AnalgesiaNCT06183528
Effects of Pericapsular Nerve Group Block on Postoperative Recovery for Total Hip Arthroplasty
A study testing Pericapsular Nerve Group (PENG) Block in people with Analgesia and Postoperative Pain, Acute, run by Umraniye Education and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
The hypothesis of this study is that patients who undergo PENG block in before Total Hip Artroplasthy (THA) surgery with spinal anesthesia will have reduced postoperative pain scores, less need for opioid analgesics and earlier mobilisation. Read more about this study
- Who is it for?
- Ages 40 to 85 years
- Conditions the study is for
- Analgesia, Postoperative Pain, Acute
- What is being tested?
- Pericapsular Nerve Group (PENG) Block
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Sep 2023to 30 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- THA performed by posterior approach
- 40-85 age range
- ASA 1-3
Who cannot join
- Under 40 years of age, over 85 years of age,
- ASA 4 and above,
- Cognitive impairment (Alzheimer's disease, dementia, delirium etc.),
- Hip fracture,
- Application site infection,
- Allergy to local anaesthetic agents,
- Patients are non-consenting patients.
Trial locations and contacts
1 site in 1 country.
About this study
The hypothesis of this study is that patients who undergo PENG block in before Total Hip Artroplasthy (THA) surgery with spinal anesthesia will have reduced postoperative pain scores, less need for opioid analgesics and earlier mobilisation.
Read the detailed description
This prospective randomised controlled study included a total of 60 patients aged 40-85 years who underwent THA surgery under spinal anaesthesia. Patients were divided into two groups as PENG block (n:30) and non-PENG block (n:30). PENG block was placed in the fascial plane between the pseudotendon and pubic ramus with USG in-plane technique, 20 ml of 0.5% bupivacaine was administered and surgery was initiated. The primary outcome of the study was to investigate the effect of preoperative PENG block application on postoperative pain, opioid requirement, mobilisation time, hip joint patency and length of hospital stay in patients undergoing THA surgery. The secondary outcome was to investigate the effect of PENG block on perioperative haemodynamics and postoperative side effects.
For multimodal analgesia, 10 ml 0.5% bupivacaine + 10 ml 2% lidocaine is infiltrated into the surgical wound incision line by the surgical team at the end of surgery. After tramadol 50 mg loading with PCA device, a basal rate of 5-10 mg/hour (20 mg bolus dose + 30 minutes lock time) is given with paracetamol 10 mg/kg iv (8 hours interval).
- Conditions
- Analgesia, Postoperative Pain, Acute
- Being tested
- Pericapsular Nerve Group (PENG) Block
- Keywords
- Multimodal analgesia, pericapsular nerve group block, total hip arthroplasty, spinal anesthesia
- Medical subject headings
- Agnosia, Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pericapsular Nerve Group (PENG) BlockProcedure or surgery
With ultrasonography-guided PENG block, the femoral, obturator and accessory obturator nerve branches that provide sensory innervation of the anterior surface of the hip joint capsule are blocked .
| Study group | Role | What they receive |
|---|---|---|
| PENG group | Active comparator | PENG block was placed in the fascial plane between the pseudotendon and pubic ramus with USG in-plane technique, 20 ml of 0.5% bupivacaine was administered after spinal anaesthesia. Receives: Procedure: Pericapsular Nerve Group (PENG) Block |
| non-PENG group | Placebo comparator | group non-PENG, surgery was started without PENG block after spinal anaesthesia. Receives: Procedure: Pericapsular Nerve Group (PENG) Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
postoperative pain score
VAS pain score
Measured: recovery room 30 min, 12., 24. and 48. hours in the postoperative period
mobilisation time
walking 5 steps with walker
Measured: 24 -48 hours
hip joint patency
Measurement of joint movement angle with goniometer (angle)
Measured: 24. hours
total opioid consumption
Tramadol total usage (mg)
Measured: 48 hours
Secondary outcomes (3)
PENG block side effects
motor block, nausea, vomiting, anaphylaxis, nerve damage
Measured: The first 48 hours after performing the PENG block
Perioperative haemodynamic data
heart rate, mean arterial pressure
Measured: T1: 30 minutes (min) after spinal anesthesia, T2: at the end of the surgical procedure, T3: at 30 minutes after recovery
length of hospital stay
hospitalization and discharge time for surgery
Measured: day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Dec 2023
- Study start1 Sep 2023
- Primary completion10 Oct 2024
- Study completion30 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnalgesiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This prospective randomised controlled study included a total of 60 patients aged 40-85 years who underwent THA surgery under spinal anaesthesia. Patients were divided into two groups as PENG block and non-PENG block (control group).
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Umraniye Education and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Zeliha Alicikus, Umraniye Education and Research Hospital
- Investigators
- zeliha tuncel, Study director, Ümraniye Training and Education hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06183528
- Sponsor's protocol ID
- UERH-AR-ZT-02
- Status last verified
- Oct 2026
- First submitted
- 30 Nov 2023
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Pericapsular Nerve Group Block on Postoperative Recovery for Total Hip Arthroplasty
- ClinicalTrials.gov ID
- NCT06183528
- Acronym / sponsor ID
- UERH-AR-ZT-02
- Conditions
- Analgesia, Postoperative Pain, Acute
- Keywords
- Multimodal analgesia, pericapsular nerve group block, total hip arthroplasty, spinal anesthesia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Umraniye Education and Research HospitalOther government
- Study start
- 1 Sep 2023 (actual)
- Primary completion
- 10 Oct 2024 (actual)
- Study completion
- 30 Dec 2025 (actual)
- First posted
- 27 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The hypothesis of this study is that patients who undergo PENG block in before Total Hip Artroplasthy (THA) surgery with spinal anesthesia will have reduced postoperative pain scores, less need for opioid analgesics and earlier mobilisation.
Detailed description
This prospective randomised controlled study included a total of 60 patients aged 40-85 years who underwent THA surgery under spinal anaesthesia. Patients were divided into two groups as PENG block (n:30) and non-PENG block (n:30). PENG block was placed in the fascial plane between the pseudotendon and pubic ramus with USG in-plane technique, 20 ml of 0.5% bupivacaine was administered and surgery was initiated. The primary outcome of the study was to investigate the effect of preoperative PENG block application on postoperative pain, opioid requirement, mobilisation time, hip joint patency and length of hospital stay in patients undergoing THA surgery. The secondary outcome was to investigate the effect of PENG block on perioperative haemodynamics and postoperative side effects.
For multimodal analgesia, 10 ml 0.5% bupivacaine + 10 ml 2% lidocaine is infiltrated into the surgical wound incision line by the surgical team at the end of surgery. After tramadol 50 mg loading with PCA device, a basal rate of 5-10 mg/hour (20 mg bolus dose + 30 minutes lock time) is given with paracetamol 10 mg/kg iv (8 hours interval).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- This prospective randomised controlled study included a total of 60 patients aged 40-85 years who underwent THA surgery under spinal anaesthesia. Patients were divided into two groups as PENG block and non-PENG block (control group).
| Arm | Type | Receives |
|---|---|---|
| PENG group | Active comparator | Procedure: Pericapsular Nerve Group (PENG) BlockPENG block was placed in the fascial plane between the pseudotendon and pubic ramus with USG in-plane technique, 20 ml of 0.5% bupivacaine was administered after spinal anaesthesia. |
| non-PENG group | Placebo comparator | Procedure: Pericapsular Nerve Group (PENG) Blockgroup non-PENG, surgery was started without PENG block after spinal anaesthesia. |
Who may qualify
- Ages
- 40 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- THA performed by posterior approach
- 40-85 age range
- ASA 1-3
Key exclusion criteria (7 listed)
- Under 40 years of age, over 85 years of age,
- ASA 4 and above,
- Cognitive impairment (Alzheimer's disease, dementia, delirium etc.),
- Hip fracture,
- Application site infection,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pericapsular Nerve Group (PENG) BlockWith ultrasonography-guided PENG block, the femoral, obturator and accessory obturator nerve branches that provide sensory innervation of the anterior surface of the hip joint capsule are blocked . | Procedure or surgery | PENG group, non-PENG group |
Primary outcome
postoperative pain score
Time frame: recovery room 30 min, 12., 24. and 48. hours in the postoperative period
VAS pain score
mobilisation time
Time frame: 24 -48 hours
walking 5 steps with walker
hip joint patency
Time frame: 24. hours
Measurement of joint movement angle with goniometer (angle)
total opioid consumption
Time frame: 48 hours
Tramadol total usage (mg)
3 secondary outcomes
PENG block side effects
Time frame: The first 48 hours after performing the PENG block
Perioperative haemodynamic data
Time frame: T1: 30 minutes (min) after spinal anesthesia, T2: at the end of the surgical procedure, T3: at 30 minutes after recovery
length of hospital stay
Time frame: day
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
zeliha tuncel study director
Ümraniye Training and Education hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pericapsular Nerve Group (PENG) Block in people with Analgesia and Postoperative Pain, Acute, run by Umraniye Education and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
postoperative pain score (time frame: recovery room 30 min, 12., 24. and 48. hours in the postoperative period). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.