Post-COVID-19 SyndromeNCT06136871
Cognitive Rehabilitation in Post-COVID-19 Syndrome
A study testing CO-OP Procedures in people with Post-COVID-19 Syndrome, run by University of Missouri-Columbia at 1 site in United States.
Trial summary
The first aim of this study is to determine the feasibility of delivering CO-OP remotely to individuals experiencing cognitive impairments that limit everyday activities in post-COVID-19 syndrome (PCS). Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Post-COVID-19 Syndrome
- What is being tested?
- CO-OP Procedures
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 65 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Feb 2024to 30 Jun 2025
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- self-reported cognitive symptoms persisting for at least 6 weeks following COVID-19 infection (Cognitive Failures Questionnaire (CFQ) score >43)
- self-identified activity performance goals per the Canadian Occupational Performance Measure (COPM)
- documented prior diagnosis of COVID-19
- read, write, and speak English fluently
- ability to provide valid informed electronic consent
Who cannot join
- diagnosis of severe neurological or psychiatric condition(s)
- dementia symptoms as indicated by a score of <23 on the Montreal Cognitive Assessment (MoCA)
- untreated sleep apnea (≥5 on the STOPBANG)
- prior cancer treatment
- severe depressive symptoms (>21 on the Patient Health Questionnaire-9)
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Missouri Department of Occupational Therapy
Columbia, Missouri, 65211
About this study
Official title: Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial
The first aim of this study is to determine the feasibility of delivering CO-OP remotely to individuals experiencing cognitive impairments that limit everyday activities in post-COVID-19 syndrome (PCS). The second aim of this study is to assess the effect of CO-OP on activity performance, subjective and objective cognition, and quality of life in a sample of individuals with PCS. The research team hypothesizes that effect size estimations will indicate that CO-OP will have a greater positive effect, compared to an inactive control group, on activity performance, subjective and objective cognition, and quality of life in a sample of individuals who self-report PCS and cognitive impairment.
Read the detailed description
Post-COVID-19 symptoms (PCS) cognitive symptoms require the rehabilitation community to investigate ways to: (1) reduce the functional impact of the symptoms on daily life and (2) support individuals with PCS to establish new habits to improve and maintain health. While the cognitive impairment associated with PCS has not been well evaluated, it is similar of cognitive symptoms seen in other conditions. Metacognitive strategy training (MCST) approaches are an evidence-based practice standard for improving capacity to self-manage chronic cognitive symptoms and reduce their functional impact on everyday life activities.
The CO-OP approach is an MCST intervention in which participants are taught a general cognitive strategy that can be applied in known and novel contexts to devise task specific strategies for engaging in an activity. Existing evidence with other populations suggests that CO-OP has more of a positive effect on improving activity performance and cognition than remediation/retraining-based approaches. These effects have been demonstrated in individuals with mild cognitive impairment that mirrors that found in PCS. The overall research hypothesis is that CO-OP can feasibly be administered remotely and will improve activity performance, subjective and objective cognitive function, and quality of life in individuals with PCS.
- Conditions
- Post-COVID-19 Syndrome
- Being tested
- CO-OP Procedures, Inactive Control Group
- Keywords
- covid-19, metacognition, cognition, telehealth, activities of daily living
- Medical subject headings
- Post-Acute COVID-19 Syndrome, COVID-19
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CO-OP ProceduresBehavioural
CO-OP is a metacognitive strategy training intervention that will be used in this study. First, five functional, everyday life goals are identified collaboratively by the participant and interventionist. In the second meeting, we introduce the approach to the subject and teach the global cognitive strategy (i.e., GOAL-PLAN-DO-CHECK). In all subsequent sessions, this strategy is used as the main problem-solving framework to facilitate skill acquisition.The subject identifies a GOAL, and then is guided by the therapist to discover a PLAN to potentially achieve the goal. The subject is then asked to DO the plan (if feasible during the therapy session otherwise asked to complete at home prior to the next treatment session), and subsequently to CHECK to see if the plan worked, i.e. the goal was achieved. This process is repeated until satisfactory performance is met for each established goal.
Inactive Control GroupBehavioural
An inactive control group will be used to control for maturation and testing effects. Weekly contact will be made via teleconferencing to (1) maintain study engagement, (2) introduce weekly social contact with researchers, mimicking some of the potential incidental effects of the experimental group, and (3) ascertain what, if any, additional steps participants have taken to reduce PCS symptoms. The content of each of these meetings will be tracked in intervention notes. Each contact will be recorded for fidelity monitoring to ensure all active ingredients of the CO-OP intervention are avoided.
| Study group | Role | What they receive |
|---|---|---|
| Cognitive Orientation to daily Occupational Performance (CO-OP) | Experimental | Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. Receives: Behavioral: CO-OP Procedures |
| Inactive Control Group | Other | Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. Receives: Behavioral: Inactive Control Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Recruitment Rate
Number of participants enrolled divided by number of individuals screened
Measured: After study completion, an average of 12 weeks
Retention Rate
Number of participants completing all study procedures divided by number of participants enrolled
Measured: After study completion, an average of 12 weeks
Telehealth Usability Questionnaire (TUQ)
Measure of telehealth usability from participant's perspective. Self-report Likert scale of 1 (disagree) to 7 (agree). Higher values represent a better outcome.
Measured: After study completion, an average of 12 weeks
Acceptability of Intervention Measure (AIM)
Measure of intervention acceptability. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree)
Measured: After study completion, an average of 12 weeks
Intervention Appropriateness Measure (IAM)
Measure of intervention appropriateness. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree)
Measured: After study completion, an average of 12 weeks
Feasibility of Intervention Measure (FIM)
Measure of intervention feasibility. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree)
Measured: After study completion, an average of 12 weeks
Canadian Occupational Performance Measure (COPM) Performance, Trained Goals
Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Canadian Occupational Performance Measure (COPM) Satisfaction, Trained Goals
Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Secondary outcomes (17)
Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time
Objective measure of inhibition and cognitive flexibility. Data are presented for condition 4 of color/word switching. Age-adjusted scale scores are presented with a mean of 10 and a standard deviation of 3. Maximum=19, minimum=1. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors
Objective measure of inhibition and cognitive flexibility. Data are presented for condition 4 of color/word switching. Age-adjusted scale scores are presented with a mean of 10 and a standard deviation of 3. Maximum=19, minimum=1. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function
Self-report measure of cognition. Maximum=5, minimum=1. T-scores are reported with a mean of 50 and a standard deviation of 10. Higher scores indicate fewer perceived cognitive deficits.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Cambridge Neuropsychological Test Automated Battery (CANTAB) Rapid Visual Information Processing Subtest
Objective measure of sustained attention. A Z-score of 0 represents the population mean. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Spatial Working Memory Subtest
Objective measure of working memory and strategy. A Z-score of 0 represents the population mean. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Stockings of Cambridge Subtest
Objective measure of planning and executive function. A Z-score of 0 represents the population mean. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Delayed Matching to Sample Subtest
Objective measure of short-term visual recognition memory and attention. A Z-score of 0 represents the population mean. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Paired Associates Learning Subtest
Objective measure of visual episodic memory. A Z-score of 0 represents the population mean. Higher scores indicate better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Canadian Occupational Performance Measure (COPM) Performance, Untrained Goals
Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Canadian Occupational Performance Measure (COPM) Satisfaction, Untrained Goals
Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Physical Domain
Self-report measure of physical health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived physical health.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Social Domain
Self-report measure of social health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived social health.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Environmental Domain
Self-report measure of environmental health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived environmental health.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Spiritual Domain
Self-report measure of spiritual health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived spiritual health.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Independence Domain
Self-report measure of independence. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived independence.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Psychological Domain
Self-report measure of psychological health. Each item is ranked on a Likert scale of 1-5 (Maximum=5, minimum=1). The range of scores for this domain is 0-100, with higher scores indicating greater perceived psychological health.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Cognitive Failures Questionnaires Total Score
Self-report measure of frequency of cognitive errors in daily life. Participants rate each item on a scale of 0 (never) to 4 (very often). Maximum total score=100, minimum total score=0. Higher scores indicate increased perceived cognitive errors.
Measured: Pre-intervention (week 0) and post-intervention (week 12)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Nov 2023
- Study start1 Feb 2024
- Primary completion30 Jun 2025
- Study completion30 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Post-COVID-19 SyndromeStudies of the same condition, open and under way.
- More trials run by University of Missouri-ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- After baseline assessment, subjects will be randomized to one of two groups: (1) a 10-session Cognitive Orientation to daily Occupational Performance (CO-OP) intervention; or (2) a 10-session inactive control group.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 65 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Missouri-Columbia
- Sponsor type
- University, hospital or other
- Collaborators
- National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Responsible party
- Principal investigator, Anna Boone, University of Missouri-Columbia
- Investigators
- Anna E Boone, PhD, OTR/L, Principal investigator, University of Missouri Occupational Therapy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06136871
- Sponsor's protocol ID
- 2096158
- Other IDs
- R21HD112373-01
- Status last verified
- Nov 2025
- First submitted
- 14 Nov 2023
- Last updated
- 13 Mar 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
McEwen S, Polatajko H, Baum C, Rios J, Cirone D, Doherty M, Wolf T. Combined Cognitive-Strategy and Task-Specific Training Improve Transfer to Untrained Activities in Subacute Stroke: An Exploratory Randomized Controlled Trial. Neurorehabil Neural Repair. 2015 Jul;29(6):526-36. doi: 10.1177/1545968314558602. Epub 2014 Nov 21.
PubMed 25416738Geusgens CA, van Heugten CM, Cooijmans JP, Jolles J, van den Heuvel WJ. Transfer effects of a cognitive strategy training for stroke patients with apraxia. J Clin Exp Neuropsychol. 2007 Nov;29(8):831-41. doi: 10.1080/13803390601125971.
PubMed 18030634Haskins EC, Cicerone KD, Trexler LE. Cognitive rehabilitation manual: Translating evidence-based recommendations into practice. ACRM Publishing; 2012.
Cicerone KD, Dahlberg C, Malec JF, Langenbahn DM, Felicetti T, Kneipp S, Ellmo W, Kalmar K, Giacino JT, Harley JP, Laatsch L, Morse PA, Catanese J. Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005 Aug;86(8):1681-92. doi: 10.1016/j.apmr.2005.03.024.
PubMed 16084827Dawson DR, Anderson ND, Burgess P, Cooper E, Krpan KM, Stuss DT. Further development of the Multiple Errands Test: standardized scoring, reliability, and ecological validity for the Baycrest version. Arch Phys Med Rehabil. 2009 Nov;90(11 Suppl):S41-51. doi: 10.1016/j.apmr.2009.07.012.
PubMed 19892074Wolf TJ, Polatajko H, Baum C, Rios J, Cirone D, Doherty M, McEwen S. Combined Cognitive-Strategy and Task-Specific Training Affects Cognition and Upper-Extremity Function in Subacute Stroke: An Exploratory Randomized Controlled Trial. Am J Occup Ther. 2016 Mar-Apr;70(2):7002290010p1-7002290010p10. doi: 10.5014/ajot.2016.017293.
PubMed 26943113
Study at a glance
From the registry record, last updated by the sponsor on 13 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial
- ClinicalTrials.gov ID
- NCT06136871
- Acronym / sponsor ID
- 2096158
- Conditions
- Post-COVID-19 Syndrome
- Keywords
- covid-19, metacognition, cognition, telehealth, activities of daily living
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 65 participants (actual)
- Lead sponsor
- University of Missouri-ColumbiaUniversity, hospital or other
- Collaborators
- National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Study start
- 1 Feb 2024 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 30 Jun 2025 (actual)
- First posted
- 18 Nov 2023 (actual)
- Results
- Posted 13 Mar 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The first aim of this study is to determine the feasibility of delivering CO-OP remotely to individuals experiencing cognitive impairments that limit everyday activities in post-COVID-19 syndrome (PCS). The second aim of this study is to assess the effect of CO-OP on activity performance, subjective and objective cognition, and quality of life in a sample of individuals with PCS. The research team hypothesizes that effect size estimations will indicate that CO-OP will have a greater positive effect, compared to an inactive control group, on activity performance, subjective and objective cognition, and quality of life in a sample of individuals who self-report PCS and cognitive impairment.
Detailed description
Post-COVID-19 symptoms (PCS) cognitive symptoms require the rehabilitation community to investigate ways to: (1) reduce the functional impact of the symptoms on daily life and (2) support individuals with PCS to establish new habits to improve and maintain health. While the cognitive impairment associated with PCS has not been well evaluated, it is similar of cognitive symptoms seen in other conditions. Metacognitive strategy training (MCST) approaches are an evidence-based practice standard for improving capacity to self-manage chronic cognitive symptoms and reduce their functional impact on everyday life activities.
The CO-OP approach is an MCST intervention in which participants are taught a general cognitive strategy that can be applied in known and novel contexts to devise task specific strategies for engaging in an activity. Existing evidence with other populations suggests that CO-OP has more of a positive effect on improving activity performance and cognition than remediation/retraining-based approaches. These effects have been demonstrated in individuals with mild cognitive impairment that mirrors that found in PCS. The overall research hypothesis is that CO-OP can feasibly be administered remotely and will improve activity performance, subjective and objective cognitive function, and quality of life in individuals with PCS.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- After baseline assessment, subjects will be randomized to one of two groups: (1) a 10-session Cognitive Orientation to daily Occupational Performance (CO-OP) intervention; or (2) a 10-session inactive control group.
| Arm | Type | Receives |
|---|---|---|
| Cognitive Orientation to daily Occupational Performance (CO-OP) | Experimental | Behavioral: CO-OP ProceduresEach CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
| Inactive Control Group | Other | Behavioral: Inactive Control GroupSubjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- self-reported cognitive symptoms persisting for at least 6 weeks following COVID-19 infection (Cognitive Failures Questionnaire (CFQ) score >43)
- self-identified activity performance goals per the Canadian Occupational Performance Measure (COPM)
- documented prior diagnosis of COVID-19
- read, write, and speak English fluently
- ability to provide valid informed electronic consent
Key exclusion criteria (5 listed)
- diagnosis of severe neurological or psychiatric condition(s)
- dementia symptoms as indicated by a score of <23 on the Montreal Cognitive Assessment (MoCA)
- untreated sleep apnea (≥5 on the STOPBANG)
- prior cancer treatment
- severe depressive symptoms (>21 on the Patient Health Questionnaire-9)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CO-OP ProceduresCO-OP is a metacognitive strategy training intervention that will be used in this study. First, five functional, everyday life goals are identified collaboratively by the participant and interventionist. In the second meeting, we introduce the approach to the subject and teach the global cognitive strategy (i.e., GOAL-PLAN-DO-CHECK). In all subsequent sessions, this strategy is used as the main problem-solving framework to facilitate skill acquisition.The subject identifies a GOAL, and then is guided by the therapist to discover a PLAN to potentially achieve the goal. The subject is then asked to DO the plan (if feasible during the therapy session otherwise asked to complete at home prior to the next treatment session), and subsequently to CHECK to see if the plan worked, i.e. the goal was achieved. This process is repeated until satisfactory performance is met for each established goal. | Behavioural | Cognitive Orientation to daily Occupational Performance (CO-OP) |
| Inactive Control GroupAn inactive control group will be used to control for maturation and testing effects. Weekly contact will be made via teleconferencing to (1) maintain study engagement, (2) introduce weekly social contact with researchers, mimicking some of the potential incidental effects of the experimental group, and (3) ascertain what, if any, additional steps participants have taken to reduce PCS symptoms. The content of each of these meetings will be tracked in intervention notes. Each contact will be recorded for fidelity monitoring to ensure all active ingredients of the CO-OP intervention are avoided. | Behavioural | Inactive Control Group |
Primary outcome
Recruitment Rate
Time frame: After study completion, an average of 12 weeks
Number of participants enrolled divided by number of individuals screened
Retention Rate
Time frame: After study completion, an average of 12 weeks
Number of participants completing all study procedures divided by number of participants enrolled
Telehealth Usability Questionnaire (TUQ)
Time frame: After study completion, an average of 12 weeks
Measure of telehealth usability from participant's perspective. Self-report Likert scale of 1 (disagree) to 7 (agree). Higher values represent a better outcome.
Acceptability of Intervention Measure (AIM)
Time frame: After study completion, an average of 12 weeks
Measure of intervention acceptability. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree)
Intervention Appropriateness Measure (IAM)
Time frame: After study completion, an average of 12 weeks
Measure of intervention appropriateness. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree)
Feasibility of Intervention Measure (FIM)
Time frame: After study completion, an average of 12 weeks
Measure of intervention feasibility. Self-report Likert scale of 1 (completely disagree) to 5 (completely agree)
Canadian Occupational Performance Measure (COPM) Performance, Trained Goals
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Self-report measure of activity performance. Minimum = 1, Maximum = 10. Higher scores mean better performance.
Canadian Occupational Performance Measure (COPM) Satisfaction, Trained Goals
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Self-report measure of satisfaction level with activity performance. Minimum = 1, Maximum = 10. Higher scores mean higher satisfaction.
17 secondary outcomes
Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Cambridge Neuropsychological Test Automated Battery (CANTAB) Rapid Visual Information Processing Subtest
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Spatial Working Memory Subtest
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Stockings of Cambridge Subtest
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Delayed Matching to Sample Subtest
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
CANTAB Paired Associates Learning Subtest
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Canadian Occupational Performance Measure (COPM) Performance, Untrained Goals
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Canadian Occupational Performance Measure (COPM) Satisfaction, Untrained Goals
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Physical Domain
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Social Domain
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Environmental Domain
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Spiritual Domain
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Independence Domain
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) - Psychological Domain
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Cognitive Failures Questionnaires Total Score
Time frame: Pre-intervention (week 0) and post-intervention (week 12)
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Mar 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 25416738McEwen S, Polatajko H, Baum C, Rios J, Cirone D, Doherty M, Wolf T. Combined Cognitive-Strategy and Task-Specific Training Improve Transfer to Untrained Activities in Subacute Stroke: An Exploratory Randomized Controlled Trial. Neurorehabil Neural Repair. 2015 Jul;29(6):526-36. doi: 10.1177/1545968314558602. Epub 2014 Nov 21.
- Background: PubMed 18030634Geusgens CA, van Heugten CM, Cooijmans JP, Jolles J, van den Heuvel WJ. Transfer effects of a cognitive strategy training for stroke patients with apraxia. J Clin Exp Neuropsychol. 2007 Nov;29(8):831-41. doi: 10.1080/13803390601125971.
- BackgroundHaskins EC, Cicerone KD, Trexler LE. Cognitive rehabilitation manual: Translating evidence-based recommendations into practice. ACRM Publishing; 2012.
- Background: PubMed 16084827Cicerone KD, Dahlberg C, Malec JF, Langenbahn DM, Felicetti T, Kneipp S, Ellmo W, Kalmar K, Giacino JT, Harley JP, Laatsch L, Morse PA, Catanese J. Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005 Aug;86(8):1681-92. doi: 10.1016/j.apmr.2005.03.024.
- Background: PubMed 19892074Dawson DR, Anderson ND, Burgess P, Cooper E, Krpan KM, Stuss DT. Further development of the Multiple Errands Test: standardized scoring, reliability, and ecological validity for the Baycrest version. Arch Phys Med Rehabil. 2009 Nov;90(11 Suppl):S41-51. doi: 10.1016/j.apmr.2009.07.012.
- Background: PubMed 26943113Wolf TJ, Polatajko H, Baum C, Rios J, Cirone D, Doherty M, McEwen S. Combined Cognitive-Strategy and Task-Specific Training Affects Cognition and Upper-Extremity Function in Subacute Stroke: An Exploratory Randomized Controlled Trial. Am J Occup Ther. 2016 Mar-Apr;70(2):7002290010p1-7002290010p10. doi: 10.5014/ajot.2016.017293.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anna E Boone, PhD, OTR/L principal investigator
University of Missouri Occupational Therapy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing CO-OP Procedures in people with Post-COVID-19 Syndrome, run by University of Missouri-Columbia at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 13 Mar 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Recruitment Rate (time frame: After study completion, an average of 12 weeks). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06136871, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Mar 2026.