SurgeryNCT05690633

Feasibility of Obtaining Pulse Oximetry Readings From the Oropharynx

A study testing Pulse oximetry in people with Surgery and Arterial Catheterization, Peripheral, run by Joseph D. Tobias at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Who is it for?: Any age
Conditions the study is for: Surgery, Arterial Catheterization, Peripheral
What is being tested?: Pulse oximetry
Type of treatment: Pill or oral medicine, Medical device
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 100 participants
Where: 1 siteUnited States
Study dates: 9 Jan 2024to 27 Jan 2025
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages Any age
All sexes
No healthy volunteers
Child, Adult, Older adult

Who may be able to join

Patients undergoing a surgical procedure with general anesthesia and requiring an invasive arterial cannula

Who cannot join

Patients in whom an arterial cannula is not indicated for the surgical procedure
Patients in whom a peripheral pulse oximeter value cannot be obtained
Patients in whom an invasive arterial cannula cannot be placed
Patients with any type of intra-oral pathology or injury
Patients in whom access to the oropharynx is restricted or not feasible for any clinical reason

Trial locations and contacts

1 site in 1 country.

United States1 site

Nationwide Children's Hospital
Columbus, Ohio, 43205

Other trials in United States

About this study

This is a prospective study to evaluate the feasibility of obtaining a pulse oximetry ready from the oropharynx with a standard oximeter probe that has been attached to an oral airway or a tongue blade. The study will compare the values from the peripheral pulse oximeter on a finger, toe, foot or hand with the that from the oropharyngeal oximeter. The study will also compare the saturation from an arterial blood gas (ABG) collected as standard of care with that obtained from the oropharyngeal oximeter.

Conditions: Surgery, Arterial Catheterization, Peripheral
Being tested: Pulse oximetry

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Pulse oximetryDevice
Noninvasive method of measuring the saturation of oxygen in the blood.

Study groups in NCT05690633
Study group	Role	What they receive
Palate	Experimental	The use of a pulse oximeter attached to an oral airway that is in contact with the palate in the oropharynx. Receives: Device: Pulse oximetry
Tongue	Experimental	The use of a pulse oximeter attached to an oral airway that is in contact with the tongue in the oropharynx. Receives: Device: Pulse oximetry

What is being measured

The primary outcome is the main question the study is designed to answer.

Oropharyngeal vs Extremity Saturation
Difference between the average oropharyngeal oxygen saturation and the average extremity oxygen saturation which were recorded every 2 minutes for a total of 30 minutes.
Measured: Baseline
ABG PaO2
The arterial blood gas (ABG) partial pressure of oxygen (PaO2) collected at the same time as the oropharyngeal oxygen saturation (SpO2) recording.
Measured: Baseline
Oropharyngeal SpO2
The oropharyngeal oxygen saturation (SpO2) recorded at the same time as the arterial blood gas (ABG) partial pressure of oxygen (PaO2) collection.
Measured: Baseline

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

9 Jan 202427 Jan 2025

First posted19 Jan 2023
Study start9 Jan 2024
Primary completion27 Jan 2025
Study completion27 Jan 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Publications (1)Papers the sponsor has linked to this study.
Other trials for SurgeryStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Diagnosis
Allocation: Non-randomised
Intervention model: Single group
Masking: None (open label)
Enrolment: 100 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT05690633
Sponsor's protocol ID: STUDY00003039
Status last verified: Mar 2026
First submitted: 10 Jan 2023
Last updated: 13 May 2026
Results posted: Yes, on ClinicalTrials.gov
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: Yes
Individual data sharing: No

Publications

Syed H, Villalobos EE, Kitio SAY, Hall B, Bryant J, Tobias JD. Feasibility of Obtaining Pulse Oximetry Readings From the Oropharynx. Paediatr Anaesth. 2025 Oct;35(10):816-821. doi: 10.1111/pan.70023. Epub 2025 Jul 31.
PubMed 40742001

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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Study at a glance

From the registry record, last updated by the sponsor on 13 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Feasibility of Obtaining Pulse Oximetry Readings From the Oropharynx
ClinicalTrials.gov ID: NCT05690633
Acronym / sponsor ID: STUDY00003039
Conditions: Surgery, Arterial Catheterization, Peripheral
Study type: Interventional
Recruitment status: Completed
Enrolment: 100 participants (actual)
Lead sponsor: Joseph D. TobiasUniversity, hospital or other
Study start: 9 Jan 2024 (actual)
Primary completion: 27 Jan 2025 (actual)
Study completion: 27 Jan 2025 (actual)
First posted: 19 Jan 2023 (actual)
Results: Posted 13 May 2026

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Diagnosis
Allocation: Non-randomised
Intervention model: Single group
Masking: None (open label)
Number of arms: 2

Arm	Type	Receives
Palate	Experimental	Device: Pulse oximetryThe use of a pulse oximeter attached to an oral airway that is in contact with the palate in the oropharynx.
Tongue	Experimental	Device: Pulse oximetryThe use of a pulse oximeter attached to an oral airway that is in contact with the tongue in the oropharynx.

Who may qualify

Sex: All
Healthy volunteers: Not accepted
Age groups: Child, Adult, Older adult

Key inclusion criteria (1 listed)

Patients undergoing a surgical procedure with general anesthesia and requiring an invasive arterial cannula

Key exclusion criteria (5 listed)

Patients in whom an arterial cannula is not indicated for the surgical procedure
Patients in whom a peripheral pulse oximeter value cannot be obtained
Patients in whom an invasive arterial cannula cannot be placed
Patients with any type of intra-oral pathology or injury
Patients in whom access to the oropharynx is restricted or not feasible for any clinical reason

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Pulse oximetryNoninvasive method of measuring the saturation of oxygen in the blood.	Device	Palate, Tongue

Primary outcome

Oropharyngeal vs Extremity Saturation
Time frame: Baseline
Difference between the average oropharyngeal oxygen saturation and the average extremity oxygen saturation which were recorded every 2 minutes for a total of 30 minutes.
ABG PaO2
Time frame: Baseline
The arterial blood gas (ABG) partial pressure of oxygen (PaO2) collected at the same time as the oropharyngeal oxygen saturation (SpO2) recording.
Oropharyngeal SpO2
Time frame: Baseline
The oropharyngeal oxygen saturation (SpO2) recorded at the same time as the arterial blood gas (ABG) partial pressure of oxygen (PaO2) collection.

Results and safety

Results posted to the registry on 13 May 2026, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
Palate	50	50
Tongue	50	50

Primary outcome: Oropharyngeal vs Extremity Saturation

Time frame: Baseline. Median (Inter-Quartile Range). Unit: percent of oxygen saturation

Measure	Palate n = 50	Tongue n = 50
Extremity	98 (97 to 99)	98 (97 to 99)
Oropharyngeal	95 (92 to 96)	99 (97 to 100)

Primary outcome: ABG PaO2

Time frame: Baseline. Median (Inter-Quartile Range). Unit: mmHg

Measure	Palate n = 50	Tongue n = 50
Value	167 (135 to 210)	237 (170 to 286)

Primary outcome: Oropharyngeal SpO2

Time frame: Baseline. Median (Inter-Quartile Range). Unit: percentage of oxygen saturation

Measure	Palate n = 50	Tongue n = 50
Value	100 (99.8 to 100)	100 (100 to 100)

Adverse events

Time frame: Day of surgery. Other adverse events reported at 5% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
Palate	0 of 50 (0%)	0 of 50 (0%)	0 of 50
Tongue	0 of 50 (0%)	0 of 50 (0%)	0 of 50

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 13 May 2026.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Derived from this study: PubMed 40742001Syed H, Villalobos EE, Kitio SAY, Hall B, Bryant J, Tobias JD. Feasibility of Obtaining Pulse Oximetry Readings From the Oropharynx. Paediatr Anaesth. 2025 Oct;35(10):816-821. doi: 10.1111/pan.70023. Epub 2025 Jul 31.
Individual participant dataSharing planned: No

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Spinal (Fusion) Surgery, Total Intravenous Anesthesia
RecruitingPhase 1
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RecruitingPhase 2
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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Pulse oximetry in people with Surgery and Arterial Catheterization, Peripheral, run by Joseph D. Tobias at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 13 May 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Oropharyngeal vs Extremity Saturation (time frame: Baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05690633, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2026.