SarcopeniaKOREANCT05869513
Krill Oil and Resistance Exercise in Older Adults
A study testing Vegetable oil, Krill oil and Home-based resistance exercise in people with Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
Trial summary
The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Read more about this study
- Who is it for?
- Ages 60 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Sarcopenia
- What is being tested?
- Vegetable oil, Krill oil and Home-based resistance exercise
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 60 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 5 May 2023to 1 Feb 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Over the age of 60 years
- scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).
Who cannot join
- Diabetes
- severe cardiovascular disease
- seizure disorders
- uncontrolled hypertension (>150/90mmHg at baseline measurement)
- cancer or cancer that has been in remission <5 years
- ambulatory impairments which would limit ability to perform assessments of muscle function
Show all 21Show fewer
- dementia
- taking medication known to affect muscle (e.g. steroids)
- have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
- on anticoagulant therapy
- allergies to seafood
- regular consumption of more than 1 portion of oily fish per week
- already taking fish or krill oil or other n3 PUFA supplements
- femoral neck fracture or other severe of hip or knee operations
- stroke
- Parkinson's disease
- COPD
- kidney disease
- hyperlipidaemia
- obesity
- osteoporosis.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effects of Krill Oil Supplementation on Adaptations in Muscle Strength, Function, Mass and Neuromuscular Function to a Pragmatic Home-based Resistance Exercise Intervention in Sedentary Older Adults: a Randomised Controlled Trial
The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.
- Conditions
- Sarcopenia
- Being tested
- Vegetable oil, Krill oil, Home-based resistance exercise
- Keywords
- Home exercise, Resistance exercise, Exercise, Krill oil, Muscle strength, Neuromuscular function, Physical function
- Medical subject headings
- Sarcopenia, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vegetable oilDietary supplement
Mixed vegetable oil
Krill oilDietary supplement
Superba Krill Oil
Home-based resistance exerciseOther
Home based resistance band and body weight exercise
| Study group | Role | What they receive |
|---|---|---|
| Vegetable oil + Resistance exercise | Placebo comparator | 4g/day vegetable oil and home based resistance exercise for 16 weeks Receives: Dietary Supplement: Vegetable oil; Other: Home-based resistance exercise |
| Krill oil + Resistance exercise | Active comparator | 4g/day krill oil and home based resistance exercise for 16 weeks Receives: Dietary Supplement: Krill oil; Other: Home-based resistance exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Nueromuscular Junction (NMJ) transmission instability
NMJ transmission instability will be measured by iEMG
Measured: Change from baseline to 16 weeks
Secondary outcomes (7)
Knee extensor maximal torque
Knee extensor maximal torque will be measured by a load cell
Measured: Change from baseline to 8 16 weeks
30s chair stand test
measuring the functional abilities
Measured: Change from baseline to 16 weeks
Gait speed
measuring the functional abilities
Measured: Change from baseline to 16 weeks
Force steadiness during submaximal isometric knee extensor contractions
Steadiness of force whilst contracting
Measured: Change from baseline to 16 weeks
Red Blood Cell Omega-3 levels
Measured: Change from baseline to 16 weeks
Grip strength
Grip strength will be measured by handgrip dynamometer
Measured: Change from baseline to 16 weeks
Muscle thickness
Vastus Lateralis muscle thickness will be measured by ultrasound
Measured: Change from baseline to 16 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2023
- Study start5 May 2023
- Primary completion1 Feb 2024
- Study completion1 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SarcopeniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- 1:1 parallel group design
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Glasgow
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stuart Gray, University of Glasgow
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05869513
- Sponsor's protocol ID
- KOREA
- Acronym
- KOREA
- Status last verified
- Mar 2025
- First submitted
- 11 May 2023
- Last updated
- 30 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Krill Oil Supplementation on Adaptations in Muscle Strength, Function, Mass and Neuromuscular Function to a Pragmatic Home-based Resistance Exercise Intervention in Sedentary Older Adults: a Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT05869513
- Acronym / sponsor ID
- KOREA / KOREA
- Conditions
- Sarcopenia
- Keywords
- Home exercise, Resistance exercise, Exercise, Krill oil, Muscle strength, Neuromuscular function, Physical function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- University of GlasgowUniversity, hospital or other
- Study start
- 5 May 2023 (actual)
- Primary completion
- 1 Feb 2024 (actual)
- Study completion
- 1 Feb 2024 (actual)
- First posted
- 22 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- 1:1 parallel group design
| Arm | Type | Receives |
|---|---|---|
| Vegetable oil + Resistance exercise | Placebo comparator | Dietary Supplement: Vegetable oil, Other: Home-based resistance exercise4g/day vegetable oil and home based resistance exercise for 16 weeks |
| Krill oil + Resistance exercise | Active comparator | Dietary Supplement: Krill oil, Other: Home-based resistance exercise4g/day krill oil and home based resistance exercise for 16 weeks |
Who may qualify
- Ages
- 60 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Over the age of 60 years
- scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).
Key exclusion criteria (21 listed)
- Diabetes
- severe cardiovascular disease
- seizure disorders
- uncontrolled hypertension (>150/90mmHg at baseline measurement)
- cancer or cancer that has been in remission <5 years
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vegetable oilMixed vegetable oil | Dietary supplement | Vegetable oil + Resistance exercise |
| Krill oilSuperba Krill Oil | Dietary supplement | Krill oil + Resistance exercise |
| Home-based resistance exerciseHome based resistance band and body weight exercise | Other | Krill oil + Resistance exercise, Vegetable oil + Resistance exercise |
Primary outcome
Nueromuscular Junction (NMJ) transmission instability
Time frame: Change from baseline to 16 weeks
NMJ transmission instability will be measured by iEMG
7 secondary outcomes
Knee extensor maximal torque
Time frame: Change from baseline to 8 16 weeks
30s chair stand test
Time frame: Change from baseline to 16 weeks
Gait speed
Time frame: Change from baseline to 16 weeks
Force steadiness during submaximal isometric knee extensor contractions
Time frame: Change from baseline to 16 weeks
Red Blood Cell Omega-3 levels
Time frame: Change from baseline to 16 weeks
Grip strength
Time frame: Change from baseline to 16 weeks
Muscle thickness
Time frame: Change from baseline to 16 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vegetable oil, Krill oil and Home-based resistance exercise in people with Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 21 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Nueromuscular Junction (NMJ) transmission instability (time frame: Change from baseline to 16 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2025.