Eating BehaviorNCT06223282
Effects of Exercise on Energy Intake-Prescription of Resistance Exercise
A study testing short inter-set rest resistance exercise, medium inter-set rest and long inter-set rest in people with Eating Behavior and Food Reward, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary control. During each trial, blood samples will be collected. Read more about this study
- Who is it for?
- Ages 20 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Eating Behavior, Food Reward
- What is being tested?
- short inter-set rest resistance exercise, medium inter-set rest and long inter-set rest
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteTaiwan
- Study dates
- 28 Oct 2022to 31 Mar 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age: 20-30
- Healthy male
Who cannot join
- No acute or chronic musculoskeletal symptoms
- Smoking
- Alcohol or drug abuse
- Failure to conduct resistance exercise
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Acute Resistance Exercise With Varying Training Volume and Rest Intervals Under Equal Load on Appetite Control, Food Reward, and Energy Intake: a Five-arm Crossover Randomized Controlled Trial
Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary control. During each trial, blood samples will be collected.
The investigators hypothesized that different inter-set rest and training volume would affect subjective appetite and energy intake.
- Conditions
- Eating Behavior, Food Reward
- Being tested
- short inter-set rest resistance exercise, medium inter-set rest, long inter-set rest, medium inter-set rest with failure
- Medical subject headings
- Feeding Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
short inter-set rest resistance exerciseOther
Subjects in short inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 60 sec of rest between sets.
medium inter-set restOther
Subjects in medium inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 120 sec of rest between sets.
long inter-set restOther
Subjects in long inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 180 sec of rest between sets.
medium inter-set rest with failureOther
Subjects in long inter-set rest trial performed 3 sets per exercise, repeated to failure with load of 70%-1RM with 120 sec of rest between sets.
| Study group | Role | What they receive |
|---|---|---|
| short inter-set rest | Experimental | 3 multi-joints resistance exercise with short (60s) inter-set rest Receives: Other: short inter-set rest resistance exercise |
| medium inter-set rest | Experimental | 3 multi-joints resistance exercise with medium(120s) inter-set rest Receives: Other: medium inter-set rest |
| long inter-set rest | Experimental | 3 multi-joints resistance exercise with long (180s) inter-set rest Receives: Other: long inter-set rest |
| medium inter-set rest with failure | Experimental | 3 multi-joints resistance exercise with medium (120s) inter-set rest repeated to failure each set Receives: Other: medium inter-set rest with failure |
| control | No intervention | stayed sedentary during the period. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Subjective appetite
The appetite perceptions were obtained through a 0-100 mm visual analog scale. The variables assessed included perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".
Measured: 4-hour during each study intervention
Change in acyl-Ghrelin
acyl-Ghrelin in pg/mL
Measured: 4-hour during each study intervention
Change in total-Ghrelin
total-Ghrelin in pg/mL
Measured: 4-hour during each study intervention
Change in PYY
PYY in pg/mL
Measured: 4-hour during each study intervention
Change in active-GLP-1
active-GLP-1 in pg/mL
Measured: 4-hour during each study intervention
Change in total-GLP-1
total-GLP-1 in pg/mL
Measured: 4-hour during each study intervention
Change in lactate
insulin in mmol/L
Measured: 4-hour during each study intervention
Secondary outcomes (10)
Explicit liking
A visual analog scale ranging from 0 to 100 mm was utilized to evaluate the question, "How pleasant would it be to taste some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."
Measured: 4 hours during each study intervention
Explicit wanting
A visual analog scale ranging from 0 to 100 mm was utilized to evaluate the question, "How much do you want some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."
Measured: 4 hours during each study intervention
Implicit wanting
Participants were given a set of food image pairs and were asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The implicit wanting calculation involved further consideration of response time data based on preference choices using a standardized equation.
Measured: 4 hours during each study intervention
Relative preference
Participants were given a set of food image pairs and were asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The relative preference was the sum of the times each type of food was chosen, with a maximum value of 48 and a minimum value of 0.
Measured: 4 hours during each study intervention
Fat appeal bias
Fat preference (high or low) was calculated by subtracting the mean low-fat scores from the mean high-fat scores. Positive values suggest a preference for high-fat foods, while negative scores indicate a preference for low-fat or savory foods, and a score of 0 signifies an equal preference between fat content.
Measured: 4 hours during each study intervention
Taste appeal bias
Taste preference (savoury or sweet) was calculated by subtracting the mean savory scores from the mean sweet scores. Positive values suggest a preference for sweet foods, while negative scores indicate a preference for savory foods, and a score of 0 signifies an equal preference between taste categories.
Measured: 4 hours during each study intervention
Change in glucose
glucose in mg/dL
Measured: 4 hours during each study intervention
Change in TG
TG in mg/dL
Measured: 4 hours during each study intervention
Change in insulin
insulin in mU/L
Measured: 4 hours during each study intervention
Energy intake
Participants are required to record their diet for the day before, the current day, and the day following the experiment.
Measured: 3 days during each study intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jan 2024
- Study start28 Oct 2022
- Primary completion31 Mar 2023
- Study completion31 Mar 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eating BehaviorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Hung-Wen Liu, Ph.D., Principal investigator, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06223282
- Sponsor's protocol ID
- 202112HM039
- Status last verified
- Jan 2024
- First submitted
- 4 Jan 2024
- Last updated
- 25 Jan 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Jan 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Acute Resistance Exercise With Varying Training Volume and Rest Intervals Under Equal Load on Appetite Control, Food Reward, and Energy Intake: a Five-arm Crossover Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT06223282
- Acronym / sponsor ID
- 202112HM039
- Conditions
- Eating Behavior, Food Reward
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 28 Oct 2022 (actual)
- Primary completion
- 31 Mar 2023 (actual)
- Study completion
- 31 Mar 2023 (actual)
- First posted
- 25 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary control. During each trial, blood samples will be collected.
The investigators hypothesized that different inter-set rest and training volume would affect subjective appetite and energy intake.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| short inter-set rest | Experimental | Other: short inter-set rest resistance exercise3 multi-joints resistance exercise with short (60s) inter-set rest |
| medium inter-set rest | Experimental | Other: medium inter-set rest3 multi-joints resistance exercise with medium(120s) inter-set rest |
| long inter-set rest | Experimental | Other: long inter-set rest3 multi-joints resistance exercise with long (180s) inter-set rest |
| medium inter-set rest with failure | Experimental | Other: medium inter-set rest with failure3 multi-joints resistance exercise with medium (120s) inter-set rest repeated to failure each set |
| control | No intervention | –stayed sedentary during the period. |
Who may qualify
- Ages
- 20 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Age: 20-30
- Healthy male
Key exclusion criteria (4 listed)
- No acute or chronic musculoskeletal symptoms
- Smoking
- Alcohol or drug abuse
- Failure to conduct resistance exercise
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| short inter-set rest resistance exerciseSubjects in short inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 60 sec of rest between sets. | Other | short inter-set rest |
| medium inter-set restSubjects in medium inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 120 sec of rest between sets. | Other | medium inter-set rest |
| long inter-set restSubjects in long inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 180 sec of rest between sets. | Other | long inter-set rest |
| medium inter-set rest with failureSubjects in long inter-set rest trial performed 3 sets per exercise, repeated to failure with load of 70%-1RM with 120 sec of rest between sets. | Other | medium inter-set rest with failure |
Primary outcome
Subjective appetite
Time frame: 4-hour during each study intervention
The appetite perceptions were obtained through a 0-100 mm visual analog scale. The variables assessed included perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".
Change in acyl-Ghrelin
Time frame: 4-hour during each study intervention
acyl-Ghrelin in pg/mL
Change in total-Ghrelin
Time frame: 4-hour during each study intervention
total-Ghrelin in pg/mL
Change in PYY
Time frame: 4-hour during each study intervention
PYY in pg/mL
Change in active-GLP-1
Time frame: 4-hour during each study intervention
active-GLP-1 in pg/mL
Change in total-GLP-1
Time frame: 4-hour during each study intervention
total-GLP-1 in pg/mL
Change in lactate
Time frame: 4-hour during each study intervention
insulin in mmol/L
10 secondary outcomes
Explicit liking
Time frame: 4 hours during each study intervention
Explicit wanting
Time frame: 4 hours during each study intervention
Implicit wanting
Time frame: 4 hours during each study intervention
Relative preference
Time frame: 4 hours during each study intervention
Fat appeal bias
Time frame: 4 hours during each study intervention
Taste appeal bias
Time frame: 4 hours during each study intervention
Change in glucose
Time frame: 4 hours during each study intervention
Change in TG
Time frame: 4 hours during each study intervention
Change in insulin
Time frame: 4 hours during each study intervention
Energy intake
Time frame: 3 days during each study intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Jan 2024.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hung-Wen Liu, Ph.D. principal investigator
National Taiwan Normal University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing short inter-set rest resistance exercise, medium inter-set rest and long inter-set rest in people with Eating Behavior and Food Reward, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Jan 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Subjective appetite (time frame: 4-hour during each study intervention). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Jan 2024.