Appetitive BehaviorNCT05725681
Satiety of High-Protein Ramen Noodles
A study testing High protein ramen and Standard ramen in people with Appetitive Behavior, run by Texas Tech University at 1 site in United States.
Trial summary
The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. Read more about this study
- Who is it for?
- Ages 25 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Appetitive Behavior
- What is being tested?
- High protein ramen and Standard ramen
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jun 2023to 2 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Body Mass Index 20-30 kg/m2
Who cannot join
- Unwilling or unable to have an IV catheter inserted
- Body weight <110 pounds
- Diabetes (any type)
- Fasting capillary glucose ≥100 mg/dL
- Unstable systemic medical condition
- •>10% change in body weight in the prior 3 months
Show all 16Show fewer
- Medications that affect appetite or glucose regulation
- Prior bariatric surgery
- Uncontrolled hypertension (i.e., unmedicated blood pressure >130/90 mmHg)
- Intolerance, dislike or allergy to the study food
- Current or recent (within 6 months) tobacco use
- High alcohol consumption (>14 drinks/week)
- Currently following a weight loss diet
- Irregular menstrual cycle
- Currently pregnant or lactating
- Principal investigator discretion (e.g., disrespectful or inappropriate interactions with study staff
Trial locations and contacts
1 site in 1 country.
United States1 site
Nutrition and Metabolic Health Initiative
Lubbock, Texas, 79409
About this study
Official title: The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety: Acute, Randomized, Crossover Study
The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles.
Read the detailed description
The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles. Subjects meeting the eligibility criteria will be recruited and offered a 2-condition, randomized, crossover postprandial study. Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, in random order, participants will consume: 1) one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods); 2) an isocaloric, weight matched portion of standard instant ramen noodles. The participants will have to finish consuming the noodles within 15 minutes. Water will be provided at the time of breakfast and for the next two hours. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. Subjects will leave the clinic at this point. The process will be repeated for the second condition after at least 7 d washout period.
- Conditions
- Appetitive Behavior
- Being tested
- High protein ramen, Standard ramen
- Medical subject headings
- Appetitive Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High protein ramenOther
Participants will be served one portion of high-protein instant ramen noodles [CHEF WOO Roasted Chicken Flavor Ramen Cup Noodles, Borealis Foods; 71 g]
Standard ramenOther
Participants will be served one portion of standard instant ramen noodles [RAMEN EXPRESS Chicken Flavor Ramen Cup Noodle Chef Woo, Borealis Foods; 71 g]
| Study group | Role | What they receive |
|---|---|---|
| High protein ramen | Experimental | Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods). In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. Receives: Other: High protein ramen |
| Standard ramen | Active comparator | Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume an isocaloric, weight matched portion of standard instant ramen noodles. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. Receives: Other: Standard ramen |
What is being measured
The primary outcome is the main question the study is designed to answer.
Appetite Score Area Under the Curve (mm*180 minutes)
Calculated as satiety + fullness + (100 - hunger) + (100 - prospective food consumption)/4. Questions 1-4 from the Visual Analogue Scale will be used to assess satiety, fullness, hunger and prospective food consumption and calculate the Appetite Score
Measured: 0 to 180 minutes
Secondary outcomes (28)
Ghrelin Area Under the Curve (pg/mL*180 minutes)
Measured in plasma
Measured: 0 to 180 minutes
Glucagon like peptide-1 (GLP-1) Area Under the Curve (pg/mL*180 minutes)
Measured in plasma
Measured: 0 to 180 minutes
Peptide-YY (PYY) Area Under the Curve (pg/mL*180 minutes)
Measured in plasma
Measured: 0 to 180 minutes
Glucose Area Under the Curve (mg/dL*180 minutes)
Measured in plasma
Measured: 0 to 180 minutes
Insulin Area Under the Curve (mUI*180 minutes)
Measured in serum
Measured: 0 to 180 minutes
Perceived Hunger Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived Satiety Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived Fullness Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Prospective Food Consumption Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Minimum ghrelin (pg/mL)
Measured in plasma
Measured: 0 to 180 minutes
Peak Glucagon like peptide-1 (GLP-1) (pg/mL)
Measured in plasma
Measured: 0 to 180 minutes
Peak Peptide-YY (PYY) (pg/mL)
Measured in plasma
Measured: 0 to 180 minutes
Peak Glucose (mg/dL)
Measured in plasma
Measured: 0 to 180 minutes
Peak Insulin (mUI)
Measured in serum
Measured: 0 to 180 minutes
Desire to eat something fatty Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Desire to eat something salty Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Desire to eat something savory Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Desire to eat something sweet Area Under the Curve (mm*180 minutes)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Energy intake at the buffet lunch (kcal)
Food consumed during the buffet lunch
Measured: Served approximately 3.5 hours following the ramen meal test
Perceived hunger at peak GLP1 (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived satiety at peak GLP1 (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived fullness at peak GLP1 (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived hunger at peak PYY (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived satiety at peak PYY (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived fullness at peak PYY (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived hunger at minimum ghrelin (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived satiety at minimum ghrelin (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Perceived fullness at minimum ghrelin (mm)
Assessed by visual analogue scale.
Measured: 0 to 180 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2023
- Study start1 Jun 2023
- Primary completion2 Dec 2023
- Study completion2 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Appetitive BehaviorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Texas Tech University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Nikhil Dhurandhar, Principal investigator, Department of Nutritional Sciences Texas Tech UniversityKristina Petersen, Principal investigator, Department of Nutritional Sciences Texas Tech University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05725681
- Sponsor's protocol ID
- 22-0729
- Status last verified
- Apr 2025
- First submitted
- 3 Feb 2023
- Last updated
- 23 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Ozioma PU, Kudchadkar GM, Ranjbar S, Hefner M, Kale T, Hia RA, Zaroudi M, Niraula S, Dhurandhar NV. The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety: Acute, Randomized, Crossover Study. Nutr Diabetes. 2026 Apr 22;16(1):13. doi: 10.1038/s41387-026-00421-1.
PubMed 42020359
Study at a glance
From the registry record, last updated by the sponsor on 23 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety: Acute, Randomized, Crossover Study
- ClinicalTrials.gov ID
- NCT05725681
- Acronym / sponsor ID
- 22-0729
- Conditions
- Appetitive Behavior
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Texas Tech UniversityUniversity, hospital or other
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 2 Dec 2023 (actual)
- Study completion
- 2 Dec 2023 (actual)
- First posted
- 13 Feb 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles.
Detailed description
The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles. Subjects meeting the eligibility criteria will be recruited and offered a 2-condition, randomized, crossover postprandial study. Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, in random order, participants will consume: 1) one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods); 2) an isocaloric, weight matched portion of standard instant ramen noodles. The participants will have to finish consuming the noodles within 15 minutes. Water will be provided at the time of breakfast and for the next two hours. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. Subjects will leave the clinic at this point. The process will be repeated for the second condition after at least 7 d washout period.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High protein ramen | Experimental | Other: High protein ramenParticipants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods). In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. |
| Standard ramen | Active comparator | Other: Standard ramenParticipants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume an isocaloric, weight matched portion of standard instant ramen noodles. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed. |
Who may qualify
- Ages
- 25 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Body Mass Index 20-30 kg/m2
Key exclusion criteria (16 listed)
- Unwilling or unable to have an IV catheter inserted
- Body weight <110 pounds
- Diabetes (any type)
- Fasting capillary glucose ≥100 mg/dL
- Unstable systemic medical condition
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High protein ramenParticipants will be served one portion of high-protein instant ramen noodles [CHEF WOO Roasted Chicken Flavor Ramen Cup Noodles, Borealis Foods; 71 g] | Other | High protein ramen |
| Standard ramenParticipants will be served one portion of standard instant ramen noodles [RAMEN EXPRESS Chicken Flavor Ramen Cup Noodle Chef Woo, Borealis Foods; 71 g] | Other | Standard ramen |
Primary outcome
Appetite Score Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Calculated as satiety + fullness + (100 - hunger) + (100 - prospective food consumption)/4. Questions 1-4 from the Visual Analogue Scale will be used to assess satiety, fullness, hunger and prospective food consumption and calculate the Appetite Score
28 secondary outcomes
Ghrelin Area Under the Curve (pg/mL*180 minutes)
Time frame: 0 to 180 minutes
Glucagon like peptide-1 (GLP-1) Area Under the Curve (pg/mL*180 minutes)
Time frame: 0 to 180 minutes
Peptide-YY (PYY) Area Under the Curve (pg/mL*180 minutes)
Time frame: 0 to 180 minutes
Glucose Area Under the Curve (mg/dL*180 minutes)
Time frame: 0 to 180 minutes
Insulin Area Under the Curve (mUI*180 minutes)
Time frame: 0 to 180 minutes
Perceived Hunger Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Perceived Satiety Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Perceived Fullness Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Prospective Food Consumption Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Minimum ghrelin (pg/mL)
Time frame: 0 to 180 minutes
Peak Glucagon like peptide-1 (GLP-1) (pg/mL)
Time frame: 0 to 180 minutes
Peak Peptide-YY (PYY) (pg/mL)
Time frame: 0 to 180 minutes
Peak Glucose (mg/dL)
Time frame: 0 to 180 minutes
Peak Insulin (mUI)
Time frame: 0 to 180 minutes
Desire to eat something fatty Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Desire to eat something salty Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Desire to eat something savory Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Desire to eat something sweet Area Under the Curve (mm*180 minutes)
Time frame: 0 to 180 minutes
Energy intake at the buffet lunch (kcal)
Time frame: Served approximately 3.5 hours following the ramen meal test
Perceived hunger at peak GLP1 (mm)
Time frame: 0 to 180 minutes
Perceived satiety at peak GLP1 (mm)
Time frame: 0 to 180 minutes
Perceived fullness at peak GLP1 (mm)
Time frame: 0 to 180 minutes
Perceived hunger at peak PYY (mm)
Time frame: 0 to 180 minutes
Perceived satiety at peak PYY (mm)
Time frame: 0 to 180 minutes
Perceived fullness at peak PYY (mm)
Time frame: 0 to 180 minutes
Perceived hunger at minimum ghrelin (mm)
Time frame: 0 to 180 minutes
Perceived satiety at minimum ghrelin (mm)
Time frame: 0 to 180 minutes
Perceived fullness at minimum ghrelin (mm)
Time frame: 0 to 180 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Apr 2025.
- Derived from this study: PubMed 42020359Ozioma PU, Kudchadkar GM, Ranjbar S, Hefner M, Kale T, Hia RA, Zaroudi M, Niraula S, Dhurandhar NV. The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety: Acute, Randomized, Crossover Study. Nutr Diabetes. 2026 Apr 22;16(1):13. doi: 10.1038/s41387-026-00421-1.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nikhil Dhurandhar principal investigator
Department of Nutritional Sciences Texas Tech University
Kristina Petersen principal investigator
Department of Nutritional Sciences Texas Tech University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High protein ramen and Standard ramen in people with Appetitive Behavior, run by Texas Tech University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Appetite Score Area Under the Curve (mm*180 minutes) (time frame: 0 to 180 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05725681, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Apr 2025.