Physical ExerciseEPICANCT05910814
Effect of Physical Exercise on Motor Learning Acquired With Physical or Mental Practice
A study testing Sleep Deprivation (SD), Normal Night (Night) and Physical Exercise (HIIE) in people with Physical Exercise and Motor Learning, run by Hospices Civils de Lyon at 2 sites in France.
Trial summary
Motor learning is crucial for human daily routine, involving the acquisition of new movements. It consists of an online acquisition phase followed by offline consolidation, where motor memory is organized into stable representations. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Physical Exercise, Motor Learning
- What is being tested?
- Sleep Deprivation (SD), Normal Night (Night) and Physical Exercise (HIIE)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 2 sitesFrance
- Study dates
- 16 Jun 2023to 20 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male or female aged 18 to 35
- Available for the entire study (13 days maximum)
- Right-handed upper limbs with a score > 0.5 on the Edinburgh laterality test
- Having dated and signed an informed consent
- Subject affiliated or entitled to a social security scheme
- Absence of contraindication to the practice of physical activity
Show all 9Show fewer
- Considered active according to the GPAQ (Global Physical Activity Questionnaire)
- Neutral or moderate circadian typology (31 to 69)
- Regular physical activity (2h/week minimum)
Who cannot join
- Musculoskeletal injury < 6 months
- Pathology or surgical intervention resulting in a locomotor disorder < 6 months
- Chronic or disabling neurological, cardiovascular or psychic pathology
- Resting heart rate > 100 bpm
- Pittsburgh Sleep Quality Index > 10
- Taking sleeping pills or medication with a psychoactive effect during the last 6 months
Show all 17Show fewer
- Ongoing participation in an interventional research
- Pregnant or breastfeeding women
- Person deprived of judicial or administrative freedom.
- Contraindication to TMS (Transcranial Magnetic Stimulation):
- Frequent or severe headaches
- History of epilepsy
- Head trauma with loss of consciousness
- Implanted equipment (including implanted pacemaker or defibrillator, cochlear implant, pump administering medication, surgical clips, metal shrapnel)
- Neurosurgical intervention (in particular eye surgery)
- An open wound on the scalp
- Consumption of more than three glasses of alcohol per day
Trial locations and contacts
2 sites in 1 country.
France2 sites
Service d'explorations fonctionnelles respiratoires-Médecine du sport et de l'activité physique, Hôpital de la Croix-Rousse, Hospices Civils de Lyon
Lyon, 69004
Laboratoire LIBM, Université Lyon 1
Villeurbanne, 69622
About this study
Official title: The Effect of an Acute Bout of Physical Exercise on the Consolidation Phase of Motor Learning Acquired Through Physical or Mental Practice
Motor learning is crucial for human daily routine, involving the acquisition of new movements. It consists of an online acquisition phase followed by offline consolidation, where motor memory is organized into stable representations. Acquisition can be achieved through physical practice (PP, overt repetition of movement) or mental rehearsal using motor imagery (MI). Recent studies suggest that high-intensity interval physical exercise (HIIE) enhances motor learning, particularly during consolidation, by promoting neural plasticity mediated by brain-derived neurotrophic factor (BDNF). However, the impact of HIIE on sequential motor consolidation with PP or MI remains poorly understood.
In contrast, sleep deprivation (SD) reduces BDNF release and neural plasticity. Limited research has explored the effects of SD on motor acquisition, especially sequential motor learning. Considering the opposing effects of HIIE and SD, performing HIIE after SD may protect motor consolidation processes.
Read more
This study aims to examine the influence of HIIE on sequential motor learning using PP or MI under both sleep-deprived and normal sleep conditions. Six groups, each comprising 12 participants, will learn an 8-item bimanual sequence.
- MI group: acquired the motor sequence mentally during training
- MI+HIIE group: acquired the motor sequence mentally and achieve a HIIE before the consolidation
- PP: acquired the motor sequence physically
- PP+HIIE group: acquired the motor sequence physically and achieve a HIIE before the consolidation
- SD+PP group: one night of sleep deprivation prior physical motor acquisition with PP and consolidation
- SD+PP+HIIE group: one night of sleep deprivation prior physical motor acquisition and HIIE before consolidation.
All groups will be tested on the sequence at the beginning and the end of the acquisition phase (pre- and post-acquisition), and after the physical exercise (i.e. HIIE) or the rest period (post-exercise).
Hypothesis of this study are :
- Acute physical exercise (HIIE) would enhance the consolidation of motor memory (post-exercise) after physical and mental acquisition (PP,MI) compared to conditions without exercise.
- One night of sleep deprivation would affect the acquisition and consolidation of motor learning.
Physical exercise would compensate for the detrimental effects of sleep deprivation on the consolidation of motor learning.
Read the detailed description
The ability to learn new movement (i.e. motor learning) is an essential part of the human daily routine. Motor learning is typically characterized by an online acquisition phase followed by an offline consolidation phase (i.e., without further practice) whereby the motor memory traces are reorganized into stable and long-lasting representations. The acquisition can be achieved through physical practice (PP, overt repetition of the movement) or through motor imagery (MI, covert rehearsal of movement). Over the last two decades, studies have demonstrated that performing high intensity interval exercise (HIIE) can enhance motor learning and particularly the consolidation phase. It seems that HIIE induced a favourable physiological cascade that contributes to the neural plasticity. In this vein, both lactate and brain derived neurotrophic factor (BDNF) biological markers seems to play a major role in long-term memory consolidation. To date, little is known on the HIIE contribution to sequential motor consolidation with PP or MI.
By contrast to HIIE, sleep deprivation decreased the BDNF released and the neural plasticity. There are very few studies that have examined the impact of sleep deprivation (SD) on motor acquisition and only one on sequence motor learning. Considering the antagonistic effects of HIIE and SD, it might possible that performing HIIE following SD could protect the motor consolidation processes.
Therefore, the main goal of this study is to understand the influence of HIIE on sequential motor learning through PP or MI under condition of sleep deprivation and normal night. In this study, six groups will be enrolled each including 12 participants. All groups will learn a bimanual sequence of 8 items.
- MI group: acquired the motor sequence mentally during training
- MI+HIIE group: acquired the motor sequence mentally and achieve a HIIE before the consolidation
- PP: acquired the motor sequence physically
- PP+HIIE group: acquired the motor sequence physically and achieve a HIIE before the consolidation
- SD+PP group: one night of sleep deprivation prior physical motor acquisition with PP and consolidation
- SD+PP+HIIE group: one night of sleep deprivation prior physical motor acquisition and HIIE before consolidation.
All groups will be tested on the sequence at the beginning and the end of the acquisition phase (pre- and post-acquisition), and after the physical exercise (i.e. HIIE) or the rest period (post-exercise).
Hypothesis of this study are :
- Acute physical exercise (HIIE) would enhance the consolidation of motor memory (post-exercise) after physical and mental acquisition (PP,MI) compared to conditions without exercise.
- One night of sleep deprivation would affect the acquisition and consolidation of motor learning.
- Physical exercise would compensate for the detrimental effects of sleep deprivation on the consolidation of motor learning.
- Conditions
- Physical Exercise, Motor Learning
- Being tested
- Sleep Deprivation (SD), Normal Night (Night), Physical Exercise (HIIE), Rest control, Motor imagery
- Keywords
- motor imagery, consolidation, BDNF, sleep deprivation, physical exercise
- Medical subject headings
- Motor Activity, Sleep Deprivation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sleep Deprivation (SD)Behavioural
Participants in the sleep deprivation group will spend a night awake, under the supervision of an investigator, at Croix-Rousse Hospital. The investigator will provide a list of activities to maintain the participant awake.
Normal Night (Night)Behavioural
Participants in the normal night group will spend one night sleeping in their own home.
Physical Exercise (HIIE)Behavioural
Participants in the physical exercise group (i.e. IM+HIIE, PP+HIIE, SD+PP+HIIE) will start with a 2-minute warm-up on an ergometer cycle.
After the warm-up, they will perform 3 minutes of exercise at a workload customized to their maximal aerobic power (MAP) corresponding to 80 % their MAP and then rest actively for 2 minutes at 40 % of MAP. This cycle of 5 minutes will be repeated 3 times in row, resulting in a total of 17 minutes of physical exercise including the warm-up.
Rest controlBehavioural
Participants will watch a documentary during an equivalent time as the physical exercise (i.e. 17 minutes).
Motor imageryBehavioural
On the bimanual finger tapping task composed of 8 elements, the participant will be required to repeat the motor sequence mentally using MI (mental rehearsal of movement) during twelve blocks of 30 seconds. Participant will imagine performing the sequence as fast and accurately as possible without overt movement.
Physical Practice (PP)Behavioural
Participants will practice a bimanual sequential finger tapping task composed of 8 movements. Participant will be required to perform the sequence as fast and as accurately as possible during blocs of 30 s (i.e. twelve blocs during training).
| Study group | Role | What they receive |
|---|---|---|
| PP (physical practice) | Experimental | Acquired the motor sequence physically Receives: Behavioral: Normal Night (Night); Behavioral: Rest control; Behavioral: Physical Practice (PP) |
| MI (motor imagery) | Experimental | Acquired the motor sequence mentally during training Receives: Behavioral: Normal Night (Night); Behavioral: Rest control; Behavioral: Motor imagery |
| MI+HIIE (motor imagery + high-intensity interval physical exercise) | Experimental | Acquired the motor sequence mentally and achieve a HIIE before the consolidation Receives: Behavioral: Normal Night (Night); Behavioral: Physical Exercise (HIIE); Behavioral: Motor imagery |
| PP+HIIE (physical practice + motor imagery + high-intensity interval physical exercise) | Experimental | Acquired the motor sequence physically and achieve a HIIE before the consolidation Receives: Behavioral: Normal Night (Night); Behavioral: Physical Exercise (HIIE); Behavioral: Physical Practice (PP) |
| SD + PP (sleep deprivation + physical practice) | Experimental | One night of sleep deprivation prior physical motor acquisition with PP and consolidation Receives: Behavioral: Sleep Deprivation (SD); Behavioral: Rest control; Behavioral: Physical Practice (PP) |
| SD+PP+HIIE (sleep deprivation + physical practice + high-intensity interval physical exercise) | Experimental | One night of sleep deprivation prior physical motor acquisition and HIIE before consolidation Receives: Behavioral: Sleep Deprivation (SD); Behavioral: Physical Exercise (HIIE); Behavioral: Physical Practice (PP) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of correct sequence between post-acquisition and post-exercise for PP and PP+HIIE
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice The primary outcome measure will be the difference in the number of correct sequences performed between the end of acquisition (post-acquisition) and consolidation (post-exercise) stages between the PP and PP+HIIE.
Measured: Through study completion, an average of 13 days.
Secondary outcomes (9)
Number of correct sequence between post-acquisition and post-exercise for IM and IM+HIIE
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice.
This secondary outcome measure will be the difference in the number of correct sequences performed between the end of acquisition (post-acquisition) and consolidation (post-exercise) stages between the IM and IM+HIIE.
Measured: Through study completion, an average of 13 days.
Number of correct sequence between pre-acquisition, post-acquisition, and post-exercise for SD and SD+PP
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice.
This secondary outcome measure will be the difference in the number of correct sequences performed between the beginning of the acquisition (pre-acquisition), the end of acquisition (post-acquisition) and the consolidation (post-exercise) stages between the SD and SD+PP groups.
Measured: Through study completion, an average of 13 days.
Number of correct sequence between post-acquisition and post-exercise for SD+PP and SD+PP+HIIE
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice.
This secondary outcome measure will be the difference in the number of correct sequences performed between the end of acquisition (post-acquisition) and consolidation (post-exercise) stages between the SD+PP and SD+PP+HIIE groups.
Measured: Through study completion, an average of 13 days.
Neurophysiological informations between pre-acquisition, post-acquisition and post-exercise for all groups (IM, PP, IM+HIIE, PP+HIIE, SD+PP, SD+PP+HIIE)
Neurophysiological measurement will be collected with transcranial magnetic stimulation (TMS). TMS is a tool that generate a magnetic field that depolarizes the neuron in primary motor cortex and offers the opportunity to probe the cortico-spinal excitability (CSE) through motor evoked potential (MEP).
To consider the muscle fibers excitability when analysing MEP amplitude, responses will be normalized to the maximal M-wave. The assessment of M-wave for the first dorsal interosseous muscle will be achieved with a single constant-current stimulation applied on the ulnar nerves via a 30-mm anode-cathode bipolar felt pad.
The average of MEP will be normalised to M wave using this formula :
MEP normalised=((Mean MEP (mV))/(Mean Mmax (mV) ))*100 The MEP Normalised will be compared for all groups between the three-time frame pre-acquisition, post-acquisition and post-exercise
Measured: Through study completion, an average of 13 days.
BDNF assessment between pre-acquisition and post-exercise for all groups
Biological variables will include the measurement of three molecules: lactate, BDNF and cortisol.
A 5 ml blood sample will be collected from an antecubital vein and will be immediately centrifuged. The plasma will be separated from the serum and stored at -80 °C. BDNF(brain-derived neurotrophic factor) levels will be analysed by means of enzyme-linked immunosorbent assay method (ELISA Kit) at the end of study.
BDNF will be compared for all groups between the two-time frames pre-acquisition and post-exercise
Measured: Through study completion, an average of 13 days.
Lactate assessment between pre-acquisition and post-exercise for all groups
Biological variables will include the measurement of three molecules: lactate, BDNF and cortisol.
Blood lactate will be collected from a capillary blood on the finger and will be immediately analysed using a lactate analyser device.
Lactate will be compared for all groups between the two-time frames pre-acquisition and post-exercise
Measured: Through study completion, an average of 12 days.
Cortisol assessment between pre-acquisition and post-exercise for all groups
Biological variables will include the measurement of three molecules: lactate, BDNF and cortisol.
A 5 ml blood sample will be collected from an antecubital vein and will be immediately centrifuged. The plasma will be separated from the serum and stored at -80 °C. Cortisol levels will be analysed by means of enzyme-linked immunosorbent assay method (ELISA Kit) at the end of study.
Cortisol will be compared for all groups between the two-time frames pre-acquisition and post-exercise
Measured: Through study completion, an average of 13 days.
Number of correct sequence between post-acquisition and post-exercise for PP and MI groups
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice.
This secondary outcome measure will be the difference in the number of correct sequences performed between the end of acquisition (post-acquisition) and consolidation (post-exercise) stages between the PP and MI groups.
Measured: Through study completion, an average of 13 days.
Number of correct sequence between post-acquisition and post-24h for all groups
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice.
This secondary outcome measure will be the difference in the number of correct sequences performed between the end of acquisition (post-acquisition) and the next day after a night's sleep (post-24h) for all groups.
Measured: Through study completion, an average of 13 days.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jun 2023
- Study start16 Jun 2023
- Primary completion20 Sep 2024
- Study completion20 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Physical ExerciseStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- 6 arms will be enrolled, with 12 participants per group.
- Masking
- None (open label)
- Enrolment
- 70 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Maxime PINGON, MD, Principal investigator, EFR-Médecine du sport et de l'activité physique, HCL
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05910814
- Sponsor's protocol ID
- 69HCL22_0425
- Other IDs
- 2023-A00155-40
- Acronym
- EPICA
- Status last verified
- Nov 2024
- First submitted
- 30 May 2023
- Last updated
- 29 Nov 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Nov 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of an Acute Bout of Physical Exercise on the Consolidation Phase of Motor Learning Acquired Through Physical or Mental Practice
- ClinicalTrials.gov ID
- NCT05910814
- Acronym / sponsor ID
- EPICA / 69HCL22_0425
- Conditions
- Physical Exercise, Motor Learning
- Keywords
- motor imagery, consolidation, BDNF, sleep deprivation, physical exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 70 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 16 Jun 2023 (actual)
- Primary completion
- 20 Sep 2024 (actual)
- Study completion
- 20 Sep 2024 (actual)
- First posted
- 20 Jun 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Motor learning is crucial for human daily routine, involving the acquisition of new movements. It consists of an online acquisition phase followed by offline consolidation, where motor memory is organized into stable representations. Acquisition can be achieved through physical practice (PP, overt repetition of movement) or mental rehearsal using motor imagery (MI). Recent studies suggest that high-intensity interval physical exercise (HIIE) enhances motor learning, particularly during consolidation, by promoting neural plasticity mediated by brain-derived neurotrophic factor (BDNF). However, the impact of HIIE on sequential motor consolidation with PP or MI remains poorly understood.
In contrast, sleep deprivation (SD) reduces BDNF release and neural plasticity. Limited research has explored the effects of SD on motor acquisition, especially sequential motor learning. Considering the opposing effects of HIIE and SD, performing HIIE after SD may protect motor consolidation processes.
This study aims to examine the influence of HIIE on sequential motor learning using PP or MI under both sleep-deprived and normal sleep conditions. Six groups, each comprising 12 participants, will learn an 8-item bimanual sequence.
- MI group: acquired the motor sequence mentally during training
- MI+HIIE group: acquired the motor sequence mentally and achieve a HIIE before the consolidation
- PP: acquired the motor sequence physically
- PP+HIIE group: acquired the motor sequence physically and achieve a HIIE before the consolidation
- SD+PP group: one night of sleep deprivation prior physical motor acquisition with PP and consolidation
- SD+PP+HIIE group: one night of sleep deprivation prior physical motor acquisition and HIIE before consolidation.
All groups will be tested on the sequence at the beginning and the end of the acquisition phase (pre- and post-acquisition), and after the physical exercise (i.e. HIIE) or the rest period (post-exercise).
Hypothesis of this study are :
- Acute physical exercise (HIIE) would enhance the consolidation of motor memory (post-exercise) after physical and mental acquisition (PP,MI) compared to conditions without exercise.
- One night of sleep deprivation would affect the acquisition and consolidation of motor learning.
Physical exercise would compensate for the detrimental effects of sleep deprivation on the consolidation of motor learning.
Detailed description
The ability to learn new movement (i.e. motor learning) is an essential part of the human daily routine. Motor learning is typically characterized by an online acquisition phase followed by an offline consolidation phase (i.e., without further practice) whereby the motor memory traces are reorganized into stable and long-lasting representations. The acquisition can be achieved through physical practice (PP, overt repetition of the movement) or through motor imagery (MI, covert rehearsal of movement). Over the last two decades, studies have demonstrated that performing high intensity interval exercise (HIIE) can enhance motor learning and particularly the consolidation phase. It seems that HIIE induced a favourable physiological cascade that contributes to the neural plasticity. In this vein, both lactate and brain derived neurotrophic factor (BDNF) biological markers seems to play a major role in long-term memory consolidation. To date, little is known on the HIIE contribution to sequential motor consolidation with PP or MI.
By contrast to HIIE, sleep deprivation decreased the BDNF released and the neural plasticity. There are very few studies that have examined the impact of sleep deprivation (SD) on motor acquisition and only one on sequence motor learning. Considering the antagonistic effects of HIIE and SD, it might possible that performing HIIE following SD could protect the motor consolidation processes.
Therefore, the main goal of this study is to understand the influence of HIIE on sequential motor learning through PP or MI under condition of sleep deprivation and normal night. In this study, six groups will be enrolled each including 12 participants. All groups will learn a bimanual sequence of 8 items.
- MI group: acquired the motor sequence mentally during training
- MI+HIIE group: acquired the motor sequence mentally and achieve a HIIE before the consolidation
- PP: acquired the motor sequence physically
- PP+HIIE group: acquired the motor sequence physically and achieve a HIIE before the consolidation
- SD+PP group: one night of sleep deprivation prior physical motor acquisition with PP and consolidation
- SD+PP+HIIE group: one night of sleep deprivation prior physical motor acquisition and HIIE before consolidation.
All groups will be tested on the sequence at the beginning and the end of the acquisition phase (pre- and post-acquisition), and after the physical exercise (i.e. HIIE) or the rest period (post-exercise).
Hypothesis of this study are :
- Acute physical exercise (HIIE) would enhance the consolidation of motor memory (post-exercise) after physical and mental acquisition (PP,MI) compared to conditions without exercise.
- One night of sleep deprivation would affect the acquisition and consolidation of motor learning.
- Physical exercise would compensate for the detrimental effects of sleep deprivation on the consolidation of motor learning.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 6
- Model description
- 6 arms will be enrolled, with 12 participants per group.
| Arm | Type | Receives |
|---|---|---|
| PP (physical practice) | Experimental | Behavioral: Normal Night (Night), Behavioral: Rest control, Behavioral: Physical Practice (PP)Acquired the motor sequence physically |
| MI (motor imagery) | Experimental | Behavioral: Normal Night (Night), Behavioral: Rest control, Behavioral: Motor imageryAcquired the motor sequence mentally during training |
| MI+HIIE (motor imagery + high-intensity interval physical exercise) | Experimental | Behavioral: Normal Night (Night), Behavioral: Physical Exercise (HIIE), Behavioral: Motor imageryAcquired the motor sequence mentally and achieve a HIIE before the consolidation |
| PP+HIIE (physical practice + motor imagery + high-intensity interval physical exercise) | Experimental | Behavioral: Normal Night (Night), Behavioral: Physical Exercise (HIIE), Behavioral: Physical Practice (PP)Acquired the motor sequence physically and achieve a HIIE before the consolidation |
| SD + PP (sleep deprivation + physical practice) | Experimental | Behavioral: Sleep Deprivation (SD), Behavioral: Rest control, Behavioral: Physical Practice (PP)One night of sleep deprivation prior physical motor acquisition with PP and consolidation |
| SD+PP+HIIE (sleep deprivation + physical practice + high-intensity interval physical exercise) | Experimental | Behavioral: Sleep Deprivation (SD), Behavioral: Physical Exercise (HIIE), Behavioral: Physical Practice (PP)One night of sleep deprivation prior physical motor acquisition and HIIE before consolidation |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (9 listed)
- Male or female aged 18 to 35
- Available for the entire study (13 days maximum)
- Right-handed upper limbs with a score > 0.5 on the Edinburgh laterality test
- Having dated and signed an informed consent
- Subject affiliated or entitled to a social security scheme
Key exclusion criteria (17 listed)
- Musculoskeletal injury < 6 months
- Pathology or surgical intervention resulting in a locomotor disorder < 6 months
- Chronic or disabling neurological, cardiovascular or psychic pathology
- Resting heart rate > 100 bpm
- Pittsburgh Sleep Quality Index > 10
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sleep Deprivation (SD)Participants in the sleep deprivation group will spend a night awake, under the supervision of an investigator, at Croix-Rousse Hospital. The investigator will provide a list of activities to maintain the participant awake. | Behavioural | SD + PP (sleep deprivation + physical practice), SD+PP+HIIE (sleep deprivation + physical practice + high-intensity interval physical exercise) |
| Normal Night (Night)Participants in the normal night group will spend one night sleeping in their own home. | Behavioural | MI (motor imagery), MI+HIIE (motor imagery + high-intensity interval physical exercise), PP (physical practice), PP+HIIE (physical practice + motor imagery + high-intensity interval physical exercise) |
| Physical Exercise (HIIE)Participants in the physical exercise group (i.e. IM+HIIE, PP+HIIE, SD+PP+HIIE) will start with a 2-minute warm-up on an ergometer cycle. After the warm-up, they will perform 3 minutes of exercise at a workload customized to their maximal aerobic power (MAP) corresponding to 80 % their MAP and then rest actively for 2 minutes at 40 % of MAP. This cycle of 5 minutes will be repeated 3 times in row, resulting in a total of 17 minutes of physical exercise including the warm-up. | Behavioural | MI+HIIE (motor imagery + high-intensity interval physical exercise), PP+HIIE (physical practice + motor imagery + high-intensity interval physical exercise), SD+PP+HIIE (sleep deprivation + physical practice + high-intensity interval physical exercise) |
| Rest controlParticipants will watch a documentary during an equivalent time as the physical exercise (i.e. 17 minutes). | Behavioural | MI (motor imagery), PP (physical practice), SD + PP (sleep deprivation + physical practice) |
| Motor imageryOn the bimanual finger tapping task composed of 8 elements, the participant will be required to repeat the motor sequence mentally using MI (mental rehearsal of movement) during twelve blocks of 30 seconds. Participant will imagine performing the sequence as fast and accurately as possible without overt movement. | Behavioural | MI (motor imagery), MI+HIIE (motor imagery + high-intensity interval physical exercise) |
| Physical Practice (PP)Participants will practice a bimanual sequential finger tapping task composed of 8 movements. Participant will be required to perform the sequence as fast and as accurately as possible during blocs of 30 s (i.e. twelve blocs during training). | Behavioural | PP (physical practice), PP+HIIE (physical practice + motor imagery + high-intensity interval physical exercise), SD + PP (sleep deprivation + physical practice), SD+PP+HIIE (sleep deprivation + physical practice + high-intensity interval physical exercise) |
Primary outcome
Number of correct sequence between post-acquisition and post-exercise for PP and PP+HIIE
Time frame: Through study completion, an average of 13 days.
In the bimanual finger tapping task, the accuracy corresponds to the number correct sequence performed during a block of practice The primary outcome measure will be the difference in the number of correct sequences performed between the end of acquisition (post-acquisition) and consolidation (post-exercise) stages between the PP and PP+HIIE.
9 secondary outcomes
Number of correct sequence between post-acquisition and post-exercise for IM and IM+HIIE
Time frame: Through study completion, an average of 13 days.
Number of correct sequence between pre-acquisition, post-acquisition, and post-exercise for SD and SD+PP
Time frame: Through study completion, an average of 13 days.
Number of correct sequence between post-acquisition and post-exercise for SD+PP and SD+PP+HIIE
Time frame: Through study completion, an average of 13 days.
Neurophysiological informations between pre-acquisition, post-acquisition and post-exercise for all groups (IM, PP, IM+HIIE, PP+HIIE, SD+PP, SD+PP+HIIE)
Time frame: Through study completion, an average of 13 days.
BDNF assessment between pre-acquisition and post-exercise for all groups
Time frame: Through study completion, an average of 13 days.
Lactate assessment between pre-acquisition and post-exercise for all groups
Time frame: Through study completion, an average of 12 days.
Cortisol assessment between pre-acquisition and post-exercise for all groups
Time frame: Through study completion, an average of 13 days.
Number of correct sequence between post-acquisition and post-exercise for PP and MI groups
Time frame: Through study completion, an average of 13 days.
Number of correct sequence between post-acquisition and post-24h for all groups
Time frame: Through study completion, an average of 13 days.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Nov 2024.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Maxime PINGON, MD principal investigator
EFR-Médecine du sport et de l'activité physique, HCL
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sleep Deprivation (SD), Normal Night (Night) and Physical Exercise (HIIE) in people with Physical Exercise and Motor Learning, run by Hospices Civils de Lyon at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 17 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Nov 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of correct sequence between post-acquisition and post-exercise for PP and PP+HIIE (time frame: Through study completion, an average of 13 days.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Nov 2024; AzTrials last refreshed its copy on 6 Nov 2026.