Anomic AphasiaAphasia360NCT05793879
Virtual Reality Training for Aphasia Rehabilitation
A study testing Video 360 and Standard videos in people with Anomic Aphasia, run by Catholic University of the Sacred Heart at 1 site in Italy.
Trial summary
Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Anomic Aphasia
- What is being tested?
- Video 360 and Standard videos
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteItaly
- Study dates
- 2 May 2023to Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- naming disorder in the post-acute phase (index event occurring at least 6 months earlier)
- to have already received rehabilitation treatment in the acute phase
- noun naming below cut-off
- verbs naming below cut- off
Who cannot join
- concomitant or pre-existing (with respect to the index event) neurological and psychiatric deficits
- epilepsy
- balance disorders
- neglect
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Anomias Rehabilitation Training Through 360° Videos
Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Anomia refers to the difficulty in finding words, in particular when trying to name objects and actions. According to the Embodied Cognition approach (EC), language is tightly connected to the motor system. In this view, language rehabilitation programs should stimulate language through the activation of the motor system. In this approach, since anomic deficits are often due to a weak link between the meaning of the word and its lemma, the Hebbs' principles of coincident and correlated learning can be exploited, i.e., by intensifying the synchronous activation of lexicon and semantics and connecting them with the motor counterpart. In this study, the investigators present an innovative training, based on the EC framework, in which they will make use of new technologies for anomia rehabilitation in post-stroke patients. Specifically, the researchers will use immersive 360° videos representing everyday actions displayed from the first-person point of view, experienced through a head-mounted display. The training will be administered 3 times a week for 4 weeks. The control group will watch standard videos representing the same actions recorded from the third-person perspective. Naming abilities will be tested before and after the training together with other cognitive and psychological measures. The investigators expect that the group who will undergo the 360° video-based training will show greater improvement of performance compared to the control group.
- Conditions
- Anomic Aphasia
- Being tested
- Video 360, Standard videos
- Keywords
- virtual reality, embodied cognition, rehabilitation
- Medical subject headings
- Anomia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Video 360Behavioural
Patients will undergo 12 sessions, 3 per weeks, 4 weeks
Standard videosBehavioural
Patients will undergo 12 sessions, 3 per weeks, 4 weeks
| Study group | Role | What they receive |
|---|---|---|
| Video 360 | Experimental | Patients will watch spherical videos displaying everyday actions towards objects; an audio is embedded describing the action and the object represented (i.e. "I'm cutting the potatoes"). Receives: Behavioral: Video 360 |
| Standard video | Active comparator | Patients will watch standard videos displaying everyday actions towards objects; an audio is embedded describing the action and the object represented (i.e. "I'm cutting the potatoes") Receives: Behavioral: Standard videos |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of verbs and objects correctly named
All the trained videos will be presented and the patient will be asked to name the verb and the object depicted. The accuracy will be registered
Measured: post treatment, 1 month
Secondary outcomes (3)
Batteria per l'Analisi dei Deficit Afasici (BADA), naming subtest
It is an Italian validated neuropsychological battery aiming at testing all the language abilities. It includes several tests tapping into the different linguistic abilities, but for the purpose of the present study only the verb and object naming subtest will be administered. Higher scores indicate greater naming abilities
Measured: post treatment, 1 month
EuroQol Health-related quality of life (EQ-5D-3L)
The test consists of 2 sections. The first one is made of 5 questions scored from 1 to 5 points each. The final score ranges from 5 to 15, where the lesser the better. The second section is a visual scale on which the best state the patient can imagine is marked 100 and the worst state is marked 0.
Measured: post treatment, 1 month
Functional Outcome Questionnaire (FOQ-A)
The survey is administered to the caregiver. It includes 32 questions each scored from 1 to 5 points. The final scores ranges from 32 to 160, where higher scores indicate greater communication abilities
Measured: post treatment, 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Mar 2023
- Study start2 May 2023
- Primary completion31 Dec 2025
- Study completionMar 2026 (estimated)
Why it stopped: No more opportunities to recruit patients
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anomic AphasiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Catholic University of the Sacred Heart
- Sponsor type
- University, hospital or other
- Collaborators
- Fondazione Poliambulanza
- Responsible party
- Principal investigator, Claudia Repetto, Catholic University of the Sacred Heart
- Investigators
- Claudia Repetto, Prof, Principal investigator, Catholic University of the Sacred Heart
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05793879
- Sponsor's protocol ID
- UC
- Acronym
- Aphasia360
- Status last verified
- Sep 2025
- First submitted
- 7 Mar 2023
- Last updated
- 19 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Anomias Rehabilitation Training Through 360° Videos
- ClinicalTrials.gov ID
- NCT05793879
- Acronym / sponsor ID
- Aphasia360 / UC
- Conditions
- Anomic Aphasia
- Keywords
- virtual reality, embodied cognition, rehabilitation
- Study type
- Interventional
- Recruitment status
- SuspendedReason stopped: No more opportunities to recruit patients
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Catholic University of the Sacred HeartUniversity, hospital or other
- Collaborators
- Fondazione Poliambulanza
- Study start
- 2 May 2023 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- Mar 2026 (estimated)
- First posted
- 31 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Anomia refers to the difficulty in finding words, in particular when trying to name objects and actions. According to the Embodied Cognition approach (EC), language is tightly connected to the motor system. In this view, language rehabilitation programs should stimulate language through the activation of the motor system. In this approach, since anomic deficits are often due to a weak link between the meaning of the word and its lemma, the Hebbs' principles of coincident and correlated learning can be exploited, i.e., by intensifying the synchronous activation of lexicon and semantics and connecting them with the motor counterpart. In this study, the investigators present an innovative training, based on the EC framework, in which they will make use of new technologies for anomia rehabilitation in post-stroke patients. Specifically, the researchers will use immersive 360° videos representing everyday actions displayed from the first-person point of view, experienced through a head-mounted display. The training will be administered 3 times a week for 4 weeks. The control group will watch standard videos representing the same actions recorded from the third-person perspective. Naming abilities will be tested before and after the training together with other cognitive and psychological measures. The investigators expect that the group who will undergo the 360° video-based training will show greater improvement of performance compared to the control group.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Video 360 | Experimental | Behavioral: Video 360Patients will watch spherical videos displaying everyday actions towards objects; an audio is embedded describing the action and the object represented (i.e. "I'm cutting the potatoes"). |
| Standard video | Active comparator | Behavioral: Standard videosPatients will watch standard videos displaying everyday actions towards objects; an audio is embedded describing the action and the object represented (i.e. "I'm cutting the potatoes") |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- naming disorder in the post-acute phase (index event occurring at least 6 months earlier)
- to have already received rehabilitation treatment in the acute phase
- noun naming below cut-off
- verbs naming below cut- off
Key exclusion criteria (4 listed)
- concomitant or pre-existing (with respect to the index event) neurological and psychiatric deficits
- epilepsy
- balance disorders
- neglect
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Video 360Patients will undergo 12 sessions, 3 per weeks, 4 weeks | Behavioural | Video 360 |
| Standard videosPatients will undergo 12 sessions, 3 per weeks, 4 weeks | Behavioural | Standard video |
Primary outcome
Number of verbs and objects correctly named
Time frame: post treatment, 1 month
All the trained videos will be presented and the patient will be asked to name the verb and the object depicted. The accuracy will be registered
3 secondary outcomes
Batteria per l'Analisi dei Deficit Afasici (BADA), naming subtest
Time frame: post treatment, 1 month
EuroQol Health-related quality of life (EQ-5D-3L)
Time frame: post treatment, 1 month
Functional Outcome Questionnaire (FOQ-A)
Time frame: post treatment, 1 month
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Mar 2026.
Related trials for Anomic Aphasia
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Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
Aphasia, Stroke
Not yet recruiting
Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
Aphasia, Stroke
Enrolling by invitation
Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia
Aphasia
Recruiting
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
Primary Progressive Aphasia
Recruiting
Ecological Momentary Intervention for Post-Stroke Anomia
Post-Stroke Chronic Aphasia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Claudia Repetto, Prof principal investigator
Catholic University of the Sacred Heart
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Video 360 and Standard videos in people with Anomic Aphasia, run by Catholic University of the Sacred Heart at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: paused, as of the sponsor's last update on 19 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of verbs and objects correctly named (time frame: post treatment, 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Mar 2026.