demeyer H, Loeckx M, Rodrigues FM, Maes K, Gayan-Ramirez G, Janssens W, Troosters T. Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial. Eur Respir J. 2020 Sep 17;56(3):2000639. doi: 10.1183/13993003.00639-2020. Print 2020 Sep.
- Background: PubMed 10029398Leidy NK. Psychometric properties of the functional performance inventory in patients with chronic obstructive pulmonary disease. Nurs Res. 1999 Jan-Feb;48(1):20-8. doi: 10.1097/00006199-199901000-00004.
- Individual participant dataSharing planned: No
Related trials for Pulmonary Disease, Chronic Obstructive
Active, not recruiting
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
COPD, Smoking
Not yet recruitingPhase 2/3
An Open-Label Extension Study to Evaluate Inhaled Treprostinil SMI in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD)
Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease
Not yet recruiting
The Aim of the Study is to Decipher the Alterations in Signalling Pathways of Skeletal Muscle Stem Cells (Satellite Cells (SCs)) in Individuals With COPD, as Well as to Examine the Effect of Exercise Training on SCs.
COPD (Chronic Obstructive Pulmonary Disease), Sarcopenia in Elderly
Not yet recruitingPhase 2
Study of Treprostinil Administered Via Soft Mist Inhaler (SMI) in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD)
Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease
RecruitingPhase 3
A Study to Investigate the Efficacy and Safety of Belumosudil Compared With Best Available Therapy in Participants Aged 12 Years or Older With Chronic Graft-versus-host Disease
Chronic Graft Versus Host Disease
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Alis Kostanoğlu, Assoc. Prof. contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Downhill walking training, Level walking training and Uphill walking training in people with Pulmonary Disease, Chronic Obstructive, run by Acibadem University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Meryem Bektaş Karakuş, Res Asst. (+90 216 500 4195, meryem.bektas@acibadem.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
6 Minutes Walking Distance (6MWD) (time frame: Up to 8 weeks.). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06283004, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jun 2025.