OCD3TOCNCT05843604
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder
An observational study of OCD, run by Centre Hospitalier Henri Laborit at 1 site in France.
Trial summary
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response. Read more about this study
- Who is it for?
- Ages 18 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- OCD
- What is being tested?
- Functional MRI
- How many people
- 100 participants
- Where
- 1 siteFrance
- Study dates
- 3 Jul 2023to Sep 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients will be recruited from the Clinical Research Unit of Poitiers. All volunteer patients included in this study will be included regardless of the degree of resistance to treatment or the severity of their disease. Patients will not be hospitalized for the duration of the study unless their condition requires it. Healthy volunteers will be recruited locally by advertisement or through acquaintances, and will be matched to each patient based on age, gender, laterality, and education level. They must not have an acute pathology being treated, nor take psychotropic drugs, nor be followed in psychotherapy. In their history, we must not find hospitalization in a psychiatric environment or a psychiatric illness according to the M.I.N.I. version 5.0.0.
Who may be able to join
- Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
- Understand and accept the constraints of the study
- Be a beneficiary or affiliated to a Health Insurance scheme
Who cannot join
- Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Have a serious intercurrent pathology
- Being a pregnant woman
- Being a woman of childbearing age without effective contraception.
- Being hospitalized under duress or on an outpatient basis in a care program
- Being under judicial protection (reinforced curatorship, guardianship)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Centre Hospitalier Henri Laborit
Poitiers
Damien Doolub, MD
About this study
Official title: Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
- Conditions
- OCD
- Being tested
- Functional MRI
- Keywords
- functional MRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Functional MRIOther
Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task
| Study group | Role | What they receive |
|---|---|---|
| obsessive compulsive disorder patients | Not described Receives: Other: Functional MRI | |
| Control Patients | Not described Receives: Other: Functional MRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cerebral activity modification during N-back task
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Measured: Day 1
Cerebral activity modification during Stroop task
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Measured: Day 1
Cerebral activity modification during switching task (Monsell et Mizon task )
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2023
- Study start3 Jul 2023
- Primary completionJul 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OCDStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Henri Laborit
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05843604
- Sponsor's protocol ID
- 2022-A00463-40
- Acronym
- 3TOC
- Status last verified
- Jan 2026
- First submitted
- 25 Apr 2023
- Last updated
- 13 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 13 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care
- ClinicalTrials.gov ID
- NCT05843604
- Acronym / sponsor ID
- 3TOC / 2022-A00463-40
- Conditions
- OCD
- Keywords
- functional MRI
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Centre Hospitalier Henri LaboritUniversity, hospital or other
- Study start
- 3 Jul 2023 (actual)
- Primary completion
- Jul 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 6 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| obsessive compulsive disorder patients | – | Other: Functional MRI |
| Control Patients | – | Other: Functional MRI |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients will be recruited from the Clinical Research Unit of Poitiers. All volunteer patients included in this study will be included regardless of the degree of resistance to treatment or the severity of their disease. Patients will not be hospitalized for the duration of the study unless their condition requires it. Healthy volunteers will be recruited locally by advertisement or through acquaintances, and will be matched to each patient based on age, gender, laterality, and education level. They must not have an acute pathology being treated, nor take psychotropic drugs, nor be followed in psychotherapy. In their history, we must not find hospitalization in a psychiatric environment or a psychiatric illness according to the M.I.N.I. version 5.0.0.
Key inclusion criteria (3 listed)
- Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
- Understand and accept the constraints of the study
- Be a beneficiary or affiliated to a Health Insurance scheme
Key exclusion criteria (7 listed)
- Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- Have a serious intercurrent pathology
- Being a pregnant woman
- Being a woman of childbearing age without effective contraception.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Functional MRIThree cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task | Other | Control Patients, obsessive compulsive disorder patients |
Primary outcome
Cerebral activity modification during N-back task
Time frame: Day 1
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Cerebral activity modification during Stroop task
Time frame: Day 1
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Cerebral activity modification during switching task (Monsell et Mizon task )
Time frame: Day 1
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jan 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of OCD, run by Centre Hospitalier Henri Laborit at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Damien Doolub, MD (+33 (0)5 16 61 18, damien.doolub@ch-poitiers.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cerebral activity modification during N-back task (time frame: Day 1). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2026.