HealthyNCT06218264
BCAAs, Muscle Protein Synthesis and Glucose Uptake
A study testing Ingestion of an amino acid supplement in people with Healthy, run by Wageningen University at 1 site in Netherlands.
Trial summary
The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Ingestion of an amino acid supplement
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteNetherlands
- Study dates
- 10 Jan 2024to 13 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged from 18-35 years
- 18.5 < Body mass index < 30 kg·m2
- Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
Who cannot join
- Smoking
- Diabetes (Type 1, Type 2, or genetic form of diabetes)
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- Known allergy to lidocaine
- Regular use of dietary protein and/or amino acid supplements (>3 times per week)
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- Currently involved in a structured progressive resistance training programme (>3 times per week)
- A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
- Any previous motor disorders or disorders in muscle and/or lipid metabolism
- Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- Known severe kidney problems
- Pregnant or breastfeeding
- Unable to give consent
Trial locations and contacts
1 site in 1 country.
Netherlands1 site
Wageningen University and Research
Wageningen, Gelderland, 6708 WD
About this study
Official title: The Role of Branched-chain Amino Acids (BCAAs) in the Stimulation of Skeletal Muscle Protein Synthesis and Glucose Uptake in Healthy Young Volunteers
The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.
Read the detailed description
Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).
- Conditions
- Healthy
- Being tested
- Ingestion of an amino acid supplement
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ingestion of an amino acid supplementDietary supplement
Oral intake of a supplement containing amino acids
| Study group | Role | What they receive |
|---|---|---|
| FullAA | Active comparator | Amino acid drink containing all amino acids Receives: Dietary Supplement: Ingestion of an amino acid supplement |
| NoBCAA | Active comparator | Amino acid drink containing all amino acids except for BCAAs. Receives: Dietary Supplement: Ingestion of an amino acid supplement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postprandial muscle protein synthesis
Muscle protein synthesis rate (FSR) prior to and following ingestion of an amino acid drink
Measured: 4 hours
Secondary outcomes (3)
Forearm muscle glucose uptake
Insulin sensitivity, measured as forearm glucose uptake, prior to and following ingestion of an amino acid drink
Measured: 7.5 hours
Whole-body insulin sensitivity
Whole-body insulin sensitivity, calculated using a modified Matsuda index
Measured: Four hours following ingestion of an amino acid drink
Forearm amino acid kinetics
Plasma phenylalanine kinetics using a stable isotope tracer infusion
Measured: Prior to and for 4 hours following amino acid intake
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2024
- Study start10 Jan 2024
- Primary completion13 Feb 2026
- Study completion13 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Wageningen University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Marlou Dirks, Wageningen University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06218264
- Sponsor's protocol ID
- NL82984.028.23
- Status last verified
- Feb 2026
- First submitted
- 11 Jan 2024
- Last updated
- 20 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Role of Branched-chain Amino Acids (BCAAs) in the Stimulation of Skeletal Muscle Protein Synthesis and Glucose Uptake in Healthy Young Volunteers
- ClinicalTrials.gov ID
- NCT06218264
- Acronym / sponsor ID
- NL82984.028.23
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Wageningen UniversityUniversity, hospital or other
- Study start
- 10 Jan 2024 (actual)
- Primary completion
- 13 Feb 2026 (actual)
- Study completion
- 13 Feb 2026 (actual)
- First posted
- 23 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.
Detailed description
Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| FullAA | Active comparator | Dietary Supplement: Ingestion of an amino acid supplementAmino acid drink containing all amino acids |
| NoBCAA | Active comparator | Dietary Supplement: Ingestion of an amino acid supplementAmino acid drink containing all amino acids except for BCAAs. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Aged from 18-35 years
- 18.5 < Body mass index < 30 kg·m2
- Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
Key exclusion criteria (13 listed)
- Smoking
- Diabetes (Type 1, Type 2, or genetic form of diabetes)
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- Known allergy to lidocaine
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ingestion of an amino acid supplementOral intake of a supplement containing amino acids | Dietary supplement | FullAA, NoBCAA |
Primary outcome
Postprandial muscle protein synthesis
Time frame: 4 hours
Muscle protein synthesis rate (FSR) prior to and following ingestion of an amino acid drink
3 secondary outcomes
Forearm muscle glucose uptake
Time frame: 7.5 hours
Whole-body insulin sensitivity
Time frame: Four hours following ingestion of an amino acid drink
Forearm amino acid kinetics
Time frame: Prior to and for 4 hours following amino acid intake
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ingestion of an amino acid supplement in people with Healthy, run by Wageningen University at 1 site in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postprandial muscle protein synthesis (time frame: 4 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2026.