Substance UseCASTNCT06003725
Cultural Adaptation of Drug Treatment for DJJ Youth
A study testing Culturally Adapted Adolescent Substance Use Treatment in people with Substance Use, run by University of California, San Francisco at 2 sites in United States.
Trial summary
This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Read more about this study
- Who is it for?
- Ages 13 to 17 yearsHealthy volunteers can take part
- Conditions the study is for
- Substance Use
- What is being tested?
- Culturally Adapted Adolescent Substance Use Treatment
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 55 participants
- Where
- 2 sitesUnited States
- Study dates
- 15 May 2024to 30 Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 13 to 17 years
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- 1) Between the ages of 13-17; 2) identify as Black or African American; and 3) on community probation.
- A guardian of JIY
- An advocate (someone who supports change and reform in the justice community) for Black JIY.
- Between the ages of 13 and 17
- Identify as Black or African American
- Be on community probation
Show all 9Show fewer
- Meet criteria for alcohol, cannabis, or other drug misuse as defined by the DSM 5
- Be experiencing at least 1 problem related to AOD;
- The frequency of AOD must be weekly use over a 3-month period
Who cannot join
- Will be excluded if they do not have parental consent to participate.
- For Focus Groups and Interviews:
- Adult Participants
- Will be excluded if they do not provide consent to participate.
- For pilot feasibility study:
- Black JIY Participants:
- Will be excluded if they do not have parental consent to participate
- Parole violation
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 1 recruiting
- Completed
Medical University of South Carolina
Charleston, South Carolina, 29425
- Recruiting
University of California, San Francisco
San Francisco, California, 94110
Brittany Bryant, DSW, 843-973-0867, brittany.bryant@ucsf.edu
About this study
Official title: The Cultural Adaptation of an Alcohol and Other Drug Use Treatment for Black Justice Involved Youth
This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Individual interviews with Black JIY and focus groups with parents and guardians of Black JIY and community members who support change and reform in the justice community for Black JIY will be conducted.
Read the detailed description
Black JIY are overrepresented in the criminal justice system due to institutional racism and discrimination. The General Strain Theory posits that high levels of ethnic and racial discrimination (ERD), paired with elevated levels of witnessing or experiencing police brutality, places Black JIY at unique risk of increased alcohol and other drug use (AOD) as a means of coping with stressful events. Black JIY report engaging in comorbid alcohol and cannabis use to achieve temporary respite from discrimination-induced stress. While JIY engage in higher rates of comorbid alcohol and cannabis use compared to non-justice-involved youth, overall, Black JIY are less likely to be diverted to substance use treatment programs, less likely to engage in care after being released on probation, less likely to benefit from substance use treatment in terms of reduced risk of recidivism, and are more adversely affected by early onset of AOD activity than White JIY. To date, no known adolescent substance use treatment directly addresses ERD, the increased risk of AOD due to ERD, or explicitly presents tools on how to appropriately respond to AOD and discrimination distress among Black JIY. To address this problem, the investigator's research program aspires to improve the understanding of the impact of ERD on adolescent AOD within the Black JIY population. Individual interviews with Black JIY and focus groups with guardians of Black JIY and community members will be conducted. Data will be used to culturally adapt an adolescent substance use intervention. The culturally adapted intervention will then be piloted with 30 Black JIY.
- Conditions
- Substance Use
- Being tested
- Culturally Adapted Adolescent Substance Use Treatment
- Keywords
- Substance use, substance misuse, adolescent, cultural adaptation
- Medical subject headings
- Substance-Related Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Culturally Adapted Adolescent Substance Use TreatmentBehavioural
Also called Cannabis Youth Treatment Series
The Cannabis Youth Treatment Series (CYT) (MET/CBT12 model) aims to reduce alcohol and cannabis use.
| Study group | Role | What they receive |
|---|---|---|
| ADAP-ITT Phase 8 | Experimental | Phase 8 consists of piloting the culturally adapted CYT intervention with 30 Black JIY to examine feasibility and acceptability. Receives: Behavioral: Culturally Adapted Adolescent Substance Use Treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Feasibility and Acceptability
Participants will complete feasibility and acceptability questionnaires and provide qualitative data on likes and dislikes about the intervention, delivery, session structure, and content.
Measured: After study completion, an average of 3 months
Secondary outcomes (3)
Change in substance use
Participants will complete urinalysis
Measured: Baseline, after each study visit, at study completion, up to 3 months post-intervention, an average of 6 months.
Change in mental health symptoms
Participants will complete measures and questionnaires to monitor anxiety, depression, and trauma symptoms
Measured: Baseline, after each study visit, at study completion, up to 3 months post-intervention, an average of 6 months.
Change in discrimination distress
Participants will complete a discrimination distress assessment measure
Measured: baseline, after study completion, and up to 3 months post-intervention, an average of 6 months.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Aug 2023
- Study start15 May 2024
- Primary completion30 Apr 2027 (estimated)
- Study completion30 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Substance UseStudies of the same condition, open and under way.
- More trials run by University of California, San FranciscoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Sequential
- Model description
- Individual interviews with Black justice-involved youth (JIY) and focus groups with guardians of Black JIY and community members will be conducted. Data from focus groups and interviews will be used to inform the cultural adaptation of an evidence-based adolescent substance use treatment. The cultural adapted treatment will then be piloted with 30 Black JIY for feasibility and acceptability.
- Masking
- None (open label)
- Enrolment
- 55 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, San Francisco
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Responsible party
- Sponsor
- Investigators
- Brittany Bryant, DSW, Principal investigator, University of California, San Francisco
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06003725
- Sponsor's protocol ID
- 23-40126
- Other IDs
- K23DA057412
- Acronym
- CAST
- Status last verified
- Jul 2026
- First submitted
- 18 Jul 2023
- Last updated
- 13 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The datasets generated and/or analyzed during the current study are not publicly available since data is still being collected. De-identified data will be available upon reasonable request after the study is completed, and results have been reported to the public.
Publications
Bryant BE, Tolou-Shams M, Ezimora I, Zapolski TC, DiClemente R, Jordan A, Becker SJ, Squeglia LM. Adapting substance use treatment for black adolescents in the US legal system: protocol for a mixed-method, exploratory, feasibility and acceptability study using the eight-step ADAPT-ITT framework. BMJ Open. 2026 Mar 2;16(3):e115193. doi: 10.1136/bmjopen-2025-115193.
PubMed 41771593
Study at a glance
From the registry record, last updated by the sponsor on 13 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Cultural Adaptation of an Alcohol and Other Drug Use Treatment for Black Justice Involved Youth
- ClinicalTrials.gov ID
- NCT06003725
- Acronym / sponsor ID
- CAST / 23-40126
- Conditions
- Substance Use
- Keywords
- Substance use, substance misuse, adolescent, cultural adaptation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 55 participants (estimated)
- Lead sponsor
- University of California, San FranciscoUniversity, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Study start
- 15 May 2024 (actual)
- Primary completion
- 30 Apr 2027 (estimated)
- Study completion
- 30 Aug 2027 (estimated)
- First posted
- 22 Aug 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Individual interviews with Black JIY and focus groups with parents and guardians of Black JIY and community members who support change and reform in the justice community for Black JIY will be conducted.
Detailed description
Black JIY are overrepresented in the criminal justice system due to institutional racism and discrimination. The General Strain Theory posits that high levels of ethnic and racial discrimination (ERD), paired with elevated levels of witnessing or experiencing police brutality, places Black JIY at unique risk of increased alcohol and other drug use (AOD) as a means of coping with stressful events. Black JIY report engaging in comorbid alcohol and cannabis use to achieve temporary respite from discrimination-induced stress. While JIY engage in higher rates of comorbid alcohol and cannabis use compared to non-justice-involved youth, overall, Black JIY are less likely to be diverted to substance use treatment programs, less likely to engage in care after being released on probation, less likely to benefit from substance use treatment in terms of reduced risk of recidivism, and are more adversely affected by early onset of AOD activity than White JIY. To date, no known adolescent substance use treatment directly addresses ERD, the increased risk of AOD due to ERD, or explicitly presents tools on how to appropriately respond to AOD and discrimination distress among Black JIY. To address this problem, the investigator's research program aspires to improve the understanding of the impact of ERD on adolescent AOD within the Black JIY population. Individual interviews with Black JIY and focus groups with guardians of Black JIY and community members will be conducted. Data will be used to culturally adapt an adolescent substance use intervention. The culturally adapted intervention will then be piloted with 30 Black JIY.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Sequential
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Individual interviews with Black justice-involved youth (JIY) and focus groups with guardians of Black JIY and community members will be conducted. Data from focus groups and interviews will be used to inform the cultural adaptation of an evidence-based adolescent substance use treatment. The cultural adapted treatment will then be piloted with 30 Black JIY for feasibility and acceptability.
| Arm | Type | Receives |
|---|---|---|
| ADAP-ITT Phase 8 | Experimental | Behavioral: Culturally Adapted Adolescent Substance Use TreatmentPhase 8 consists of piloting the culturally adapted CYT intervention with 30 Black JIY to examine feasibility and acceptability. |
Who may qualify
- Ages
- 13 to 17 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (9 listed)
- 1) Between the ages of 13-17; 2) identify as Black or African American; and 3) on community probation.
- A guardian of JIY
- An advocate (someone who supports change and reform in the justice community) for Black JIY.
- Between the ages of 13 and 17
- Identify as Black or African American
Key exclusion criteria (8 listed)
- Will be excluded if they do not have parental consent to participate.
- Adult Participants
- Will be excluded if they do not provide consent to participate.
- Will be excluded if they do not have parental consent to participate
- Parole violation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Culturally Adapted Adolescent Substance Use TreatmentAlso: Cannabis Youth Treatment SeriesThe Cannabis Youth Treatment Series (CYT) (MET/CBT12 model) aims to reduce alcohol and cannabis use. | Behavioural | ADAP-ITT Phase 8 |
Primary outcome
Feasibility and Acceptability
Time frame: After study completion, an average of 3 months
Participants will complete feasibility and acceptability questionnaires and provide qualitative data on likes and dislikes about the intervention, delivery, session structure, and content.
3 secondary outcomes
Change in substance use
Time frame: Baseline, after each study visit, at study completion, up to 3 months post-intervention, an average of 6 months.
Change in mental health symptoms
Time frame: Baseline, after each study visit, at study completion, up to 3 months post-intervention, an average of 6 months.
Change in discrimination distress
Time frame: baseline, after study completion, and up to 3 months post-intervention, an average of 6 months.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jul 2026.
- Derived from this study: PubMed 41771593Bryant BE, Tolou-Shams M, Ezimora I, Zapolski TC, DiClemente R, Jordan A, Becker SJ, Squeglia LM. Adapting substance use treatment for black adolescents in the US legal system: protocol for a mixed-method, exploratory, feasibility and acceptability study using the eight-step ADAPT-ITT framework. BMJ Open. 2026 Mar 2;16(3):e115193. doi: 10.1136/bmjopen-2025-115193.
- Individual participant dataSharing planned: Yes. The datasets generated and/or analyzed during the current study are not publicly available since data is still being collected. De-identified data will be available upon reasonable request after the study is completed, and results have been reported to the public.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Brittany Bryant, DSW principal investigator
University of California, San Francisco
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Culturally Adapted Adolescent Substance Use Treatment in people with Substance Use, run by University of California, San Francisco at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Brittany E Bryant, DSW (843-973-0867, brittany.bryant@ucsf.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Feasibility and Acceptability (time frame: After study completion, an average of 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06003725, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jul 2026.