Acute Coronary SyndromePhase 3LIBREXIA-ACSNCT05754957
A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
A Phase 3 study testing Milvexian in people with Acute Coronary Syndrome, run by Janssen Research & Development, LLC at 1,003 sites in 44 countries.
Trial summary
The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular [CV] death, myocardial infarction [MI], and ischemic stroke). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Coronary Syndrome
- What is being tested?
- Milvexian
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 14,194 participants
- Where
- 1,003 sitesin 44 countries
- Study dates
- 7 Apr 2023to 6 Feb 2026
- Phase
- Phase 3
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants must have an index event that meets all 3 of the following criteria within 7 days prior to randomization: a) clinical syndrome consistent with spontaneous cardiac ischemia, b) diagnosis of acute coronary syndrome (ACS) (that is, ST-elevation myocardial infarction [STEMI], non-STEMI, or unstable angina [UA]), c) cardiac biomarker elevation (example, troponin I, troponin T, creatine kinase-MB [CK-MB]) above the upper limit of normal as determined by the local laboratory
- Participants must have at least 2 of the following risk factors:a) age 65 or older, b) diabetes mellitus, c) history of a prior myocardial infarction (MI) (other than index ACS event), d) multivessel coronary artery disease (CAD), e) history of coronary artery bypass graft (CABG) surgery prior to index ACS event, f) history of peripheral artery disease (PAD) or cerebrovascular disease (example, carotid atherosclerosis, intracranial artery stenosis, g) conservative management (that is, no percutaneous intervention [PCI] or CABG after index ACS event), h) Any one or more of the following high-risk angiographic features i) total stent length of greater than (>) 30 millimeters (mm), ii) thrombotic target lesion, iii) bifurcation lesion treated with more than one stent, iv) calcified target lesion treated with atherectomy, v) treatment of obstructive left main or proximal left anterior descending artery for index ACS (or clinical diagnosis of an anterior STEMI)
- All female participants of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (hCG) or urine test at screening
- A female participant must not be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half-lives) after the last dose of study intervention
Who cannot join
- MI secondary to ischemia due to either increased oxygen demand or decreased supply (Type 2 MI) or periprocedural MI as the index ACS event
- Planned CABG or staged PCI after randomization
- Any condition that requires chronic anticoagulation at the discretion of the investigator and/or local guidelines
- Conditions with a significant increased risk of bleeding (example, clinically significant bleeding within previous 3 months, known bleeding diathesis, et cetera)
Trial locations and contacts
1,003 sites in 44 countries.
1003 sites in 44 countries
United States162 sites
Summa Health System
Akron, Ohio, 44304
Advanced Cardiovascular, LLC
Alexander City, Alabama, 35010
Cambridge Medical Trials
Alexandria, Louisiana, 71301
Amarillo Heart Clinical Research Institute
Amarillo, Texas, 79106
PharmaTex Research
Amarillo, Texas, 79109
AnMed Health
Anderson, South Carolina, 29621
University of Michigan
Ann Arbor, Michigan, 48109
Grady Memorial Hospital
Atlanta, Georgia, 30303
Bakersfield Memorial Hospital
Bakersfield, California, 93306
Johns Hopkins University School of Medicine
Baltimore, Maryland, 21231
Eastern Maine Medical Center Northeast Cardiology Associates
Bangor, Maine, 04401
Ascension Medical Group - St. John Clinic Infectious Disease
Bartlesville, Oklahoma, 74006
Suburban Hospital
Bethesda, Maryland, 20814
Advanced Cardiac Care
Bethlehem, Pennsylvania, 18017
SORRA Research
Birmingham, Alabama, 35203
Ascension St. Vincent's Health System
Birmingham, Alabama, 35205
St. Joseph Mercy Oakland
Bloomfield Hills, Michigan, 48302
FWD Clinical Research
Boca Raton, Florida, 33434
Ash Research Clinic
Brick, New Jersey, 08724
Buffalo General Medical Center
Buffalo, New York, 14203-1154
Atlanta Clinical Research Center
Cartersville, Georgia, 30121
Clinical Trials of America 1
Cary, North Carolina, 27518
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201
UNC School of Medicine
Chapel Hill, North Carolina, 27599-5021
Erlanger Health System
Chattanooga, Tennessee, 37403
Mercy Medical Research Institute
Chesterfield, Missouri, 63017
Insight Hospital and Medical Center Chicago
Chicago, Illinois, 60616
Illinois Heart and Vascular Foundation
Chicago, Illinois, 60657
University of Cincinnati
Cincinnati, Ohio, 45267
Clearwater Cardiovascular Consultants
Clearwater, Florida, 33756
Metro Health Hospital
Cleveland, Ohio, 44109
Kootenai Medical Center
Coeur d'Alene, Idaho, 83814
The Curators of the University of Missouri on behalf of University of Missouri Health Care
Columbia, Missouri, 65211
Ohio Health
Columbus, Ohio, 43214
Nuvance Health Medical Practices Cardiology Danbury
Danbury, Connecticut, 06810
Advocate Heart Institute
Downers Grove, Illinois, 60515
St. Luke's Cardiology Associates
Duluth, Minnesota, 55802-2207
Med Research, Inc.
El Paso, Texas, 79902
Texas Tech University Health Sciences Center-El Paso
El Paso, Texas, 79905
Midwest Cardiovascular Research Foundation
Elkhart, Indiana, 46514-2487
Englewood Health
Englewood, New Jersey, 07631
Hamot Medical Center
Erie, Pennsylvania, 16507
Providence Regional Medical Center Everett
Everett, Washington, 98201
Virginia Heart
Falls Church, Virginia, 22042
AAMRC
Flint, Michigan, 48504
Holy Cross Hospital Inc.
Fort Lauderdale, Florida, 33308
Integrative Research Associates
Fort Lauderdale, Florida, 33312
Northern Indiana Research Alliance
Fort Wayne, Indiana, 46804
Baylor Scott and White Research Institute 1
Fort Worth, Texas, 76104
Mission Cardiovascular Research Institute
Fremont, California, 94538
University of Florida Health Jacksonville
Gainesville, Florida, 32610-0236
Northeast Georgia Heart Center
Gainesville, Georgia, 30501
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297
The Moses H. Cone Memorial Hospital
Greensboro, North Carolina, 27401
Prisma Health
Greenville, South Carolina, 29065
St. Francis Physician Services, Inc, DBA Upstate Cardiology Research
Greenville, South Carolina, 29607
Clinical Investigation Specialists, Inc.
Gurnee, Illinois, 60031
UPMC Pinnacle Health
Harrisburg, Pennsylvania, 17110
Pentucket Medical Associates
Haverhill, Massachusetts, 01830
Inpatient Research Clinic LLC
Hialeah, Florida, 33014
Atrium Health Wake Forest Baptist
High Point, North Carolina, 27262
Cardiovascular Institute of the South
Houma, Louisiana, 70360
East Texas Cardiology, PA
Houston, Texas, 77002
Physician Research Network
Houston, Texas, 77027
Vital Heart and Vein
Humble, Texas, 77338
Jackson Heart Clinic
Jackson, Michigan, 39216
Apex Cardiology
Jackson, Tennessee, 38301
Shands Jacksonville Medical Center Inc dba UF Health Jacksonville
Jacksonville, Florida, 32209
Jamaica Hospital Medical Center
Jamaica, New York, 11418
North Kansas City Hospital
Kansas City, Missouri, 64116
Spectrum Clinical Research
Kansas City, Missouri, 64118
Kettering Medical Center
Kettering, Ohio, 45429
Texas Cardiology Research Center
Kingwood, Texas, 77339
Ascension Texas Cardiovascular
Kyle, Texas, 78640
Mayo Clinic Health System
La Crosse, Wisconsin, 54601-4795
St. Mary Medical Center
Langhorne, Pennsylvania, 19047
Captiol Cardiology Associates
Lanham, Maryland, 20706
Sparrow Clinical Research Institute
Lansing, Michigan, 48912-1811
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102
Clinical Trials of America
Lenoir, North Carolina, 28645
Bryan LGH Heart Institute
Lincoln, Nebraska, 68506
Arkansas Heart Hospital
Little Rock, Arkansas, 72211
South Denver Cardiology Associates PC
Littleton, Colorado, 80120
University of Louisville
Louisville, Kentucky, 40202
Norton Cardiovascular Associates
Louisville, Kentucky, 40205
Cardiology Partners Clinical Research Institute
Loxahatchee Groves, Florida, 33470
Marshfield Clinic
Marshfield, Wisconsin, 54449
Novant Health
Matthews, North Carolina, 28105
Baptist Hospital of Miami
Miami, Florida, 33173
Trinity Medical Group
Minot, North Dakota, 58701
IMC-Diagnostic and Medical Clinic
Mobile, Alabama, 36604
Cardiology Associates of Mobile Inc
Mobile, Alabama, 36608
IU Health Ball Memorial Hospital
Muncie, Indiana, 47303
Advanced Research for Health Improvement
Naples, Florida, 34102
Ascension Saint Thomas West Hospital
Nashville, Tennessee, 37205
Vanderbilt University
Nashville, Tennessee, 37232
Ochsner Clinic And Hospital
New Orleans, Louisiana, 70121
Columbia University Medical Center
New York, New York, 10032
Weil Cornell University
New York, New York, 10065
Weill Cornell Medicine
New York, New York, 10065
Newark Beth Israel Medical Center
Newark, New Jersey, 07112
Radin Cardiovascular Medical Group
Newport Beach, California, 92663
Riverside Regional Medical Center
Newport News, Virginia, 23601
Sentara Cardiovascular Research Institute
Norfolk, Virginia, 23507
Amavita Clinical Research (Dr. Pedro Martinez-Clark)
North Miami Beach, Florida, 33169
Valley Clinical Trials, Inc.
Northridge, California, 91325
Parkway Cardiology Associates PC
Oak Ridge, Tennessee, 37830
South Oklahoma Heart Research
Oklahoma City, Oklahoma, 73135
Methodist Physicians Clinic Heart Consultants
Omaha, Nebraska, 68114
Health Midwest Ventures Group, Inc d b a HCA MidAmerica Division, LLC
Overland Park, Kansas, 66209
Stanford University School of Medicine
Palo Alto, California, 94304
VA Palo Alto Healthcare System
Palo Alto, California, 94304
Essential Concepts Research Solutions
Palos Hills, Illinois, 60465
Huntington Hospital
Pasadena, California, 91105
South Florida Research Solutions LLC
Pembroke Pines, Florida, 33028
OSF HealthCare Cardiovascular Institute
Peoria, Illinois, 61614
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104
Valleywise Health Medical Center
Phoenix, Arizona, 85008
Atlanticare Regional Medical Center
Pomona, New Jersey, 08240
Hudson Valley Cardiovascular Practice, PC
Poughkeepsie, New York, 12601
Rex Hospital
Raleigh, North Carolina, 27607
Monument Health Clinical Research
Rapid City, South Dakota, 57701
The Cardiovascular Center
Redding, California, 96001
Reid Health
Richmond, Indiana, 47374
Carolina Cardiology Associates
Rock Hill, South Carolina, 29732
Shady Grove Office
Rockville, Maryland, 20850
Coastal Cardiology Consultants
Safety Harbor, Florida, 34695
HealthEast Medical Research Institute
Saint Paul, Minnesota, 55102
Tidal Health Peninsula Regional Inc.
Salisbury, Maryland, 21801
University Of California San Diego
San Diego, California, 92103
San Diego Cardiac Center
San Diego, California, 92123
VA San Diego Health Care System
San Diego, California, 92161
Sanford Cardiology
Sanford, North Carolina, 27330
UCLA
Santa Monica, California, 90401
NorthBay Clinical Research, LLC
Santa Rosa, California, 95405
Cardiovascular Center of Sarasota
Sarasota, Florida, 34239-3513
HonorHealth Neurology
Scottsdale, Arizona, 85258
Cardiovoyage
Sherman, Texas, 75090
Louisiana Heart Center
Slidell, Louisiana, 70458
Cardio Metabolic Institute
Somerset, New Jersey, 08873
Prairie Cardiovascular Consultants, Ltd.
Springfield, Illinois, 62701
Cox Health
Springfield, Missouri, 65807
The Heart House
Springfield, Ohio, 45504
Saint Louis University
St Louis, Missouri, 63110
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, 06905
Ramin Manshadi, MD
Stockton, California, 95204
Cardiac Surgery Group
Tacoma, Washington, 98405
MultiCare Health System
Tacoma, Washington, 98405
Tampa Cardiovascular Interventions and Research
Tampa, Florida, 33614
Cardiac Care & Vascular Medicine, PLLC
The Bronx, New York, 10469
Cardiovascular Consultants of South Georgia LLC
Thomasville, Georgia, 31792
Northwest Heart Clinical Research, LLC.
Tomball, Texas, 77375
Interventional Cardiac Consultants
Trinity, Florida, 34655
St John Health System Inc
Tulsa, Oklahoma, 74104
Carle Foundation Hospital
Urbana, Illinois, 61801
Westchester Medical Center
Valhalla, New York, 10532
George Washington University Medical Center
Washington D.C., District of Columbia, 20037
Cardiology Partners Clinical Research Institute 1
Wellington, Florida, 33449
Monroe Research LLC
West Monroe, Louisiana, 71291
Winchester Medical Center
Winchester, Virginia, 22601
Lankenau Institute for Medical Research
Wynnewood, Pennsylvania, 19096
Japan71 sites
Kasugai Municipal Hospital
Aichi, 486-8510
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki Shi, 660 8550
Chiba University Hospital
Chiba, 260 8677
Funabashi Municipal Medical Center
Chiba, 273 8588
Saiseikai Futsukaichi Hospital
Chikushino-shi, 818-8516
Fukui Prefectural Hospital
Fukui-shi, 910-8526
National Hospital Organization Kyushu Medical Center
Fukuoka, 810 8563
Fukuoka Wajiro Hospital
Fukuoka, 811-0213
Kyushu University Hospital
Fukuoka, 812-8582
Gifu Prefectural General Medical Center
Gifu, 500-8717
National Hospital Organization Takasaki General Medical Center
Gunma, 370-0829
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji-shi, 670-8560
Hiratsuka Kyosai Hospital
Hiratsuka-shi, 254-8502
Hirosaki University Hospital
Hirosaki, 036-8203
Hiroshima City Hiroshima Citizens Hospital
Hiroshima, 730-8518
Tokai University Hospital
Isehara, 259-1193
Public Central Hospital of Matto Ishikawa
Ishikawa, 924-0865
Juntendo University Shizuoka Hospital
Izunokuni-shi, 410-2295
Tesshokai Kameda Clinic
Kamogawa, 2960041
Showa University Fujigaoka Hospital
Kanagawa, 227-8501
Asanokawa, Kanazawa Cardiovascular Hospital
Kanazawa, 920-0007
Fukuoka Tokushukai Hospital
Kasuga-shi, 816-0864
Kimitsu Chuo Hospital
Kisarazu-shi, 292-8535
Kokura Memorial Hospital
Kitakyushu-shi, 802-8555
Chikamori Hospital
Kochi, 780-8522
National Hospital Organization Fukuoka Higashi Medical Center
Koga, 811-3195
Kumamoto University Hospital
Kumamoto, 860-8556
Saiseikai Kumamoto Hospital
Kumamoto, 861-4193
Kurashiki Central Hospital
Kurashiki, 710-8602
National Hospital Organization Kure Medical Center and Chugoku Cancer Center
Kure-shi, 736-0023
Kyoto University Hospital
Kyoto, 606-8507
National Hospital Organization Kyoto Medical Center
Kyoto, 612-8555
Tokushukai Chiba-Nishi General Hospital
Matsudo-shi, 270-2251
Jisenkai Aizawa Hospital
Matsumoto-shi, 390-8510
Toho University Medical Center, Ohashi Hospital
Meguro-ku, 153-8515
Tokyo Saiseikai Central Hospital
Minatoku, 108-0073
Miyazaki Medical Association Hospital
Miyazaki, 880-2102
NHO Nagoya Medical Center
Nagoya, 460-0001
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
Nagoya, 466-8650
Hyogo Medical University Hospital
Nishinomiya Shi, 663 8501
Okayama Rosai Hospital
Okayama, 702-8055
Osaka City General Hospital
Osaka, 534-0021
National Hospital Organization Osaka National Hospital
Osaka, 540-0006
Osaka Police Hospital
Osaka, 543-0035
Saga University Hospital
Saga, 849-8501
Kitasato University Hospital
Sagamihara, 252-0375
National Hospital Organization Saitama National Hospital
Saitama, 351-0102
Iwatsuki Minami Hospital
Saitama-shi, 339-0033
Tohoku University Hospital
Sendai, 980 8574
Showa University Hospital
Shinagawa City, 142 8666
Tokyo Women's Medical University Hospital
Shinjuku-ku, 162-8666
Iwate Medical University Hospital
Shiwa-gun, 028-3695
National Cerebral and Cardiovascular Center
Suita-Shi, 564-8565
Teikyo University Hospital
tabashi City, 173 8606
Kagawa Prefectural Central Hospital
Takamatsu, 760-8557
Tokushima University Hospital
Tokushima, 770-8503
Mitsui Memorial Hospital
Tokyo, 101-8643
St. Luke's International Hospital
Tokyo, 104 8560
Nippon Medical School Hospital
Tokyo, 113 8603
National Hospital Organization Tokyo Medical Center
Tokyo, 152-8902
Nihon University Itabashi Hospital
Tokyo, 173 8610
Ome Medical Center
Tokyo, 198-0042
Toyama Prefectural Central Hospital
Toyama, 930-8550
Mie University Hospital
Tsu, 514-8507
Tsuchiura Kyodo General Hospital
Tsuchiura, 300-0028
Tsukuba Medical Center Hospital
Tsukuba, 305 8558
Yamaguchi University Hospital
Ube, 755-8505
Tokyo Bay Urayasu Ichikawa Medical Center
Urayasu-shi, 279-0001
National Hospital Organization Ureshino Medical Center
Ureshino-shi, 843-0393
Wakayama Medical University Hospital
Wakayama, 641 8510
Yokohama City University Medical Center
Yokohama, 232 0024
China61 sites
Baotou Central Hospital
Baotou, 014040
Beijing Anzhen Hospital, Capital Medical University
Beijing, 100029
Peking University First Hospital
Beijing, 100034
Beijing Shijitan Hospital
Beijing, 100038
Chinese PLA General Hospital
Beijing, 100039
Beijing Friendship Hospital Capital Medical University
Beijing, 100050
Peking University Third Hospital
Beijing, 100083
The First Hospital of Jilin University
Changchun, 130021
Changzhou No 2 Peoples Hospital
Changzhou, 213000
West China Hospital Sichuan University
Chengdu, 610041
Sichuan Provincial Peoples Hospital
Chengdu, 610072
The First Affiliated Hospital of Chongqing Medical University
Chongqing, 400016
Dongguan People s Hospital
Dongguan, 523059
The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005
Guangdong Provincial People's Hospital
Guangzhou, 510080
The First Affiliated Hospital of Sun Yat-Sen University
Guangzhou, 510080
The Affiliated Hospital of Guizhou Medical University
Guiyang, 550000
GuiZhou Privicial Peoples Hospital
Guiyang, 550002
Zhejiang Provincial People's Hospital
Hangzhou, 310000
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
Hangzhou, 310006
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, 310016
Anhui Province Hospital
Hefei, 230001
Huizhou Municipal Central Hospital
Huizhou, 516001
Qilu Hospital of Shandong University
Jinan, 250012
The Second Affiliated Hospital, Shandong University
Jinan, 250033
Shandong Jining No.1 People's Hospital
Jining, 272011
Lanzhou University Second Hospital
Lanzhou, 730030
Linfen Central Hospital
Linfen, 041000
The Second Affiliated Hospital of Nanchang University
Nanchang, 330006
Nanjing Drum Tower Hospital
Nanjing, 210000
Zhongda Hospital Southeast University
Nanjing, 210009
Jiangsu Province Hospital
Nanjing, 210029
The First Affiliated Hospital of Nanyang Medical College
Nanyang, 473000
Ningbo First Hospital
Ningbo, 315010
Shanghai Ninth Peoples Hospital
Shanghai, 200011
Shanghai Chest Hospital
Shanghai, 200030
Zhongshan Hospital Fudan University
Shanghai, 200032
The First Affiliated Hospital of Shantou University Medical
Shantou, 515041
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, 518052
The Second Affiliatted Hospital of Soochow University
Suzhou, 210009
The First Affiliated Hospital of Soochow University
Suzhou, 215006
Shanxi Cardiovascular Hospital
Taiyuan, 030013
Tianjin Medical University General Hospital
Tianjin, 300052
Tianjin People's Hospital
Tianjin, 300121
The Second Hospital Of Tianjin Medical University
Tianjin, 300211
Tianjin Chest Hospital
Tianjin, 300222
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
Wenzhou Peoples Hospital
Wenzhou, 325000
The Central Hospital of Wuhan
Wuhan, 430014
Hubei Zhongshan Hospital The Third Peoples Hospital of Hubei Province
Wuhan, 430033
Wuxi People s Hospital
Wuxi, 214023
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, 710061
The Third Affiliated Hospital of Xinxiang Medical University
Xinxiang, 453003
The Affiliated Hospital of Xuzhou Medical College
Xuzhou
Yanbian University Hospital
Yanji, 133000
Yichang Central Pepole's Hospital
Yichang, 443003
General Hospital of Ningxia Medical Hospital
Yinchuan, 750004
Affiliated Hospital Of Guangdong Medical University
Zhanjiang, 524001
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, 450052
Zhongshan City Peoples Hospital
Zhongshan, 528403
Affiliated Hospital of Zunyi Medical University
Zunyi, 563000
Brazil52 sites
Hospital Vera Cruz
Belo Horizonte, 30140-062
IMINC Instituto Mineiro de Intervencao Cardiologica LTDA
Belo Horizonte, 30140-073
Cardresearch - Cardiologia Assistencial
Belo Horizonte, 30150-240
Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
Belo Horizonte, 30380-090
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu
Botucatu, 18618-686
Hospital do Coracao do Brasil
Brasília, 70390903
Centro de Cardiologia Clinica e Pesquisa Doutora Juliana Souza Ltda CECAP Centro de Cardiologia Clinica
Brasília, 70710 149
Sociedade Hospitalar Angelina Caron
Campina Grande do Sul, 83430-000
C.E.C.-Centro Especializado em Cardiologia Ltda.- Loema Medicina e Bem Estar
Campinas, 13010-001
Instituto de Pesquisa Clinica de Campinas
Campinas, 13060-080
Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose
Criciúma, 88811-508
Irmandade Santa Casa de Misericordia de Curitiba
Curitiba, 80010-030
Associacao Paranaense de Cultura PUCPR
Curitiba, 80230-130
Hospital Cardiológico Costantini
Curitiba, 80320-320
Hospital Das Clinicas Da Universidade Federal De Goias
Goiânia, 74605-020
Instituto do Coracao de Marília
Marília, 17515-000
Instituto Atena de Pesquisa Clinica
Natal, 59020-035
Instituto Mederi de Pesquisa e Saude
Passo Fundo, 99010-120
Santa Casa de Misericordia de Pelotas
Pelotas, 96015-290
Hospital Maternidade e Pronto Socorro Santa Lucia
Poços de Caldas, 37701-033
Associacao Hospitalar Moinhos de Vento
Porto Alegre, 90035-001
Hospital das Clinicas de Porto Alegre
Porto Alegre, 90035-903
IMV Pesquisa Cardiologica Sociedade Simples HMD COR l
Porto Alegre, 90110-270
Hospital Ernesto Dornelles
Porto Alegre, 90160-093
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
Porto Alegre, 90610-000
Fundacao Universitaria de Cardiologia
Porto Alegre, 90620-001
Hospital Nossa Senhora da Conceicao S A
Porto Alegre, 91350 200
PROCAPE - Universidade de Pernambuco Pronto Socorro Cardiológico de Pernambuco prof Luiz Tavares
Recife, 50100-060
Secretaria de Saude Hospital Agamenon Magalhaes
Recife, 52051-380
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
Ribeirão Preto, 14098-900
Hospital sao lucas
Rio de Janeiro, 22061-080
Hospital Santa Izabel Santa Casa de Misericordia da Bahia
Salvador, 40050-410
Instituto CardioPulmonar
Salvador, 40170310
Fundacao Bahiana de Cardiologia
Salvador, 41810-010
Hospital da Bahia
Salvador, 41810011
Pesquisare Saude
Santo André, 09080-110
CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, 09715-090
Instituto de Cardiologia de Santa Catarina
São José, 88103-460
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
São José do Rio Preto, 15090-000
Irmandade Da Santa Casa De Misericordia De Sao Paulo
São Paulo, 01221-020
FGM Clinica Paulista de Doencas Cardiovasculares Ltda
São Paulo, 01323 000
Real e Benemerita Associacao Portuguesa de Beneficencia
São Paulo, 01323 900
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903
Instituto Dante Pazzanese de Cardiologia
São Paulo, 04012-909
Hospital Das Clinicas Da Faculdade De Medicina Da USP
São Paulo, 05403-000
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05652000
Casa de Saude Santa Marcelina - Hospital Santa Marcelina
São Paulo, 08270-120
Instituto de Moléstias Cardiovasculares Tatuí
Tatuí, 18270-170
HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro
Uberaba, 38025-350
CEDOES
Vitória, 29055-450
Clinica Cardioped Ltda
Vitória, 29702-020
Santa Casa de Misericórdia de Votuporanga
Votuporanga, 15500-003
Argentina40 sites
Hospital Espanol De Bahia Blanca
Bahía Blanca, 8000
Hospital Italiano Regional Del Sur
Bahía Blanca, B8001HXM
Hospital Italiano de Buenos Aires
Buenos Aires, C1181ACH
Sanatorio Finochietto
Buenos Aires, C1187AAN
Hospital Britanico de Buenos Aires
Buenos Aires, C1280AEB
Sanatorio Guemes
CABA, C1180AAX
Centro Medico Dra. Laura Maffei - Investigacion Clinica Aplicada
Ciudad Autonoma Buenos Aires, 1425
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, 1428
Fundacion Favaloro
Ciudad Autonoma Buenos Aires, C1093AAS
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, C1430EGF
Clínica Chutro
Córdoba, 5000
Hospital San Roque
Córdoba, 5000
Sanatorio Duarte Quiroz
Córdoba, 5000
Clinica Romagosa
Córdoba, X5000AAI
Clinica Privada del Prado
Córdoba, X5000AAW
Sanatorio Allende
Córdoba, X5000JHQ
Sanatorio de la Canada
Córdoba, X5000
Instituto Privado De Especialidades Medicas S.A. Fundacion J Robert Cade
Córdoba, X5002HWE
Hospital Cordoba
Córdoba, X5004CDT
Centro Medico Luquez
Córdoba, X5006CBI
Hospital Privado Centro Medico de Cordoba
Córdoba, X5016KEH
Clinica Coronel Suarez
Coronel Suárez, B7540GHD
Hospital Italiano de La Plata
La Plata, B1900AXI
Centro de Investigaciones Medicas Mar Del Plata
Mar del Plata, B7600FYK
Sanatorio Modelo de Quilmes
Quilmes, B1878DKF
Instituto Cardiovascular de Rosario
Rosario, S2000DSR
Sanatorio Parque
Rosario, S2000SDV
Hospital Italiano Garibaldi
Rosario, S2001ODA
Hospital Provincial del Centenario
Rosario, S2002KDS
Centro Cardiovascular Salta
Salta, 4400
Centro de Investigaciones Clinicas Salta
Salta, 4400
Hospital El Cruce
San Juan Bautista, B1888AAE
Corporacion Medica de Gral. San Martin S.A.
San Martin, 1650
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL
Estudios Clinicos de los Arroyos
San Nicolás, 2900
Sanatorio Mayo SA
Santa Fe, S3000AZH
Hospital José María Cullen
Santa Fe, S3000EOZ
Sanatorio Medico de Diagnostico y Tratamiento
Santa Fe, S3000FUJ
Sanatorio San Martin
Venado Tuerto, S2600KUE
Clinica Privada Fusavim SRL
Villa María, X5900JKA
Germany36 sites
Klinikum am Plattenwald
Bad Friedrichshall, 74177
Universitaetsklinikum Freiburg 1
Bad Krozingen, 79189
Universitaetsklinikum Freiburg
Bad Krozingen, 79189
Kerckhoff-Klinik Bad Nauheim
Bad Nauheim, 61231
Vivantes Klinikum Im Friedrichshain
Berlin, 10249
Charite Campus Benjamin Franklin
Berlin, 12200
Charité Campus Virchow
Berlin, 13353
Vivantes Humboldt Klinikum
Berlin, 13509
GFO Kliniken Bonn, Betriebsstaette St. Marien
Beuel, 53225
Klinikum Bielefeld
Bielefeld, 33604
Marienhausklinikum Eifel Bitburg
Bitburg, 54634
Universitatsklinikum Bonn
Bonn, 53127
Staedisches Klinikum Brandenburg
Brandenburg an der Havel, 14770
Hospital Bremen Mitte
Bremen, 28277
Regiomed Klinikum Coburg
Coburg, 96450
St. Johannes-Hospital
Dortmund, 44137
Staedtisches Klinikum Dresden Standort Dresden Friedrichstadt
Dresden, 01067
Katholisches Krankenhaus St. Josef gGmbH - Abtlg. für Gynäkologie
Erfurt, 99097
Klinikum der Johann Wolfgang Goethe -Universitaet
Frankfurt, 60590
Universitaetsmedizin Greifswald
Greifswald, 17475
Universitaetsklinikum Hamburg Eppendorf
Hamburg, 20246
Asklepios Klinik Barmbek
Hamburg, 22307
Asklepios Klinik St. Georg
Hamburg, 22587
Klinikum Leverkusen gGmbH
Leverkusen, 51375
Klinikum Luedenscheid
Lüdenscheid, 58515
Herzzentrum Ludwigshafen
Ludwigshafen, 67063
Universitätsklinikum Magdeburg
Magdeburg, 39120
Katholisches Klinikum Mainz; Innere Medizin I- Kardiologie
Mainz, 55131
Universitatsmedizin der Johannes Gutenberg Universitat Mainz
Mainz, 55131
Universitaetsklinikum Mannheim
Mannheim, 68167
Kliniken Maria Hilf GmbH
Mönchengladbach, 41063
Marienhaus Klinikum
Neuwied, 56564
Sana-Klinikum Remscheid GmbH
Remscheid, 42859
Universitaetsmedizin Rostock
Rostock, 18057
Universitaetsklinikum Tuebingen
Tübingen, 72076
Klinikum Worms gGmbH
Worms, 67550
United Kingdom35 sites
Basingstoke And North Hampshire Hospital
Basingstoke, RG24 9NA
Royal United Hospital
Bath, BA1 3NG
Queen Elizabeth Hospital
Birmingham, B15 2WB
Birmingham Heartlands Hospital
Birmingham, B9 5SS
Blackpool Victoria Hospital
Blackpool, FY3 8NR
Royal Bournemouth Hospital
Bournemouth, BH7 7DW
University Hospital Bristol and Weston NHS trust
Bristol, BS1 3NU
Dorset County Hospital
Dorchester, DT1 2JY
Russels Hall Hospital
Dudley, DY1 2HQ
Hairmyres Hospital
East Kilbride, G75 8RG
Royal Infirmary of Edinburgh
Edinburgh, EH16 4SA
Royal Devon and Exeter Hospital(Wonford)
Exeter, EX2 5DW
Royal Free Hospital
Hampstead, NW3 2QG
Harefield Hospital
Harefield, UB9 6JH
West Middlesex University Hospital
Isleworth, TW7 6AF
Kingston Hospital
Kingston upon Thames, KT2 7QB
Leeds General Infirmary
Leeds, LS1 3EX
Lincoln County Hospital
Lincoln, LN2 5QY
Barts Hospital
London, EC1A 7BE
Hammersmith Hospital
London, W12 0HS
Altnagelvin Hospital
Londonderry, BT47 6SB
North Manchester General Hospital
Manchester, M8 6RL
James Cook University Hospital
Middlesbrough, TS4 3BW
Freeman Hospital
Newcastle upon Tyne, NE7 7DN
Peterborough City Hospital
Peterborough, PE3 9GZ
Derriford Hospital
Plymouth, PL6 8DH
Queen Alexandra Hospital
Portsmouth, PO6 3LY
East Surrey Hospital
Redhill, RH1 5RH
Lister Hospital
Stevenage, SG1 4AB
Morriston Hospital
Swansea, SA6 6NL
Musgrove Park Hospital
Taunton, TA1 5DA
Torbay Hospital-Devon
Torquay, TQ2 7AA
Sandwell and West Birmingham Hospitals NHS Trust-Sandwell Gene
West Bromwich, B71 4HJ
Royal Albert Edward Infirmary
Wigan, WN1 2NN
Yeovil District Hospital
Yeovil, BA214AT
France30 sites
CHU Angers - Hopital Hotel Dieu
Angers, 49033
CH Prive Saint-Martin
Caen, 14050
CHRU de Tours - Hopital Trousseau
Chambray-lès-Tours, 37170
Centre Hospitalier Sud Francilien
Corbeil-Essonnes, 91106
Hopital Henri Mondor
Créteil, 94000
CHU Dijon
Dijon, 21033
CHU de Grenoble Hopital Albert Michallon
La Tronche, 38700
CH de Chartres - Hôpital Louis Pasteur
Le Coudray, 28630
CHRU de Lille Hopital Claude Huriez
Lille, 59037
Centre Hospitalier Saint Joseph Et Saint Luc
Lyon, 69007
Clinique Du Pont De Chaume
Montauban, 82017
CHU de Montpellier Hopital Saint Eloi
Montpellier, 34295
Centre Hospitalier Emile Muller
Mulhouse, 68051
CHU Nantes, Institut du thorax
Nantes, 44093
Centre Hospitalier Universitaire - de Nice - Hopital Pasteur
Nice, 06002
Hopital Caremeau
Nîmes, 30029
Hopital Lariboisiere
Paris, 75010
Hopital Saint-Antoine
Paris, 75012
Hôpital Bichat - Claude Bernard
Paris, 75018
Hopital Cochin
Paris, 75679
Centre Hospitalier de Pau
Pau, 64046
Hôpital du Haut Lévêque
Pessac, 33604
CHU Poitiers - Hopital la Miletrie
Poitiers, 86000
Hopital de Bicetre
Potigny, 14420
CHU Rouen Hopital Charles Nicolle
Rouen, 76031
Clinique Saint-Hilaire - Centre Frédéric Joliot
Rouen, 78000
Nouvel Hopital Civil - CHU Strasbourg
Strasbourg, 67200
Hopital Rangueil
Toulouse, 31059
CHU de Nancy - Hopital de Brabois
Vandœuvre-lès-Nancy, 54500
Hopital Andre Mignot
Versailles, 78157
India29 sites
NHL Medical College (SVP Hospital IMSR)
Ahmedabad, 380006
Jawaharlal Nehru Medical College and Hospital
Aligarh, 202001
Sri Jayadeva Institute
Bangalore, 560069
KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC)
Belagavi, 590010
S.P.Medical College & AG of Hospitals
Bikaner, 334003
Tamil Nadu Government Multi Super Speciality Hospital
Chennai, 600002
Apollo Hospitals 1
Chennai, 600006
Batra Hospital And Medical Research Centre
Delhi, 110062
Osmania General Hospital
Hyderabad, 500012
Care Hospitals
Hyderbad, 500034
Lisie Hospital
Kochi, 682018
NRS Medical College
Kolkata, 700014
IPGMER and SSKM Hospital
Kolkata, 700020
Rabindranath Tagore International Institute of Cardiac Sciences
Kolkata, 700099
Dayanand Medical College & Hospital, Tagore Nagar, Civil Lines
Ludhiana, 141001
Kasturba Medical College Hospital
Mangalore, 575001
Seth G S Medical College and KEM Hospital
Mumbai, 400012
Arneja Heart Institute
Nagpur, 440010
Crescent Hospital & Heart Center
Nagpur, 440012
Central India Cardiology Hospital and Research Institute
Nagpur, 440015
All India Institute of Medical Sciences
New Delhi, 110029
Sir Ganga Ram Hospital
New Delhi, 110060
Indira Gandhi Institute of Medical Sciences
Patna, 800014
Ruby Hall Clinic
Pune, 411001
KEM Hospital & Research Centre
Pune, 411011
Nanjappa Hospital
Shimoga, 577205
Unicare Heart Institute
Surat, 395002
Government Siddhartha Medical College
Vijayawada, 520008
King George Hospital
Visakhapatnam, 530002
South Korea29 sites
Bucheon St. Mary's Hospital
Bucheon-si, 14647
Inje University Busan Paik Hospital
Busan, 47392
Pusan National University Hospital
Busan, 49241
Dong-A University Hospital
Busan, 602 812
Chungbuk National University Hospital
Cheongju-si, 28644
Kangwon National University Hospital
Chuncheon, 24289
Keimyung University Dongsan Hospital
Daegu, 42601
Konyang University Hospital
Daejeon, 302-718
Chungnam National University Hospital
Daejeon, 35015
Ewha Woman's University Seoul Hospital
Gangseo-gu, 7804
Myongji Hospital
Goyang-si, 10475
Chonnam National University Hospital
Gwangju, 61469
Seoul National University Bundang Hospital
Gyeonggi-do, 13620
Gachon University Gil Medical Center
Incheon, 21565
The Catholic University of Korea, Incheon St. Mary's Hospital
Incheon, 403-720
Chungnam National University Sejong Hospital
Sejong-si, 30099
Korea University Anam Hospital
Seoul, 02841
Seoul National University Hospital
Seoul, 03080
VHS Medical Center
Seoul, 05368
Asan Medical Center
Seoul, 05505
Gangnam Severance Hospital, Yonsei University Health System
Seoul, 06273
Seoul St.Mary s Hospital
Seoul, 06591
Severance Hospital Yonsei University Health System
Seoul, 120-752
Kyung Hee University Hospital
Seoul, 130 050
Kyung Hee University Hospital at Gangdong
Seoul, 134-727
Hanyang University Hospital
Seoul, 4763
Korea University Guro Hospital
Seoul, 8308
WonJu Severance Christian Hospital
Wŏnju, 220-701
Pusan National University Yangsan Hospital
Yangsan, 50612
Netherlands27 sites
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, 5223 GZ
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD
Ziekenhuisgroep Twente
Almelo, 7609PP
Meander Medisch Centrum
Amersfoort, 3813 TZ
Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091 AC
Deventer Ziekenhuis
Deventer, 7416 SE
Ziekenhuis Gelderse Vallei
Ede, 6716 RP
Catharina Ziekenhuis
Eindhoven, 5623 EJ
Treant Zorggroep
Emmen, 7824 AA
Medisch Spectrum Twente
Enschede, 7512 KZ
Admiraal De Ruyter Ziekenhuis - Goes
Goes, 4462 RA
Groene Hart Ziekenhuis
Gouda, 2803 HH
Ziekenhuis St Jansdal
Harderwijk, 3844 DG
Zuyderland Medical Center
Heerlen, 6419 PC
Elkerliek Ziekenhuis
Helmond, 5707 HA
Alrijne Ziekenhuis Leiden ; Cardiology
Leiderdorp, 2353 GA
Maastricht UMC
Maastricht, 6229 HX
St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, 3435 CM
Radboudumc
Nijmegen, 6525GA
Bravis
Roosendaal, 4708 AE
Sint Franciscus Gasthuis
Rotterdam, 3045 PM
D & A Research
Sneek, 8601 ZR
Ziekenhuis Rivierenland
Tiel, 4002 WA
Diakonessenhuis
Utrecht, 3582 KE
Maxima Medisch Centrum
Veldhoven, 5504 DB
VieCuri Medisch Centrum
Venlo, 5912 BL
Gelre Ziekenhuizen Zutphen
Zutphen, 7207
Poland27 sites
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15 276
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85 231
Samodzielny Publiczny Zaklad Opieki Zdrowotnej
Bytom, 41 902
Wojewodzki Szpital Zespolony w Elblagu
Elblag, 82 300
Clinical Medical Research Sp. z o.o.
Katowice, 40-156
Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego
Kielce, 25-525
Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
Krakow, 30-082
Krakowskie Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii
Krakow, 30-693
Krakowski Szpital Specjalistyczny im Jana Pawla II
Krakow, 31 202
SPZOZ Centralny Szpital Kliniczny UM w Lodzi
Lodz, 92-213
1 Wojskowy Szpital Kliniczny Z Poliklinika SPZOZ W Lublinie
Lublin, 20 049
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
Lublin, 20-954
NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia
Nałęczów, 24-140
Wojewodzki Szpital Specjalistyczny w Olsztynie
Olsztyn, 10 561
FutureMeds Olsztyn
Olsztyn, 10-010
Medicome Sp. Z O.O.
Oświęcim, 32-600
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Poznan, 61 848
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
Przemyśl, 37-700
Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
Siedlce, 08-110
ETG Skierniewice
Skierniewice, 96-100
NZOZ PRO CORDIS Sopockie Centrum Badan Kardiologicznych
Sopot, 81 717
Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu
Torun, 87 100
Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu
Wałbrzych, 58 309
Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego Panstwowy Instytut Badawczy
Warsaw, 04-628
Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
Wroclaw, 50 368
4 Wojskowy Szpital Kliniczny Z Poliklinika SP ZOZ
Wroclaw, 50 981
Wojewodzki Szpital Specjalistyczny we Wroclawiu
Wroclaw, 51 124
Canada26 sites
Foothills Hospital
Calgary, Alberta, T2N4N2
Dr. Saul Vizel Cardiac Research Office
Cambridge, Ontario, N1R 7R1
University of Alberta
Edmonton, Alberta, T6G 2B7
Dalhousie University
Halifax, Nova Scotia, B3J 3R4
Hamilton Health Sciences Corporation
Hamilton, Ontario, L8L 2X2
Clinique de Cardiologie de Levis
Lévis, Quebec, G6V 4Z5
London Health Sciences Centre
London, Ontario, N6A 5A5
Centre de Recherche du CHUM
Montreal, Quebec, H2L 4M1
Montreal General Hospital
Montreal, Quebec, H3G 1A4
Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2R2
Halton Healthcare Services Corporation
Oakville, Ontario, L6M 0L8
University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
Montreal Heart Institute
Québec, Quebec, 00
Centre de Recherche Clinique de Quebec
Québec, Quebec, G1J 1Z6
Institut Universitaire De Cardiologie Et De Pneumologie De Québec
Québec, Quebec, G1V 4G5
CardioVasc HR
Saint-Jean-sur-Richelieu, Quebec, J3A1C3
Royal University Hospital
Saskatoon, Saskatchewan, S7N 0W8
Niagara Health System
St. Catharines, Ontario, L2S 0A9
Surrey Memorial Hospital
Surrey, British Columbia, V2V 0C6
CSSS du Sud de Lanaudiere - Hopital Pierre-Le Gardeur d/b/a CISSS de Lanaudiere
Terrebonne, Quebec, J6V 2H2
Toronto Sunnybrook Hospital
Toronto, Ontario, M4N 3M5
CIUSSS de la Mauricie-et-du-Centre-du-Quebec
Trois-Rivières, Quebec, G8Z 3R9
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9
Office of Dr. Anthony Glanz
Windsor, Ontario, N8X 5A6
Saint Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6
Spain24 sites
Hosp. Gral. Univ. de Alicante
Alicante, 03010
Hosp. Del Mar
Barcelona, 08003
Hosp. de La Santa Creu I Sant Pau
Barcelona, 08025
Hosp Univ Vall D Hebron
Barcelona, 08035
Hosp Clinic de Barcelona
Barcelona, 08036
Hosp. Univ. Virgen de La Arrixaca
El Palmar, 30120
Hosp. de Cabuenes
Gijón, 33206
Hosp. Univ. Arnau de Vilanova de Lleida
Lleida, 25198
Hosp. Virgen de La Luz
Madrid, 28003
Hosp. Univ. de La Princesa
Madrid, 28006
Hosp. Univ. Ramon Y Cajal
Madrid, 28034
Hosp. Clinico San Carlos
Madrid, 28040
Hosp. Univ. 12 de Octubre
Madrid, 28041
Hosp. Univ. La Paz
Madrid, 28046
Hosp. Univ. Hm Monteprincipe
Madrid, 28660
Hosp Virgen de La Victoria
Málaga, 29010
Hosp. de Manises
Manises, 46940
Complejo Hosp. de Navarra
Pamplona, 31008
Hosp. Clinico Univ. de Santiago
Santiago de Compostela, 15706
Hosp. Univ. Joan Xxiii
Tarragona, 43007
Hosp. Clinico Univ. de Valencia 1
Valencia, 46010
Hosp. Gral. Univ. Valencia
Valencia, 46014
Hosp. Alvaro Cunqueiro
Vigo, 36312
Hosp. Univ. Miguel Servet
Zaragoza, 50009
Italy23 sites
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
Alessandria, 15121
Cliniche Humanitas Gavazzeni
Bergamo, 24125
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII)
Bergamo, 24127
Azienda USL di Bologna - Ospedale Maggiore
Bologna, 40100
Universita D Annunzio
Chieti, 66013
Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant Anna
Ferrara, 44123
Ospedale Sant'Andrea
La Spezia, 19021
Azienda Ulss 3 Serenissima distretto di Mirano
Mestre, 30035
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122
Centro Cardiologico Monzino
Milan, 20138
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
Milan, 20162
Azienda Ospedaliera Universitaria Federico II
Naples, 80131
Azienda Ospedaliero Universitaria di Parma
Parma, 43100
Fondazione IRCCS Policlinico San Matteo
Pavia, 27100
A. O.U. Pisana Ospedale di Cisanello
Pisa, 56124
AOU Policlinico Umberto I
Roma, 00161
Fondazione Policlinico Universitario A Gemelli IRCCS
Roma, 00168
Istituto Clinico Humanitas
Rozzano, 20089
Ospedale San Francesco
Sassari, 07100
Ospedale Bolognini
Seriate, 24068
IRCCS Multimedica di Sesto San Giovanni
Sesto San Giovanni, 20099
Azienda Ospedaliero Universitaria Ospedali Riuniti
Torrette Di Ancona, 60126
Azienda Ospedaliera Ospedale Treviglio-Caravaggio di Treviglio
Treviglio, 24047
Bulgaria19 sites
MHAT Puls
Blagoevgrad, 2700
MHAT Heart and Brain
Burgas, 8000
Multiprofile Hospital for Active Treatment Dr. Tota Venkova
Gabrovo, 5300
Multiprofile Hospital for Active Treatment - Haskovo
Haskovo, 6300
MHAT Uni Hospital
Panagyurishte, 4500
SHATC Sveti Georgi-Pernik OOD
Pernik, 2300
Multiprofile Hospital for Active Treatment Heart and Brain, Pleven
Pleven, 5800
UMHAT 'Dr. Georgi Stranski', EAD
Pleven, 5800
UMHAT 'Sv. Georgi' EAD
Plovdiv, 4002
MHAT Sv. Karidad EAD
Plovdiv, 4004
2th MHAT - Sofia
Sofia, 1202
National Heart Hospital
Sofia, 1309
Diagnostic Consultation Centre 'Alexandrovska' EOOD
Sofia, 1431
UMHAT Prof. Dr. Aleksandar Chirkov
Sofia, 1431
University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD
Sofia, 1527
UMHATEM N I Pirogov
Sofia, 1606
University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
Sofia, 1750
UMHAT Sofia Med
Sofia, 1797
UMHAT Prof. Dr. St. Kirkovich AD
Stara Zagora, 6003
Israel19 sites
Haemek Medical Center
Afula, 18101
Samson Assuta Ashdod University Hospital
Ashdod, 7747629
Barzilai Medical Center
Ashkelon, 78278
Soroka University Medical Center
Beersheba, 84101
Bnai Zion Medical Center
Haifa, 31048
Rambam Health Care Campus
Haifa, 31096
Carmel Medical Center
Haifa, 3436212
Wolfson Medical Center
Holon, 58100
Shaare Zedek Medical Center
Jerusalem, 9103102
Hadassah University Hospita Ein Kerem
Jerusalem, 9112001
Hadassah Medical Center
Jerusalem, 9124001
Meir Medical Center
Kfar Saba, 4428164
Health Corporation of Galilee Medical Center
Naharya, 2633737
Rabin Medical Center
Petah Tikva, 49100
Chaim Sheba Medical Center
Ramat Gan, 5262001
Kaplan Medical Center
Rehovot, 7610001
Assaf Harofeh Medical Center
Rishon LeZiyyon, 70300
Ziv Medical Center
Safed, 13100
Baruch Padeh Medical Center
Tiberias, 15208
Serbia19 sites
Clinical Center Dr Dragisa Misovic Dedinje
Belgrade, 11000
Institute for Cardiovascular diseases Dedinje 1
Belgrade, 11000
Institute for Cardiovascular diseases Dedinje
Belgrade, 11000
University Clinical Center of Serbia 1
Belgrade, 11000
University Clinical Center of Serbia 2
Belgrade, 11000
University Clinical Center of Serbia
Belgrade, 11000
Clinical Hospital Center Zemun
Belgrade, 11080
University Clinical Hospital Center Dr Dragisa Misovic- Dedi
Belgrade, 11080
Institute of Cardiovascular Diseases of Vojvodina 1
Kamenitz, 21204
Institute of Cardiovascular Diseases of Vojvodina
Kamenitz, 21204
University Clinical Center Kragujevac
Kragujevac, 34000
Clinical Center Nis 1
Niš, 18000
Clinical Center Nis
Niš, 18000
Institute for Treatment and Rehabilitation Niska Banja
Niška Banja, 18205
General Hospital Pancevo
Pančevo, 26000
General Hospital Smederevo
Smederevo, 11300
General Hospital Sremska Mitrovica
Sremska Mitrovica, 22000
General Hospital Uzice
Užice, 31000
Health Center Zajecar
Zaječar, 19000
Australia18 sites
Royal Adelaide Hospital
Adelaide, 5000
Flinders Medical Centre
Adelaide, 5042
Ballarat Base Hospital
Ballarat, 3350
Sunshine Coast University Hospital
Birtinya, 4575
Cairns Base Hospital
Cairns, 4870
Royal Prince Alfred Hospital
Camperdown, 2050
Concord Repatriation General Hospital
Concord, 2139
The Canberra Hospital
Garran, 2605
Royal Brisbane and Women's Hospital
Herston, 4029
Royal Hobart Hospital
Hobart, 7000
Nepean Hospital
Kingswood, 2747
Core Research Group
Milton, 4064
Fiona Stanley Hospital
Murdoch, 6150
Gold Coast University Hospital
Southport, 4215
Westmead Hospital
Sydney, 2145
Latrobe Regional Hospital
Traralgon, 3844
Wollongong Hospital
Wollongong, 2500
The Queen Elizabeth Hospital
Woodville South, 5011
Czechia18 sites
Fakultni nemocnice Brno
Brno, 625 00
Vojenska nemocnice Brno
Brno, 636 00
Fakultni nemocnice u sv. Anny v Brne
Brno, 65691
Nemocnice Ceske Budejovice a s
České Budějovice, 370 87
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
Kardiocentrum Vysocina CZ a.s.
Jihlava, 586 01
Oblastní nemocnice Kolín
Kolín, 280 02
Krajská nemocnice Liberec a.s.
Liberec, 46001
Fakultni Nemocnice Ostrava
Ostrava-Poruba, 708 52
Pardubicka krajska nemocnice a s
Pardubice, 530 03
Fakultni nemocnice Plzen
Pilsen, 304 60
Fakultni nemocnice Kralovske Vinohrady
Prague, 100 34
Kardiologie Vinohrady s r o
Prague, 120 00
Vseobecna fakultni nemocnice v Praze
Prague, 12808
Institut klinicke a experimentalni mediciny
Prague, 14000
Ustredni vojenske nemocnice Praha
Prague, 169 02
Nemocnice Slany
Slaný, 274 01
Nemocnice AGEL - Podlesi a.s.
Třinec, 73961
Philippines18 sites
The Heart Specialists Clinic and Diagnostic Center
Angeles, 2009
Silang Specialists Medical Center
Cavite, 4118
Cebu Doctors University Hospital
Cebu, 6000
Central Lab Diabetes Wellness, Heart and Kidneys, Inc
Davao City, 8000
Davao Doctors Hospital
Davao City, 8000
Southern Philippines Medical Center
Davao City, 8000
St.Paul's Hospital-Iloilo
Iloilo City, 5000
Mary Mediatrix Medical Center
Lipa City, 4217
Health Cube Medical Clinics
Mandaluyong, 1552
Manila Doctors Hospital
Manila, 1000
Medical Center Manila
Manila, 1000
Philippine General Hospital 1
Manila, 1000
Chinese General Hospital & Medical Center
Manila, 1003
Amang Rodriguez Memorial Medical Center
Marikina City, 1800
The Medical City
Pasig, 1605
St. Luke's Medical Center 1
Quezon, 1102
Cardinal Santos Medical Center
San Juan City, 1502
The Medical City South Luzon
Santa Rosa, 4026
Romania18 sites
Spitalul Judetean de Urgenta Dr. Constantin Opris
Baia Mare, 430031
Spitalul Clinic Judetean de Urgenta Brasov
Brasov, 500326
Spitalul Universitar de Urgenta Militar Central 'Dr. Carol Davila'
Bucharest, 010825
Spitalul Universitar de Urgenta Elias, Clinica de Cardiologie
Bucharest, 011461
Spitalul Clinic de Urgenta Bucuresti
Bucharest, 014461
Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu
Bucharest, 022328
Spitalul Angiocare SRL
Cluj-Napoca, 400000
Spitalul Clinic Judetean de Urgenta Cluj Napoca
Cluj-Napoca, 400006
Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
Constanța, 900591
Spitalul Clinic Judetean de Urgenta Craiova
Craiova, 200147
Institutul de Boli Cardiovasculare Iasi
Iași, 700503
Spitalul Clinic Judetean de Urgenta Oradea
Oradea, 410167
SAL MED Pitesti
Piteşti, 110424
Spitalul Clinic Judetean de Urgenta Targu Mures 1
Târgu Mureş, 540136
Spitalul Clinic Judetean de Urgenta Targu Mures
Tg. Mures, 540136
Clinica Medicaliss
Timișoara, 300043
Spitalul Clinic Municipal de Urgenta Timisoara
Timișoara, 300079
Institutul de Boli Cardiovasculare Timisoara
Timișoara, 300310
Belgium16 sites
Imeldaziekenhuis
Bonheiden, 2820
AZ Klina
Brasschaat, 2930
AZ Sint-Jan
Bruges, 8000
C.H.U. Brugmann
Brussels, 1020
CUB Hôpital Erasme
Brussels, 1070
Universitair Ziekenhuis Brussel
Brussels, 1090
Cliniques Universitaires Saint Luc
Brussels, 1200
Ziekenhuis Oost-Limburg
Genk, 3600
AZ Sint-Lucas
Ghent, 9000
Jessa Ziekenhuis
Hasselt, 3500
CHR de la Citadelle
Liège, 4000
Az Sint-Maarten
Mechelen, 97770
Heilig Hart Ziekenhuis Lier
Mol, 2400
CHU Ambroise Pare
Mons, 7000
AZ Delta
Roeselare, 8800
AZ Turnhout
Turnhout, 2300
Greece16 sites
Uni General Hospital of Alexandroupolis
Alexandroupoli, 68100
Henry Dunant Hospital
Athens, 115 26
General Hospital of Athens G Gennimatas
Athens, 115 27
Hippokration Hospital
Athens, 11527
General Hospital of Athens Attikon
Athens, 12462
General Hospital of Attiki 'KAT'
Athens, 14561
Athens Medical Center
Athens, 15125
General Per Hospital of Athens Asklipiio Voulas
Athens, 16673
University Hospital of Heraklion
Heraklion, 71110
University General Hospital of Ioannina
Ioannina, 45500
University Hospital Of Larissa
Larissa, 41110
General University Hospital of Patras
Pátrai, 26500
Ahepa University General Hospital of Thessaloniki
Thessaloniki, 54636
Hippokration Hospital 1
Thessaloniki, 54642
Papageorgiou General Hospital
Thessaloniki, 56429
Papanikolaou General Hospital of Thessaloniki
Thessaloniki, 57010
Taiwan16 sites
Changhua Christian Hospital
Changhua, 50006
Kaohsiung Medical University Chung Ho Memorial Hospital
Kaohsiung City, 807
E-DA Hospital
Kaohsiung City, 82445
Far Eastern Memorial Hospital
New Taipei City, 22060
Mackay Memorial Hospital
New Taipei City, 25160
China Medical University Hospital
Taichung, 404327
Chi Mei Medical Center Yong Kang
Tainan, 71004
National Taiwan University Hospital
Taipei, 10002
Cathay General Hospital
Taipei, 106
Taipei Medical University
Taipei, 110
Taipei Veterans General Hospital
Taipei, 11217
Cheng Hsin General Hospital
Taipei, 112
Tri-Service General Hospital
Taipei, 114202
Taipei Municipal Wanfang Hospital
Taipei, 116
Chang Gung Memorial Hospital- Linkou
Taoyuan County, 33305
National Yang-Ming University Hospital
Yilan County, 260
Hungary15 sites
Budai Irgalmasrendi Korhaz
Budapest, 1023
Semmelweis Egyetem
Budapest, 1085
Gottsegen György Országos Kardiológiai Intézet
Budapest, 1096
Bajcsy-Zsilinszky Kórház és Rendelőintézet
Budapest, 1106
Semmelweis Egyetem Varosmajor Sziv es Ergyogyaszati Klinika
Budapest, 1122
Debreceni Egyetem
Debrecen, 4032
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula, 5700
Somogy Megyei Kaposi Mor Oktato Korhaz
Kaposvár, 7400
Bacs-kiskun Megyei Korhaz
Kecskemét, 6000
Pecsi Tudomanyegyetem
Pécs, 7624
Szegedi Tudomanyegyetem Aok Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, 6725
Tolna Megyei Balassa Janos Korhaz
Szekszárd, 7100
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointez
Szolnok, 5000
Markusovszky Egyetemi Oktatokorhaz
Szombathely, 9700
Belvarosi Egeszseghaz Kft. (Leda-Platan Maganklinika es Sebeszeti Kozpont)
Zalaegerszeg, 8900
Slovakia15 sites
Stredoslovensky ustav srdcovych a cievnych chorob a.s
Banská Bystrica, 97401
Alian s.r.o.
Bardejov, 08501
Premedix Clinic
Bratislava, 811 02
Nemocnica s poliklinikou Brezno
Brezno, 977 01
Východoslovenský Ústav Srdcových A Cievnych Chorôb, A.S.
Košice, 040 11
Interno Kardio s r o
Košice, 04001
Kardiologicka ambulancia CARDIO D&R s.r.o.
Košice, 4022
Kardio 1 S.R.O.
Lučenec, 98439
Univerzitna nemocnica Martin 1
Martin, 036 59
Kardiologicka ambulancia MEDI M&M s.r.o.
Moldava nad Bodvou, 4501
Kardiocentrum Nitra s.r.o.
Nitra, 95001
Cardioinvest s.r.o.
Nové Zámky, 94052
Interna SK s.r.o.
Svidník, 08901
MEDIVASA s.r.o.
Žilina, 01001
Nemocnica AGEL Zvolen a s
Zvolen, 960 01
Turkey (Türkiye)14 sites
Afyon Kocatepe University Medical Faculty
Afyonkarahisar, 03200
Ankara Etlik Speciality Hospital
Ankara, 06010
Ankara University Medical Faculty
Ankara, 06100
Ankara Numune Research and Training Hospital
Ankara, 06800
Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, 16330
Osmangazi University Medical Faculty
Eskişehir, 26480
Bezmi Alem Vakif University Medical Faculty Hospital
Istanbul, 34093
Marmara University Pendik Training Hospital
Istanbul, 34899
Dokuz Eylul University Medical Faculty
Izmir, 35340
Karabuk University Medical Faculty
Karabük, 06100
Erciyes University Medical Faculty
Kayseri, 38039
Kutahya Health Science University Evliya Celebi Research and Training Hospital
Kütahya, 43040
Mersin University Medical Faculty
Mersin, 33020
Ondokuz Mayis University
Samsun, 55139
Malaysia11 sites
Hospital University Sains Malaysia
Kota Bharu, 15200
Hospital Raja Perempuan Zainab Ii
Kota Bharu, 15586
Hospital Queen Elizabeth
Kota Kinabalu, 88500
Institut Jantung Negara
Kuala Lumpur, 50400
Pusat Perubatan Universiti Kebangsaan Malaysia
Kuala Lumpur, 56000
University Malaya Medical Centre
Kuala Lumpur, 59100
Sarawak General Hospital
Kuching, 93200
Hospital Miri
Miri, 98000
Hospital Pulau Pinang
Pulau Pinang, 10990
Hospital Seberang Jaya
Seberang Jaya, 13700
Universiti Teknologi Mara
Selayang Baru Utara, 68000
Portugal11 sites
Centro Hospitalar do Baixo Vouga E P E Unidade de Aveiro
Aveiro, 3814-501
Hospital de Braga
Braga, 4710-243
Uls Coimbra - Hosp. Univ. Coimbra
Coimbra, 3000-075
Centro Hospitalar Cova da Beira, EPE - Hospital Pêro da Covilhã
Covilha, 6200-074
Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes
Guimarães, 4835 044
Centro Hospitalar de Leiria
Leiria, 2410-197
Centro Hospitalar de Lisboa Central
Lisbon, 1169-024
Centro Hospitalar de Lisboa Norte Hospital Santa Maria
Lisbon, 1649-035
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
Santa Maria da Feira, 4520-211
Centro Hospitalar de Vila Nova de Gaia Espinho E P E
Vila Nova de Gaia, 4434-502
Centro Hospitalar de Trás os Montes e Alto Douro- Vila Real
Vila Real, 5000-508
South Africa11 sites
Panorama MediClinic
Cape Town, 7500
Tread Research
Cape Town, 7500
Tiervlei Trial Centre
Cape Town, 7530
Groote Schur Hospital
Cape Town, 7925
Johese Clinical Research
Centurion, 0157
Durban Medical Centre
Durban, 4001
Garda, RA
Johannesburg, 2192
Eden Heart
Mossel Bay, 6506
Dr J.M. Engelbrecht Trial Site
Somerset West, 7130
Helderberg Research Institute
Somerset West, 7130
Clinical Projects Research SA (PTY) LTD
Worcester, 6850
Mexico10 sites
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230
Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C.
Culiacán, 80230
Centro de Estudios de de alta Especialidad de Sinaloa
Mazatlán, 82126
Instituto Nacional de Cardiologia Dr. Ignacio Chavez
México, 14080
Private Practice Dr Amaya
Monterrey, 64718
Centro de Estudios Clinicos de Queretaro S.C
Querétaro, 76000
Centro de Atencion e Investigacion Cardiovascular del Potosi S C
San Luis Potosí City, 78200
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, 22500
Centro de Investigacion Dr. Alberto Esteban Bazzoni Ruiz
Torreón, 27000
Dr Enrique Lopez Rosas
Xalapa, 91193
New Zealand10 sites
North Shore Hospital
Auckland, 0740
Auckland City Hospital
Auckland, 1030
University of Otago
Christchurch, 4710
Dunedin Public Hospital
Dunedin, 9016
Hawkes Bay Hospital
Hastings, 4120
Taranaki Base Hospital
New Plymouth, 4342
Middlemore Hospital
Otahuhu, 2025
Rotorua Hospital
Rotorua, 3010
Tauranga Hospital
Tauranga, 3143
Whangarei Hospital
Whangarei, 110
Denmark9 sites
Aarhus University Hospital
Aahus N, 8200
Amager Hospital
Copenhagen S, 2300
Bispebjerg Og Frederiksberg Hospital
Frederiksberg, 2000
Herning Regional Hospital
Herning, 7400
Holbæk Sygehus
Holbæk, 4300
Hvidovre Hospital
Hvidovre, 2650
Slagelse Sygehus
Slagelse, 4200
Odense University Hospital
Svendborg, 5700
Viborg Hospital
Viborg, 8800
Vietnam9 sites
Bach Mai Hospital
Hanoi, 100000
Tam Anh General Hospital
Hanoi, 100000
103 Military Hospital
Hanoi
Hanoi Heart Hospital
Hanoi
Hanoi Medical University Hospital
Hanoi
People's Hospital 115
Ho Chi Minh City, 700000
Tam Anh Hospital
Ho Chi Minh City, 700000
Thong Nhat HOSPITAL
Ho Chi Minh City, 700000
Tam Duc Heart Hospital
Ho Chi Minh City
Croatia6 sites
General Hospital Dubrovnik
Dubrovnik, 20000
Special Hospital for medical rehabilitation
Krapinske Toplice, 49217
Clinical Hospital Centre Rijeka
Rijeka, 51000
General Hospital Slavonski Brod
Slavonski Brod, 35000
Poliklinika Solmed
Zagreb, 10000
University Hospital Dubrava
Zagreb, 10000
Austria5 sites
KH St.Josef Braunau am Inn
Braunau am Inn, 5280
Landeskrankenhaus Feldkirch
Feldkirch, A-6807
LKH-Univ. Klinikum Graz
Graz, 8036
Krankenhaus der Elisabethinen Linz
Linz, 4020
AKH - Medizinische Universitat Wien
Vienna, 1090
Chile5 sites
Quantum Research
Puerto Varas, 5551070
Centro de Investigacion Clinica Universidad Catolica de Chile CICUC
Santiago, 8330024
Centro de Investigacion Clinica del Sur
Temuco, 4781156
Centro de Estudios Cardiologicos y de Medicina Interna
Temuco, 4813299
Centro de Estudios Clinicos V Region Ltda
Viña del Mar, 2520997
Singapore5 sites
National University Hospital
Singapore, 119074
National Heart Centre (NHC) Singapore
Singapore, 169609
Changi General Hospital
Singapore, 529889
Ng Teng Fong General Hospital
Singapore, 609606
Khootech Puat Hospital
Singapore, 768828
Switzerland5 sites
Universitatsspital Basel
Basel, 4031
Universitätspital Bern, Universitätsklinik für Frauenheilkunde
Bern, 3010
Hopitaux Universitaires de Geneve - HUG
Geneva, 1211
Istituto Cardiocentro Ticino
Lugano, 6900
UniversitaetsSpital Zuerich
Zurich, 8091
Thailand5 sites
Ramathibodi Hospital
Bangkok, 10400
Siriraj Hospital
Bangkoknoi, 10700
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, 50200
Srinagarind Hospital
Nai Mueang Subdistrict Mueang, 40000
King Chulalongkorn Memorial Hospital
Pathum Wan, 10330
Latvia3 sites
Daugavpils Regional Hospital
Daugavpils, LV5417
Riga East Clinical University Hospital
Riga, LV-1038
Pauls Stradins Clinical University Hospital
Riga, LV1002
Lithuania3 sites
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
Kaunas, LT-50161
Klaipeda Seamen's Hospital, Public Institution
Klaipėda, LT-92288
Vilnius University Hospital Santariskiu Clinic, Public Institution
Vilnius, LT-08661
North Macedonia2 sites
University Clinic of Cardiology
Skopje, 1109
Clinical Hospital Tetovo
Tetovo, 1200
About this study
Official title: A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome
The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular [CV] death, myocardial infarction [MI], and ischemic stroke).
- Conditions
- Acute Coronary Syndrome
- Being tested
- Milvexian, Placebo
- Medical subject headings
- Acute Coronary Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MilvexianDrug
Also called JNJ-70033093, BMS-986177
Milvexian will be administered orally.
PlaceboOther
Placebo will be administered orally.
| Study group | Role | What they receive |
|---|---|---|
| Milvexian | Experimental | Participants enrolled within 7 days of an acute coronary syndrome (ACS), who have undergone cardiac catheterization with percutaneous intervention (PCI) or who are being managed conservatively with or without catheterization, and who are receiving antiplatelet therapy standard-of-care (single antiplatelet therapy [SAPT] or dual antiplatelet therapy [DAPT]) as determined by the investigator will receive milvexian 25 milligrams (mg), orally, twice daily. Receives: Drug: Milvexian |
| Placebo | Placebo comparator | Participants enrolled within 7 days of an ACS, who have undergone cardiac catheterization with PCI or who are being managed conservatively with or without catheterization, and who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) as determined by the investigator will receive placebo orally, twice daily. Receives: Other: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to First Occurrence of Major Adverse Cardiovascular Event (MACE)
Time to first occurrence of any component of MACE will be reported. MACE is a composite of cardiovascular (CV) death, myocardial infarction (MI), and ischemic stroke.
Measured: Up to 3 years 6 months
Secondary outcomes (4)
Time to the First Occurrence of Major Adverse Vascular Event (MAVE)
Time to first occurrence of any component of MAVE will be reported. MAVE is a composite of CV death, MI, ischemic stroke, major adverse limb event (MALE), and symptomatic venous thromboembolism (VTE).
Measured: Up to 3 years 6 months
Time to the First Occurrence of Composite of All-cause Mortality (ACM), Myocardial Infarction (MI) and Ischemic Stroke
Time to the first occurrence of composite of ACM, MI and ischemic stroke will be reported.
Measured: Up to 3 years 6 months
Time to Cardiovascular (CV) Death
Time to CV death will be reported.
Measured: Up to 3 years 6 months
Time to All-cause Mortality (ACM)
Time to ACM will reported. ACM will be categorized into CV death, non-CV death, and death due to unknown cause.
Measured: Up to 3 years 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2023
- Study start7 Apr 2023
- Primary completion6 Feb 2026
- Study completion6 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Acute Coronary SyndromeStudies of the same condition, open and under way.
- More trials run by Janssen Research & Development, LLCThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 14,194 participants (actual)
Sponsor and investigators
- Lead sponsor
- Janssen Research & Development, LLC
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Bristol-Myers Squibb
- Responsible party
- Sponsor
- Investigators
- Janssen Research & Development, LLC Clinical Trial, Study director, Janssen Research & Development, LLC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05754957
- Sponsor's protocol ID
- CR109271
- Other IDs
- 70033093ACS3003, 2022-501418-69-00
- Acronym
- LIBREXIA-ACS
- Status last verified
- Jul 2026
- First submitted
- 23 Feb 2023
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu
Publications
Gibson CM, Steg PG, Bahit MC, Al-Lamee R, Mehta SR, Mehran R, Weitz JI, Goto S, Nicolau JC, Lopes RD, Ge J, Tasic N, Angiolillo DJ, Baron SJ, Kirtane AJ, Xavier D, Yasuda S, Lewis BS, Park DW, Cornel JH, Johnson TW, Trebacz J, Duerschmied D, Bode C, Merkely B, Dorobantu M, Vinereanu D, Motovska Z, Bueno H, Lopez-Sendon JL, Ducrocq G, Ambrosio G, Burgess L, Bohm A, Chiang CE, Morais J, Fong A, Guray U, Leiva-Pons JL, Vranckx P, White HD, Kedev S, Valgimigli M, Cerovec D, Tousoulis D, Figtree G, Ho TD, Sy RG, Bottcher M, Huber K, Slapikas R, Erglis A, Tan JWC, Pincetti C, Pieper KS, Mahaffey KW, Lam CSP, Johnston SC, Hankey GJ, Zheng L, Aronson R, Li D, Notani R, Vieira Pires P, Povsic TJ, Lindsay AC, Plotnikov A, Deng H, Barnathan ES, Harrington RA; LIBREXIA ACS Committees and Investigators. Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event. N Engl J Med. 2026 Aug 29. doi: 10.1056/NEJMoa2608717. Online ahead of print.
PubMed 42670965Gibson CM, Bahit MC, Mehran R, Mehta SR, Lamee RA, Goto S, Weitz JI, Horrow J, Barnathan ES, Harrington RA, Mahaffey KW, Lam CSP, Pieper KS, Johnston SC, Hankey GJ, Plotnikov AN, Li D, Deng H, Steg PG; Librexia ACS Committees and Investigators.. Oral factor xia inhibitor milvexian after a recent acute coronary syndrome: Rationale and design of the phase 3 (Librexia ACS). Am Heart J. 2025 Jul;285:21-28. doi: 10.1016/j.ahj.2025.02.011. Epub 2025 Feb 20.
PubMed 39986336
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome
- ClinicalTrials.gov ID
- NCT05754957
- Acronym / sponsor ID
- LIBREXIA-ACS / CR109271
- Conditions
- Acute Coronary Syndrome
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 14,194 participants (actual)
- Lead sponsor
- Janssen Research & Development, LLCIndustry (pharma, biotech, devices)
- Collaborators
- Bristol-Myers Squibb
- Study start
- 7 Apr 2023 (actual)
- Primary completion
- 6 Feb 2026 (actual)
- Study completion
- 6 Feb 2026 (actual)
- First posted
- 6 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular [CV] death, myocardial infarction [MI], and ischemic stroke).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Milvexian | Experimental | Drug: MilvexianParticipants enrolled within 7 days of an acute coronary syndrome (ACS), who have undergone cardiac catheterization with percutaneous intervention (PCI) or who are being managed conservatively with or without catheterization, and who are receiving antiplatelet therapy standard-of-care (single antiplatelet therapy [SAPT] or dual antiplatelet therapy [DAPT]) as determined by the investigator will receive milvexian 25 milligrams (mg), orally, twice daily. |
| Placebo | Placebo comparator | Other: PlaceboParticipants enrolled within 7 days of an ACS, who have undergone cardiac catheterization with PCI or who are being managed conservatively with or without catheterization, and who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) as determined by the investigator will receive placebo orally, twice daily. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Participants must have an index event that meets all 3 of the following criteria within 7 days prior to randomization: a) clinical syndrome consistent with spontaneous cardiac ischemia, b) diagnosis of acute coronary syndrome (ACS) (that is, ST-elevation myocardial infarction [STEMI], non-STEMI, or unstable angina [UA]), c) cardiac biomarker elevation (example, troponin I, troponin T, creatine kinase-MB [CK-MB]) above the upper limit of normal as determined by the local laboratory
- Participants must have at least 2 of the following risk factors:a) age 65 or older, b) diabetes mellitus, c) history of a prior myocardial infarction (MI) (other than index ACS event), d) multivessel coronary artery disease (CAD), e) history of coronary artery bypass graft (CABG) surgery prior to index ACS event, f) history of peripheral artery disease (PAD) or cerebrovascular disease (example, carotid atherosclerosis, intracranial artery stenosis, g) conservative management (that is, no percutaneous intervention [PCI] or CABG after index ACS event), h) Any one or more of the following high-risk angiographic features i) total stent length of greater than (>) 30 millimeters (mm), ii) thrombotic target lesion, iii) bifurcation lesion treated with more than one stent, iv) calcified target lesion treated with atherectomy, v) treatment of obstructive left main or proximal left anterior descending artery for index ACS (or clinical diagnosis of an anterior STEMI)
- All female participants of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (hCG) or urine test at screening
- A female participant must not be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half-lives) after the last dose of study intervention
Key exclusion criteria (4 listed)
- MI secondary to ischemia due to either increased oxygen demand or decreased supply (Type 2 MI) or periprocedural MI as the index ACS event
- Planned CABG or staged PCI after randomization
- Any condition that requires chronic anticoagulation at the discretion of the investigator and/or local guidelines
- Conditions with a significant increased risk of bleeding (example, clinically significant bleeding within previous 3 months, known bleeding diathesis, et cetera)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MilvexianAlso: JNJ-70033093, BMS-986177Milvexian will be administered orally. | Drug | Milvexian |
| PlaceboPlacebo will be administered orally. | Other | Placebo |
Primary outcome
Time to First Occurrence of Major Adverse Cardiovascular Event (MACE)
Time frame: Up to 3 years 6 months
Time to first occurrence of any component of MACE will be reported. MACE is a composite of cardiovascular (CV) death, myocardial infarction (MI), and ischemic stroke.
4 secondary outcomes
Time to the First Occurrence of Major Adverse Vascular Event (MAVE)
Time frame: Up to 3 years 6 months
Time to the First Occurrence of Composite of All-cause Mortality (ACM), Myocardial Infarction (MI) and Ischemic Stroke
Time frame: Up to 3 years 6 months
Time to Cardiovascular (CV) Death
Time frame: Up to 3 years 6 months
Time to All-cause Mortality (ACM)
Time frame: Up to 3 years 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Derived from this study: PubMed 42670965Gibson CM, Steg PG, Bahit MC, Al-Lamee R, Mehta SR, Mehran R, Weitz JI, Goto S, Nicolau JC, Lopes RD, Ge J, Tasic N, Angiolillo DJ, Baron SJ, Kirtane AJ, Xavier D, Yasuda S, Lewis BS, Park DW, Cornel JH, Johnson TW, Trebacz J, Duerschmied D, Bode C, Merkely B, Dorobantu M, Vinereanu D, Motovska Z, Bueno H, Lopez-Sendon JL, Ducrocq G, Ambrosio G, Burgess L, Bohm A, Chiang CE, Morais J, Fong A, Guray U, Leiva-Pons JL, Vranckx P, White HD, Kedev S, Valgimigli M, Cerovec D, Tousoulis D, Figtree G, Ho TD, Sy RG, Bottcher M, Huber K, Slapikas R, Erglis A, Tan JWC, Pincetti C, Pieper KS, Mahaffey KW, Lam CSP, Johnston SC, Hankey GJ, Zheng L, Aronson R, Li D, Notani R, Vieira Pires P, Povsic TJ, Lindsay AC, Plotnikov A, Deng H, Barnathan ES, Harrington RA; LIBREXIA ACS Committees and Investigators. Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event. N Engl J Med. 2026 Aug 29. doi: 10.1056/NEJMoa2608717. Online ahead of print.
- Derived from this study: PubMed 39986336Gibson CM, Bahit MC, Mehran R, Mehta SR, Lamee RA, Goto S, Weitz JI, Horrow J, Barnathan ES, Harrington RA, Mahaffey KW, Lam CSP, Pieper KS, Johnston SC, Hankey GJ, Plotnikov AN, Li D, Deng H, Steg PG; Librexia ACS Committees and Investigators.. Oral factor xia inhibitor milvexian after a recent acute coronary syndrome: Rationale and design of the phase 3 (Librexia ACS). Am Heart J. 2025 Jul;285:21-28. doi: 10.1016/j.ahj.2025.02.011. Epub 2025 Feb 20.
- Individual participant dataSharing planned: Yes. The data sharing policy of the Janssen Pharmaceutical Companies of Johnson \& Johnson is available at www.janssen.com/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Janssen Research & Development, LLC Clinical Trial study director
Janssen Research & Development, LLC
1,003 sites in 44 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Milvexian in people with Acute Coronary Syndrome, run by Janssen Research & Development, LLC at 1,003 sites in 44 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1,003 sites in United States, Japan, China, Brazil, Argentina and 39 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to First Occurrence of Major Adverse Cardiovascular Event (MACE) (time frame: Up to 3 years 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05754957, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026.