Mental Health IssueNCT06105970
Chinese Community Sample of Hierarchical Model of Psychopathology
An observational study of Mental Health Issue and Adverse Childhood Experience, run by Shanghai Mental Health Center at 1 site in China.
Trial summary
By validating Hierarchy Model of psychopathology(HiTOP) in Chinese community samples, this study aims for illumating the problem of diagnostic heterogeneity and high comorbidity within existing psychiatric classification systems in Chinese culture. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Mental Health Issue, Adverse Childhood Experience
- How many people
- 4,000 participants
- Where
- 1 siteChina
- Study dates
- 26 Sep 2023to 1 Nov 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: This study aims to recruits partcipants across the whole regions of China, with the aim of collecting representative Chinese community sample.
Who may be able to join
- Chinese citizens
- Years of education > =9 years.
- age >= 18 years old.
Who cannot join
- (1)Subjects who have insufficient self-awareness, and are unable to obtain complete informed consent, such as: schizophrenia, manic episode of bipolar disorder, severe depression.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Shanghai Mental Health Center
Shanghai
Zhen Wang, MD,PhD, 862164387259 ext. 73516, wangzhen@smhc.org.cn
Zhen Wang, MD,PhD
About this study
Official title: Chinese Community Sample of Hierarchical Model of Psychopathology : Validation and Analysis of Underline Trans-diagnostic Risk Factors
By validating Hierarchy Model of psychopathology(HiTOP) in Chinese community samples, this study aims for illumating the problem of diagnostic heterogeneity and high comorbidity within existing psychiatric classification systems in Chinese culture. Concurrently, this study also focuses on exploring trans-diagonostic risk and proctective factors underline HiTOP dimensions.
the main questions it aims to answer are:
Read more
- Explore HiTOP model cultural differences between western culture and eastern culture.
- Understand the impact of different dimension of adverse childhood experience on HiTOP structure.
- Investigate the relationship between individual unique psychological variables and psychopathological dimensions.
Participants will receive a detailed survey trying to measure their psychopathology symptoms, adverse childhood experience and psychological variables. This study expects to fallow up participants for 4 years to monitor the symptom changes.
- Conditions
- Mental Health Issue, Adverse Childhood Experience
- Being tested
- No intervention
- Keywords
- Hierarchical Model of Psychopathology
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No interventionOther
cross sectional study#no intervention
| Study group | Role | What they receive |
|---|---|---|
| Community sample | Using social media to randomly inviting participants across all regions of China. Receives: Other: No intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Chinese version of Hierarchy Model of psychopathology
Constructing the Chinese version of Hierarchy Model of psychopathology. Comparing the differences between Chinese version and western version.
Measured: 1 year
Mapping different dimension of adverse childhood experience on Hierarchy Model of psychopathology structure
Measured: 1 year
Secondary outcomes (1)
Investigate the relationship between individual unique psychological variables and psychopathological dimensions.
Measured: 4 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Oct 2023
- Study start26 Sep 2023
- Primary completion1 Nov 2024
- Study completion1 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mental Health IssueStudies of the same condition, open and under way.
- More trials run by Shanghai Mental Health CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Enrolment
- 4,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Shanghai Mental Health Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zhen Wang, Shanghai Mental Health Center
- Investigators
- Zhen Wang, PhD, MD, Principal investigator, Shanghai Mental Health Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06105970
- Sponsor's protocol ID
- HiTOP001
- Status last verified
- Jul 2025
- First submitted
- 24 Oct 2023
- Last updated
- 10 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Chinese Community Sample of Hierarchical Model of Psychopathology : Validation and Analysis of Underline Trans-diagnostic Risk Factors
- ClinicalTrials.gov ID
- NCT06105970
- Acronym / sponsor ID
- HiTOP001
- Conditions
- Mental Health Issue, Adverse Childhood Experience
- Keywords
- Hierarchical Model of Psychopathology
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 4,000 participants (estimated)
- Lead sponsor
- Shanghai Mental Health CenterUniversity, hospital or other
- Study start
- 26 Sep 2023 (actual)
- Primary completion
- 1 Nov 2024 (actual)
- Study completion
- 1 Nov 2027 (estimated)
- First posted
- 30 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
By validating Hierarchy Model of psychopathology(HiTOP) in Chinese community samples, this study aims for illumating the problem of diagnostic heterogeneity and high comorbidity within existing psychiatric classification systems in Chinese culture. Concurrently, this study also focuses on exploring trans-diagonostic risk and proctective factors underline HiTOP dimensions.
the main questions it aims to answer are:
- Explore HiTOP model cultural differences between western culture and eastern culture.
- Understand the impact of different dimension of adverse childhood experience on HiTOP structure.
- Investigate the relationship between individual unique psychological variables and psychopathological dimensions.
Participants will receive a detailed survey trying to measure their psychopathology symptoms, adverse childhood experience and psychological variables. This study expects to fallow up participants for 4 years to monitor the symptom changes.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Community sample | – | Other: No interventionUsing social media to randomly inviting participants across all regions of China. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- This study aims to recruits partcipants across the whole regions of China, with the aim of collecting representative Chinese community sample.
Key inclusion criteria (3 listed)
- Chinese citizens
- Years of education > =9 years.
- age >= 18 years old.
Key exclusion criteria (1 listed)
- (1)Subjects who have insufficient self-awareness, and are unable to obtain complete informed consent, such as: schizophrenia, manic episode of bipolar disorder, severe depression.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No interventioncross sectional study#no intervention | Other | Community sample |
Primary outcome
Chinese version of Hierarchy Model of psychopathology
Time frame: 1 year
Constructing the Chinese version of Hierarchy Model of psychopathology. Comparing the differences between Chinese version and western version.
Mapping different dimension of adverse childhood experience on Hierarchy Model of psychopathology structure
Time frame: 1 year
1 secondary outcome
Investigate the relationship between individual unique psychological variables and psychopathological dimensions.
Time frame: 4 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Zhen Wang, PhD, MD principal investigator
Shanghai Mental Health Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Mental Health Issue and Adverse Childhood Experience, run by Shanghai Mental Health Center at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zhen Wang, Phd, MD (+8634773516, wangzhen@smhc.org.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Chinese version of Hierarchy Model of psychopathology (time frame: 1 year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2025.